 For information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base |
 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.
Thursday, July 21, 2011 Volume 27 Number 3
Spotlight
CDC has issued a Request for Information (RFI) [PDF 185.98 KB] for comments, data, and other information helpful to assess the current research, policy, and practice environment in public health genomics, as part of a process to assess the most important steps for the field in the next five years. Submit comments in response to the RFI here.
Announcements
- The National Human Genome Research Institute, along with several other NIH Institutes, published three new program announcements to encourage research that identifies, examines and addresses the ethical, legal and social implications (ELSI) of advances in genomic research and technology.
New blog post: Medications for the Masses? Pharmacogenomics is an Important Public Health Issue- New publication, Use of Oncotype DX in Women with Node-Positive Breast Cancer, published in PLoS Currents: Evidence on Genomic Tests 2011 July 21. Authors: Naoko Ishibe, Sheri Schully, Andrew Freedman and Scott David Ramsey
- The journal Public Health Genomics has published a special topic issue on Health Literacy
- CDC Feature: Fragile X Syndrome and Associated Disorders
- July is National Hemochromatosis Awareness Month
- July is Colorectal Cancer Month
- New CDC Vital Signs: Colorectal Cancer Screening, Incidence, and Mortality
- Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives [PDF 219.30 KB]
- Recommendations from the EGAPP Working Group: can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? [PDF 200.16KB]
- CDC Podcast: Genetic Testing for Lynch Syndrome in Colorectal Cancer
- New publication, Genetic Testing for Lynch Syndrome in Individuals Newly Diagnosed with Colorectal Cancer to Reduce Morbidity and Mortality from Colorectal Cancer in Their Relatives, published in PLoS Currents: Evidence on Genomic Tests 2011 July 6. Authors: Ralph Coates, Marc Williams, Stephanie Melillo, Jim Gudgeon.
- New publication, Strategies to Identify the Lynch Syndrome Among Patients With Colorectal Cancer: A Cost-Effectiveness Analysis, published in Annals of Internal Medicine 2011; vol. 155 no. 2 69-79. Authors: Ladabaum U, Wang G, Terdiman J, Blanco A, Kuppermann M, Boland CR, Ford J, Elkin E, Phillips KA.
- New summary for patients, Comparing the benefits and costs of testing for genetic causes of colon cancer, published in Annals of Internal Medicine 2011 Jul; 155(2):I36.
- New editorial, Who Should Have Genetic Testing for the Lynch Syndrome, published in Annals of Internal Medicine 2011 Jul; 155(2):127-8. Author: Randall W. Burt.
Topics
Genomic Tests
A 20 gene model for predicting nodal involvement in bladder cancer patients with muscle invasive tumors
Garrett Dancik, Dara Aisner and Dan Theodorescu. PLoS Currents: Evidence on Genomic Tests 2011 July 21
Use of Oncotype DX in Women with Node-Positive Breast Cancer
Naoko Ishibe, Sheri Schully, Andrew Freedman and Scott David Ramsey. PLoS Currents: Evidence on Genomic Tests 2011 July 21
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base.
Family Health History
A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact
Macinnis RJ, et al. Genet Epidemiol 2011 Jul
Community attitudes to genetic susceptibility-based mental health interventions for healthy people in a large national sample
Wilde A, et al. J Affect Disord 2011 Jul
Clinically relevant changes in family history of cancer over time.
Ziogas A, Horick NK, Kinney AY, et al. JAMA. 2011 Jul 13;306(2):172-8.
Family history of cancer important in screening assessment, Medscape, July 19
How a family tree can save your life, The Independent, July 19
Practice and Programs
The California Prenatal Screening Program: "options and choices" not "coercion and eugenics"
Flessel MC & Lorey FW Genet Med 2011 Jul
Policy and Legislation
Biobanking and public health: is a human rights approach the tie that binds?
