Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, July 1, 2010 Volume 25 Number 1
Spotlight
GAPPNet™ Launches New Online Genomic Products
CDC’s Office of Public Health Genomics and its partners recently announced the release of new online products of the Genomic Applications in Practice and Prevention Network (GAPPNet™). The GAPPNet™ independent Web site, GAPP Knowledge Base, and Evidence for Genomic Applications (EGA) online journal provide information about genomic applications for use in preventing disease and improving health. Read more.
Access the new products:
Announcements
- CDC announces a fellowship in the Division of Laboratory Science and Standards through the ORISE Research Participation Program. Find out more and apply.
- New publication, Sudden Cardiac Death of the Young in Michigan: Development and Implementation of a Novel Mortality Review System, published ahead of print on April 27, 2010 in the Journal of Community Health. Authors: Mukerji S, Hanna B, Duquette D, Bach J, Rosenman K.
- The 30-day public comment period on the NIH-led Genetic Testing Registry project to close on July 12, 2010. The Genetic Testing Registry will serve as a repository of information about genetic tests submitted by researchers, test developers, and manufacturers, and will include information about how the tests are used, about their validity and utility, and about how they are accessed.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Autoimmune Disorders
Acclaimed geneticist finds basis of alopecia areata, Medical News Today, July 1
Cancer
Genome studies start to unravel prostate cancer’s complexity, NCI Cancer Bulletin, June 29
The prostate cancer quandary, The Wall Street Journal, June 29
Gene study backs promise of breast cancer drugs to treat hereditary prostate cancer, Medical News Today, June 25
Large scale genetic analysis of multiple prostate cancer samples providing exciting new insight, Medical News Today, June 25
The P53 family: New book reviews research on the 'Guardian of the genome', Medical News Today, June 25
Profiling prostate cancer, EurekAlert, June 24
Cardiovascular Disease
How genetic 'chips' could help to understand heart disease, Red Orbit, June 24
Chronic Disease
Subtle mutations in immune gene may increase risk for asthma, Medical News Today, June 30
Diabetes
Further novel type 2 diabetes loci uncovered, PHG Foundation, June 30
12 new genes linked to Type 2 diabetes, Medical News Today, June 28
Genetic counselor may provide key link needed for diabetes intervention team, Endocrine Today, June 28
Genetic links to diabetic kidney disease, kidney failure identified by TGen-led studies, Medical News Today, June 28
Ethical, Legal, and Social Issues (ELSI)
US Supreme Court avoids clarifying patent stance, Nature News, June 29
Web genomics exposes ethics gaps, The Scientist, June 24
Genetic Testing
Personal genetic tests may not be worthwhile, experts say, The Spokeman-Review, June 29
Testing can predict future of eye disease glaucoma, Adelaide Now, June 29
Genome sequencing for the rest of us, Scientific American, June 28
Home gene tests may be research bonanza, ABC News, June 27
Significant proportion of parents support genetic testing of minors, in some instances, HemOnc Today, June 25
Neurologic Conditions
Huntington's 'far more prevalent', BBC News, June 30
Novel approach to study neurological disorders developed, Medical News Today, June 28
Personalized Medicine
Pathologists call for new training program to support personalized medicine, Physorg.com, June 30
Personalized medicine in the genomic era, Scientific American, June 24
Smoking, Tobacco and Alcohol
In older women, smoking-related colorectal cancer is associated with molecularly-defined DNA changes, Medical News Today, June 30
Other
Doctoral candidate devises genetic prediction algorithm, HPC Wire, June 29
Finding has new implications for understanding genetic diseases, Medical News Today, June 29
Human heredity and health in Africa project, PHG Foundation, June 29
View of the initial peopling of North America revised by mitochondrial genome analysis, Medical News Today, June 29
Ten years ago today, it was revealed that the human genome had been decoded. A medical revolution beckoned. So what happened next, The Independent, June 26
Has decoding the genome lived up to hype, BBC News, June 25
More variation in human genome than expected: surprisingly common transposons or 'jumping genes' are known to cause disease, Science Daily, June 25
Mysterious cilium functions as cellular communication hub, Stanford study shows, EurekAlert, June 24
New form of gene regulation hints at hidden dimension of DNA, Wired, June 24
New UM School of Medicine study finds more variation in human genome than expected, EurekAlert, June 24
Ten years on, genomic revolution only just starting, Reuters Health, June 24
Genomics in the Scientific Literature
Autoimmune Disease
Genetics of the Autoimmune Polyglandular Syndrome Type 3 Variant
Dittmar M & Kahaly GJ
Thyroid 2010 Jun
Cancer
Hereditary breast and ovarian cancer - indications for genetic testing, counseling and options for mutation carriers
Burki N
Ther Umsch 2010 Jul;67(7):359-66
Genetic variant associated with aggressive not indolent prostate cancer
Kirkland CT, et al.
