Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, February 25, 2010 Volume 24 Number 8
Spotlight
CDC Announces a New Genomics Funding Opportunity
CDC's Office of Public Health Genomics is announcing a new funding opportunity for the creation of a Genomics Knowledge Synthesis Center. The proposed center, working collaboratively with CDC’s Office of Public Health Genomics (OPHG), will plan and develop systematic evidence reviews on selected genomic applications, topic briefs on genomic applications, and methods to enhance the efficiency and quality of systematic evidence reviews. Read more.
Announcements
- February is American Heart Month. Family medical history offers important information for identifying risk of heart disease in individuals and populations. Learn more.
- The U.S. Surgeon General will collaborate with Microsoft HealthVault to enhance features of the My Family Health Portrait for collecting family health history and sharing this information with health care providers. Read the press release.
- NIH’s National Heart, Lung, and Blood Institute is partnering with the CDC and state health departments to launch the new Registry and Surveillance System in Hemoglobinopathies (RuSH) project to collect information on people living with sickle cell disease and thalassemia in California, Florida, Georgia, Michigan, North Carolina, and Pennsylvania. Read the press release.
- The Wellcome Trust releases a strategic plan for 2010-2020 [PDF 973.36 KB] with five major challenges, the first of which focuses on maximizing the health benefits of genetics and genomics.
- Save the date for the 4th National Conference on Genomics and Public Health on December 8-10, 2010, in Bethesda, Maryland.
- CDC's Office of Public Heath Genomics is inviting health care providers, health care payers and purchasers, policy makers, and the general public to participate in a 7-10 minute survey to assess awareness and interest in Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) initiative, and to get feedback on EGAPP™-sponsored evidence reports and EGAPP™ Working Group recommendations on genetic testing for Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer or HNPCC) and the UGT1A1 gene. Access the survey.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Birth Defects
Genetic health risks in children of assisted reproductive technology, EurekAlert, February 21
Cancer
Oral cancer study shows full tumor genome, Medical News Today, February 24
Patient/Physician team walks you through the genetics, diagnosis and treatment if at high risk for breast or ovarian cancer, Medical News Today, February 24
Melanoma transcriptome reveals novel genomic alterations not seen before, Science Daily, February 23
Researchers use new technology to reveal different genetic patterns of neuroblastoma, News-Medical.Net, February 22
Breast cancer growth gene identified, Official Wire, February 19
Discovery of genetic link to leukemias with an unknown origin, Medical News Today, February 19
Scientists develop personalized blood tests for cancer using whole genome sequencing, Medical News Today, February 19
Personalized cancer diagnostics and next generation sequencing, PHG Foundation, February 18
Cardiovascular Disease
Scientists map genetic regulatory elements for the heart, Medical News Today, February 25
Clues emerge about origins of coronary artery disease from uncharted region of human genome, Medical News Today, February 23
Common gene variant may increase risk for a type of cardiac arrhythmia, Medical News Today, February 22
Chronic Disease
Genetic factors can help predict risk for kidney disease, Medical News Today, February
Ethical, Legal, and Social Issues (ELSI)
Cancer Council and Clinical Oncological Society of Australia applaud US government recommendations on gene patent policy, Medical News Today, February 25
Stanford researcher addresses genome ethics and ownership at AAAS, Genome Web, February 23 [by free subscription only]
Family History
Surgeon General with Microsoft HealthVault expands consumer benefits for the My Family Health Portrait offering, HHS News, February 24
Genetic Testing
North Carolina couple finds hope for a healthy baby through technology that screens embryos for genetic disorders, Medical News Today, February 24
Technology overview: Faster tools to scrutinize the genome, Technology Review, February 23
Complete Genomics books orders for more than 500 human genomes; Eli Lilly among new customers, Genome Web, February 22 [by free subscription only]
Infectious Disease
Evidence that infectious diseases in the general population are frequently genetic disorders, Medical News Today, February 22
Other
Dermatology study identifies genetic key in treatment of female hair loss, Medical News Today, February 25
Genetic link between misery and death discovered; Novel strategy probes 'Genetic haystack', Science Daily, February 25
Wellcome Trust points to genomics, genetics as key priorities in 10-year plan, Genome Web, February 24 [by free subscription only]
Genes responsible for ability to recognize faces, Medical News Today, February 23
NHGRI to fund centralized protein data center, Genome Web, February 23 [by free subscription only]
Web-based tools, called 'Galaxy,' simplify genomic analysis, Physorg.com, February 23
Genomics gets personal for Duke professor, The News & Observer, February 22
How genes and environment interact to cause disease, Medical News Today, February 19
HHS Committee reviewing genetic education needs, Genome Web, February 18 [by free subscription only]
NHLBI, CDC launch surveillance and research program for inherited blood diseases, NIH News, February 18
Genomics in the Scientific Literature
Topics in the Scientific Literature
Aging
Genome-Wide Association Study of Bone Mineral Density in Premenopausal European-American Women and Replication in African-American Women
Koller DL, et al.
J Clin Endocrinol Metab 2010 Feb
Autoimmune Disease
Genetic regulation of serum cytokines in systemic lupus erythematosus
Kariuki SN & Niewold TB
Transl Res 2010 Mar;155(3):109-17
Cancer
CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies
Yin M, et al.
Carcinogenesis 2010 Feb
Cardiovascular Disease
Advances in Genomic Analysis of Stroke. What Have We Learned and Where Are We Headed?
