Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: firstname.lastname@example.org.
Thursday, August 11, 2011 Volume 27 Number 6
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism.
Hallmayer J, Cleveland S, Torres A, et al. Arch Gen Psychiatry. 2011 Jul 4.
- ‘Environment’ poses a knotty challenge in autism, The New York Times, August 8
- CDC Public Health Grand Rounds next session Newborn Screening: Improving Outcomes will be held on August 18th from 1 to 2pm.
- The Agency for Healthcare Research and Quality (AHRQ) Effective Health Care (EHC) Program has announced that a draft comparative effectiveness review: Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults is available and open for comment on EHC Web site until August 30, 2011.
- The AHRQ EHC Program has also announced that key questions for the comparative effectiveness review: Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment are available and open for comment on the EHC Program Web site until August 23, 2011.
An Introduction to Assessing Genomic Screening and Diagnostic Tests
James E. Haddow, Glenn E. Palomaki. Nutrition Today. 2011; 46(4):169-170
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis
Bauer T, Bouman H, Werkum J, et al. BMJ 2011; 343:d4588
Putting genomics into practice
Holmes M, Casas J, Hingorani A. BMJ 2011; 343:d4953
Correlates of Family Health History Discussions Between College Students and Physicians: Does Family Cancer History Make a Difference?
Smith ML, et al. J Prim Prev 2011 Aug
Risk stratification could reduce costs in primary prevention of cardiovascular disease
Dalton A, Bull R. BMJ 2011; 343:d4913
Attitudes to reproductive genetic testing in women who had a positive BRCA test before having children: a qualitative analysis
Ormondroyd E, et al. Eur J Hum Genet 2011 Aug
Effect of Pre-test Genetic Counseling for Deaf Adults on Knowledge of Genetic Testing
Baldwin EE, et al. J Genet Couns 2011 Aug
Effectiveness of Pre-counseling Genetic Education Workshops at a Large Urban Community Health Center Serving Low-Income Chinese American Women
Sim SC, et al. J Genet Couns 2011 Aug
Influence of Genetic Risk Information on Parental Role Identity in Adolescent Girls and Young Women from Families with Fragile X Syndrome
McConkie-Rosell A, et al. J Genet Couns 2011 Aug
Providers' Perceptions and Practices Regarding BRCA1/2 Genetic Counseling and Testing in African American Women
Graves KD, et al. J Genet Couns 2011 Aug
Quality Assessment of Genetic Counseling Process in the Context of Presymptomatic Testing for Late-Onset Disorders: A Thematic Analysis of Three Review Articles
Paneque M, et al. Genet Test Mol Biomarkers 2011 Aug
Major ruling overturned as gene patents are declared valid, amednews,com, August 8
Myriad retains BRCA gene patents in latest legal ruling, PHG Foundation, August 5
Impact of gene patents on diagnostic testing: a new patent landscaping method applied to spinocerebellar ataxia
Berthels N, et al. Eur J Hum Genet 2011 Aug
Growth of genome screening needs debate
Goldstein DB Nature 2011 Aug;476(7358):27-8
NHS doctors’ use of genetic tests leading to infringement of patent rights, News-Medical.Net, August 8
Commentary: Children and Predictive Genomic Testing: Disease Prevention, Research Protection, and Our Future.
Tarini BA, Tercyak KP, Wilfond BS. J Pediatr Psychol. 2011 Aug 4.
Common concerns about testing children are rooted in assumption; more research is necessary to determine true effects, Medical News Today, August 8
Pan-ethnic carrier screening and prenatal diagnosis for spinal muscular atrophy: clinical laboratory analysis of >72 400 specimens
Sugarman EA, et al. Eur J Hum Genet 2011 Aug
Noninvasive Fetal Sex Determination Using Cell-Free Fetal DNA
Stephanie A. Devaney, Glenn E. Palomaki, Joan A. Scott, et al. JAMA 2011;306(6):627-636.
New study finds blood test can identify fetal sex as early as 7 weeks gestation, Genetics & Public Policy Center, August 9
Germline mutations in RAD51D confer susceptibility to ovarian cancer.
Loveday C, Turnbull C, Ramsay E, et al. Nat Genet. 2011 Aug 7.
Women with RAD51D gene fault more likely to develop ovarian cancer, News-Medical.Net, August 8
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma.
Bettegowda C, Agrawal N, Jiao Y, et al. Science. 2011 Aug 4.
Johns Hopkins scientists map genes for common form of brain cancer, Medical News Today, August 5
Progress made in understanding breast cancer risk, Medical News Today, August 4
T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
Kalos M, Levine B, Porter D, et al. Sci Transl Med 2011; Aug 10; 3 (95): p. 95ra73
Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
Porter D, Levine B, Kalos M, et al. New England Journal of Medicine 2011, Aug 11
Redirecting T Cells
Urba W, Longo D. New England Journal of Medicine 2011, Aug 10
CDC authors are indicated in bold
Ethical implications and practical considerations of ethnically targeted screening for genetic disorders: the case of hemoglobinopathy screening
Hinton CF, Grant AM, Grosse SD.
Ethn Health. 2011 Aug-Oct;16(4-5):377-88.
Is there a need for PGxceptionalism
Khoury MJ, Gwinn M, Dotson WD, Bowen MS.
Genet Med. 2011 Jul 27.
Measuring enzymatic HIV-1 susceptibility to two reverse transcriptase inhibitors as a rapid and simple approach to HIV-1 drug-resistance testing
Hoffmann D, Garcia AD, Harrigan PR, Johnston IC, Nakasone T, Garcia-Lerma JG, Heneine W.
PLoS One. 2011;6(7):e22019.
Novel surveillance network for norovirus gastroenteritis outbreaks, United States
Vega E, Barclay L, Gregoricus N, Williams K, Lee D, Vinje J.
Emerg Infect Dis. 2011 Aug;17(8):1389-95.
Using single-nucleotide polymorphisms to discriminate disease-associated from carried genomes of Neisseria meningitidis
Katz LS, Sharma NV, Harcourt BH, Thomas JD, Wang X, Mayer LW, Jordan IK.
J Bacteriol. 2011 Jul;193(14):3633-41.
Genomic Technology Applied to Pharmacological Traits
Jun J. Yang, Robert M. Plenge. JAMA 2011;306(6):652-653
New biobank could hold secret to anti-ageing, PHG Foundation, August 9
23andMe offers free genetic tests to African Americans, Technology Review, August 8
Gene Revolution: Your DNA details, CBS 42, August 7
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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