Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, October 22, 2009       Volume 23   Number 17

 

Spotlight

NIH Announces New Comparative Effectiveness Research Projects in Genomics and Personalized Medicine

This month NIH’s National Cancer Institute announces seven new projects comparing and evaluating the clinical validity and utility and cost-effectiveness of genomic and personalized medicine applications to existing standards of care and prevention for cancer treatment and prevention. These projects will become part of the new CDC initiative called Genomic Applications in Practice and Prevention Network (GAPPNet). Learn more about the new funded projects. Learn about public health genomics at NCI.

 

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Announcements

• New Healthy People 2020 objectives now posted, including new genomics-related objectives. Public comment will open on October 30, 2009.
• Michigan’s Department of Community Health has launched a new Web page for their genomics translation project which is helping to promote best clinical and public health practices in cancer genomics.  Visit the Web page.
• October is breast and ovarian cancer month. Learn more about: the role of family health history and risk categories, genetic testing information and guidelines, and genetic counseling.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Aging

Sequential genomic analysis links gene with human kidney aging, Medical News Today, October 16

Autoimmune Disease

More than a dozen different genes may play a role in causing lupus, WebMD, October 19

Cancer

Genetic 'co-dependence' exploited to kill treatment-resistant tumor cells, Science Daily, October 22

Developments in melanoma genetics, PHG Foundation, October 21

Duplicated gene may explain rare cancer in some families, NCI Cancer Bulletin, October 20

Genetic testing helpful in cancer detection, Yankton Press & Dakotan, October 20

New chromosomal abnormality identified in leukemia associated with Down Syndrome, Medical News Today, October 19

Cardiovascular Disease

Diagnosis of cardiovascular disease associated with risk of subsequent hip fracture, EurekAlert, October 20

Infants with congenital heart disease benefit from routine genetic testing, ultrasound: Presented at AAP, Doctor’s Guide, October 19

Diabetes

Eleven genetic variations linked to Type 2 Diabetes, Science Daily, December 19

Ethical, Legal, and Social Issues (ELSI)

NIH to update data-sharing policy for sequence and related genomic data, Genome Web, October 21 [by free subscription only]

Standards for a new genomic era, EurekAlert, October 21

Wellness programs may face regulations to protect genetic information, Medical News Today, October 15

Genetic Testing

NIH set to enhance diagnostic testing in newborns, Private MD, October 20

Genetic testing for disease heredity gains favor, The Detroit News, October 19

Jumping on genetic testing—The war of the SNPs, Genetic Engineering & Biotechnology News, October 16

Gynecologic Disease

Hand-foot genital syndrome in women without HOXA13 gene mutation, Medical News Today, October 20

Mental Health

Twin study suggests genetic link between major depression and heart disease risk, DepNet, October 16

Neurologic Conditions

Gene behind Gaucher disease a player in Parkinson's, Healthgrades, October 21

Study surprise yields new target for assessing genes linked to autism, EurekAlert, October 21

Genetic clue may predict multiple sclerosis severity, WebMD, October 19

Novel genetic loci for autism susceptibility, PHG Foundation, October 16

Respiratory Disease

Gene mutation may reveal clues for treating lung diseases, Medical News Today, October 16

Other News

NHGRI launches improved online talking glossary of genetic terms, NIH News, October 20

Power and promise of new genetic technology illustrated in Yale's scan of Turkish infant's genome, Medical News Today, October 20

Second genetics meet set to begin on Oct 31, Gulf Times, October 20

Genome folding offers clues to gene activity, PHG Foundation, October 16

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Genomics in Scientific Literature

 

Cancer

BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications
Kurian AW
Curr Opin Obstet Gynecol 2009 Oct

The effect of genetic variability on drug response in conventional breast cancer  treatment
Wiechec E & Hansen LL
Eur J Pharmacol 2009 Oct

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome  5p15 Associated with Risk for Adenocarcinoma
Landi MT, et al.
Am J Hum Genet 2009 Oct

Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics
Ishikawa T & Nakagawa H
J Exp Ther Oncol 2009;8(1):5-24

Chronic Disease

Collaborative Meta-analysis: Associations of 150 Candidate Genes With Osteoporosis and Osteoporotic Fracture
Richards JB, et al.
Ann Intern Med 2009 Oct;151(8):528-37

Commentary. Genetic variants and omega-6, omega-3 Fatty acids: their role in the  determination of nutritional requirements and chronic disease risk
Simopoulos AP
J Nutrigenet Nutrigenomics 2009;2(3):117-8

Susceptibility genes in common complex kidney disease
Divers J & Freedman BI
Curr Opin Nephrol Hypertens 2009 Oct

