Genomics

Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, July 15, 2010 Volume 25 Number 3

Spotlight

GAPPNet™ Launches New Online Genomic Products

CDC’s Office of Public Health Genomics and its partners recently announced the release of new online products of the Genomic Applications in Practice and Prevention Network (GAPPNet™). The GAPPNet™ independent Web site, GAPP Knowledge Base, and Evidence for Genomic Applications (EGA) online journal provide information about genomic applications for use in preventing disease and improving health. Read more.

Access the new products:

Announcements

Abstracts will be accepted August 1-31st, 2010 for the 4th National Conference on Genomics and Public Health, which will be held on December 8-10, 2010, in Bethesda, Maryland. Learn more about submitting an abstract [PDF 69 KB]. Learn more about the conference.

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Genomics In The News

The following are headlines from on-line news articles published during the past week.
The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
Free registration required for some articles.

A new spin on gene delivery, Medical News Today, July 9

Researchers discover new way diseases develop, Medical News Today, July 9

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Genomics in the Scientific Literature

Topics in the Scientific Literature

Autoimmune Disease
Cancer
Cardiovascular Disease
Chronic Disease
Diabetes
Ethical, Legal, and Social Issues (ELSI)
Family History
Genetic Testing
Infectious Disease
Maternal and Child Health
Mental Health
Neurologic Conditions
Newborn Screening
HuGE

Autoimmune Disease

Updating the genetics of systemic sclerosis
Allanore Y, et al.
Curr Opin Rheumatol 2010 Jul

Cancer

BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications
Linger RJ & Kruk PA
FEBS J 2010 Jul

Pancreatic cancer risk counselling and screening: impact on perceived risk and psychological functioning
Maheu C, et al.
Fam Cancer 2010 Jul

Cardiovascular Disease

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
Gretarsdottir S, et al.
Nat Genet 2010 Jul

Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction
Bezzina CR, et al.
Nat Genet 2010 Jul

Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
Akiyama K, et al.
J Hum Genet 2010 Jul

Translating genomic analyses into improved management of coronary artery disease
Johansen CT, et al.
Future Cardiol 2010 Jul;6(4):507-21

Chronic Disease

Factors influencing disease phenotype and penetrance in HFE haemochromatosis
Rochette J, et al.
Hum Genet 2010 Jul

Multiple sclerosis genetics-is the glass half full, or half empty?
Oksenberg JR & Baranzini SE
Nat Rev Neurol 2010 Jul

The genetics of pain: implications for evaluation and treatment of spinal disease
Kim DH & Schwartz CE
Spine J 2010 Jul

UMD-CFTR: a database dedicated to CF and CFTR-related disorders
Bareil C, et al.
Hum Mutat 2010 Jul

Diabetes

The Genetics of Vascular Complications in Diabetes Mellitus
Farbstein D & Levy AP
Cardiol Clin 2010 Aug;28(3):477-96

Ethical, Legal, and Social Issues (ELSI)

How to Handle Genetic Information: A Comparison of Attitudes among Patients and the General Population
Wolff K, et al.
Public Health Genomics 2010 Jul

Informing family members about a hereditary predisposition to cancer: attitudes and practices among clinical geneticists
Stol YH, et al.
J Med Ethics 2010 Jul;36(7):391-5

Family History

Family history and personal genomics as tools for improving health in an era of evidence-based medicine
Khoury MJ, et al.
Am J Prev Med 2010 Aug;39(2):184-8

Genetic Testing

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing
Walsh T, et al.
Proc Natl Acad Sci U S A 2010 Jun

Infectious Disease

The recent breakthroughs in the understanding of host genomics in hepatitis C
Rauch A, et al.
Eur J Clin Invest 2010 Jul

Maternal and Child Health

Gene variants predisposing to SIDS: current knowledge
Opdal SH & Rognum TO
Forensic Sci Med Pathol 2010 Jul

Mental Health

A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition
Sundermann EE, et al.
Menopause 2010 Jul;17(4):874-86

Neurologic Conditions

Genome Variation and Complexity in the Autism Spectrum
van de Lagemaat LN & Grant SG
Neuron 2010 Jul;67(1):8-10

Mitochondrial dysfunction and Alzheimer's disease
Maruszak A & Zekanowski C
Prog Neuropsychopharmacol Biol Psychiatry 2010 Jul

Newborn Screening

Guidelines on the early management of infants diagnosed with cystic fibrosis following newborn screening
Sermet-Gaudelus I, et al.
J Cyst Fibros 2010 Jun

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.

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