Cancer Biol Ther 2010 Jun;9(12)
Genome-Wide Association Studies of Cancer
Stadler ZK, et al.
J Clin Oncol 2010 Jun
The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriers
Vargas AC, et al.
Fam Cancer 2010 Jun
Cardiovascular Disease
Genetic Polymorphisms in Homocysteine Metabolism and Response to Folate Intake: A Comprehensive Strategy to Elucidate Useful Genetic Information
Miyaki K
J Epidemiol 2010 Jun
Chronic Disease
Carrier screening for Beta-thalassaemia: a review of international practice
Cousens NE, et al.
Eur J Hum Genet 2010 Jun
Peutz-Jeghers syndrome: a systematic review and recommendations for management
Beggs AD, et al.
Gut 2010 Jul;59(7):975-86
The Alport syndrome COL4A5 variant database
Crockett DK, et al.
Hum Mutat 2010 Jun
The Genetics of the Thyroid Stimulating Hormone Receptor: History and Relevance
Davies TF, et al.
Thyroid 2010 Jun
Diabetes
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Voight BF, et al.
Nat Genet 2010 Jun
Epigenomics
Epigenetics in pain and analgesia: An imminent research field
Doehring A, et al.
Eur J Pain 2010 Jun
IBS: an epigenetic perspective
Dinan TG, et al.
Nat Rev Gastroenterol Hepatol 2010 Jun
Ethical, Legal, and Social Issues (ELSI)
Disclosing cancer genetic information within families: perspectives of counselees and their at-risk relatives
Hayat Roshanai A, et al.
Fam Cancer 2010 Jun
Informed consent for genetic research
Botkin JR
Curr Protoc Hum Genet 2010 Jul;Chapter 1:Unit 1.16
The right to ignore genetic status of late onset genetic disease in the genomic era; Prenatal testing for Huntington disease as a paradigm
Erez A, et al.
Am J Med Genet A 2010 Jun;152A(7):1774-80
Family History
Cleft Lip and Palate in Family Members of Cancer Survivors
Taioli E, et al.
Cancer Invest 2010 Jun
Mental Health
ADHD and genetic syndromes
Lo-Castro A, et al.
Brain Dev 2010 Jun
Genome-wide association study of conduct disorder symptomatology
Dick DM, et al.
Mol Psychiatry 2010 Jun
Neurologic Conditions
Genome-wide association studies: the key to unlocking neurodegeneration?
Gandhi S & Wood NW
Nat Neurosci 2010 Jul;13(7):789-94
Newborn Screening
Sudden death in medium chain acyl-coenzyme a dehydrogenase deficiency (MCADD) despite newborn screening
Yusupov R, et al.
Mol Genet Metab 2010 Jun
Obesity
Obesity genes and insulin resistance
Belkina AC & Denis GV
Curr Opin Endocrinol Diabetes Obes 2010 Jun
Personalized Medicine
Familial Syndromes Associated with Thyroid Cancer in the Era of Personalized Medicine
Richards ML
Thyroid 2010 Jun
Pharmacogenomics
Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy
Gervasini G, et al.
Eur J Clin Pharmacol 2010 Jun
The Canadian Pharmacogenomics Network for Drug Safety: A Model for Safety Pharmacology
Ross CJ, et al.
Thyroid 2010 Jun
The Pharmacogenetics of Calcineurin Inhibitor-Related Nephrotoxicity
Hesselink DA, et al.
Ther Drug Monit 2010 Jun
Other
Adult-onset presentations of genetic immunodeficiencies: genes can throw slow curves
Nelson KS & Lewis DB
Curr Opin Infect Dis 2010 Jun
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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