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Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, February 3, 2011       Volume 26   Number 5


blue helix

Making Strides in Public Health Genomics Practice and Research

Five genomics translation projects in state health departments, universities, and the Veteran’s Administration present their latest achievements. These projects started in 2008 and are being funded by CDC’s Office of Public Health Genomics to translate human-genome information and applications into public health education, surveillance, and policy interventions. Read the latest achievements. Learn more about the projects.



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Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.


Researchers pinpoint how one cancer gene functions, Medical News Today, February 3

A diagnostic marker in hepatocellular carcinoma, Medical News Today, February 1

NIH researchers extend use of gene therapy to treat a soft tissue tumor, NIH News, January 31

Researchers solve decades-old medical mysteries with the help of genetics, Medical News Today, January 31

Improved prediction of breast cancer outcomes: new test discovered, Medical News Today, January 29

Cardiovascular Disease

Link between a women's heart attack risk and maternal stroke history, Medical News Today, February 2

NIH researchers identify genetic cause of new vascular disease, NIH News, February 2

Wear Red Day: Bring awareness to women and heart disease, ivillage, February 2

Altered gene protects some African-Americans from coronary artery disease, Medical News Today, January 28

Chronic Disease

Celiac disease and Crohn's disease share part of their genetic background, Medical News Today, January 28

Ethical, Legal, and Social Issues (ELSI)

Personalized medicine regulation needs more than band-aids, Xconomy, January 28

Specialists rush to develop ways to know our genes while patients wrestle with whether they want to know, Monterey County Weekly, January 27

Neurologic Conditions

BUSM researchers involved in first international collaboration on the genetics of Alzheimer's disease, Medical News Today, February 2

Researchers identify 5 new genetic variations in total of 11 thought to be important in Parkinson's disease risk, Medical News Today, February 2

Researchers uncover genetic clues to compulsive, self-injurious behavior in rare childhood disorder, Medical News Today, January 31

Newborn Screening

Genetic Alliance funds innovation in newborn screening through Challenge Awards, Genetic Alliance, January 27


A study from The 1000 Genomes Project yields data for analyzing structural variants in DNA, Medical News Today, February 3

China joins Human Variome Project, PHG Foundation, February 2

Rock 'n rollin' DNA, Medical News Today, January 31

New website provides information about how to benefit from latest advances in genetics, Benzinga, January 27

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Genomics in the Scientific Literature


Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system
Zintzaras E, et al.
BMC Med 2011 Jan;9(1):9

Autoimmune Disease

The epigenetics of autoimmunity
Meda F, et al.
Cell Mol Immunol 2011 Jan

Birth Defects

Preventing the aortic complications of Marfan syndrome: a case-example of translational genomic medicine
Li-Wan-Po A, et al.
Br J Clin Pharmacol 2011 Jan


Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
Julian-Reynier C, et al.
Eur J Hum Genet 2011 Jan

Genomics and the continuum of cancer care
McDermott U, et al.
N Engl J Med 2011 Jan;364(4):340-50

Nasopharyngeal carcinoma as a paradigm of cancer genetics
Simons MJ
Chin J Cancer 2011 Feb;30(2):79-84

The American College of Gastroenterology Emily Couric Lecture-The Adenoma-Carcinoma Sequence Revisited: Has the Era of Genetic Tailoring Finally Arrived?
Ahnen DJ
Am J Gastroenterol 2011 Jan:1


Genetic risk profiling for prediction of type 2 diabetes
Mihaescu R, et al.
PLoS Curr 2011;3:RRN1208


Effect of maternal diet on the epigenome: implications for human metabolic disease
Lillycrop KA
Proc Nutr Soc 2011 Feb;70(1):64-72

Epigenetic changes of DNA repair genes in cancer
Lahtz C & Pfeifer GP
J Mol Cell Biol 2011 Feb;3(1):51-8

Review: A high capacity of the human placenta for genetic and epigenetic variation: Implications for assessing pregnancy outcome
Yuen RK & Robinson WP
Placenta 2011 Jan

Ethical, Legal, and Social Issues (ELSI)

Publishing SNP Genotypes of Human Embryonic Stem Cell Lines: Policy Statement of  the International Stem Cell Forum Ethics Working Party
Knoppers BM, et al.
Stem Cell Rev 2011 Jan

Family History

Family history of heart disease the re-emergence of a traditional risk factor
Assimes TL
J Am Coll Cardiol 2011 Feb;57(5):628-9

Family history of psychiatric disorders and the outcome of psychiatric patients with DSM-IV major depressive disorder
Holma KM, et al.
J Affect Disord 2011 Jan

