Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, August 12, 2010 Volume 25 Number 7
Spotlight
4th National Conference on Genomics Announces Call for Abstracts
Abstracts will be accepted August 1-31st, 2010 for the 4th National Conference on Genomics and Public Health, which will be held on December 8-10, 2010, in Bethesda, Maryland. The conference planning committee invites abstracts for both oral and poster presentation related to genomic and public health practice, knowledge synthesis, communication, global health, preparedness and response, and new developments. Learn more about submitting an abstract [PDF 69 KB]. Learn more about the conference.
Announcements
- New article and invited commentaries published online in the American Journal of Epidemiology, August 5, 2010:
- The Emergence of Translational Epidemiology: From Scientific Discovery to Population Health Impact. Authors: Khoury MJ, Gwinn M, and Ioannidis JPA.
- Invited Commentary: The Epicenter of Translational Science. Author: Hiatt RA.
- Khoury et al. respond to ‘‘The Epicenter of Translational Science’’: Crossing All the T’s. Authors: Khoury MJ, Gwinn M, and Ioannidis JPA.
- As part of CDC's Expert Commentary Series on Medscape, Muin Khoury, MD, PhD, director of CDC’s Office of Public Health Genomics, explains why personal genomic tests that consumers can buy on the Internet are still not ready for primetime. View the online video.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Cancer
Personalized genome sequencing in cancer treatment - a major breakthrough in care, Medical News Today, August 12
Familial link in rare childhood leukemia, Medical News Today, August 10
Gene target may block breast cancer recurrence and boost survival, Medical News Today, August 10
K-State research team investigates mutated gene's role in breast cancer, Medical News Today, August 10
Research into suspicious gene tied to breast cancer, Medical News Today, August 10
Families with cancer in their genes get clues to staying well, Freep.com, August 8
Cardiovascular Disease
Common genetic variants associated with blood lipids, PHG Foundation, August 9
Genome scanning finds genes for cholesterol and heart disease that could be important targets for treatment, Medical News Today, August 5
Ethical, Legal, and Social Issues (ELSI)
Gene carriers argue against discrimination, China Economic Net, August 12
Boston Globe opinion piece considers ethics of passing on defective genes through infertility techniques, Medical News Today, August 11
Genetics experts consider tighter regulation, potential ban on DTC genetic testing, Genome Web, August 11 [by free subscription only]
Should we regulate people's access to their own genome data, Ars technical, August 11
Family History
Family medical histories are often skipped when kids come to doctors' offices, Cleveland.com, August 9
Genetic Testing
Compulsory genetic test ruling in Australian legal case, PHG Foundation, August 12
Drug managers Medco, CVS giving gene tests to millions in U.S., Bloomberg, August 11
Genetic testing ordered for girl, Brisbane Times, August 11
UC Berkeley professors defend student genetic testing, The Sacramento Bee, August 11
Georgetown hospital shuts lab after problems with genetic testing for breast cancer, Medical News Today, August 10
Newest fair attraction: DNA on a stick, Star Tribune, August 8
DNA dilemma, Day five: Time to decide, Newsweek, August 6
Genetic testing best left out of pharmacies/internet, SLU geneticist warns, Medical News Today, August 6
DNA dilemma: Day four, Newsweek, August 5
Infectious Disease
Scientists worry new superbug could spread worldwide, MSNBC, August 11
Genes for meningitis susceptibility and resistance revealed, Medical News Today, August 9
Genetic variant linked to TB susceptibility in Africans identified by genome study, Medical News Today, August 9
Neurologic Conditions
Large risk schizophrenia marker revealed, Medical News Today, August 7
Newborn Screening
Prenatal test not linked to blood pressure problems, Reuters Health, August 6
Other
Docs falling behind in race to help patients with genetics, Sign on San Diego, August 11
Francis Collins: One year at the helm, Nature News, August 11
Team from Pitt, Helicos BioSciences say human cells can copy not only DNA, but also RNA, Medical News Today, August 11
DNA song: Beethoven's genetic code turned into music, The Times of India, August 9
Gene brings teeth in shape, Medical News Today, August 6
Genomics in the Scientific Literature
Aging
Genetic aspects of osteoporosis
Hosoi T
J Bone Miner Metab 2010 Aug
Birth Defects
Understanding the population structure of North American patients with cystic fibrosis
Li W, et al.
Clin Genet 2010 Jul
Cancer
An "Omics" based Survey of Human Colon Cancer
Nambiar PR, et al.
Mutat Res 2010 Aug
Does race modify the association between CYP1B1 Val432Leu polymorphism and breast cancer risk? A critical appraisal of a recent meta-analysis
Economopoulos KP & Sergentanis TN
Breast Cancer Res Treat 2010 Aug
Genome-wide association study of pancreatic cancer in Japanese population
Low SK, et al.
