 For information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base |
 For information on genomic applications in cancer care and prevention, please visit the CancerGEM Knowledge Base |
Genomics & Health Impact Update
The Office of Public Health Genomics (OPHG) provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation. We hope the update is informative to practitioners, policy makers, consumers, and researchers. Please send your comments to: genetics@cdc.gov.
Thursday, August 4, 2011 Volume 27 Number 5
Spotlight
New blog: “We asked...you answered...thank you!”
The HHS/CDC Request for Information [PDF 185.98KB] on public health genomics priorities for the next five years has closed. Our sincere thanks to the many individuals, groups and organizations that responded. Read the responses, and learn about ongoing opportunities to provide input.
Announcements
- The Agency for Healthcare Research and Quality (AHRQ) Effective Health Care (EHC) Program has announced that a draft comparative effectiveness review: Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults is available and open for comment on EHC Web site until August 30, 2011.
- The AHRQ EHC Program has also announced that key questions for the comparative effectiveness review: Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment are available and open for comment on the EHC Program Web site until August 23, 2011.
- CDC Grand Rounds August 18: Newborn Screening: Improving Outcomes
- New OPHG publications:
- Is there a need for PGxceptionalism? Khoury MJ, Gwinn M, Dotson WD, Bowen MS. Genet Med. 2011 Jul 27. [Epub ahead of print]
- Population Sciences, Translational Research and the Promise of Genomics to Reduce the Burden of Cancer in the 21st Century. Khoury M, Clauser SB, Freedman AN, Gillanders EM, Glasgow RE, Klein WM, Schully SD. Cancer Epidemiol Biomarkers Prev. 2011 Jul 27. [Epub ahead of print]
Topics
Genomic Tests
A systematic review on pharmacogenetics in cardiovascular disease: is it ready for clinical application?
Verschuren JJ, et al. Eur Heart J 2011 Jul
For more information on genomic applications in practice and prevention, please visit the GAPP Finder in the GAPP Knowledge Base.
Practice and Programs
Are videoconferenced consultations as effective as face-to-face consultations for hereditary breast and ovarian cancer genetic counseling?
Zilliacus EM, et al. Genet Med 2011 Jul
Child-Parent Screening for Familial Hypercholesterolemia
Wald DS, et al. J Pediatr 2011 Jul
Commentary: to genotype or not to genotype? Addressing the debate through the development of a genomics and personalized medicine curriculum
Salari K, et al. Acad Med 2011 Aug;86(8):925-7
Communicating BRCA1/2 genetic test results within the family: A qualitative analysis
Dancyger C, et al. Psychol Health 2011 Jul
Policy and Legislation
New IOM report: Medical Devices and the Public's Health: The FDA 510(k) Clearance Process at 35 Years, IOM, July 29
Nature News Blog: US Court upholds Myriad's breast cancer gene patents - July 29, 2011, Nature, July 29
Ethical implications and practical considerations of ethnically targeted screening for genetic disorders: the case of hemoglobinopathy screening
Hinton CF, et al. Ethn Health 2011 Aug-2011 Oct;16(4-5):377-88
Ethics watch: The G.I. genome: ethical implications of genome sequencing in the military
Allyse M, et al. Nat Rev Genet 2011 Aug
Growth of genome screening needs debate, Nature, August 3
Race reemerges in debate over ‘personalized medicine’, The Washington Post National, July 31
Data and Statistics
Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability
Mihaescu R, et al. Genome Med 2011 Jul;3(7):51
Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians: A Vignette-Based Study
Trivers KF, et al. Cancer 2011 Jul
Genetic Variation in Myeloperoxidase Modifies the Association of Serum {alpha}-Tocopherol with Aggressive Prostate Cancer among Current Smokers.
Cheng TY, Barnett MJ, Kristal AR, et al. J Nutr. 2011 Jul 27
Genetic differences may affect vitamin E – cancer relationship, Nutra, August 3
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Mexico City Childhood Asthma Study (MCAAS), Torgerson DG, Ampleford EJ, et al. Nat Genet. 2011 Jul 31.
First results released by national asthma genetics consortium, Medical News Today, August 2
Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy.
Tan IB, Ivanova T, Lim KH, et al. Gastroenterology 2011 Apr 28
First large-scale genomic analysis of gastric cancer confirms two discrete tumor types, Medical News Today, August 2,
216 human genome epidemiology articles have recently been added, please visit the HuGE Literature Finder in the HuGE Navigator.
CDC-Authored Genomics Publications
CDC authors are indicated in bold
Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians: a vignette-based study
Trivers KF, Baldwin LM, Miller JW, Matthews B, Andrilla CH, Lishner DM, Goff BA. Cancer. 2011 Jul 25.
Investigation of a researcher's death due to septicemic plague
Frank KM, Schneewind O, Shieh WJ. N Engl J Med. 2011 Jun 30;364(26):2563-4.
Serum paraoxonase-1 (PON-1) genotype and exposure to organophosphorous insectides - is there a high-risk population?
Matthews AR, Sutter ME, Rentz DE. J Med Toxicol. 2011 Jul 23.
Subtyping salmonella enterica serovar Enteritidis isolates from different sources by using sequence typing based on virulence genes and clustered regularly interspaced short palindromic repeats (CRISPRs)
Liu F, Kariyawasam S, Jayarao BM, Barrangou R, Gerner-Smidt P, Ribot EM, Knabel SJ, Dudley EG. Appl Environ Microbiol. 2011 Jul;77(13):4520-6.
Uric acid as a potential cue to screen for iron overload
Mainous AG, Knoll ME, Everett CJ, Matheson EM, Hulihan MM, Grant AM. J Am Board Fam Med. 2011 Jul-Aug;24(4):415-21.
Detection of North American orthopoxviruses by real time-PCR
Gallardo-Romero NF, Velasco-Villa A, Weiss SL, Emerson GL, Carroll DS, Hughes CM, Li Y, Karem KL, Damon IK, Olson VA. Virol J. 2011 ;8:313.
View previous CDC-authored publications
Let's Go Surfing
Personalized medicine for individuals with Down syndrome.
McCabe, LL, McCabe ER. Mol Genet Metab. 2011 Jul 19. [Epub ahead of print]
Genome pioneer Francis Collins looks within, loses weight, USA Today, August 3
Want to Know Who is at Risk For Inheriting Genetic Diseases -Download a Free Gene Screen App to Learn More, The Sacramento Bee, August 4
Events and Training
International Conference on Developmental, Translational and Clinical Pharmacogenomics
Harmonizing Genetic Testing Across Europe
International Society of Nurses in Genetics
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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