Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: firstname.lastname@example.org.
Thursday, July 28, 2011 Volume 27 Number 4
CDC has issued a Request for Information (RFI) [PDF 185.98 KB] for comments, data, and other information helpful to assess the current research, policy, and practice environment in public health genomics, as part of a process to assess the most important steps for the field in the next five years. Submit comments in response to the RFI here.
- Blog post: Medications for the Masses? Pharmacogenomics is an Important Public Health Issue
- July is Colorectal Cancer Month
- New CDC Vital Signs: Colorectal Cancer Screening, Incidence, and Mortality
- Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives [PDF 219.30 KB]
- Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? [PDF 200.16KB]
- CDC Podcast: Genetic Testing for Lynch Syndrome in Colorectal Cancer.
Using a Family History Intervention to Improve Cancer Risk Perception in a Black Community
Murthy VS, et al. J Genet Couns 2011 Jul
Relative Familial Clustering of Cerebral Versus Coronary Ischaemic Events
Amitava Banerjee, Louise E. Silver, Carl Heneghan, et al. Circulation: Cardiovascular Genetics 2011 July 26
Inherited risk greater for heart attacks than for strokes, Medical News Today, July 27
Facilitating clinical implementation of pharmacogenomics
Mrazek DA & Lerman C JAMA 2011 Jul;306(3):304-5
Genetics and variable drug response
Wilke RA & Dolan ME JAMA 2011 Jul;306(3):306-7
Professional Perspectives About Pharmacogenetic Testing and Managing Ancillary Findings
Haga SB, et al. Genet Test Mol Biomarkers 2011 Jul
The clinical utility of gene testing for Alzheimer's disease
Atkins ER & Panegyres PK Neurol Int 2011 Jun;3(1):e1
Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians
Trivers K, Baldwin L, Miller J, et al. Cancer 2011 July 25
Mismatch between cancer genetics counseling and testing guidelines and physician practices, Medical News Today, July 25
Ethics of human genetic studies in Sub-Saharan Africa: the case of Cameroon through a bibliometric analysis
Wonkam A, et al. Dev World Bioeth 2011 Jul
The ethical implications of genetic testing in the classroom
Taylor AT & Rogers JC Biochem Mol Biol Educ 2011 Jul;39(4):253-60
Towards a data sharing Code of Conduct for international genomic research
Knoppers BM, et al. Genome Med 2011 Jul;3(7):46
Genetic testing of embryos to become legal in Germany, PHG Foundation, July 25
Rule changes proposed for research on humans, The New York Times, July 24
Children's Hospital, Genethon get FDA OK for gene therapy trial, Mass High Tech, July 22
Clinical implementation of pharmacogenetics: a nonrepresentative explorative survey to participants of WorldPharma 2010
Ghaddar F, et al. Pharmacogenomics 2011 Jul;12(7):1051-9
Evidence for Age As a Modifier of Genetic Associations for Lipid Levels
Dumitrescu L, et al. Ann Hum Genet 2011 Jul
Predictors of Heart-Focused Anxiety in Patients Undergoing Genetic Investigation and Counseling of Long QT Syndrome or Hypertrophic Cardiomyopathy: A One Year Follow-up
Hamang A, et al. J Genet Couns 2011 Ju
Genetic Association of Recovery from Eating Disorders: The Role of GABA Receptor SNPs
Cinnamon S Bloss, Wade Berrettini, Andrew W Bergen, et al. Neuropsychopharmacology 2011, July 13
Study sheds light on role of genetics in eating disorders, Medical News Today, July 27
Germline Mutations in MSR1, ASCC1, and CTHRC1 in Patients With Barrett Esophagus and Esophageal Adenocarcinoma
Mohammed Orloff, Charissa Peterson, Xin He, et al. JAMA 2011: 306(4):410-419
Researchers identify genetic mutations associated with diseases of the esophagus, Science Daily, July 26
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
Timothy Best, Dalin Li, Andrew D Skol, et al. Nature Medicine 2011 July 24
Predicting second cancers after radiation for children with Hodgkin lymphoma, Medical News Today, July 25
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development.
Wu J, Matthaei H, Maitra A, et al. Sci Transl Med. 2011 Jul 20;3(92):92ra66.
Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts, Science Daily, July 22
Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis
Grenert JP, Smith A, Ruan W, et al. Clin Chim Acta. 2011 Jul 15;412(15-16):1462-4.
Molecular test aids in identifying cancers of unknown origin, Medscape, July 22
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
Caicun Zhou, Yi-Long Wu, Gongyan Chen, et al, Lancet Oncol. July 22
Another study shows Erlotinib Benefit in EGFR-positive NSCLC, Medscape, July 21 [by free subscription only]
CDC authors are indicated in bold
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK. PLoS One. 2011 ;6(6):e20215.
Employment and work schedule are related to telomere length in women
Parks CG, Deroo LA, Miller DB, McCanlies EC, Cawthon RM, Sandler DP. Occup Environ Med. 2011 Aug;68(8):582-9.
Scientists retract report on predicting longevity, The New York Times, July 22
Massive project to study the link between genetics and health, Technology Review, July 26
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly
Li Y, Zheng H, Luo R, et al. Nat Biotechnol. 2011 Jul 24.
New strategy to uncover structural variations of human genomes, Science Daily, July 26
NHGRI to dive into ethical, legal, social issues, Genome Web, July 26 [by free subscription only]
Genetic testing can help the US cut costs and improve health care, Bio-Medicine, July 25
Genomics for the world,
Bustamante CD, Burchard EG, De la Vega FM. Nature 2011 Jul 13;475(7355):163-5.
Genomic studies focus too heavily on Europeans, Bio News July 25
Oh, the potential, Genome Web, July 25 [by free subscription only]
NIH to fund substance use gene-environment studies, Genome Web, July 22 [by free subscription only]
Decoding DNA with semiconductors, The New York Times, July 21
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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