PLoS One 2010;5(7):e11824
SGO White Paper Ovarian Education Campaign
Schorge JO, et al.
Gynecol Oncol 2010 Aug
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: Dual role in nicotine addiction and lung cancer
Improgo MR, et al.
Prog Neurobiol 2010 Jun
Cardiovascular Disease
Apolipoprotein E Genotype and Cardiovascular Diseases in the Elderly
Haan MN & Mayeda ER
Curr Cardiovasc Risk Rep 2010 Sep;4(5):361-8
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich TM, et al.
Nature 2010 Aug;466(7307):707-13
Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease
Lin JP, et al.
Clin Chem 2010 Aug
Chronic Disease
Hereditary pancreatitis
Lal A & Lal DR
Pediatr Surg Int 2010 Aug
Psoriasis genetics: breaking the barrier
Roberson ED & Bowcock AM
Trends Genet 2010 Aug
The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans
Freedman BI, et al.
J Am Soc Nephrol 2010 Aug
Diabetes
Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis
Bao W, et al.
Am J Epidemiol 2010 Aug
Epigenomics
Epigenomics of Human Colon Cancer
Carmona FJ & Esteller M
Mutat Res 2010 Aug
Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders
Szic KS, et al.
Biochem Pharmacol 2010 Aug
Ethical, Legal, and Social Issues (ELSI)
Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs)
Povey S, et al.
Hum Mutat 2010 Aug
Women's Constructions of the 'Right Time' to Consider Decisions about Risk-Reducing Mastectomy and Risk-Reducing Oophorectomy
Howard AF, et al.
BMC Womens Health 20
Family History
Comparison of the impaired fasting blood glucose in young healthy individuals with diabetic and non-diabetic first degree relatives
Shaikh MA, et al.
J Coll Physicians Surg Pak 2010 Aug;20(8):499-501
Parental consanguinity and family history of coronary artery disease strongly predict early stenosis
Youhanna S, et al.
Atherosclerosis 2010 Jul
Genetic Testing
Genetic testing services are to be regulated to protect UK patients
O'Dowd A
BMJ 2010;341:c4215
Size of the direct-to-consumer genomic testing market
Wright CF & Gregory-Jones S
Genet Med 2010 Aug
Which way for genetic-test regulation? Leave test interpretation to specialists
Beaudet AL
Nature 2010 Aug;466(7308):816-7
Infectious Disease
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
Thye T, et al.
Nat Genet 2010 Aug
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease
Davila S, et al.
Nat Genet 2010 Aug
Mental Health
Clock genes at the heart of depression
Kennaway DJ
J Psychopharmacol 2010 Aug;24(2 Suppl):5-14
Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data
Yoshimi A, et al.
Schizophr Res 2010 Aug
The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
Donohoe G, et al.
Schizophr Bull 2010 Aug
Personalized Medicine
Analysis of the genome to personalize therapy for melanoma
Davies MA & Samuels Y
Oncogene 2010 Aug
Genetic Self Knowledge and the Future of Epidemiologic Confounding
Weele TV
Am J Hum Genet 2010 Aug;87(2):168-72
Personalized Medicine: Marking a New Epoch in Cancer Patient Management
Diamandis M, et al.
Mol Cancer Res 2010 Aug
The path to personalized medicine
Hamburg MA & Collins FS
N Engl J Med 2010 Jul;363(4):301-4
Pharmacogenomics
Considerations in patients receiving oral antiplatelet therapy after acute coronary syndrome and percutaneous coronary intervention
Roffman DS
Am J Health Syst Pharm 2010 Aug;67(15 Suppl 7):S18-24
Genetic polymorphisms and atrial fibrillation: Insights into the prothrombotic state and thromboembolic risk
Lopez-Cuenca A, et al.
Ann Med 2010 Aug
Leveraging Learning From a Phase III Colorectal Cancer Clinical Trial: Outcomes, Methodology, Meta-Analysis and Pharmacogenetics
Goldberg RM, et al.
Trans Am Clin Climatol Assoc 2010;121:21-33
Pharmacogenetics of the Metabolic Disturbances and Atherosclerosis Associated with Antiretroviral Therapy in HIV-Infected Patients
Veloso S, et al.
Curr Pharm Des 2010 Aug
Respiratory Disease
Using genetics to predict the natural history of asthma?
Holloway JW, et al.
J Allergy Clin Immunol 2010 Aug;126(2):200-9
Other
Consumers' Views of Direct-to-Consumer Genetic Information
McBride CM, et al.
Annu Rev Genomics Hum Genet 2010 Jun
GeneCards Version 3: the human gene integrator
Safran M, et al.
Database (Oxford) 2010;2010:baq020
Public Attitudes and Beliefs About Genetics
Condit CM
Annu Rev Genomics Hum Genet 2010 Jun
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
GAPP
For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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