Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: email@example.com.
Thursday, July 7, 2011 Volume 27 Number 1
CDC has issued a Request for Information (RFI) [PDF 185.98 KB] for comments, data, and other information helpful to assess the current research, policy, and practice environment in public health genomics, as part of a process to assess the most important steps for the field in the next five years. Submit comments in response to the RFI here.
New publication, Genetic Testing for Lynch Syndrome in Individuals Newly Diagnosed with Colorectal Cancer to Reduce Morbidity and Mortality from Colorectal Cancer in Their Relatives, published in PLoS Currents: Evidence on Genomic Tests 2011 July 6. Authors: Ralph Coates, Marc Williams, Stephanie Melillo, Jim Gudgeon.
The Centers for Disease Control and Prevention announces a new funding opportunity for programs to assist the adoption of evidence-based recommendations for breast cancer genomic tests and other related interventions into health practice maximizing health benefits and minimizing harm to individuals and populations.
The Need for Vigilance: The Case of a False-Negative Newborn Screen for Cystic Fibrosis
Dunn CT, et al. Pediatrics 2011 Jul
What questions should newborn screening long-term follow-up be able to answer? A statement of the US Secretary for Health and Human Services' Advisory Committee on Heritable Disorders in Newborns and Children
Hinton CF, et al. Genet Med 2011 Jun
Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association Expert Panel on Familial Hypercholesterolemia.
Goldberg AC, Hopkins PN, Toth PP, et al. J Clin Lipidol. 2011 Jun;5(3 Suppl):S1-8. Epub 2011 Apr 12.
Screening for lipid disorders in kids, Medscape Today, July 5
Familial Hypercholesterolemia, Medscape, June 29
Born Healthy - new global community to tackle birth defects, PHG Foundation, June 30
Long-term outcomes of BRCA1/BRCA2 testing: risk reduction and surveillance
Schwartz MD, et al. Cancer 2011 Jun
The General Public's Understanding and Perception of Direct-to-Consumer Genetic Test Results
Leighton JW, et al. Public Health Genomics 2011 Jun
Integrated genomic analyses of ovarian carcinoma.
The Cancer Genome Atlas Research Network, et al. Nature. 2011 Jun 29;474(7353):609-615.
Mapping of ovarian cancer genome, PHG Foundation, July 6
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.
Miki D, Ochi H, Hayes CN, et al. Nat Genet. 2011 Jul 3. doi: 10.1038/ng.876.
Genetic variant linked to development of liver cancer In Hepatitis C virus carriers, Medical News Today, July 5
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism.
Hallmayer J, Cleveland S, Torres A, et al. Arch Gen Psychiatry. 2011 Jul 4
Balance tips toward environment as heritability ebbs in autism? NIH News, July 5
New study implicates environmental factors in autism, The New York Times, July 4
Clinical effect of point mutations in myelodysplastic syndromes.
Bejar R, Stevenson K, Abdel-Wahab O, Galili N, et al. N Engl J Med. 2011 Jun 30;364(26):2496-506.
Improved diagnosis of myelodysplastic syndromes following discovery of genetic mutations, Medical News Today, July 1
Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals.
Chugh PloS Genetics 2011 published online 30 June 2011
Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest, Medical News Today, July 1
Multiplicity: an organizing principle for cancers and somatic mutations.
Frey LJ, Piccolo SR, Edgerton ME. BMC Med Genomics. 2011 Jun 29;4(1):52.
Novel analysis method organizes genomic cancer data, Medical News Today, June 30
CDC authors are indicated in bold
Efficient DNA extraction for HPV genotyping in formalin-fixed, paraffin-embedded tissues
Steinau M, Patel SS, Unger ER. J Mol Diagn. 2011 Jul;13(4):377-81.
Phylogenetic analysis of eastern equine encephalitis virus isolates from Florida
White GS, Pickett BE, Lefkowitz EJ, Johnson AG, Ottendorfer C, Stark LM, Unnasch TR. Am J Trop Med Hyg. 2011 May;84(5):709-17.
Roots of disease found to vary by continent, The New York Times, July 4
'Data gone wrong': Unreproducible cancer genomics studies, Medscape, June 30
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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