Genomics

Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, August 26, 2010 Volume 25 Number 9

Spotlight

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4^th National Conference on Genomics Announces Call for Abstracts

Abstracts will be accepted August 1-31^st, 2010 for the 4^th National Conference on Genomics and Public Health, which will be held on December 8-10, 2010, in Bethesda, Maryland. The conference planning committee invites abstracts for both oral and poster presentation related to genomic and public health practice, knowledge synthesis, communication, global health, preparedness and response, and new developments. Learn more about submitting an abstract [PDF 69 KB]. Learn more about the conference.

Announcements

CDC’s Office of Public Health Genomics (OPHG) has released new translational materials summarizing recommendations by the Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) Working Group on tumor gene expression profiling for women diagnosed with breast cancer. Learn more.
New feature called the Project Locator added to the GAPP Knowledge Base, allowing users to search for current and recently completed genomic translation projects. The GAPP Knowledge Base was released in June 2010, by CDC’s Office of Public Health Genomics, and stakeholders and partners of the Genomic Applications in Practice and Prevention Network (GAPPNet™). Submit your project(s) to be included in the Project Locator.

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Genomics In The News

The following are headlines from on-line news articles published during the past week.
The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
Free registration required for some articles.

Fitting into the world, The Jerusalem Post, August 22

Is autism genetic, Ivanhoe, August 20

Smoking, Tobacco and Alcohol

How secondhand cigarette smoke changes your genes, Time, August 20

Is alcoholism genetic, Ivanhoe, August 20

Other

Gene involved in Fuchs corneal dystrophy is found, Medical News Today, August 26

How well do you know your genes, Medical News Today, August 25

Scientists develop the first atomic view of key genetic processes (w/ Video), Physorg.com, August 25

Over 200 genes influenced by vitamin D, highlighting links to disease, Medical News Today, August 24

Physical model describes the distribution of nucleosome, Medical News Today, August 24

Road signs and traffic signals on DNA, Medical News Today, August 23

New study points the way to muscular dystrophy therapies, PHG Foundation, August 20

Discovery opens door to therapeutic development for FSH muscular dystrophy, NIH News, August 19

Reanimated ‘Junk’ DNA is found to cause disease, The New York Times, August 19

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Genomics in the Scientific Literature

Topics in the Scientific Literature

Autoimmune Disease
Cancer
Cardiovascular Disease
Chronic Disease
Diabetes
Epigenomics
Ethical, Legal, and Social Issues (ELSI)
Family History
Genetic Testing
Infectious Disease
Mental Health
Neurologic Conditions
Newborn Screening
Personalized Medicine
Pharmacogenomics
Other
HuGE

Autoimmune Disease

A towards-multidimensional screening approach to predict candidate genes of rheumatoid arthritis based on SNP, structural and functional annotations
Zhang L, et al.
BMC Med Genomics 2010 Aug;3(1):38

Endocrine autoimmune disease: genetics become complex
Wiebolt J, et al.
Eur J Clin Invest 2010 Aug

Cancer

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
Abnet CC, et al.
Nat Genet 2010 Aug

Familial thyroid neoplasia: impact of technological advances on detection and monitoring
Tran T & Gianoukakis AG
Curr Opin Endocrinol Diabetes Obes 2010 Aug

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54
Wang LD, et al.
Nat Genet 2010 Aug

Cardiovascular Disease

Genetics of stroke
Guo JM, et al.
Acta Pharmacol Sin 2010 Aug

Chronic Disease

Genome-Wide Association Studies in Nephrology Research
Kottgen A
Am J Kidney Dis 2010 Aug

Diabetes

Biobanking, consent, and commercialization in international genetics research: the Type 1 Diabetes Genetics Consortium
Hall MA, et al.
Clin Trials 2010;7(1 Suppl):S33-45

The emerging genetics of type 2 diabetes
Bonnefond A, et al.
Trends Mol Med 2010 Aug

Epigenomics

Allele-specific methylation in the human genome Implications for genetic studies of complex disease
Meaburn EL, et al.
Epigenetics 2010 Oct;5(7)

Ethical, Legal, and Social Issues (ELSI)

Health, inequality and the politics of genes
Whittle PM
N Z Med J 2010;123(1320):67-75

