Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, February 24, 2011 Volume 26 Number 8
February is Heart Month
Heart disease is the leading cause of death and a major cause of disability in the United States. More than 600,000 Americans die of heart disease annually. Having close biological relatives with heart disease can increase your risk of developing this disease. Family health history offers important information to help you and your family members understand health risks and prevent disease. Learn more.
- Special February issue of Genetics in Medicine celebrates the founding of the American College of Medical Genetics twenty years ago this month. This issue features a look back, a glimpse of the present, and commentaries that describe contrasting futures for medical genetics, as well as a world-wide collaboration on newborn screening of metabolic disorders.
- New publication of interest published in special issue of Genetics in Medicine, February 2011: Public health genomics: The end of the beginning. Author: Khoury MJ.
- NIH will celebrate the Fourth Annual Rare Disease Day on February 28th, with a day-long celebration co-sponsored by NIH’s Office of Rare Diseases Research and the Clinical Center. Learn more and register.
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
FDA approves product to prevent bleeding in people with rare genetic defect, Medical News Today, February 18
New technology pinpoints genetic differences between cancer, non-cancer patients, Medical News Today, February 23
Gene test for prostate cancer in the works, Medical News Today, February 17
Gene mutation linked to high blood pressure, Ivanhoe, February 18
University team's genetic breakthrough in kidney research, Bristol, February 19
Cancer Center of Santa Barbara offers genetic counseling services, The Santa Barbara Independent, February 22
Family health history is important screening tool, Medical News Today, February 23
Genetic testing should be conducted by qualified health professionals, The Medical News, February 23
Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversity, Eurekalert, February 23
Home genetic testing, CBC News, February 21
Program gives women whose genetic testing shows high risk for cancer…, Mlive.com, February 20
Researchers use genomics to investigate TB outbreak, EurekAlert, February 23
Vaccine made with synthetic gene protects against deadly pneumonia, Medical News Today, February 22
Reverse genetics allow scientists to slow the spread of the Rubella virus, Medical News Today, February 18
Metastatic childhood cancers investigated via new genomics research, Medical News Today, February 23
CHEO launches new genetics study, CBCNews, February 22
Schizophrenia gene mutation found; Target for new drugs, Science Daily, February 23
A new clue to the genetics of bipolar disorder: Piccolo, Physorg.com, February 23
An EU-wide study has found five new genetic variants for Parkinson's disease, Balkans.com, February 21
Genetic treatment for epilepsy unlikely, The Hindu, February 20
Trial shows cystic fibrosis drug helped ease breathing, New York Times, February 23
Study shows alcohol intoxication, driving intention linked to genes, PRNewswire, February 23
International study shows that reprogramming cells leads to genomic aberrations, Medical News Today, February 22
Wellcome Trust reviews progress in human genetics, PHG Foundation, February 21
Promise of genomics research needs a realistic view, Medical News Today, February 18
Rare Disease Day at NIH presents latest research from various agencies and advocacy groups, NIH News, February 17
Cleft lip and palate: understanding genetic and environmental influences
Dixon MJ, et al.
Nat Rev Genet 2011 Mar;12(3):167-78
Descriptive study of nonsyndromic atrioventricular septal defects in the National Birth Defects Prevention Study, 1997-2005
Hartman RJ, et al.
Am J Med Genet A 2011 Feb
A novel network model identified a 13-gene lung cancer prognostic signature
Guo NL, et al.
Int J Comput Biol Drug Des 2011;4(1):19-39
Identification of SNPs associated with susceptibility for development of adverse reactions to radiotherapy
Pharmacogenomics 2011 Feb;12(2):267-75
New insights into the prevention and treatment of familial breast cancer
J Surg Oncol 2011 Mar;103(4):294-8
Pathology of hereditary breast cancer
van der Groep P, et al.
Cell Oncol (Dordr) 2011 Feb
Polymorphisms of Tumor Necrosis Factor-Alpha and Hepatocellular Carcinoma Risk: A HuGE Systematic Review and Meta-Analysis
Wei Y, et al.
Dig Dis Sci 2011 Feb
The Role of Genetics in IBS
Gastroenterol Clin North Am 2011 Mar;40(1):45-67
Genetics of occupational asthma
Curr Opin Allergy Clin Immunol 2011 Feb
Ethical issues in developing pharmacogenetic research partnerships with american indigenous communities
Boyer BB, et al.
Clin Pharmacol Ther 2011 Mar;89(3):343-5
A New Method for FMR1 Gene Methylation Screening by Multiplex Methylation-Specific Real-Time Polymerase Chain Reaction
Elias MH, et al.
Genet Test Mol Biomarkers 2011 Feb
Familial Hyperparathyroidism Due to a Germline Mutation of the CDC73 gene: Implications for Management and Age-Appropriate Testing of Relatives at Risk
Pichardo-Lowden AR, et al.
Endocr Pract 2011 Feb:1-20
Lynch Syndrome and MYH-Associated Polyposis: Review and Testing Strategy
Goodenberger M & Lindor NM
J Clin Gastroenterol 2011 Feb
Reflex testing of resected stage I through III lung adenocarcinomas for EGFR and KRAS mutation: report on initial experience and clinical utility at a single center
D'Angelo SP, et al.
J Thorac Cardiovasc Surg 2011 Feb;141(2):476-80
Molecular immunity to mycobacteria: knowledge from the mutation and phenotype spectrum analysis of Mendelian susceptibility to mycobacterial diseases
Qu HQ, et al.
Int J Infect Dis 2011 Feb
Genomics for disease treatment and prevention
Bloss CS, et al.
Psychiatr Clin North Am 2011 Mar;34(1):147-66
Pharmacogenomics: "noninferiority" is sufficient for initial implementation
Clin Pharmacol Ther 2011 Mar;89(3):348-50
Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity
Kim KP, et al.
Br J Cancer 2011 Feb;104(4):605-12
Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practice
Schnoll RA & Shields AE
Clin Pharmacol Ther 2011 Mar;89(3):345-7
Genetic vulnerability and susceptibility to substance dependence
Neuron 2011 Feb;69(4):618-27
Pharmacogenetics of Smoking Cessation in General Practice: Results From the Patch II and Patch in Practice Trials
David SP, et al.
Nicotine Tob Res 2011 Jan
Genetic educational needs and the role of genetics in primary care: a focus group study with multiple perspectives
Houwink IJ, et al.
BMC Fam Pract 2011 Feb;12(1):5
Parents' and children's communication about genetic risk: a qualitative study, learning from families' experiences
Metcalfe A, et al.
Eur J Hum Genet 2011 Feb
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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