Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, December 9, 2010 Volume 25 Number 24
Spotlight
New Global Public Health Genomics Report Released
This month, a new report entitled Public Health in an Era of Genome-based and Personalized Medicine was released by an international, multidisciplinary expert group. The report focuses on key issues for the future of global public health given the rapid developments in genomic medicine and technologies. The expert group was convened in the United Kingdom in May 2010, by the PHG Foundation, the Center for Bioethics, the Centre of Genomics and Policy, and the Telethon Institute for Child Health Research. Read the report and press release. Read a compendium article published in Genetics in Medicine.
Announcements
- The U.S. Department of Health and Human Services has released the new Healthy People 2020 national objectives for improving the health of all Americans. View the Healthy People 2020 Launch Webcast. Read about the new genomics objectives.
- Presentations on public health genomics that were given at the 2010 American Public Health Association conference are now available. Access the genomics presentations.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Cancer
Boost for cancer genetics in Wales, PHG Foundation, December 7
New international cancer effort akin to Human Genome Project, Medical News Today, December 6
Disappearance of certain genetic material may give insight into melanoma, Tehran Times, December 4
Genetic mutations associated with increased PSA and prostate cancer, EurekAlert, December 2
Cardiovascular Disease
Discovery of a mechanistic link between genetic variation and risk of cardiovascular disease, Medical News Today, December 3
Chronic Disease
Genetic link found between spinal arthritis and inflammatory bowel disease, Medical News Today, December 3
Ethical, Legal, and Social Issues (ELSI)
The time to speak out on gene patents is now, Australia, Medical News Today, December 8
Report urges curbs on gene patenting, The Australian, December 4
Family History
Get together, get health details, Rocky Mount Telegram, December 6
Family health history beats personal genomic screening for cancer risk, Internal Medicine News, December 3
Genetic Testing
Decoding fetal DNA from mother's blood opens door to single prenatal test for multiple genetic disorders, Medical News Today, December 9
Next generation sequencing for non-invasive prenatal diagnosis, PHG Foundation, December 9
CGC Genetics introduces test for molecular diagnosis of Noonan and other genetically related syndromes, Medical News Today, December 6
Word still out on genetic testing accuracy, cincinnati.com, December 2
Maternal and Child Health
Vanderbilt doing long-term study of child health, necn.com, December 3
Neurologic Conditions
Spontaneous mutations important cause of mental retardation, research finds, Science Daily, December 7
Earliest brain changes linked to Alzheimer's genetic risk point to possible prevention therapies, Science Daily, December 6
Scientists finding genes related to autism, Newsday, December 5
Newborn Screening
New UCLA study raises questions about genetic testing of newborns, EurekAlert, December 7
Other
$6.4M NIH award supports research in TB genetics, brain tumor treatment, cancer genetics, ethical and societal issues in human genetic research, Medical News Today, December 9
The genomic handymen, Genome Web December [by free subscription only]
The causes of common diseases are not genetic concludes a new analysis, Medical News Today, December 7
Gene therapy corrected rare bleeding disorder: Study, MedicineNet, December 5
Human cells 'hacked' with programmable circuits, PHG Foundation, December 6
'Clueless' housekeeping genes are activated randomly, study finds, Science Daily, December 6
Elsevier announces title change for Cancer Genetics and Cytogenetics journal, News-Medical.Net, December 6
Changes in genetic networks caused by DNA damage mapped by scientists, Medical News Today, December 4
30 new genes responsible for early-onset puberty unlocked, Medical News Today, December 4
Greater input to genetic research from developing countries, PHG Foundation, December 3
NZ family provides clues to gene 'switch', TVNZ, December 3
Genomics in the Scientific Literature
Aging
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application
Charbel Issa P, et al.
Graefes Arch Clin Exp Ophthalmol 2010 Dec
Cancer
Clinical cancer genomics: how soon is now?
Taylor BS & Ladanyi M
J Pathol 2011 Jan;223(2):319-27
Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction
Antoniou AC, et al.
Cancer Res 2010 Nov
Do the recent American Thyroid Association (ATA) Guidelines accurately guide the timing of prophylactic thyroidectomy in MEN2A?
Grubbs EG, et al.
Surgery 2010 Dec;148(6):1302-10
Genetic Risk, Perceived Risk, and Cancer Worry in Daughters of Breast Cancer Patients
Quillin JM, et al.
J Genet Couns 2010 Dec
Identification and Management of Women With BRCA Mutations or Hereditary Predisposition for Breast and Ovarian Cancer
Pruthi S, et al.
Mayo Clin Proc 2010 Dec;85(12):1111-20
Impact of Genetics on the Diagnosis and Treatment of Renal Cancer
Singer EA, et al.