Meslin EM & Garba I Hum Genet 2011 Jul
Discovery of genetic susceptibility factors for human birth defects: An opportunity for a national agenda
Olshan AF, et al. Am J Med Genet A 2011 Jul
Germany allows restricted access to preimplantation genetic testing
Tuffs A BMJ 2011;343:d4425
KRAS and Colorectal Cancer: Ethical and Pragmatic Issues in Effecting Real-Time Change in Oncology Clinical Trials and Practice
Blanke CD, et al. Oncologist 2011 Jul
Personalized medicine and tobacco-related health disparities: is there a role for genetics?
Carlsten C, et al. Ann Fam Med 2011 Jul-2011 Aug;9(4):366-71
A regulatory framework for sequencing based diagnostics, PHG Foundation, July 15
FDA proposals on regulation of stratified medicines, PHG Foundation, July 14
Data and Statistics
Community attitudes to genetic susceptibility-based mental health interventions for healthy people in a large national sample
Wilde A, et al. J Affect Disord 2011 Jul
Integrating Genetic Studies of Nicotine Addiction into Public Health Practice: Stakeholder Views on Challenges, Barriers and Opportunities
Dingel MJ, et al. Public Health Genomics 2011 Jul
Primary Care Physicians' Awareness, Experience and Opinions of Direct-to-Consumer Genetic Testing
Powell KP, et al. J Genet Couns 2011 Jul
Successful recruitment of healthy African American men to genomic studies from high-volume community health fairs: Implications for future genomic research in minority populations
Patel YR, et al. Cancer 2011 Jul
Willingness to Pay for Genetic Testing for Alzheimer's Disease: A Measure of Personal Utility
Kopits IM, et al. Genet Test Mol Biomarkers 2011 Jul
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Kote-Jarai Z, Olama AA, Giles GG, et al. Nat Genet. 2011 Jul 10.
Seven novel prostate susceptibility loci identified, PHG Foundation, July 19
704 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Genetic testing for Lynch syndrome in individuals newly diagnosed with colorectal cancer to reduce morbidity and mortality from colorectal cancer in their relatives
Coates R, Williams M, Melillo S, Gudgeon J. PLoS Curr. 2011 ;3:RRN1246.
Genetic variability in susceptibility to occupational respiratory sensitization
Yucesoy B, Johnson VJ. J Allergy (Cairo). 2011 ;2011:346719.
Genomic evolution and phenotypic distinctions of Chikungunya viruses causing the Indian Ocean outbreak
Powers AM. Exp Biol Med (Maywood). 2011 Jul 12.
Identification of Leishmania spp. by molecular amplification and DNA sequencing analysis of a fragment of the rRNA Internal Transcribed Spacer 2 (ITS2
de Almeida ME, Steurer FJ, Koru O, Herwaldt BL, Pieniazek NJ, da Silva AJ. J Clin Microbiol. 2011 Jul 13.
View previous CDC-authored publications
Let's Go Surfing
CDC wants near-term public health genomics plans, Genome Web, July 20 [by free subscription only]
Gregor Mendel Google logo gives peas a chance, Search Engine Watch, July 20
Personalized medicine: a windfall for science, but what about patients
Browman G, Hebert PC, Coutts J, et al. CMAJ. 2011 Jul 18.
Unrealistic expectations by the public of personalized medicine, Medical News Today, July 19
Add patience to a leap of faith to discover cancer signatures, The New York Times, July 18
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth.
Eskiocak U, Kim SB, Ly P, et al. Cancer Res. 2011 Jul 1;71(13):4359-65.
Research reveals that significantly more genetic mutations lead to colon cancer, Medical News Today, July 16
Over-the-counter genetic tests: Buyer beware, AARP, July 15
Genetic code of E. Coli is hijacked by biologists, The New York Times, July 14
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Possemato R, Marks KM, Shaul YD, et al. Nature. 2011 Jul 14.
Gene link to 70% of hard-to-treat breast cancers, BBC News, July 14
Events and Training
The Leena Peltonen School of Human Genomics
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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