 For information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base |
 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
Published by the Office of Public Health Genomics (OPHG), the Update offers links to genomics news and publications relevant to population health and health care. The Update highlights family health history and genomic tests, along with relevant data, policy, and legislation. Please send your comments to: genetics@cdc.gov.
Thursday, December 22, 2011 Volume 27 Number 25
Spotlight
New CDC Feature: Gather and Share Your Family Health History
Blog Post: Family Health History and the Holidays
Access the Surgeon General's Family History Collection tool: My Family Health Portrait.
Announcements
- Learn Your Family History Part 1 and Part 2 and a Family History Worksheet, The Dr. Oz Show, December 12
- "The Dr. Oz Show" teams up with the CDC to underscore the importance of uncovering your relatives' medical background and making the pledge to reduce risk factors for heart disease, Yahoo, December 12
- New Publication: Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives
Janssens AC, Henneman L, Detmar SB, Khoury MJ, Steyerberg EW, Eijkemans MJ, Mushkudiani N, Oostra BA, van Duijn CM, Mackenbach JP. J Clin Epidemiol. 2012 Jan;65(1):82-9. - New Publication: Family history of colorectal cancer: clinicians' preventive recommendations and patient behavior
Zlot AI, Silvey K, Newell N, Leman R, Coates RJ. Prev Chronic Dis 2012 Jan;9:E2 - New Publication: Use of family history in clinical guidelines for diabetes and colorectal cancer
Peterson BA, Gwinn ML, Valdez RA. Am J Prev Med 2012 Jan;42(1):65-70 - New Publication: Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States
Vassy JL, Shrader P, Yang QLiu T, Yesupriya A, Chang MH, Dowling NF, Ned RM, Dupuis J, Florez JC, Khoury MJ, Meigs JB. Metab Syndr Relat Disord. 2011 Dec;9(6):475-82. - New Publication: A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults
Jill M. Ferdinands , Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay Emerging Infectious Diseases 2011 17(12) Dec - Report: Priorities for Public Health Genomics 2012-2017 Stakeholder consultation and conference report [PDF 5.17 MB]
- Genomics and Health Impact Blog: Beyond base pairs to bedside: a community consultation on closing the gap between genomic discoveries and the public’s health
- Stakeholders say Public Health Genomics needs attention, Funding, Genome Web, December 22 [by free subscription only]
Topics
Genomic Tests
Clinical utility gene card for: acrodermatitis enteropathica
Kury S, et al. Eur J Hum Genet 2011 Dec
Clinical utility gene card for: Alport syndrome
Hertz JM, et al. Eur J Hum Genet 2011 Dec
Validation of warfarin pharmacogenetic algorithms in clinical practice
Marin-Leblanc M, et al. Pharmacogenomics 2012 Jan;13(1):21-9
Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
Rijkaart D, Berkhof J, Rozendaal L, et al. The Lancet Oncology, Early Online Publication, 15 December 2011
HPV DNA Testing advised for females over 30, Medical News Today, December 15
Report on Newborn Screening for Thalassaemia and invitation to submit comments on the report and its recommendations, NHS Sickle Cell & Thalassaemia
Screening Program
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base and PLoS Currents Evidence on Genomic Tests.
Family Health History
Family History for Prenatal Providers, NCHPEG, December 14
Practice and Programs
Identification of Individuals at Risk for Lynch Syndrome Using Targeted Evaluations and Genetic Testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer Joint Practice Guideline
Weissman SM, et al. J Genet Couns 2011 Dec
Integrating breast cancer genetics into clinical practice
Mukherjee A & Rakha EA Womens Health (Lond Engl) 2012 Jan;8(1):99-112
Newborn screening for medium chain acyl-CoA dehydrogenase deficiency in England: prevalence, predictive value and test validity based on 1.5 million screened babies
Oerton J, et al. J Med Screen 2011 Dec
Preimplantation genetic diagnosis for inherited breast cancer: first clinical application and live birth in Spain
Ramon Y Cajal T, et al. Fam Cancer 2011 Dec
Uncertainty Management and Communication Preferences Related to Genetic Relativism Among Families Affected by Down Syndrome, Marfan Syndrome, and Neurofibromatosis
Parrott R, et al. Health Commun 2011 Dec
14th Annual NCHPEG Meeting, NCHPEG, December 15
Invited Commentary: Report on the Genetics, Primary Care, and Developing Countries Workshop, NCHPEG, December 14
Policy and Legislation
Law, bioethics and the current status of ownership, privacy, informed consent in the genomic age
Hampikian G & Meslin EM Pac Symp Biocomput 2012:441
Testing the ethics of genetic testing in sports
Collier R CMAJ 2011 Dec
Public Health Science
Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record
Ding K, et al. BMC Cardiovasc Disord 2011;11:66
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
Toprak E, Veres A, Michel J, et al. Nature Genetics, doi:10.1038/ng.1034, 2011.
Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes
Comas I, Borrell S, Roetzer A, et al., Nature Genetics, doi:10.1038/ng.1038, 2011.
The evolution of drug resistance, The Scientist, December 18
170 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives
Janssens AC, Henneman L, Detmar SB, Khoury MJ, Steyerberg EW, Eijkemans MJ, Mushkudiani N, Oostra BA, van Duijn CM, Mackenbach JP. J Clin Epidemiol. 2012 Jan;65(1):82-9.
Family history of colorectal cancer: clinicians' preventive recommendations and patient behavior
Zlot AI, Silvey K, Newell N, Leman R, Coates RJ. Prev Chronic Dis 2012 Jan;9:E2
Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States
Vassy JL, Shrader P, Yang QLiu T, Yesupriya A, Chang MH, Dowling NF, Ned RM, Dupuis J, Florez JC, Khoury MJ, Meigs JB. Metab Syndr Relat Disord. 2011 Dec;9(6):475-82.
A Pilot Study of Host Genetic Variants Associated with Influenza-associated Deaths among Children and Young Adults
Jill M. Ferdinands , Amy M. Denison, Nicole F. Dowling, Heather A. Jost, Marta L. Gwinn, Lindy Liu, Sherif R. Zaki, and David K. Shay Emerging Infectious Diseases 2011 17(12) Dec
Restricted enzooticity of hepatitis E virus genotypes 1 to 4 in the United States
Dong C, Meng J, Dai X, Liang JH, Feagins AR, Meng XJ, Belfiore NM, Bradford C, Corn JL, Cray C, Glass GE, Gordon ML, Hesse RA, Montgomery DL, Nicholson WL, Pilny AA, Ramamoorthy S, Shaver DD, Drobeniuc J, Purdy MA, Fields HA, Kamili S, Teo CG. J Clin Microbiol. 2011 Dec;49(12):4164-72.
Use of family history in clinical guidelines for diabetes and colorectal cancer
Peterson BA, Gwinn ML, Valdez RA. Am J Prev Med 2012 Jan;42(1):65-70
View previous CDC-authored publications
Let's Go Surfing
Era of Personalized Medicine May Herald End of Soaring Cancer Costs
Keogh B J Natl Cancer Inst 2011 Dec
Another Cambridge idea – celebrating 15 years of public health genomics, PHG Foundation, December 22
NHGRI expands PhenX project with standards, measures initiative, Genome Web, December 21 [by free subscription only]
Horizon Scanning Protocol and Operations Manual, AHRQ, December 19Events and Training
Using Whole Genome Sequencing for Health
Complex Traits: Genomics and Computational Approaches
2012 Training Institute for Dissemination and Implementation Research in Health (TIDIRH)
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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