Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, September 10, 2009       Volume 23   Number 11

 

Spotlight

NIH Releases Statement on Family Health History State-of-the Science
A multidisciplinary panel released a draft statement following the Family History State-of-the-Science Conference hosted by the National Institutes of Health in Bethesda, Maryland this week. Recommendations were aimed at informing the research agenda for using family history to improve health, focusing on these areas: what information should be collected, what are the optimal ways to collect and use this information, and patient outcomes. Read the draft statement.  Watch webinars of the proceedings.

 

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Announcements

• NIH’s National Cancer Institute releases a new monograph, Phenotypes and Endophenotypes: Foundations for Genetic Studies of Nicotine Use and Dependence. Access the monograph  (PDF 7.72 MB) .
• New interview with Muin J Khoury, MD, PhD, about personal genomic tests, published in the September 8, 2009 issue of the National Cancer Institute Bulletin. Access the interview.
• Presentation slides and audio recordings of the National Academies workshop on DTC genetic testing (August 31-September 1, 2009) are now available. View also C-SPAN videos of this workshop:
  • Consumer genetic testing issues
  • Regulation of genetic testing
  • Genetic testing and privacy
  • Genetic testing and research
• Obtain free access to the August 2009 issue of Genetics in Medicine, focusing on personal genomics.
• Registration is now open for the 2009 Healthy People 2020 Public Meetings hosted by the U.S. Department of Health and Human Services. Participation is open to all individuals who are interested in commenting on the draft Healthy People 2020 objectives and topic areas. Meetings will be held in Kansas City, KS, Philadelphia, PA, and Seattle, WA in October and November 2009.  Learn more. Register online.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Genetic study points to potential treatment for melanoma, NCI Cancer Bulletin, September 8

Common genetic variation influences risk of lung cancer, PHG Foundation, September 4

Diabetes

New Type 2 Diabetes gene identified, Medical News Today, September 8

Ethical, Legal, and Social Issues (ELSI)

Move to regulate genetic tests sold to public, FT.com, September 8

Topics and trends | Genetic information, Kansas City, September 7

Genetic Testing

Consumer genetic testing needs international standards, Science Business, September 9

Genetic information available for consumer purchase, The Daily Texan, September 8

HGC public consultation on DTC genetic testing services, PHG Foundation, September 8

People with genetic risk of bowel cancer decline genetic testing, News-Medical.Net, September 7

Should you get genetic testing, Consumer Affairs, September 4

Users should beware of at-home genetic tests, stltoday.com, September 3

The scary, scary genes, Genome Web, September 3 [by free subscription only]

Mental Health

Genetic variations may underlie multiple psychiatric conditions, Medical News Today, September 8

Scientists identify two gene variants associated with Alzheimer's risk, NIH News, September 6

Other News

Mathematicians identify genes linked to Lou Gehrig's disease, Medical News Today, September 10

Research reveals genetic conversation between X and Y chromosomes, News-Medical.Net, September 10

Gene variant heightens risk of severe liver disease in cystic fibrosis, Medical News Today, September 9

New method to measure mutation rate, PHG Foundation, September 8

1000 Genomes Project to sequence nearly 1,000 more samples by early 2010; new samples collected, Genome Web, September 8 [by free subscription only]

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Genomics in Scientific Literature

 

Family History

Additive Utility of Family History and Waist Circumference to Body Mass Index in  Childhood for Predicting Metabolic Syndrome in Adulthood
Schubert CM, et al.
J Pediatr 2009 Sep;155(3):S6.e9-S6.e13

How can we reach them? Information seeking and preferences for a cancer family history campaign in underserved communities
Kelly KM, et al.
J Health Commun 2009 Sep;14(6):573-89

Do Colorectal Cancer Patients Understand That Their Family Is at Risk?
Rubin DT, et al.
Dig Dis Sci 2009 Sep

Risk of cancer among children of cancer patients - A nationwide study in Finland
Madanat-Harjuoja LM, et al.
Int J Cancer 2009 Sep

Genetic Testing

The clinical application of genetic testing in type 2 diabetes: a patient and physician survey
Grant RW, et al.
Diabetologia 2009 Sep

Living with genetic test results for hereditary breast and ovarian cancer
Hamilton R, et al.
J Nurs Scholarsh 2009;41(3):276-83

Genome Wide

A genomewide association study points to multiple Loci that predict antidepressant drug treatment outcome in depression
Ising M, et al.
Arch Gen Psychiatry 2009 Sep;66(9):966-75

Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults
DE Moor MH, et al.
Med Sci Sports Exerc 2009 Sep

Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom
Spain SL, et al.
Cancer Res 2009 Sep

Genome-Wide Association Identifies the ABO Blood Group as a Major Locus Associated With Serum Levels of Soluble E-Selectin
Paterson AD, et al.
Arterioscler Thromb Vasc Biol 2009 Sep

Genetic Variation in GPR133 is Associated with Height - Genome Wide Association Study in the Self-contained Population of Sorbs
Tonjes A, et al.
Hum Mol Genet 2009 Sep

Genome-wide association study identifies variants at CLU and CR1 associated with  Alzheimer's disease
Lambert JC, et al.
Nat Genet 2009 Sep

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
Harold D, et al.
Nat Genet 2009 Sep

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
van Es MA, et al.
Nat Genet 2009 Sep

A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery
Need AC, et al.
Hum Mol Genet 2009 Sep

Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients
Laje G, et al.
Pharmacogenet Genomics 2009 Sep;19(9):666-74

Pharmacogenomics

Pharmacogenomics and therapeutic strategies for dementia
Cacabelos R
Expert Rev Mol Diagn 2009 Sep;9(6):567-611

Pharmacogenomics in chemotherapy for GI tract cancer
Furuta T
J Gastroenterol 2009 Sep

General Articles

Huntington's disease: the case for genetic modifiers
Gusella JF & Macdonald ME
Genome Med 2009 Aug;1(8):80

The Use of Predictive or Prognostic Genetic Biomarkers in Endometrial and Other Hormone-Related Cancers: Justification for Extensive Candidate Gene Single Nucleotide Polymorphism Studies of the Matrix Metalloproteinase Family and their  Inhibitors
O'Mara TA, et al.
Cancer Epidemiol Biomarkers Prev 2009 Sep

Integrating genomics, proteomics and bioinformatics in translational studies of molecular medicine
Ostrowski J & Wyrwicz LS
Expert Rev Mol Diagn 2009 Sep;9(6):623-30

Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network
Linghu B, et al.
Genome Biol 2009 Sep;10(9):R91

Epistasis and Its Implications for Personal Genetics
Moore JH & Williams SM
Am J Hum Genet 2009 Sep;85(3):309-20

Genetics and the Young Woman with Breast Cancer
Evans JP, et al.
Breast Dis 2009 Sep;23:17-29

Ranking of genome-wide association scan signals by different measures
Stromberg U, et al.
Int J Epidemiol 2009 Sep

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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