Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, April 29, 2010 Volume 24 Number 17
Spotlight
April is National Autism Awareness Month
Autism is one of a group of developmental disorders known as autism spectrum disorders (ASDs). Scientists think that both genes and the environment play a role in ASDs. Family studies have been helpful in understanding how genes contribute to autism. Read more.
Announcements
- CDC, the Association of Public Health Laboratories, and the Jeffrey Modell Foundation are now accepting applications for the inaugural Dr. Ronald H. Laessig Memorial Newborn Screening Fellowship. Learn more [PDF 30.84 KB].
- CDC's Office of Public Health Genomics seeks three new health scientists. For more information about these positions, click on the U.S. Department of Health and Human Services Web site and enter the vacancy number (below). The deadline to apply is May 10, 2010.
- Federal applicants: Use HHS-CDC-T2-2010-0338 if you have current or prior federal employment.
- All other U.S. citizens: Use HHS-CDC-D2-2010-0194 if you are a non-federal applicant.
- New publication by a CDC-funded genomics translation project, Stakeholder Perspectives on a Risk-Benefit Framework for Genetic Testing, published April 2010 in Public Health Genomics. Authors: Roth JA, Garrison LP, Burke W, Ramsey SD, Carlson R, Veenstra DL. Learn more about this project on the University of Washington Web site.
- New publication, Improvements in Ability to Detect Undiagnosed Diabetes by Using Information on Family History Among Adults in the United States, published Epub ahead of print on April 25, 2010 in the American Journal of Epidemiology. Authors: Yang Q, Liu T, Valdez R, Moonesinghe R, Khoury MJ.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Autoimmune Disorders
Genetic map gives detailed look MS, San Francisco Chronicle, April 29
Unraveling Crohn's genetic trail, The Wall Street Journal, April 27
Cancer
Researchers attack stem cells that cause colon cancer: Tumor cell 'factories' may be difficult to defeat, Science Daily, April 28
Brain tumor growth linked to lowered expression of hundreds of immune function genes, Medical News Today, April 27
Ethnic differences in genetic factors may affect susceptibility to development of breast cancer, News-Medical.Net, April 26
Prostate cancer: Risk increases with the number of affected family members, EurekAlert, April 23
Bowel cancer screening launch, BBC News, April 22
Effectiveness of comparative effectiveness, Genome Web, April 22 [by free subscription only]
Diabetes
Scientists reveal how genetic mutations may cause type 1 diabetes, NephrOnline, April 22
Epigenetics
'Epigenetic' concepts offer new approach to degenerative disease, EurekAlert, April 28
Ethical, Legal, and Social Issues (ELSI)
Gene discrimination suit filed by Conn. Woman, MSNBC, April 29
Compensation for inadequate consent to genetic research, PHG Foundation, April 27
‘Informed consent’ and the ethics of DNA research, The New York Times, April 23
Genetic Testing
New genetic tests may predict leading cause of hospital readmissions in newborns & improve outcomes for Asthma patients, Medical News Today, April 29
Maternal and Child Health
One of six national studies chosen for work to predict and prevent preterm birth, Medical News Today, April 28
'She was born perfect, but she was not born healthy', Komo News, April 28
Mental Health
Independent panel finds insufficient evidence to support preventive measures for Alzheimer's disease, NIH News, April 28
Study of Williams Syndrome patients reveals specific gene's role in intelligence, Medical News Today, April 23
Personalized Medicine
Advances in personalized medicine take center stage, EurekAlert, April 28
OICR invests in personalized medicine spin-offs, Genome Web, April 26 [by free subscription only]
Smoking, Tobacco and Alcohol
Researchers find genetic variants linked to smoking behaviors, Medical News Today, April 26
Scientists find genes that influence brain wave patterns, NIH News, April 26
Other
Child health director has background in genetics, The New York Times, April 26
New computational method to uncover gene regulation, Medical News Today, April 26
Southampton genetics scientist recognized by National Academy of Sciences, Medical News Today, April 23
What Is Androgen Insensitivity Syndrome (AIS)? What causes Androgen Insensitivity Syndrome, Medical News Today, April 23
The silence of the genes, EurekAlert, April 22
Genomics in the Scientific Literature
Topics in the Scientific Literature
Birth Defects
Epidemiologic and genetic aspects of spina bifida and other neural tube defects
Au KS, et al.
Dev Disabil Res Rev 2010;16(1):6-15
Cancer
Architecture of inherited susceptibility to common cancer
Fletcher O & Houlston RS
Nat Rev Cancer 2010 May;10(5):353-61
Candidate gene association studies: successes and failures
Pasche B & Yi N
Curr Opin Genet Dev 2010 Apr
Common variants associated with breast cancer in genome wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
Wang X, et al.
