Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: firstname.lastname@example.org.
Thursday, June 30, 2011 Volume 26 Number 26
CDC has issued a Request for Information [PDF 185.98 KB] for comments, data, and other information helpful to assess the current research, policy, and practice environment in public health genomics, as part of a process to assess the most important steps for the field in the next five years.
New blog post: Genome vs. genome: E. coli sprouts in Germany
CDC information on the E. coli outbreak: Investigation Update: Outbreak of Shiga toxin-producing E. coli O104 (STEC O104:H4) Infections Associated with Travel to Germany
Latest news articles:
- A Decade of Inaction at USDA on Non-O157 E. coli, Food Safety News, June 29
- Sprout seeds suspected in French E coli cluster, CIDRAP, June 27
- E Coli in German outbreak has gene profile that may explain severity, Medical News Today, June 23
- New publication, Use of Epidermal Growth Factor Receptor Mutation Analysis in Patients with Advanced Non-Small-Cell Lung Cancer to Determine Erlotinib Use as First-Line Therapy, published in PLoS Currents: Evidence on Genomic Tests 2011 June 29. Authors: Naoko Ishibe, Josh Carlson, Scott D Ramsey, Andrew Freedman, Sheri Schully.
- The Centers for Disease Control and Prevention announces a new funding opportunity for programs to assist the adoption of evidence-based recommendations for breast cancer genomic tests and other related interventions into health practice maximizing health benefits and minimizing harm to individuals and populations.
Use of Epidermal Growth Factor Receptor Mutation Analysis in Patients with Advanced Non-Small-Cell Lung Cancer to Determine Erlotinib Use as First-Line Therapy
Naoko Ishibe, Josh Carlson, Scott D Ramsey, et al. PLoS Currents: Evidence on Genomic Tests 2011 Jun
New guide indicates when and how genetic testing is useful, Medical News Today, June 27
Clinical Use of the Surgeon General's "My Family Health Portrait" (MFHP) Tool: Opinions of Future Health Care Providers
Owens KM, et al. J Genet Couns 2011 Jun
Factors affecting encouragement of relatives among families with Lynch syndrome to seek medical assessment
Ishii N, et al. Fam Cancer 2011 Jun
A Survey of Ethical and Professional Challenges Experienced by Spanish Health-Care Professionals that Provide Genetic Counseling Services
Abad-Perotin R, et al. J Genet Couns 2011 Jun
An education model for integrating genetics and genomics into social work practice
Kingsberry SQ, et al. Soc Work Public Health 2011 Jun;26(4):392-404
Burke W, et al. Epidemiol Rev 2011 Jun
Management of Inherited Thrombophilia: Guide for Genetics Professionals
Varga EA & Kujovich JL Clin Genet 2011 Jun
Mutation analysis of KRAS prior to targeted therapy in colorectal cancer: development and evaluation of quality by a European external quality assessment scheme
Dequeker E, et al. Virchows Arch 2011 Jun
Effective drug treatment for cystic fibrosis, PHG Foundation, June 28
Closure of population biobanks and direct-to-consumer genetic testing companies
Zawati MH, et al. Hum Genet 2011 Jun
Ethical considerations for pharmacogenomic testing in pediatric clinical care and research
Moran C, et al. Pharmacogenomics 2011 Jun;12(6):889-95
Genomic databases access agreements: legal validity and possible sanctions
Joly Y, et al. Hum Genet 2011 Jun
Human genomics: challenges for African Americans and policy implications for direct social work practice
Walton LM Soc Work Public Health 2011 Jun;26(4):366-79
A new scoring system for the diagnosis of BRCA1/2 associated breast-ovarian cancer predisposition
Bonaiti B, et al. Bull Cancer 2011 Jun
Attitudes on DNA ancestry tests
Wagner JK & Weiss KM Hum Genet 2011 Jun
Keeping up with genetic discoveries in amyotrophic lateral sclerosis: The ALSoD and ALSGene databases
Lill CM, et al. Amyotroph Lateral Scler 2011 Jul;12(4):238-49
Parents' Experiences of Expanded Newborn Screening Evaluations
Deluca JM, et al. Pediatrics 2011 Jun
Using Alzheimer's disease as a model for genetic risk disclosure: Implications for personal genomics
Roberts JS, et al. Clin Genet 2011 Jun
Where in the Genome Are Significant Single Nucleotide Polymorphisms from Genome-Wide Association Studies Located?
