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Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.


Thursday, February 10, 2011       Volume 26   Number 6


Spotlight

blue helix

Making Strides in Public Health Genomics Practice and Research

Five genomics translation projects in state health departments, universities, and the Veteran’s Administration present their latest achievements. These projects started in 2008 and are being funded by CDC’s Office of Public Health Genomics to translate human-genome information and applications into public health education, surveillance, and policy interventions. Read the latest achievements. Learn more about the projects.

 




Announcements

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Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Sweeping view of prostate cancer genome yields deep insights, Medical News Today, February 10

Gene test could solve prostate cancer riddle and spare thousands from surgery, Medical News Today, February 9

A conversation with the matriarch of modern cancer genetics, The New York Times, February 7

New clues to treat prostate cancer, The Wall Street Journal, February 3


Cardiovascular Disease

The genotype of disorders causing cardiac sudden death syndrome identified, Medical News Today, February 10

Searching for the soul of the genome, EurekAlert, February 9

Ohio State launches personalized genetics study on heart failure patients, Health Canal, February 8


Chronic Disease

Genome regions are signposts to the biology of inflammatory bowel disease, Medical News Today, February 7


Ethical, Legal, and Social Issues (ELSI)

They're baaaaaack! Genome Web, February 9 [by free subscription only]

Ethics of genetic testing, Forest Park Review, February 8

Gene patent debate on in Australia, Bio Spectrum, February 8

Update: FDA taking another (public) look at DTC genetic tests, Genomics Law Report, February 8


Family History

Family health histories, Advance for Nurses, February 8


Genetic Testing

James Evans' plan to make genetic testing data manageable for the clinic, Genome Web, February 7 [by free subscription only]


Mental Health

Gene linked to major depression, Medical News Today, February 8

Immune system genes associated with increased risk of mental illness, Medical News Today, February 8

Schizophrenia gene mutation found, Ivanhoe, February 8


Neurologic Conditions

Genetic link to sleepwalking, PHG Foundation, February 10

International collaboration on genetics of Alzheimer's disease, PHG Foundation, February 10

Early risk of Alzheimer's may be identified by combining brain imaging and genetic analysis, Medical News Today, February 9

2nd member in Alzheimer's toxic duo identified, EurekAlert, February 3

Parkinson's influenced by more genes than previously thought, PHG Foundation, February 3


Personalized Medicine

Patients' genome information to be included in electronic medical records, Marketwire, February 8


Pharmacogenomics

APhA releases new pharmacogenomics textbook, Medical News Today, February 8


Other

'Language gene' effect explored by Edinburgh scientists, BBC News, February 9

NHGRI charts course for the next phase of genomics research, NIH News, February 9

Researchers reflect on a decade of human genomics, Genome Web, February 9 [by free subscription only]

Dubai to host first international Genetic Metabolic conference, AME Info, February 7

European project to standardize human genome sequencing, PHG Foundation, February 7

US Undiagnosed Diseases Program identifies new genetic condition, Bio News, February 7

Electronic medical records to be used to research genetics of drug-induced SAEs, Medical News Today, February 4


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Genomics in the Scientific Literature

Aging

'Immunogenetics of Aging'
Naumova E, et al.
Tissue Antigens 2011 Mar;77(3):187-92


Autoimmune Disease

Genetic predisposition to autoimmunity - What have we learned?
Rai E & Wakeland EK
Semin Immunol 2011 Jan


Cancer

A new era: melanoma genetics and therapeutics
Ko JM & Fisher DE
J Pathol 2011 Jan;223(2):241-50

Genetically informed lung cancer medicine
Pao W, et al.
J Pathol 2011 Jan;223(2):230-40


Cardiovascular Disease

Genetic analysis in cardiovascular disease: a clinical perspective
Ho E, et al.
Cardiol Rev 2011 Mar-2011 Apr;19(2):81-9

Recent progress in the genetics of cardiomyopathy and its role in the clinical evaluation of patients with cardiomyopathy
Ghosh N & Haddad H
Curr Opin Cardiol 2011 Feb


Chronic Disease

Genetics of Liver Injury and Fibrosis
Weber SN & Lammert F
Alcohol Clin Exp Res 2011 Feb

Genome-wide association studies of sleep disorders
Raizen DM & Wu MN
Chest 2011 Feb;139(2):446-52

New IBD genetics: common pathways with other diseases
Lees CW, et al.
Gut 2011 Feb