Family History

Does a family history of male breast cancer influence risk perception and use of genetic testing?
Schiffman SC & Chagpar AB
Am Surg 2010 Aug;76(8):879-82

Familial aggregation of personality disorder: epidemiological evidence from high school students 18 years and older in Beijing, China
Cheng H, et al.
Compr Psychiatry 2010 Sep-2010 Oct;51(5):524-30

Prognostic Factors and Family History for Survival of Esophageal Squamous Cell Carcinoma Patients After Surgery
Yuequan J, et al.
Ann Thorac Surg 2010 Sep;90(3):908-13

Genetic Testing

Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in Germany
Wolf E, et al.
Eur J Med Res 2010 Apr;15(4):145-51

Development of a Scoring System to Screen for BRCA1/2 Mutations
Evans GR & Lalloo F
Methods Mol Biol 2010;653:237-47

Not Your Grandfather's Genetic Testing Oversight
Ritsick J & Terry S
Genet Test Mol Biomarkers 2010 Aug;14(4):439

Personal Factors Associated with Reported Benefits of Huntington Disease Family History or Genetic Testing
Williams JK, et al.
Genet Test Mol Biomarkers 2010 Aug

The Basis and Rational Use of Molecular Genetic Testing in Mature B-cell Lymphomas
Roullet M & Bagg A
Adv Anat Pathol 2010 Sep;17(5):333-58

Infectious Disease

Host genetic basis for hepatitis C virus clearance: a role for blood collection centers
Selvarajah S, et al.
Curr Opin Hematol 2010 Aug

Mental Health

Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder
Neale BM, et al.
J Am Acad Child Adolesc Psychiatry 2010 Sep;49(9):906-20

Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease
Bassett AS, et al.
Am J Psychiatry 2010 Aug;167(8):899-914

Family-Based Genome-Wide Association Scan of Attention-Deficit/Hyperactivity Disorder
Mick E, et al.
J Am Acad Child Adolesc Psychiatry 2010 Sep;49(9):898-905.e3

Meta-Analysis of Genome-Wide Association Studies of Attention-Deficit/Hyperactivity Disorder
Neale BM, et al.
J Am Acad Child Adolesc Psychiatry 2010 Sep;49(9):884-97

Neurologic Conditions

The genetics of spinal muscular atrophies
Wee CD, et al.
Curr Opin Neurol 2010 Aug

Newborn Screening

Evaluation of the universal newborn hearing screening and intervention program
Shulman S, et al.
Pediatrics 2010 Aug;126 Suppl 1:S19-27

Expanded newborn screening in Greece: 30 months of experience
Loukas YL, et al.
J Inherit Metab Dis 2010 Aug

Personalized Medicine

Consumer perceptions of direct-to-consumer personalized genomic risk assessments
Bloss CS, et al.
Genet Med 2010 Aug

Pharmacogenomics

Clinical and economic consequences of pharmacogenetic-guided dosing of warfarin
Verhoef TI, et al.
Expert Rev Pharmacoecon Outcomes Res 2010 Aug;10(4):375-8

Emerging clinical applications in cardiovascular pharmacogenomics
Damani SB & Topol EJ
Wiley Interdiscip Rev Syst Biol Med 2010 Aug

Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer
Osawa K
Zhongguo Fei Ai Za Zhi 2009 Aug;12(8):837-40

Genomics and Pharmacogenomics of Dementia
Cacabelos R & Martinez-Bouza R
CNS Neurosci Ther 2010 Aug

Genomics and Pharmacogenomics of Schizophrenia
Cacabelos R & Martinez-Bouza R
CNS Neurosci Ther 2010 Aug

Pharmacogenetics in immunosuppressants: impact on dose requirement of calcineurin inhibitors in renal and liver pediatric transplant recipients
Quteineh L & Verstuyft C
Curr Opin Organ Transplant 2010 Aug

Other

Genomewide association studies in allergy and the influence of ethnicity
Barnes KC
Curr Opin Allergy Clin Immunol 2010 Aug

Leiden open variation database of the MUTYH gene
Out AA, et al.
Hum Mutat 2010 Aug

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

GAPP

For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.

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