How well does family history predict who will get colorectal cancer? Implications for cancer screening and counseling
Taylor DP, et al.
Genet Med 2011 Jan

The impact of co-morbid conditions on family history of venous thromboembolism in Whites and Blacks
Mili FD, et al.
Thromb Res 2011 Jan

Young age and a positive family history of colorectal cancer are complementary selection criteria for the identification of Lynch syndrome
Manders P, et al.
Eur J Cancer 2011 Jan

Genetic Testing

Answering the hard questions: the genetic testing registry and its request for information
Field A, et al.
Genet Test Mol Biomarkers 2011 Jan-2011 Feb;15(1-2):1-2

Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk
Christensen KD, et al.
Genet Med 2011 Jan

Charcot-marie-tooth disease subtypes and genetic testing strategies
Saporta AS, et al.
Ann Neurol 2011 Jan;69(1):22-33

Genetic testing and common disorders in a public health framework
van El CG & Cornel MC
Eur J Hum Genet 2011 Jan

Genetic tests need the human variome project
Cotton RG, et al.
Genet Test Mol Biomarkers 2011 Jan-2011 Feb;15(1-2):3

Infectious Disease

Genetic epidemiology of tuberculosis susceptibility: impact of study design
Stein CM
PLoS Pathog 2011 Jan;7(1):e1001189

SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis
Li X, et al.
PLoS One 2011;6(1):e15831

Mental Health

Developments in schizophrenia genetics: From linkage to microchips, deletions and duplications
Haraldsson HM, et al.
Nord J Psychiatry 2011 Jan

The genetics of Tourette disorder
State MW
Curr Opin Genet Dev 2011 Jan

Where are the missing pieces of the schizophrenia genetics puzzle?
Girard SL, et al.
Curr Opin Genet Dev 2011 Jan

Neurologic Conditions

Epilepsy genetics-past, present, and future
Poduri A & Lowenstein D
Curr Opin Genet Dev 2011 Jan


Overview of Symposium "Systems Genetics in Nutrition and Obesity Research"
Kalupahana NS & Moustaid-Moussa N
J Nutr 2011 Jan

Personalized Medicine

Genomes, race and health. Racial profiling in medicine might just be a stepping stone towards personalized health care
Wolinsky H
EMBO Rep 2011 Feb;12(2):107-9

Medical and graduate students' attitudes toward personal genomics
Ormond KE, et al.
Genet Med 2011 Jan

Patient reactions to personalized medicine vignettes: An experimental design
Butrick M, et al.
Genet Med 2011 Jan

The Cost-Effectiveness of Personalized Genetic Medicine: The case of genetic testing in neonatal diabetes
Greeley SA, et al.
Diabetes Care 2011 Jan

The eMERGE Network: A consortium of biorepositories linked to electronic medical  records data for conducting genomic studies
McCarty CA, et al.
BMC Med Genomics 2011 Jan;4(1):13


Pharmacogenetics and pharmacogenomics of methotrexate: Current status and novel aspects
Muhl H & Pfeilschifter J
Z Rheumatol 2011 Jan

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing
Relling MV, et al.
Clin Pharmacol Ther 2011 Jan

CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
Relling MV & Klein TE
Clin Pharmacol Ther 2011 Jan

Early Human Screening of Medications to Treat Drug Addiction: Novel Paradigms and the Relevance of Pharmacogenetics
Perkins KA & Lerman C
Clin Pharmacol Ther 2011 Jan

Genetic warfarin dosing tables versus algorithms
Finkelman BS, et al.
J Am Coll Cardiol 2011 Feb;57(5):612-8

Pharmacogenomics of antipsychotics efficacy for schizophrenia
Cacabelos R, et al.
Psychiatry Clin Neurosci 2011 Feb;65(1):3-19

Respiratory Disease

Genome-wide Association Studies for Discovery of Genes Involved in Asthma
Akhabir L & Sandford AJ
Respirology 2011 Jan

The genetics of asthma and allergic disorders
March ME, et al.
Discov Med 2011 Jan;11(56):35-45


A guide to web tools to prioritize candidate genes
Tranchevent LC, et al.
Brief Bioinform 2011 Jan;12(1):22-32

Alan Guttmacher--a visionary leader of developmental research
Morris K
Lancet 2011 Jan;377(9760):117

Nutritional Genomics: Defining the Dietary Requirement and Effects of Choline
Zeisel SH
J Nutr 2011 Jan

Systems Genetics: a Powerful Approach for Gene-Environment Interactions
Voy BH
J Nutr 2011 Jan


For this week's human genome epidemiology articles, please visit the HuGE Navigator.


For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.



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