Epigenomics

Angelman syndrome - the research model of epigenetic mechanisms expression genes regulation
Szpecht-Potocka A, et al.
Med Wieku Rozwoj 2009;XIII(2):123-30

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies
Urdinguio RG, et al.
Lancet Neurol 2009 Nov;8(11):1056-72

The epigenetics of sex differences in the brain
McCarthy MM, et al.
J Neurosci 2009 Oct;29(41):12815-23

Ethical, Legal, and Social Issues (ELSI)

Ethical and Social Issues in Pharmacogenomics Testing
Vijverberg SJ, et al.
Curr Pharm Des 2009 Oct

Ethical considerations of genetic presymptomatic testing for Huntington's disease
Coustasse A, et al.
J Hosp Mark Public Relations 2009 Jul-2009 Dec;19(2):129-41

Next generation disparities in human genomics: concerns and remedies
Need AC & Goldstein DB
Trends Genet 2009 Oct

Public Perspectives on Informed Consent for Biobanking
Murphy J, et al.
Am J Public Health 2009 Oct

Family History

Beliefs about heritability of cancer and health information seeking and preventive behaviors
Kaphingst KA, et al.
J Cancer Educ 2009;24(4):351-6

Characteristics of Health Information Gatherers, Disseminators, and Blockers Within Families at Risk of Hereditary Cancer: Implications for Family Health Communication Interventions
Koehly LM, et al.
Am J Public Health 2009 Oct

Familial association of pancreatic cancer with other malignancies in Swedish families
Hiripi E, et al.
Br J Cancer 2009 Oct

Family history of cancer and malignant germ cell tumors in children: A report from the Children's Oncology Group
Poynter JN, et al.
Cancer Causes Control 2009 Oct

Family history of melanoma and Parkinson disease risk
Gao X, et al.
Neurology 2009 Oct;73(16):1286-91

Schizophrenia in the Offspring of Antenatally Depressed Mothers in the Northern Finland 1966 Birth Cohort: Relationship to Family History of Psychosis
Maki P, et al.
Am J Psychiatry 2009 Oct

Genetic Testing

Automated DNA mutation detection using universal conditions direct sequencing: application to ten muscular dystrophy genes
Bennett RR, et al.
BMC Genet 2009 Oct;10(1):66

BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer :  hope or reality?
Tagliaferri P, et al.
J Ovarian Res 2009 Oct;2(1):14

Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients
Erlic Z, et al.
Clin Cancer Res 2009 Oct;15(20):6378-85

Genetic association studies in drug-induced liver injury
Daly AK & Day CP
Semin Liver Dis 2009 Nov;29(4):400-11

Preventing Future Cancers by Testing Women With Ovarian Cancer for BRCA Mutations
Kwon JS, et al.
J Clin Oncol 2009 Oct

Infectious Disease

Genetic variability of innate immunity impacts human susceptibility to fungal diseases
Carvalho A, et al.
Int J Infect Dis 2009 Oct

Mental Health

Genetic, environmental, and epigenetic factors in the development of personality  disturbance
Depue RA
Dev Psychopathol 2009 Fall;21(4):1031-63

The genetics of attention-deficit/hyperactivity disorder
Coghill D & Banaschewski T
Expert Rev Neurother 2009 Oct;9(10):1547-65

Pharmacogenomics

Genes and Drugs Determine Individual Therapeutic Utility
Caskey CT
Annu Rev Med 2009 Oct

Pharmacogenetics in Oncology: A Promising Field
Houtsma D, et al.
Curr Pharm Des 2009 Oct

Pharmacogenetics in Psychiatry - A Useful Clinical Tool or Wishful Thinking for the Future?
Kirchheiner J, et al.
Curr Pharm Des 2009 Oct

Pharmacogenetics of Oral Anticoagulant Therapy
Schalekamp T & de Boer A
Curr Pharm Des 2009 Oct

Pharmacogenetics of Phase I and Phase II Drug Metabolism
Crettol S, et al.
Curr Pharm Des 2009 Oct

Pharmacogenetics of Thiopurines in Inflammatory Bowel Disease
Derijks LJ & Wong DR
Curr Pharm Des 2009 Oct

Other

Clustering and commonalities among autoimmune diseases
Mackay IR
J Autoimmun 2009 Oct

Sporadic cases are the norm for complex disease
Yang J, et al.
Eur J Hum Genet 2009 Oct

Mutation analysis in primary immunodeficiency diseases: case studies
Hsu AP, et al.
Curr Opin Allergy Clin Immunol 2009 Oct

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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