Genomics & Health Impact Update

Using a Family History Intervention to Improve Cancer Risk Perception in a Black  Community
Murthy VS, et al. J Genet Couns 2011 Jul

Relative Familial Clustering of Cerebral Versus Coronary Ischaemic Events
Amitava Banerjee, Louise E. Silver, Carl Heneghan, et al. Circulation: Cardiovascular Genetics 2011 July 26

Inherited risk greater for heart attacks than for strokes, Medical News Today, July 27

Facilitating clinical implementation of pharmacogenomics
Mrazek DA & Lerman C JAMA 2011 Jul;306(3):304-5

Genetics and variable drug response  
Wilke RA & Dolan ME JAMA 2011 Jul;306(3):306-7

Professional Perspectives About Pharmacogenetic Testing and Managing Ancillary Findings
Haga SB, et al. Genet Test Mol Biomarkers 2011 Jul

The clinical utility of gene testing for Alzheimer's disease
Atkins ER & Panegyres PK Neurol Int 2011 Jun;3(1):e1

Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians
Trivers K, Baldwin L, Miller J, et al. Cancer 2011 July 25

Mismatch between cancer genetics counseling and testing guidelines and physician practices, Medical News Today, July 25

Ethics of human genetic studies in Sub-Saharan Africa: the case of Cameroon through a bibliometric analysis
Wonkam A, et al. Dev World Bioeth 2011 Jul

The ethical implications of genetic testing in the classroom
Taylor AT & Rogers JC Biochem Mol Biol Educ 2011 Jul;39(4):253-60

Towards a data sharing Code of Conduct for international genomic research
Knoppers BM, et al. Genome Med 2011 Jul;3(7):46

Genetic testing of embryos to become legal in Germany, PHG Foundation, July 25

Rule changes proposed for research on humans, The New York Times, July 24

Children's Hospital, Genethon get FDA OK for gene therapy trial, Mass High Tech, July 22

Clinical implementation of pharmacogenetics: a nonrepresentative explorative survey to participants of WorldPharma 2010
Ghaddar F, et al. Pharmacogenomics 2011 Jul;12(7):1051-9

Evidence for Age As a Modifier of Genetic Associations for Lipid Levels
Dumitrescu L, et al. Ann Hum Genet 2011 Jul

Predictors of Heart-Focused Anxiety in Patients Undergoing Genetic Investigation  and Counseling of Long QT Syndrome or Hypertrophic Cardiomyopathy: A One Year Follow-up
Hamang A, et al. J Genet Couns 2011 Ju

Genetic Association of Recovery from Eating Disorders: The Role of GABA Receptor SNPs
Cinnamon S Bloss, Wade Berrettini, Andrew W Bergen, et al. Neuropsychopharmacology 2011, July 13

Study sheds light on role of genetics in eating disorders, Medical News Today, July 27

Germline Mutations in MSR1, ASCC1, and CTHRC1 in Patients With Barrett Esophagus and Esophageal Adenocarcinoma
Mohammed Orloff, Charissa Peterson, Xin He, et al. JAMA 2011: 306(4):410-419

Researchers identify genetic mutations associated with diseases of the esophagus, Science Daily, July 26

Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
Timothy Best, Dalin Li, Andrew D Skol, et al. Nature Medicine 2011 July 24

Predicting second cancers after radiation for children with Hodgkin lymphoma, Medical News Today, July 25

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development.
Wu J, Matthaei H, Maitra A, et al. Sci Transl Med. 2011 Jul 20;3(92):92ra66.

Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts, Science Daily, July 22

Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis
Grenert JP, Smith A, Ruan W, et al. Clin Chim Acta. 2011 Jul 15;412(15-16):1462-4.

Molecular test aids in identifying cancers of unknown origin, Medscape, July 22

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
Caicun Zhou, Yi-Long Wu, Gongyan Chen, et al, Lancet Oncol. July 22

Another study shows Erlotinib Benefit in EGFR-positive NSCLC, Medscape, July 21 [by free subscription only]

Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK. PLoS One. 2011 ;6(6):e20215.

Employment and work schedule are related to telomere length in women
Parks CG, Deroo LA, Miller DB, McCanlies EC, Cawthon RM, Sandler DP. Occup Environ Med. 2011 Aug;68(8):582-9.

Scientists retract report on predicting longevity, The New York Times, July 22

Massive project to study the link between genetics and health, Technology Review, July 26

Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly
Li Y, Zheng H, Luo R, et al. Nat Biotechnol. 2011 Jul 24.

New strategy to uncover structural variations of human genomes, Science Daily, July 26

NHGRI to dive into ethical, legal, social issues, Genome Web, July 26 [by free subscription only]

Genetic testing can help the US cut costs and improve health care, Bio-Medicine, July 25

Genomics for the world,
Bustamante CD, Burchard EG, De la Vega FM. Nature 2011 Jul 13;475(7355):163-5.

Genomic studies focus too heavily on Europeans, Bio News July 25

Oh, the potential, Genome Web, July 25 [by free subscription only] 

NIH to fund substance use gene-environment studies, Genome Web, July 22 [by free subscription only]

Decoding DNA with semiconductors, The New York Times, July 21