Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, September 24, 2009       Volume 23   Number 13

 

Spotlight

Breast and Ovarian Cancer Awareness in September and October
Breast cancer is the most common form of cancer in women. During an average lifetime, a woman’s risk to develop breast cancer is about 1 of 8 or 12%. Ovarian cancer is less common; affecting about 1 out of every 70 women (less than 2%) during their lifetime. Learn more about topics related to breast and ovarian cancer: the role of family health history and risk categories, genetic testing information and guidelines, and genetic counseling.

 

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Announcements

• New Web pages for the CDC-funded genomics translation project entitled Risk-Benefit Framework for Genetic Tests led by David Veenstra, PharmD, PhD, at the University of Washington. Visit the Web pages. Learn more about other CDC-funded translation genomics.
• New publication, Comparative Effectiveness Research and Genomic Medicine: An Evolving Partnership for 21st Century Medicine, published ahead of print in the September 11, 2009 of Genomics in Medicine. Authors: Khoury MJ, Rich EC, Randhawa G, Teutsch SM, and Niederhuber J.
• Obtain free access to the August 2009 issue of Genetics in Medicine, focusing on personal genomics.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Birth Defects

Insight into basis of chromosomal birth defects, PHG Foundation, September 23

Myriad avoids genetic counseling 'bottleneck' for BRCA testing by helping docs do it themselves, Genome Web, September 23 [by free subscription only]

Cancer

Gene variant shows strong gender bias for cancer predisposition, Medical News Today, September 23

Aspirin fights colon cancer risk of gene disorder, Reuters Health, September 21

Distinguishing breast cancer-causing mutations from those that are harmless, EurekAlert, September 21

Drugs target tumour cells with BRCA and PTEN mutations, PHG Foundation, September 21

Scientists in major prostate cancer gene discovery, Medical News Today, September 21

Dramatic breakthroughs in cancer treatment, Parade, September 20

Genetic Testing

Study finds genetic tests unreliable, The Darthmouth, September 24

Screening for genetic heart disease, Kold News, September 19

Mental Health

Historic gene therapy trial to treat Alzheimer's disease underway at Georgetown, Medical News Today, September 24

Schizophrenia gene linked with abnormal neurogenesis in adult and postnatal brain, EurekAlert, September 23

Other News

Innovative method detects genetic causes of complex diseases, U.S. News & World Report, September 23

Genomic medicine: The future is now, Philstar, September 22

Genomics shifts focus to rare diseases, Nature News, September 22

Glaucoma tied to gene variants in blacks, Medline Plus, September 22

Researchers identify gene variant linked to glaucoma, Medical News Today, September 22

Some 906 genetic disorders recorded in Arabs, Arabian Business, September 22

Junk DNA may prove invaluable in quest for gene therapies, EureAlert, September 21

NIH opens website for human embryonic stem cell lines for approval and announces members of working group, NIH News, September 21

Polymorphisms of the interleukin-1 gene complex may influence alcohol dependence, Medical News Today, September 21

Rare genetic disorder plagues southern Russian region, Russia Today, September 21

Febrile seizures and severe epilepsy in infants traced to a sodium channel gene mutation, Medical News Today, September 20

Discovery of regulatory role of key molecule provides further step towards future gene therapy to control disease, say Hebrew University researchers, Medical News Today, September 18

Mechanism related to the onset of various genetic diseases revealed, Medical News Today, September 18

Men with rare gender disorder can still have kids, Reuters Health, September 18

OGI launches genomics platform affiliates program, Genome Web, September 18 [by free subscription only]

Research and Markets adds report: A Guide to Genetic Counseling, 2nd Edition, Individual.com, September 18

The American Society of Human Genetics honors Dr. Huntington Willard as 2009 Allan Award recipient, EurekAlert, September 17

Amish aid study of genes, Lancaster Online, September 17

Are HBV genotype B/B3 and C/C1 the major genotypes in Indonesia, Medical News Today, September 17

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Genomics in Scientific Literature

 

Family History

Beta cell (dys)function in non-diabetic offspring of diabetic patients
Stadler M, et al.
Diabetologia 2009 Sep

Pattern of family history in stone patients
Fazil Marickar YM, et al.
Urol Res 2009 Sep

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe
Vasen HF, et al.
Fam Cancer 2009 Sep

Family history of cancer and risk of breast cancer in the Black Women's Health Study
Palmer JR, et al.
Cancer Causes Control 2009 Sep

Left-sided EEG focus and positive psychiatric family history are independent risk factors for affective disorders in temporal lobe epilepsy
Bragatti JA, et al.
Epilepsy Res 2009 Sep

Genetic Testing

Development and Characterization of Reference Materials for MTHFR, SERPINA1, RET, BRCA1, and BRCA2 Genetic Testing
Barker SD, et al.
J Mol Diagn 2009 Sep

Genome Wide

Genomewide Association Study of a Rapid Progression Cohort Identifies New Susceptibility Alleles for AIDS (ANRS Genomewide Association Study 03)
Le Clerc S, et al.
J Infect Dis 2009 Sep

Genetic variants associated with cardiac structure and function: a meta-analysis  and replication of genome-wide association data
Vasan RS, et al.
JAMA 2009 Jul;302(2):168-78

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Eeles RA, et al.
Nat Genet 2009 Sep

Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
Gudmundsson J, et al.
Nat Genet 2009 Sep

Pharmacogenomics

Cost-effectiveness of genotype-guided warfarin therapy for anticoagulation in elderly patients with atrial fibrillation
Leey JA, et al.
Am J Geriatr Pharmacother 2009 Aug;7(4):197-203

Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies
Daily EB & Aquilante CL
Pharmacogenomics 2009 Sep;10(9):1489-510

General Articles

Genetic polymorphisms associated with acute lung injury
Reddy AJ & Kleeberger SR
Pharmacogenomics 2009 Sep;10(9):1527-39

Drug-induced liver injury: insights from genetic studies
Andrade RJ, et al.
Pharmacogenomics 2009 Sep;10(9):1467-87

Impact of Genotype Misclassification on Genetic Association Estimates and the Bayesian Adjustment
Hossain S, et al.
Am J Epidemiol 2009 Sep

Hypothesis-Driven Candidate Gene Association Studies: Practical Design and Analytical Considerations
Jorgensen TJ, et al.
Am J Epidemiol 2009 Sep

Genome-wide association studies: hypothesis-"free" or "engaged"?
Kitsios GD & Zintzaras E
Transl Res 2009 Oct;154(4):161-4

Identification and management of familial hypercholesterolaemia: what does it mean to primary care?
Qureshi N, et al.
Br J Gen Pract 2009 Sep

Interindividual variation in epigenomic phenomena in humans
French HJ, et al.
Mamm Genome 2009 Sep

Planning and Executing a Genome Wide Association Study (GWAS)
Sale MM, et al.
Methods Mol Biol 2009;590:403-18

Basic molecular techniques for the detection of single nucleotide polymorphisms:  genome-wide applications in search for endocrine tumor related genes
Horvath A & Stratakis C
Methods Mol Biol 2009;590:143-63

Can our understanding of epigenetics assist with primary prevention of congenital defects?
Martinez-Frias ML
J Med Genet 2009 Sep

Genomics and the prospects of existing and emerging therapeutics for cardiovascular diseases
Zaiou M, et al.
Curr Pharm Des 2009;15(27):3193-206

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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