Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, September 16, 2010 Volume 25 Number 12
Spotlight
Personal Genomic Tests Not Ready
As part of CDC's Expert Commentary Series on Medscape, Muin Khoury, MD, PhD, director of CDC’s Office of Public Health Genomics, explains why personal genomic tests that consumers can buy on the Internet are still not ready for primetime. Learn more.
Announcements
- The American Public Health Association (APHA) Genomics Forum is now on Facebook and Twitter. Access the Facebook page. Follow the forum on Twitter.
- PloS Currents and CDC’s Office of Public Health Genomics are collaborating on a new section of PLoS Currents Web site, Evidence on Genomic Tests, that aims to provide updated summaries of available data and to highlight gaps in knowledge. Learn more. Read the author guidelines and submit an article using Google knol (requires a Google Account login).
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Autoimmune Disorders
Scientists Zeroing In On Genes Tied To Two Immune Disorders, Medical News Today, September 16, 2010
Cancer
Cancer's 'penicillin moment'? Gene targeting drug could herald 'end game' for disease..., Mail Online UK, September 15, 2010
Therapeutic Targets Found for Rare Cancer in Children, Science Daily, September 13, 2010
Cardiovascular Disease
Gene network reveals link between fats and heart disease signs, PLoS Genetics, September 15, 2010
New Focus on 'Sudden Death' Heart Disorder, Science Daily, September 15, 2010
Enlarged hearts in women shrink faster than those in men after aortic valve replacement, Journal of the American Heart Association, September 13, 2010
Chronic Disease
Immune System Genes Show Links to Type 1 Diabetes, MedicineNet.com, September 8, 2010
Ethical, Legal, and Social Issues (ELSI)
South Africa: Science Report - Genetic Research - Whose DNA is It Anyway?, AllAfrica.com, September 14, 2010
Family History
Family breast cancer: when to worry about genetics, JSOnline.com, September 13, 2010
Genetic Testing
Aetna Supports First National Study on Community-Based Use of Genetic Tests ..., Aetna News Releases, September 15, 2010
Breast cancer: Making the choice for genetic testing, MayoClinic.com, September 11, 2010
Tempest in a spit cup, UC Berkeley, September 10, 2010
Study Backs Prostate Screening for High Risk Men, Reuters, September 09, 2010
Good Start Genetics, Inc. Raises $18 Million to Develop and Launch Sequencing-Based Pre-Pregnancy Genetic Screening Test, FreshNews.com, September 10, 2010
Infectious Disease
New gene that turns any bacteria into drug-resistant superbugs is found in 3 states, Canada , Baltimore Sun, September 13, 2010
Influenza
OSU researcher honed program studying flu pandemic, Columbus Dispatch, September 12, 2010
Mental Health
Mutation found in some autistic boys, CBC News, September 16, 2010
UCSD Researchers Discover New Genetic Link To Autism, KPBS, September 14, 2010
Neurologic Conditions
Immune System Genetics May Contribute to Parkinson's Disease..., World Health Network, September 15, 2010
Obesity
Bacterial Bonanza: Microbes Keep Us Alive, VPR.net, September 15, 2010
Johns Hopkins scientists find genes related to body mass, Eurekalert, September 15, 2010
Physical Activity Can Reduce the Genetic Predisposition to Obesity by 40 Percent, Study Finds, Science Daily, September 13, 2010
Personalized Medicine
Newcastle To Coordinate An International Research Network To Research The Role Of Genetic Variation In Drug Induced Liver Injury, Medical News Today, September 13, 2010
Pharmacogenomics
Mayo Clinic researchers to get $16.6 million, TMCnet, September 13, 2010
Improving Drug Therapy Using Gene Profiles, Medical News Today, September 10, 2010
Other
NHGRI funds development of third generation DNA sequencing technologies, NIH News, September 14, 2010
The silver age of altitude adaptation, Discover Magazine, September 14, 2010
DNASequencing.com and a Portfolio of 318 'Genetic' Domain Names to be ..., Firece Biotech, September 14, 2010
This Week in PloS, genomeWeb, September 13, 2010
Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned, 7th Space, September 13, 2010
Kidney stones: genetics vs. lifestyle, boston.com, September 13, 2010
Genzyme to sell genetic testing unit to LabCorp for $925 million cash, StarTribune.com, September 13, 2010
Seattle Genetics says leukemia drug fails trial, Reuters, September 13, 2010
deCODE Discovers Major Genetic Risk Factor for the Most Common Form of Glaucoma, PR Newswire, September 13, 2010
Rogue gene causes short-sightedness, Prokerala News, September 13, 2010
Emerging role of radiation induced bystander effects: Cell communications and ..., Genome Integrity, September 12, 2010
Common Genetic Disease Is Tough To Crack, International Business Times, September 11, 2010
Technology From Cloud Computing Greatly Increases Gene Analysis, Medical News Today, September 10, 2010
Genomics in the Scientific Literature
Aging
Joint influence of small-effect genetic variants on human longevity
Yashin AI, et al.
Aging (Albany NY) 2010 Aug
Cancer
A Randomized Trial of Genetic and Environmental Risk Assessment (GERA) for Colorectal Cancer Risk in Primary Care: Trial Design and Baseline Findings
Myers RE, et al.