Lanktree MB, et al.
Stroke 2010 Feb
Association Between 9p21 Genomic Markers and Heart Disease: A Meta-analysis
Palomaki GE, et al.
JAMA 2010 Feb;303(7):648-56
Association between a literature-based genetic risk score and cardiovascular events in women
Paynter NP, et al.
JAMA 2010 Feb;303(7):631-7
Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants
Bentley P, et al.
PLoS One 2010;5(2):e9136
Health status in patients at risk of inherited arrhythmias and sudden unexpected death compared to the general population
Hamang A, et al.
BMC Med Genet 2010 Feb;11(1):27
The genetics of ischaemic stroke
Matarin M, et al.
J Intern Med 2010 Feb;267(2):139-55
Chronic Disease
Genetic Approaches to Functional Gastrointestinal Disorders
Saito YA, et al.
Gastroenterology 2010 Feb
Family History
Age-Specific Risk of Incident Prostate Cancer and Risk of Death from Prostate Cancer Defined by the Number of Affected Family Members
Brandt A, et al.
Eur Urol 2010 Feb
Coherence and Completeness of Population-based Family Cancer Reports
Wideroff L, et al.
Cancer Epidemiol Biomarkers Prev 2010 Feb
Family history of lung cancer and contemplation of smoking cessation
Madlensky L & Bousman CA
Prev Chronic Dis 2010 Mar;7(2):A29
Family History of Venous Thromboembolism and Identifying Factor V Leiden Carriers During Pregnancy
Horton AL, et al.
Obstet Gynecol 2010 Mar;115(3):521-5
General cardiovascular risk profile identifies advanced coronary artery calcium and is improved by family history: the multiethnic study of atherosclerosis
Scheuner MT, et al.
Circ Cardiovasc Genet 2010 Feb;3(1):97-105
Genetic Testing
Genetic screening: a conceptual framework for programmes and policy-making
Andermann A, et al.
J Health Serv Res Policy 2010 Feb
Genetic testing in cardiovascular diseases
Hofman N, et al.
Curr Opin Cardiol 2010 Feb
Molecular diagnostics for autosomal dominant polycystic kidney disease
Harris PC & Rossetti S
Nat Rev Nephrol 2010 Feb
What do patients with hereditary deafness think of genetic studies?
Abe S, et al.
Auris Nasus Larynx 2010 Feb
Will Knowledge of Gene-based Colorectal Cancer Disease Risk Influence Quality of Life and Screening Behavior? Findings from a Population-based Study
Ramsey S, et al.
Public Health Genomics 2010 Jan;13(1):nihpa102310
Mental Health
The Role of Genetics in the Etiology of Schizophrenia
Gejman PV, et al.
Psychiatr Clin North Am 2010 Mar;33(1):35-66
The Genetics of Major Depression: Moving Beyond the Monoamine Hypothesis
Shyn SI & Hamilton SP
Psychiatr Clin North Am 2010 Mar;33(1):125-40
Predictive and Diagnostic Genetic Testing in Psychiatry
Mitchell PB, et al.
Psychiatr Clin North Am 2010 Mar;33(1):225-43
Genetic Research into Bipolar Disorder: The Need for a Research Framework that Integrates Sophisticated Molecular Biology and Clinically Informed Phenotype Characterization
Schulze TG
Psychiatr Clin North Am 2010 Mar;33(1):67-82
Neurologic Conditions
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects
Sleegers K, et al.
Trends Genet 2010 Feb;26(2):84-93
Personalized Medicine
Omics-based Medicine and Systems Pathology. A New Perspective for Personalized and Predictive Medicine
Tanaka H
Methods Inf Med 2010 Feb;49(2)
Personalized Prognosis and Diagnosis of Type 2 Diabetes - Vision or Fiction?
Muller G
Pharmacology 2010 Feb;85(3):168-87
Personalized healthcare in clotting disorders
Wu HM, et al.
Per Med 2010 Jan;7(1):65-73
Pharmacogenomics
Pharmacogenomics of Maternal Tobacco Use: Metabolic Gene Polymorphisms and Risk of Adverse Pregnancy Outcomes
Aagaard-Tillery K, et al.
Obstet Gynecol 2010 Mar;115(3):568-77
The Promise and Reality of Pharmacogenetics in Psychiatry
Zandi PP & Judy JT
Psychiatr Clin North Am 2010 Mar;33(1):181-224
The role of pharmacogenomics in improving the management of asthma
Kazani S, et al.
J Allergy Clin Immunol 2010 Feb;125(2):295-302
Respiratory Disease
New insight into the genes susceptible to asthma
Gu ML, et al.
J Asthma 2010 Mar;47(2):113-6
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions
Li X, et al.
J Allergy Clin Immunol 2010 Feb;125(2):328-35.e11
Other
CandiSNPer: a web-tool for the identification of candidate SNPs for causal variants
Schmitt AO, et al.
Bioinformatics 2010 Feb
Effectiveness of an online curriculum for medical students on genetics, genetic testing and counseling
Metcalf MP, et al.
Med Educ Online 2010;15
Potential for Revealing Individual-Level Information in Genome-wide Association Studies
Lumley T & Rice K
JAMA 2010 Feb;303(7):659-60
Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells
Romanoski CE, et al.
Am J Hum Genet 2010 Feb
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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