Hum Mol Genet 2010 Apr
From "omics" to complex disease: a systems biology approach to gene-environment interactions in cancer
Knox SS
Cancer Cell Int 2010 Apr;10(1):11
Hereditary and familial colon cancer
Jasperson KW, et al.
Gastroenterology 2010 Jun;138(6):2044-58
Molecular biology from bench-to-bedside - Which colorectal cancer patients should be referred for genetic counselling and risk assessment
Jensen LH, et al.
Eur J Cancer 2010 Apr
Cardiovascular Disease
Cardiovascular genomics: outcomes and implications
Herrington DM
Can J Cardiol 2010 Mar;26 Suppl A:60A-3A
Genetic causes of high and low serum HDL-cholesterol
Weissglas-Volkov D & Pajukanta P
J Lipid Res 2010 Apr
Chronic Disease
Is there an impatience genotype leading to non-adherence to long-term therapies?
Reach G
Diabetologia 2010 Apr
Epigenomics
Epigenetics of ovarian cancer: From the lab to the clinic
Asadollahi R, et al.
Gynecol Oncol 2010 Apr
Ethical, Legal, and Social Issues (ELSI)
"The Bigger the Network the Bigger the Bowl of Cherries…”..: Exploring the Acceptability of, and Preferences for, an Ongoing Support Network for Known BRCA 1 and BRCA 2 Mutation Carriers
Hughes L & Phelps C
J Genet Couns 2010 Apr
Family History
Do we know how many cancer patients have a family history of cancer?
Andjelic-Dekic N, et al.
J BUON 2010 Jan-2010 Mar;15(1):127-30
Genetic Testing
Stakeholder Perspectives on a Risk-Benefit Framework for Genetic Testing
Roth JA, et al.
Public Health Genomics 2010 Apr
Infectious Disease
Genetic risk of acute pulmonary infections and sepsis
Waterer GW & Bruns AH
Expert Rev Respir Med 2010 Apr;4(2):229-38
Neurologic Conditions
Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study
Laumet G, et al.
J Alzheimers Dis 2010 Apr
Obesity
The Genetics of Obesity and the Metabolic Syndrome
Monda KL, et al.
Endocr Metab Immune Disord Drug Targets 2010 Apr
Personalized Medicine
Future of Personalized Medicine in Oncology: A Systems Biology Approach
Gonzalez-Angulo AM, et al.
J Clin Oncol 2010 Apr
Refocusing the war on cancer: the critical role of personalized treatment
Potti A, et al.
Sci Transl Med 2010 Apr;2(28):28cm13
Using genetics and genomics strategies to personalize therapy for cancer: focus on melanoma
Nathanson KL
Biochem Pharmacol 2010 Apr
Pharmacogenomics
Cost-effectiveness analysis in pharmacogenomics
Payne K & Shabaruddin FH
Pharmacogenomics 2010 May;11(5):643-6
Direct-to-consumer genome testing: opportunities for pharmacogenomics research?
Prainsack B & Wolinsky H
Pharmacogenomics 2010 May;11(5):651-5
How and Why to Screen for CYP2D6 Interindividual Variability in Patients Under Pharmacological Treatments
De Gregori M, et al.
Curr Drug Metab 2010 Mar;11(3):276-82
Pharmacogenomics--10 years of progress: a cardiovascular perspective
Winkelmann BR & Herrington D
Pharmacogenomics 2010 May;11(5):613-6
Real-world clinical effectiveness, regulatory transparency and payer coverage: three ingredients for translating pharmacogenomics into clinical practice
Frueh FW
Pharmacogenomics 2010 May;11(5):657-60
The past, present and future of pharmacoepigenomics
Ingelman-Sundberg M & Gomez A
Pharmacogenomics 2010 May;11(5):625-7
Smoking, Tobacco and Alcohol
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Furberg H, et al.
Nat Genet 2010 Apr
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Liu JZ, et al.
Nat Genet 2010 Apr
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
Thorgeirsson TE, et al.
Nat Genet 2010 Apr
Other
Challenges in the Use of Literature-based Meta-Analysis to Examine Gene-Environment Interactions
Palla L, et al.
Am J Epidemiol 2010 Apr
Communicating Genetic and Genomic Information: Health Literacy and Numeracy Considerations
Lea DH, et al.
Public Health Genomics 2010 Apr
Future health applications of genomics: priorities for communication, behavioral, and social sciences research
McBride CM, et al.
Am J Prev Med 2010 May;38(5):556-65
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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