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Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, February 17, 2011       Volume 26   Number 7


old woman and young man

February is Heart Month

Heart disease is the leading cause of death and a major cause of disability in the United States. More than 600,000 Americans die of heart disease annually. Having close biological relatives with heart disease can increase your risk of developing this disease. Family health history offers important information to help you and your family members understand health risks and prevent disease. Learn more.



  • Genetic Alliance invites proposals for the Family Health History Patient Education Toolkit: Health Center Program Awards. Genetic Alliance will select up to six HRSA-supported health centers, each to receive $40,000, to integrate the Does It Run In the Family? health history toolkit into their clinical care and/or outreach services. Proposals will be accepted until April 4, 2011. Contact Vaughn Edelson at or 202.966.5557 x213 for more information.

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Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.


New insight for prostate cancer treatment and prognosis, PHG Foundation, February 16

Whole genome sequencing used to help inform cancer therapy, EurekAlert, February 16

Genomics Consortium launches $20M prostate cancer project, Genome Web, February 15 [by free subscription only]

Presence of 'jumping genes,' amplified oncogenes may be key to tumor progression, Medical News Today, February 14

Cardiovascular Disease

Researchers link gene mutations to Ebstein's anomaly, EurekAlert, February 16

Researchers link gene mutations to high blood pressure, Medical News Today, February 12


Decades of dwarf research may unveil new CVD statin, Medical News Today, February 17

Ethical, Legal, and Social Issues (ELSI)

Genome protection, Genome Web, February 14 [by free subscription only]

DNA tests might cause ethical dilemmas, Top News, February 11

Genetic Bill of Rights in Mass. seeks to extend protections in life, auto, long-term care insurance, Genome Web, February 14 [by free subscription only]

New bill would require licensing of genetic counselors, OA Online, February 11

Genetic Testing

Hope for accurate diagnosis of Turner syndrome, Medical News Today, February 17

Discovery of new gene test for inherited neuromuscular disorder, Medical News Today, February 14

Recommendations on genetic testing for common disorders, PHG Foundation, February 11

ESHG makes recommendations on genetic testing, Genome Web, February 11 [by free subscription only]

Genetic testing for inherited blood-clotting abnormalities not routinely recommended for VTE patients, News-Medical.Net, February 11

Noninvasive test for trisomy 21 closer at hand, EurekAlert, February 10

Maternal and Child Health

Autoimmune genes linked to preeclampsia, Medical News Today, February 15

Mental Health

New link between genes, stress … and depression, Ivanhoe, February 11

Neurologic Conditions

An early step in Parkinson's disease: Problems with mitochondria, Medical News Today, February 15


NIH proposed budget highlights genomics, translational efforts, Genome Web, February 15 [by free subscription only]

NHGRI's new strategic plan to identify genetic bases of most single-gene disorders, News-Medical.Net, February 14

Strategic vision for the future of genomic medicine, PHG Foundation, February 14

Human Genome 10th Anniversary what would you do, Science, February 11

Genome Research Institute: The future of gene disorder study is here, Medical News Today, February 10

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Genomics in the Scientific Literature

Autoimmune Disease

Genetic susceptibility to autoimmune liver disease
Mattner J
World J Hepatol 2011 Jan;3(1):1-7

Birth Defects

Polymorphisms in genes involved in folate metabolism and orofacial clefts
Bhaskar LV, et al.
Arch Oral Biol 2011 Feb


Genetic counseling for patients and families with hereditary breast and ovarian cancer in a developing Asian country: an observational descriptive study
Yoon SY, et al.
Fam Cancer 2011 Feb

Genetic modifiers of cancer risk for BRCA1 and BRCA2 mutation carriers
Milne RL & Antoniou AC
Ann Oncol 2011 Jan;22 Suppl 1:i11-7

Cardiovascular Disease

Nutrigenetics of the Postprandial Lipoprotein Metabolism: Evidences from Human Intervention Studies
Perez-Martinez P, et al.
Curr Vasc Pharmacol 2011 Feb

Utility of genetic determinants of lipids and cardiovascular events in assessing risk
Holmes MV, et al.
Nat Rev Cardiol 2011 Feb

Chronic Disease

Gene-gene and gene-environment interactions defining lipid-related traits
Ordovas JM, et al.
Curr Opin Lipidol 2011 Feb