Curr Urol Rep 2010 Dec
Radiotherapy in the Treatment of Hereditary Breast Cancer
Pierce LJ & Haffty BG
Semin Radiat Oncol 2011 Jan;21(1):43-50
Therapeutic implications of resistance to molecular therapies in metastatic colorectal cancer
Sartore-Bianchi A, et al.
Cancer Treat Rev 2010 Nov;36S3:S1-S5
Cardiovascular Disease
Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies
Kraja AT, et al.
Curr Hypertens Rep 2010 Dec
JAK2V617F mutation in patients with thrombosis: to screen or not to screen?
Xavier SG, et al.
Int J Lab Hematol 2010 Dec
The Genetics of Blood Pressure and Hypertension: The Role of Rare Variation
Doris PA
Cardiovasc Ther 2010 Dec
Diabetes
Genetics of Type 2 Diabetes
Ahlqvist E, et al.
Clin Chem 2010 Nov
Epigenomics
DNA methylation and cancer: ghosts and angels above the genes
Sincic N & Herceg Z
Curr Opin Oncol 2010 Nov
Ethical, Legal, and Social Issues (ELSI)
Using critical literacy to explore genetics and its ethical, legal, and social issues with in-service secondary teachers
Gleason ML, et al.
CBE Life Sci Educ 2010 Winter;9(4):422-30
Family History
Familial risks of unusual forms of venous thrombosis: a nationwide epidemiological study in Sweden
Zoller B, et al.
J Intern Med 2010 Nov
Midwives Roles in Women's Improvement of Protective Behaviour against Breast Cancer Whether they have a Family History of Cancer or Not
Demireloz M, et al.
Asian Pac J Cancer Prev 2010;11(4):1037-43
The impact of cancer pathology confirmation on clinical management of a family history of cancer
Edwards E & Lucassen A
Fam Cancer 2010 Dec
The need for breast cancer screening in women undergoing elective breast surgery: an assessment of risk and risk factors for breast cancer in young women
Sharabi SE, et al.
Aesthet Surg J 2010 Nov;30(6):821-31
Infectious Disease
Leprosy and the human genome
Misch EA, et al.
Microbiol Mol Biol Rev 2010 Dec;74(4):589-620
Maternal and Child Health
Genomic risk factors in sudden infant death syndrome
Van Norstrand DW & Ackerman MJ
Genome Med 2010 Nov;2(11):86
Neurologic Conditions
The role of apolipoprotein e in the pathological events following subarachnoid hemorrhage: a review
Guo ZD, et al.
Acta Neurochir Suppl 2011;110(2):5-7
Obesity
Evidences on three relevant obesogenes: MC4R, FTO and PPARgamma. Approaches for personalized nutrition
Razquin C, et al.
Mol Nutr Food Res 2010 Dec
Impact of Genetic Causal Information on Medical Students' Clinical Encounters with an Obese Virtual Patient: Health Promotion and Social Stigma
Persky S & Eccleston CP
Ann Behav Med 2010 Dec
The Combination of Genetic Variations in the PRDX3 Gene and Dietary Fat Intake Contribute to Obesity Risk
Hiroi M, et al.
Obesity (Silver Spring) 2010 Dec
Where to go with FTO?
Larder R, et al.
Trends Endocrinol Metab 2010 Dec
Personalized Medicine
Personalized Medicine in Diabetes
Malandrino N & Smith RJ
Clin Chem 2010 Dec
Pharmacogenomics
Chemokine receptor CCR5: From AIDS to atherosclerosis
Jones KL, et al.
Br J Pharmacol 2010 Dec
Identifying genomic and developmental causes of adverse drug reactions in children
Becker ML & Leeder JS
Pharmacogenomics 2010 Nov;11(11):1591-602
Opening the gate for genomics data into clinical research: a use case in managing patients' DNA samples from the bench to drug development
Matteson S, et al.
Pharmacogenomics 2010 Nov;11(11):1603-12
Pharmacogenetics of controlled ovarian hyperstimulation: time to corroborate the clinical utility of FSH receptor genetic markers
Moron FJ & Ruiz A
Pharmacogenomics 2010 Nov;11(11):1613-8
Systematic review of pharmacoeconomic studies of pharmacogenomic tests
Beaulieu M, et al.
Pharmacogenomics 2010 Nov;11(11):1573-90
The pharmacogenetics of imanitib
Dulucq S & Krajinovic M
Genome Med 2010 Nov;2(11):85
Other
Beyond the Genome: genomics research ten years after the human genome sequence
Casto AM & Amid C
Genome Biol 2010 Nov;11(11):309
Capacity-Building in Human Genetics for Developing Countries: Initiatives and Perspectives in Sub-Saharan Africa
Wonkam A, et al.
Public Health Genomics 2010;13(7-8):492-4
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
GAPP
For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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