Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, September 3, 2009       Volume 23   Number 10

 

Spotlight

NIH Releases Statement on Family Health History State-of-the Science
A multidisciplinary panel released a draft statement following the Family History State-of-the-Science Conference hosted by the National Institutes of Health in Bethesda, Maryland this week. Recommendations were aimed at informing the research agenda for using family history to improve health, focusing on these areas: what information should be collected, what are the optimal ways to collect and use this information, and patient outcomes. Read the draft statement.  Watch webinars of the proceedings.

 

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Announcements

• New interview with Muin J Khoury, MD, PhD, on the “Future of Public Health Genomics and Why it Matters for Personalized Medicine and Global Health” published in the September 2009 issue of Current Pharmacogenomics & Personalized Medicine. Access the interview  (PDF 200.50 KB).
• Obtain free access to the August 2009 issue of Genetics in Medicine, focusing on personal genomics.
• Registration is now open for the 2009 Healthy People 2020 Public Meetings hosted by the U.S. Department of Health and Human Services. Participation is open to all individuals who are interested in commenting on the draft Healthy People 2020 objectives and topic areas. Meetings will be held in Kansas City, KS, Philadelphia, PA, and Seattle, WA in October and November 2009.  Learn more. Register online.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Asthma

Novel genetic region identified for childhood asthma in Mexicans, EurekAlert, August 28

Cancer

Ovarian cancer risk: Scientists from University of Hawaii at Manoa find genetic marker, Medical News Today, September 2

MicroRNAs in blood may be biomarkers of pancreatic cancer, NIH News, September 1

Scientists identify gene that predicts post-surgical survival from brain metastasis of breast cancer patients, EurekAlert, September 1

NIH study reveals new genetic culprit in deadly skin cancer, NIH News, August 30

Diabetes

DNA changes linked to diabetes, Medical News Today, September 3

Ethical, Legal, and Social Issues (ELSI)

Tel Aviv University researcher devises mathematical formula for protecting the genetic privacy, News-Medical.Net, September 1

Genetic Testing

Good genetic testing, Genome Web, September 1 [by free subscription only]

Illumina announces delivery of the first genome through its individual genome sequencing service, Medical News Today, September 2

Counseling is a crucial component of genetic testing, Media Newswire, September 1

Buyer beware of home DNA tests, The New York Times, August 31

Genetic tests more available, but no less complex, Health News Digest, August 31

Other Chronic Diseases

Researchers find gene that contributes to two different and common neurological movement disorders, Medical News Today, September 2

Gene variation is 'major genetic determinant of psoriasis', Science Daily, August 28

Other News

Promise of nanodiamonds for safer gene therapy, Science Daily, September 1

Researchers make first direct measurement of human genetic mutation rate, Wellcome Trust, September 1

Duplicated genome sequences counting is possible, Huliq News, August 31

Genome Research publishes special issue: Personal genomes and variation, EurekAlert, September 1

Bid to cure Tay-Sachs disease advanced by NIH grant, Medical News Today, August 29

Gene associated with language, speech and reading disorders, Medical News Today, August 29

Are we ready for personal genomics, Times Online, August 28

Innovation bridges gap between new genome data and decades of research, Medical News Today, August 28

Unravelling the genomic conundrum, Investment International, August 28

The American Society of Human Genetics hosts 59th annual meeting in Honolulu, EurekAlert, August 27

We are all mutants: Measurement of mutation rate in humans by direct sequencing, Science Daily, September 1

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Genomics in Scientific Literature

 

Family History

Familial predisposition to chronic obstructive pulmonary disease
Rowinska-Zakrzewska E
Pneumonol Alergol Pol 2009;77(4):407-10

Detailed family history of diabetes identified children at risk of type 2 diabetes: a population-based case-control study
Wei JN, et al.
Pediatr Diabetes 2009 Aug

Communication, encouragement, and cancer screening in families with and without mutations for hereditary nonpolyposis colorectal cancer: a pilot study
Ersig AL, et al.
Genet Med 2009 Aug

Synergy of BMI and family history on diabetes: the Humboldt Study
Chen Y, et al.
Public Health Nutr 2009 Aug:1-5

Genetic Testing

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?
Achatz MI, et al.
Lancet Oncol 2009 Sep;10(9):920-5

Genetic testing in the management of inherited arrhythmia syndromes
Tzou WS & Gerstenfeld EP
Curr Cardiol Rep 2009 Sep;11(5):343-51

Genome Wide

PKNOX2 gene is significantly associated with substance dependence in European-origin women
Chen X, et al.
Proc Natl Acad Sci U S A 2009 Aug

Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics
McClay JL, et al.
Mol Psychiatry 2009 Sep

General Articles

Genomic privacy and limits of individual detection in a pool.
Sankararaman S, Obozinski G, Jordan MI, Halperin E.
Nat Genet. 2009 Sep;41(9):965-7.

Nicotine dependence and genetic variation in the nicotinic receptors
Bierut LJ
Drug Alcohol Depend 2009 Oct;104 Suppl 1:S64-9

Smoking and smoking cessation in disadvantaged women: assessing genetic contributions
Uhl GR, et al.
Drug Alcohol Depend 2009 Oct;104 Suppl 1:S58-63

Sex heterogeneity in pharmacogenetic smoking cessation clinical trials
Schnoll RA & Patterson F
Drug Alcohol Depend 2009 Oct;104 Suppl 1:S94-9

Expanding the Public Health Research Agenda for Ovarian Cancer
Trivers KF, et al.
J Womens Health (Larchmt) 2009 Aug

The Role of Vascular Endothelial Growth Factor Genetic Variability in Cancer
Schneider BP, et al.
Clin Cancer Res 2009 Aug

Epigenetics: definition, mechanisms and clinical perspective
Dupont C, et al.
Semin Reprod Med 2009 Sep;27(5):351-7

Inherited susceptibility to pediatric acute lymphoblastic leukemia
Levine RL
Nat Genet 2009 Sep;41(9):957-8

Genetics/Genomics in chronic kidney disease--towards personalized medicine?
Luttropp K, et al.
Semin Dial 2009 Jul-2009 Aug;22(4):417-22

Closing the gap between genotype and phenotype
Gregersen PK
Nat Genet 2009 Sep;41(9):958-9

Genetics of attention-deficit hyperactivity disorder (ADHD)
Sharp SI, et al.
Neuropharmacology 2009 Aug

Genetic Susceptibility to Behavioural and Psychological Symptoms in Alzheimer Disease
Borroni B, et al.
Curr Alzheimer Res 2009 Dec

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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