Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, September 17, 2009       Volume 23   Number 12

 

Spotlight

NIH Releases Statement on Family Health History State-of-the Science
A multidisciplinary panel released a draft statement following the Family History State-of-the-Science Conference hosted by the National Institutes of Health in Bethesda, Maryland this week. Recommendations were aimed at informing the research agenda for using family history to improve health, focusing on these areas: what information should be collected, what are the optimal ways to collect and use this information, and patient outcomes. Read the draft statement.  Watch webinars of the proceedings.

 

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Announcements

• New grant of the U.S. Health and Human Services, Health Resources and Services Administration, Genetic Services Branch set to fund the First National Newborn Screening Clearinghouse. Read the press release
• New publication, Comparative Effectiveness Research and Genomic Medicine: An Evolving Partnership for 21st Century Medicine, published ahead of print in the September 11, 2009 issue of Genomics in Medicine. Authors: Khoury MJ, Rich EC, Randhawa G, Teutsch SM, and Niederhuber J.
• September issue of the Michigan Cancer Consortium newsletter released, including an article by the Michigan Cancer Genetics Alliance on Oncotype DX Testing in Breast Cancer Patients: What is the Evidence? Access the newsletter (PDF 399.60 KB).
• Obtain free access to the August 2009 issue of Genetics in Medicine, focusing on personal genomics.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Birth Defects

Landmark study sheds new light on human chromosomal birth defects, EurekAlert, September 16

Ethical, Legal, and Social Issues (ELSI)

Toronto statement on pre-publication biomedical data release, PHG Foundation, September 16

The company's gone, but what about the data, Genome Web, September 14 [by free subscription only]

Secure way to share genetic data, PHG Foundation, September 14

Genetic Testing

Understanding the implications of prenatal testing for Down syndrome, Medical News Today, September 15

Mental Health

The future of schizophrenia, EurekAlert, September 14

Alzheimer's gene affects brains of young adults, Medline Plus, September 11

UAB researchers looking for genetic predictors for suicide, Medical News Today, September 11

Newborn Screening

New web site promotes interoperable newborn screening data, NIH News, September 15

Obesity

The real cause of obesity, Newsweek, September 10

Other News

Genetic hint for ridding the body of Hepatitis C, Medical News Today, September 17

Breakthrough genetic test helps doctors assess risk of developing psoriatic arthritis (PsA), Medical News Today, September 16

NIH funds grantees focusing on epigenomics of human health and disease, NIH News, September 16

Two studies look at the benefits and limits of the information in personal genetics, Medical News Today, September 16

Cold Spring Harbor Laboratory gears up for 2nd annual personal genomes meeting, Medical News Today, September 15

The cost of sequencing a human genome? Answers differ, even for the same platform, Genome Web, September 15 [by free subscription only]

NIH releases innovative approach to exploring bioethics in new curriculum supplement, NIH News, September 15

Practical advice for unraveling the genetics of complex human diseases: New book, Medical News Today, September 15

The role of genetic factors in adult ADHD, EurekAlert, September 15

Comprehensive overview of genetic counseling, News-Medical.net, September 14

On the job: Valerie Loik Ramey, Licensed genetic counselor, Dept. of Pediatrics, UMass Memorial Health Care, telegram.com, September 14

What's the future of array-based GWAS? Sequencing tech, study design, funding to impact growth, Genome Web, September 14 [by free subscription only]

U. research links gene to epilepsy, Deseret News, September 12

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Genomics in Scientific Literature

 

Family History

Oral contraceptives and family history of breast cancer
Gaffield ME, et al.
Contraception 2009 Oct;80(4):372-80

Selection criteria for genetic assessment of patients with familial melanoma
Leachman SA, et al.
J Am Acad Dermatol 2009 Oct;61(4):677.e1-677.e14

Genetic Testing

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study
Jorgensen AL, et al.
Pharmacogenet Genomics 2009 Sep

Barriers to the use of genetic testing: A study of racial and ethnic disparities
Suther S & Kiros GE
Genet Med 2009 Sep;11(9):655-62

Is uptake of genetic testing for colorectal cancer influenced by knowledge of insurance implications?
Keogh LA, et al.
Med J Aust 2009 Sep;191(5):255-8

Genome Wide

Genome-wide association of IL28B with response to pegylated interferon-alpha and  ribavirin therapy for chronic hepatitis C
Tanaka Y, et al.
Nat Genet 2009 Sep

IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
Suppiah V, et al.
Nat Genet 2009 Sep

Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis
Sha Q, et al.
BMC Med Genet 2009 Sep;10(1):86

Pharmacogenomics

Pharmacogenetics in cardiovascular antithrombotic therapy
Marin F, et al.
J Am Coll Cardiol 2009 Sep;54(12):1041-57

Pharmacogenetic Testing for Guiding de novo Phenprocoumon Therapy in Stroke Patients
Arnold ML, et al.
Cerebrovasc Dis 2009 Sep;28(5):468-71

Pharmacogenetics of antiretrovirals
Tozzi V
Antiviral Res 2009 Sep

The role of pharmacogenetics in the treatment of depression and anxiety disorders
Schosser A & Kasper S
Int Clin Psychopharmacol 2009 Sep

General Articles

Comparative effectiveness research and genomic medicine: An evolving partnership  for 21st century medicine
Khoury MJ, et al.
Genet Med 2009 Sep

The ethical use of existing samples for genome research
Bathe OF & McGuire AL
Genet Med 2009 Sep

Trend tests for genetic association using population-based cross-sectional complex survey data
She D, et al.
Biostatistics 2009 Sep

Genetics and the general physician: insights, applications and future challenges
Knight JC
QJM 2009 Sep

An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations
Timshel S, et al.
Cancer Epidemiol 2009 Sep

The Role of DNA Copy Number Variation in Schizophrenia
Tam GW, et al.
Biol Psychiatry 2009 Sep

Functional Variants of the Interleukin-23 Receptor Gene in Non-Gastrointestinal Autoimmune Diseases
Safrany E & Melegh B
Curr Med Chem 2009 Sep

Planning for translational research in genomics
Hawkins N, et al.
Genome Med 2009 Sep;1(9):87

From Genetic Risk Awareness to Overt Type 1 Diabetes: Parental Stress in a Placebo-Controlled Prevention Trial
Goldstein E, et al.
Diabetes Care 2009 Sep

Cancer genetics: estimation of the needs of the population in France for the next ten years.
Bonaiti-Pellie C, et al.
Bull Cancer 2009 Sep

A pharmacogene database enhanced by the 1000 Genomes Project
Gamazon ER, et al.
Pharmacogenet Genomics 2009 Sep

Single nucleotide polymorphisms and health behaviours related to obesity - trawling the evidence in the prospect of personalised prevention
Fister K, et al.
Stud Health Technol Inform 2009;150:762-6

Genetics and genomics of chronic obstructive pulmonary disease
Silverman EK, et al.
Proc Am Thorac Soc 2009 Sep;6(6):539-42

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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