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Genomics & Health Impact Update

The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative  to practitioners, policy makers, consumers, and researchers. Please send your comments to:

Thursday, August 18, 2011       Volume 27   Number 7


A pie cut in two pieces with the smaller piece labeled Environmental and the larger labeled Genetic

New blog "Shall We Have Pie or Stew? Understanding Genetic and Environmental Causes of Human Disease"




Genomic Tests

For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base.

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Family Health History

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Practice and Programs

Child-Parent Screening for Familial Hypercholesterolemia.
Wald DS, Kasturiratne A, Godoy A, et al. J Pediatr. 2011 Jul 26.

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Policy and Legislation

FDA releases draft guidances on medical devices and biomarkers, Genome Web, August 15 [by free subscription only]

FDA approves Roche's Companion Dx and drug for melanoma, Genome Web, August 17 [by free subscription only]

GPPC releases updated list of DTC genetic testing companies, Genetics & Public Policy Center, August 11

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Data and Statistics

Awareness of Direct-to-Consumer Genetic Tests and Use of Genetic Tests Among Puerto Rican Adults, 2009
Ortiz AP, et al. Prev Chronic Dis 2011 Sep;8(5):A110

Population Composition, Public Policy, and the Genetics of Smoking
Boardman JD, et al. Demography 2011 Aug

Relationship Between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 Variation and Smoking Behaviors and Lung Cancer Risk
Wassenaar C, Dong Q, Wei Q, et al. Journal of the National Cancer Institute. 2011 July 11

Hereditary cancer risk, The University of New South Wales, August 16

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.
Amr Al-Saif, Futwan Al-Mohanna and Saeed Bohlega. Annals of Neurology; Published Online: August 12, 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, Sawcer S, et al. Nature. 2011 Aug 10;476(7359):214-9.

175 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.

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CDC-Authored Genomics Publications

CDC authors are indicated in bold

Assessing causal relationships in genomics: from Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs
Geneletti S, Gallo V, Porta M, Khoury MJ, Vineis P. Emerg Themes Epidemiol. 2011 ;8(1):5.

Cancer GAMAdb: database of cancer genetic associations from meta-analyses and genome-wide association studies
Schully SD, Yu W, McCallum V, Benedicto CB, Dong LM, Wulf A, Clyne M, Khoury MJ. Eur J Hum Genet. 2011 Aug;19(8):928-30.

Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor alpha
Bernstein DI, Kissling GE, Khurana Hershey G, Yucesoy B, Johnson VJ, Cartier A, Gautrin D, Sastre J, Boulet LP, Malo JL, Quirce S, Tarlo SM, Langmeyer S, Luster MI, Lummus ZL. J Allergy Clin Immunol. 2011 Aug;128(2):418-20.

Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology
Pacurari M, Qian Y, Porter DW, Wolfarth M, Wan Y, Luo D, Ding M, Castranova V, Guo NL. Toxicol Appl Pharmacol. 2011 Aug 15;255(1):18-31.

View previous CDC-authored publications

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Let's Go Surfing

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Events and Training

The Biology and Bioinformatics behind Environmental and Toxicologic Influences

Design and Analysis of Genetic-based Association Studies

Personal Genomes

12th International Congress of Human Genetics

Access other events

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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  • Additional information for Public Health Genomics is available on our contact page. The U.S. Government's Official Web PortalDepartment of Health and Human Services
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