Diabetes

Perceived Impact of Diabetes Genetic Risk Testing Among Patients at High Phenotypic Risk for Type 2 Diabetes
Markowitz SM, et al.
Diabetes Care 2011 Feb


Environmental and Occupational Health

Blood Lead Levels, ALAD Gene Polymorphisms, and Mortality
van Bemmel DM, et al.
Epidemiology 2011 Mar;22(2):273-8

Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century
Mortensen HM & Euling SY
Toxicol Appl Pharmacol 2011 Jan


Ethical, Legal, and Social Issues (ELSI)

Direct-to-consumer genetic testing through Internet: marketing, ethical and social issues
Ducournau P, et al.
Med Sci (Paris) 2011 Feb;27(1):95-102


Family History

Familial History of Stroke Is Associated with Acute Coronary Syndromes in Women
Banerjee A, et al.
Circ Cardiovasc Genet 2011 Feb

Family history of diabetes modifies the effect of blood pressure for incident diabetes in Middle Eastern women: Tehran Lipid and Glucose Study
Hatami M, et al.
J Hum Hypertens 2011 Feb

How does a simple enquiry compare to a detailed family history questionnaire to identify coronary heart disease or diabetic familial risk?
Wijdenes-Pijl M, et al.
Genet Med 2011 Feb

Increased Familial Clustering of Autoimmune Thyroid Diseases
Dittmar M, et al.
Horm Metab Res 2011 Feb

The importance of family health history: your patients' and your own
Alspach JG
Crit Care Nurse 2011 Feb;31(1):10-5


Genetic Testing

Beliefs About Cancer and Diet among Those Considering Genetic Testing for Colon Cancer
Palmquist AE, et al.
J Nutr Educ Behav 2011 Feb

Beware the fortune tellers peddling genetic tests
Moynihan R
BMJ 2011;342:c7233

Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients
Parker LA, et al.
Eur J Epidemiol 2011 Feb


Infectious Disease

Genomic medicine reaches HCV-related liver transplantation: hopes and clinical and Public Health implications
Lopez-Labrador FX & Berenguer M
J Hepatol 2011 Jan


Mental Health

After GWAS: Searching for Genetic Risk for Schizophrenia and Bipolar Disorder
Gershon ES, et al.
Am J Psychiatry 2011 Feb


Neurologic Conditions

An algorithm for genetic testing of frontotemporal lobar degeneration
Goldman JS, et al.
Neurology 2011 Feb;76(5):475-83


Obesity

Education Modifies Genetic and Environmental Influences on BMI
Johnson W, et al.
PLoS One 2011;6(1):e16290


Personalized Medicine

A strong case for personalized, targeted cancer prevention
Dawson MI
Cancer Prev Res (Phila) 2011 Feb;4(2):173-6


Pharmacogenomics

Cardiovascular Pharmacogenomics of Adrenergic Receptor Signaling: Clinical Implications and Future Directions
Johnson JA & Liggett SB
Clin Pharmacol Ther 2011 Feb

Current Status of Researches in Genomic Medicine and the Guidelines for Pharmacogenomics (PGx)
Kamatani N
Yakugaku Zasshi 2011 Feb;131(2):263-8

Do pharmacokinetic polymorphisms explain treatment failure in high-risk patients with neuroblastoma?
Bellanti F, et al.
Eur J Clin Pharmacol 2011 Feb

Does polymorphysm of genes coding for pro-inflammatory mediators predict the clinical response to tnf alpha blocking agents? A review analysis of the literature
Francesca I, et al.
Autoimmun Rev 2011 Feb

Genetic Marker of Statin-induced Rhabdomyolysis
Chiba K & Morimoto K
Yakugaku Zasshi 2011 Feb;131(2):247-53

Pharmacogenetic testing for warfarin dosing still awaits validation
Lefevre F, et al.
J Am Coll Cardiol 2011 Feb;57(6):756

Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application
Lee SY & McLeod HL
J Pathol 2011 Jan;223(1):15-27

Pharmacogenetics of beta2 adrenergic receptor gene polymorphisms, long-acting beta-agonists and asthma
Chung LP, et al.
Clin Exp Allergy 2011 Mar;41(3):312-26


Respiratory Disease

Asthma and COPD: Common Genes, Common Environments?
Postma DS, et al.
Am J Respir Crit Care Med 2011 Feb


HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.


GAPP

For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.

 

 

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