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Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, March 10, 2011       Volume 26   Number 10


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Genomics & Health Impact Update Coming Soon

Starting March 24 2011, the Genomics & Health Weekly Update will have a new name – Genomics & Health Impact Update –and a new mission. The update will focus on genomic information that has more direct  impact on policy and practice. We will highlight news and information on evidence for new genomic tests and other applications, the use of family health history in practice, policy and legislation, clinical and public health programs as well as data and statistics on the impact of genomic information on population health.  From time to time, we will also have a genomics and health impact blog to share ideas and opinions and get input from our readers. We hope the new Genomics & Health Impact Update will be informative and useful to practitioners, policy makers, and consumers, and researchers. Look for the new update this month. We welcome your comments. Please send to:



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Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.


Routine DNA repair test recommended for bowel cancer, Medical News Today, March 10

ADAM-12 gene could hold key to cancer, arthritis and cardiac treatments, Science Daily, March 8

New large-scale prostate cancer genome project, PHG Foundation, March 7

Buddy Check 6: DNA test could determine if cancer patients will need chemo, WJBF TV, March 7

Critical step towards DNA test to detect early bowel cancer, Medical News Today, March 4

Vanderbilt-Ingram Cancer Center launches online genetic research tool, Vanderbilt University, March 3

Cardiovascular Disease

13 new heart-disease-associated gene sites identified, Medical News Today, March 7

Scientists discover SNPs linked with high risk of sick sinus syndrome, News-Medical.Net, March 6

Ethical, Legal, and Social Issues (ELSI)

FDA panel supports medical supervision of all genetic testing, PHG Foundation, March 10

Advisory committee tells FDA clinical genetic tests should only be provided through Docs, not DTC, Genome Web, March 9 [by free subscription only]

Genetic tests sold direct to consumers should be supervised by doctors says FDA panel, Medical News Today, March 9

Calls for strict regulation of direct-to-consumer genetic testing, PHG Foundation, March 6

U.S. experts to weigh consumer gene test standards, Alert Net, March 4

Genetic Testing

Whole-genome sequencing could complement GWAS to find rare variants associated with disease risk, Genome Web, March 8 [by free subscription only]

Making genome sequencing part of clinical care, Technology Review, March 8

Breakthrough: New blood test takes risk out of Down's testing, Medical News Today, March 7

Community commentary: Knowing your genetic risk can save your life, Daily Pilot, March 5

Personalized Medicine

Combining genomics and current medicines holds great promise for personalized cancer therapy, Medical News Today, March 4


UAE to host HGM 2011, WAM, March 9

World record for DNA analysis, Medical News Today, March 9

Improving understanding of genetic mechanisms of severe bone disease, Medical News Today, March 7

Gene responsible for severe osteoporosis disorder discovered, Science Daily, March 6

New research could bring gene therapy a step closer for Rett syndrome, an incurable genetic disorder, Medical News Today, March 6

Scientists shed light on future of genomics, NIH record, March 4

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Genomics in the Scientific Literature


Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing  salpingo-oophorectomy
Fakkert IE, et al.
Breast Cancer Res Treat 2011 Mar

Cancer genomics: from discovery science to personalized medicine
Chin L, et al.
Nat Med 2011 Mar;17(3):297-303

Cognitive, emotional and behavioral impact of an uncertain outcome after study of BRCA1/2: review of the literature
Leblond D, et al.
Bull Cancer 2011 Feb

Development and Evaluation of a Decision Aid for BRCA Carriers with Breast Cancer
Culver JO, et al.
J Genet Couns 2011 Mar

Effectiveness of alternating mammography and magnetic resonance imaging for screening women with deleterious BRCA mutations at high risk of breast cancer
Le-Petross HT, et al.
Cancer 2011 Mar

Fecal DNA testing for Colorectal Cancer Screening: the ColoSure™ test
Ned RM., Melillo, S and Marrone M.
PLoS Curr. 2011 March 8.

Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
Golka K, et al.
Arch Toxicol 2011 Mar

Cardiovascular Disease

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Peden JF, et al.
Nat Genet 2011 Mar

Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
Wang F, et al.
Nat Genet 2011 Mar

Genome-Wide Association Studies in Atherosclerosis
Sivapalaratnam S, et al.
Curr Atheroscler Rep 2011 Mar

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Schunkert H, et al.
Nat Genet 2011 Mar

Subjects with Molecularly Defined Familial Hypercholesterolemia or Familial Defective apoB-100 Are Not Being Adequately Treated
Leren TP & Berge KE
PLoS One 2011;6(2):e16721

Chronic Disease

Glaucoma database
K R, et al.
Bioinformation 2011;5(9):398-9


An Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program
Hivert MF, et al.
Diabetes 2011 Mar

Genomics: Drugs, diabetes and cancer
Birnbaum MJ & Shaw RJ
Nature 2011 Feb;470(7334):338-9

Ethical, Legal, and Social Issues (ELSI)

An Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program
Hivert MF, et al.
Diabetes 2011 Mar

Genomics: Drugs, diabetes and cancer
Birnbaum MJ & Shaw RJ
Nature 2011 Feb;470(7334):338-9

Family History

Adding familial risk assessment to faecal occult blood test can increase the effectiveness of population-based colorectal cancer screening
Dekker N, et al.
Eur J Cancer 2011 Feb

Incidence and mortality in epithelial ovarian cancer by family history of any cancer
Hemminki K, et al.
Cancer 2011 Mar

Genetic Testing

Genetic counselor opinions of, and experiences with telephone communication of BRCA1/2 test results
Bradbury AR, et al.
Clin Genet 2011 Feb;79(2):125-31

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice
Tester DJ & Ackerman MJ
Circulation 2011 Mar;123(9):1021-37

Teaching About Genetic Testing Issues in the Undergraduate Classroom: A Case Study
Rogers JC & Taylor AT
J Genet Couns 2011 Mar

Translational aspects of genetic factors in the prediction of drug response variability: a case study of warfarin pharmacogenomics in a multi-ethnic cohort from Asia
Chan SL, et al.
Pharmacogenomics J 2011 Mar

Neurologic Conditions

Genetics of Alzheimer's disease: new evidences for an old hypothesis?
Lambert JC & Amouyel P
Curr Opin Genet Dev 2011 Mar

Newborn Screening

Heterogeneity of hemoglobin H disease in childhood
Lal A, et al.
N Engl J Med 2011 Feb;364(8):710-8

Newborn screening for alpha-thalassemia--keeping up with globalization
Benz EJ Jr
N Engl J Med 2011 Feb;364(8):770-1


Barking up the wrong genome - we are not alone
Li-Wan-Po A & Farndon P
J Clin Pharm Ther 2011 Apr;36(2):125-7

Clinical Usefulness of Limited Sampling Strategies for Estimating AUC of Proton Pump Inhibitors
Niioka T
Yakugaku Zasshi 2011 Mar;131(3):407-13

Disposition of metformin: Variability due to polymorphisms of organic cation transporters
Zolk O
Ann Med 2011 Mar

Drug hypersensitivity: pharmacogenetics and clinical syndromes
Phillips EJ, et al.
J Allergy Clin Immunol 2011 Mar;127(3 Suppl):S60-6

From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
Wilffert B, et al.
Int J Clin Pharm 2011 Feb;33(1):3-9

Pharmacogenetics of alcohol, nicotine and drug addiction treatments
Sturgess JE, et al.
Addict Biol 2011 Mar

Pharmacogenomics in a community pharmacy: ACT now
Padgett L, et al.
J Am Pharm Assoc (2003) 2011 Mar-2011 Apr;51(2):189-93


For this week's human genome epidemiology articles, please visit the HuGE Navigator.


For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.



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