Gunther T, et al. OMICS 2011 Jun
Researchers develop new gene therapy for heart failure, Medical News Today, June 29
Impact of PNPLA3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C.
Trépo E, Pradat P, Potthoff A. Hepatology. 2011 Apr 12.
Gene variant increases fatty liver risk and fibrosis progression, EurekAlert, June 28
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Ruth J F Loos, Tuomas O Kilpeläinen, M Carola Zillikens, et al. Nature Genetics (2011)
Gene that keeps you thin may raise risk of heart disease and diabetes, Medical News Today, June 27
Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
Chuong B. Do, Joyce Y. Tung, Elizabeth Dorfman, et al. PLoS Genet 7(6): e1002141
Two novel genetic associations with Parkinson's disease identified, Medical News Today, June 26
Exome Sequencing of Ion Channel Genes Reveals Complex Profiles Confounding Personal Risk Assessment in Epilepsy
Tara Klassen, Caleb Davis, Alica Goldman, Dan Burgess, et al. Cell 145(7):1036-1048
Genetic testing in epilepsy -- it takes more than 1 gene, Medical News Today, June 25
MHC region and risk of systemic lupus erythematosus in African American women.
Ruiz-Narvaez, Fraser PA, Palmer JR, et al. Human Genetics 2011 Jun 22
New genetic risk factors of lupus found in study of African-American women, EurekAlert, June 24
Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study.
Martina Bielaszewska, Alexander Mellmann, Wenlan Zhang, et al. The Lancet Infectious Diseases, Early Online Publication, 23 June 2011
E Coli in German outbreak has gene profile that may explain severity, Medical News Today, June 23
Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non–Small-Cell Lung Cancer in Asia (IPASS)
Fukuoka M, Wu YL, Thongprasert S,et al. J Clin Oncol. 2011 Jun 13.
Final IPASS data back EGFR testing before NSCLC treatment, Medscape, June 23
CDC authors are indicated in bold
A multiplex real-time PCR assay for detection of methicillin-resistant Staphylococcus aureus and associated toxin genes
Fosheim G, Nicholson A, Albrecht V, Limbago B. J Clin Microbiol. 2011 Jun 22.
Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance is primarily due to the TR/L98H mutation in the cyp51A gene
Lockhart SR, Frade JP, Etienne KA, Pfaller MA, Diekema DJ, Balajee SA. Antimicrob Agents Chemother. 2011 Jun 20.
Characterization and allelic polymorphisms of rhesus macaque (Macaca mulatta) IgG Fc receptor genes
Nguyen DC, Scinicariello F, Attanasio R. Immunogenetics. 2011 Jun;63(6):351-62.
Genetic variability, phylogenetic relationships and gene flow in Triatoma infestans dark morphs from the Argentinean Chaco
Piccinali RV, Marcet PL, Ceballos LA, Kitron U, Gurtler RE, Dotson EM. Infect Genet Evol. 2011 Jul;11(5):895-903.
Low-risk human papillomavirus testing and other nonrecommended human papillomavirus testing practices among U.S. health care providers
Lee JW, Berkowitz Z, Saraiya M. Obstet Gynecol. 2011 Jul;118(1):4-13.
Pandemic (H1N1) 2009 virus revisited: an evolutionary retrospective
Christman MC, Kedwaii A, Xu J, Donis RO, Lu G. Infect Genet Evol. 2011 Jul;11(5):803-11.
Personalized medicine: new genomics, old lessons
Offit K Hum Genet 2011 Jun
New prenatal tests offer safer, early screenings, The Wall Street Journal, June 28
Answers in the genes, Public Service UK, June 27
Free app provides DNA data for researchers: The Human Genome -- now on an IPad near you, Medical News Today, June 24
A probabilistic disease-gene finder for personal genomes
Yandell M, Huff CD, Hu H, et al. Genome Res. 2011 Jun 23.
Using VAAST to Identify an X-Linked Disorder Resulting in Lethality in Male Infants Due to N-Terminal Acetyltransferase Deficiency.
Rope AF, Wang K, Evjenth R, et al. Am J Hum Genet. 2011 Jun 22.
Software pinpoints cause of mystery genetic disorder, Nature News, June 23
VAAST potential for new genome mutation hunting software, Bio IT World, June 23
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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