Genome-wide association studies in multiple sclerosis: lessons and future prospects
Kemppinen A, et al.
Brief Funct Genomics 2011 Feb


Cancer epigenetics: linking basic biology to clinical medicine
Tsai HC & Baylin SB
Cell Res 2011 Feb

Epigenetics meets endocrinology
Zhang X & Ho SM
J Mol Endocrinol 2011 Jan;46(1):R11-32

Epigenetics: Deciphering its role in Diabetes and its Chronic Complications
Villeneuve LM, et al.
Clin Exp Pharmacol Physiol 2011 Feb

The Path to Epigenetic Treatment of Memory Disorders
Mikaelsson MA & Miller CA
Neurobiol Learn Mem 2011 Feb

Ethical, Legal, and Social Issues (ELSI)

Downsizing genomic medicine: Approaching the ethical complexity of whole-genome sequencing by starting small
Sharp RR
Genet Med 2011 Feb

It's About Scientific Secrecy, Dummy: A Better Equilibrium Among Genomics Patenting, Scientific Research and Health Care
Bentwich M
Sci Eng Ethics 2011 Feb

On the future of genomic data
Kahn SD
Science 2011 Feb;331(6018):728-9

Social and ethical implications of BRCA testing
Surbone A
Ann Oncol 2011 Jan;22 Suppl 1:i60-6

Family History

A systematic review of gynecological cancer surveillance in women belonging to Hereditary Nonpolyposis Colorectal Cancer (Lynch syndrome) families
Auranen A & Joutsiniemi T
Acta Obstet Gynecol Scand 2011 Feb

Examining risk perception among men with a family history of prostate cancer
Matthew AG, et al.
Patient Educ Couns 2011 Feb

Family history is a risk factor for chronic obstructive pulmonary disease
Hersh CP, et al.
Chest 2011 Feb

Infectious Disease

Genetic polymorphisms in sepsis
Namath A & Patterson AJ
Crit Care Nurs Clin North Am 2011 Mar;23(1):181-202

Neurologic Conditions

Power and Pitfalls of the Genome-Wide Association Study Approach to Identify Genes for Alzheimer's Disease
Sherva R & Farrer LA
Curr Psychiatry Rep 2011 Feb

Personalized Medicine

Genomic Risk Profiling: Attitudes and Use in Personal and Clinical Care of Primary Care Physicians Who Offer Risk Profiling
Haga SB, et al.
J Gen Intern Med 2011 Feb

Platelet Function and Antiplatelet Therapy in Cardiovascular Disease: Implications of Genetic Polymorphisms
Shanker J, et al.
Curr Vasc Pharmacol 2011 Feb


Databases in the area of pharmacogenetics
Sim SC, et al.
Hum Mutat 2011 Feb

Genetic testing for aldehyde dehydrogenase 2 deficiency in young adults
Hendershot CS
Pharmacogenomics J 2011 Feb

Integrating pharmacogenetics into gemcitabine dosing-time for a change?
Ciccolini J, et al.
Nat Rev Clin Oncol 2011 Feb

Survey of US public attitudes toward pharmacogenetic testing
Haga SB, et al.
Pharmacogenomics J 2011 Feb

The Pharmacogenetic Rescue of Side-Lined Anticancer Drugs to the Front-Line: Gefitinib as a Case Example (February)
Li-Wan-Po A, et al.
Ann Pharmacother 2011 Feb

Smoking, Tobacco and Alcohol

Genetics and Alcohol: A Lethal Combination in Pancreatic Disease?
Whitcomb DC
Alcohol Clin Exp Res 2011 Feb


A decade's perspective on DNA sequencing technology
Mardis ER
Nature 2011 Feb;470(7333):198-203

Charting a course for genomic medicine from base pairs to bedside
Green ED, et al.
Nature 2011 Feb;470(7333):204-13

Emerging landscape of genomics in the electronic health record for personalized medicine
Ullman-Cullere MH & Mathew JP
Hum Mutat 2011 Feb

Initial impact of the sequencing of the human genome
Lander ES
Nature 2011 Feb;470(7333):187-97

The advent of personal genome sequencing
Drmanac R
Genet Med 2011 Feb

The American College of Medical Genetics, the first 20 years
Rimoin DL
Genet Med 2011 Feb


For this week's human genome epidemiology articles, please visit the HuGE Navigator.


For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.



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