Contemp Clin Trials 2010 Sep
A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research
Boccia S, et al.
Eur J Epidemiol 2010 Sep
Genetic variation and risk of chronic lymphocytic leukaemia
Crowther-Swanepoel D & Houlston RS
Semin Cancer Biol 2010 Sep
Cardiovascular Disease
From GWAS to the clinic: risk factors for intracranial aneurysms
Ruigrok YM & Rinkel GJ
Genome Med 2010 Sep;2(9):61
Genome-wide association studies identify new targets in cardiovascular disease
Calkin AC & Tontonoz P
Sci Transl Med 2010 Sep;2(48):48ps46
Three periods of one and a half decade of ischemic stroke susceptibility gene research: lessons we have learned
Maasz A & Melegh B
Genome Med 2010 Sep;2(9):64
Chronic Disease
Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation
Hansen JA, et al.
Curr Opin Hematol 2010 Sep
E2-2 Protein and Fuchs's Corneal Dystrophy
Baratz KH, et al.
N Engl J Med 2010 Sep;363(11):1016-24
Ethical, Legal, and Social Issues (ELSI)
Exclusion of genetic information from the medical record: ethical and medical dilemmas
Klitzman R
JAMA 2010 Sep;304(10):1120-1
Nature, nurture and socioeconomic policy-What can we learn from molecular genetics?
Lundborg P & Stenberg A
Econ Hum Biol 2010 Aug
Preferences regarding Genetic Research Results: Comparing Veterans and Nonveterans Responses
Arar N, et al.
Public Health Genomics 2010 Sep
Researcher perspectives on disclosure of incidental findings in genetic research
Meacham MC, et al.
J Empir Res Hum Res Ethics 2010 Sep;5(3):31-41
Returning individual research results: development of a cancer genetics education and risk communication protocol
Roberts JS, et al.
J Empir Res Hum Res Ethics 2010 Sep;5(3):17-30
Family History
Frequency of Known Mutations in Early-Onset Parkinson Disease: Implication for Genetic Counseling: The Consortium on Risk for Early Onset Parkinson Disease Study
Alcalay RN, et al.
Arch Neurol 2010 Sep;67(9):1116-22
Patients with premature cardiovascular disease and a positive family history for cardiovascular disease are prone to recurrent events
Mulders TA, et al.
Int J Cardiol 2010 Sep
Genetic Testing
Evaluation of the validity and utility of genetic testing for rare diseases
Grosse SD, et al.
Adv Exp Med Biol 2010;686:115-31
Predictive and diagnostic genetic testing in psychiatry
Mitchell PB, et al.
Clin Lab Med 2010 Dec;30(4):829-46
The Development of a Methodology for Examining the Process of Family Communication of Genetic Test Results
Smith JA, et al.
J Genet Couns 2010 Sep
Mental Health
From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease?
de Geus EJ
Genome Med 2010 Sep;2(9):63
Genetics of personality disorders
Reichborn-Kjennerud T
Clin Lab Med 2010 Dec;30(4):893-910
Genetics of psychiatric disorders methods: molecular approaches
Avramopoulos D
Clin Lab Med 2010 Dec;30(4):815-27
The possible contributory role of the S allele of 5-HTTLPR in the emergence of suicidality
Gonda X, et al.
J Psychopharmacol 2010 Sep
Neurologic Conditions
Copy number variation in Parkinson's disease
Toft M & Ross OA
Genome Med 2010 Sep;2(9):62
The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility
Bahreini SA, et al.
J Neuroimmunol 2010 Sep
Newborn Screening
A Pilot Study to Evaluate Knowledge and Attitudes of Illinois Pediatricians toward Newborn Screening for Sickle Cell Disease and Cystic Fibrosis
Stark AP, et al.
Am J Perinatol 2010 Sep
Inherited metabolic rare disease
Pampols T
Adv Exp Med Biol 2010;686:397-431
Obesity
Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study
Li S, et al.
PLoS Med 2010;7(8)
Personalized Medicine
Comparative effectiveness research and personalized medicine: catalyzing or colliding?
Epstein RS & Teagarden JR
Pharmacoeconomics 2010 Oct;28(10):905-13
Pharmacogenomics
Nonresponders to clopidogrel: pharmacokinetics and interactions involved
Giorgi MA, et al.
Expert Opin Pharmacother 2010 Oct;11(14):2391-403
Pharmacogenetics and schizophrenia
Foster A, et al.
Clin Lab Med 2010 Dec;30(4):975-93
Single-Nucleotide Polymorphisms in Response to Interferon-Beta Therapy in Multiple Sclerosis
Vandenbroeck K & Comabella M
J Interferon Cytokine Res 2010 Sep
Other
Age Differences in Genetic Knowledge, Health Literacy and Causal Beliefs for Health Conditions
Ashida S, et al.
Public Health Genomics 2010 Sep
Single nucleotide polymorphisms of DNA repair genes as predictors of radioresponse
Parliament MB & Murray D
Semin Radiat Oncol 2010 Oct;20(4):232-40
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
GAPP
For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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