Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, October 8, 2009       Volume 23   Number 15

 

Spotlight

Family Health History Still an Important Tool but Knowledge Gaps Remain

CDC addresses public health implications of the findings and recommendations just released by a multidisciplinary panel of the Family History State-of-the-Science Conference hosted by the National Institutes of Health in Bethesda, Maryland, on August 24-25, 2009. CDC participated as a partner in this conference. Read more. Access the panel’s statement.

 

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Announcements

• New article, Modification by ALAD of the Association Between Blood Lead and Blood Pressure in the U.S. Population: Results from NHANES III, published in the October 7, 2009 online issue of Environmental Health Perspectives. Authors: Scinicariello F, Yesupriya A, Chang M, and Fowler B for the CDC/NCI NHANES III Genomics Working Group. This paper is part of a larger study by the CDC/NCI NHANES III Genomics Working Group that recently reported prevalence estimates of selected gene variants of the U.S. population.
• New rules to protect individuals’ genetic information issued by the U.S. Departments of Health and Human Services (HHS), Labor, and the Treasury.  Read more.
• October is breast and ovarian cancer month. Learn more about: the role of family health history and risk categories, genetic testing information and guidelines, and genetic counseling.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Genes signal late-sage laryngeal cancer, poorer outcome, Medical News Today, October 8

Genetic enzyme CYP2D6 variation was associated with outcomes in breast cancer, HemOnc today, October 7

Short strand of RNA may help predict survival and response to treatment for patients with liver cancer, NIH News, October 7

New journal in 2010 on cancer biology and genetics, Medical News Today, October 7

Breast cancer gene found, The Herald Sun, October 6

The Cancer Genome Atlas Project to map 20 tumor types, NCI Cancer Bulletin, October 6

Do your genes put you at greater risk for breast cancer, Dayton Daily News, October 6

Gene mutation linked to type of childhood cancer, NCI News, October 5

New type of genetic change identified in inherited cancer, Science Daily, October 5

Study finds 231 new genes associated with head and neck cancer, Science Daily, October 5

Cardiovascular Disease

'Closed Heart Surgery': Scientists jump-start the heart by gene transfer, Science Daily, October 7

Chronic Diseases

Genes associated with onset age of Parkinson's disease identified by researchers, Medical News Today, October 8

Gene therapy study for Parkinson's disease launched by Michigan hospital, Medical News Today, October 7

Diabetes

Diabetes gene link treatment hope, BBC News, October 7

11 new genetic variations linked to type 2 diabetes, Thaindian News, October 3

Ethical, Legal, and Social Issues (ELSI)

Anonymized genetic research data still carries privacy risks, Ars Technica, October 6

Keeping DNA "All in the Family", American Friends Tel Aviv University, October 6

Federal rules protect genetic information, Health Data Management, October 2

Genetic Testing

New opinions on DTC genetic testing, PHG Foundation, October 8

Genetic counseling in the pediatric setting, Oncology Nursing News, October 7

Two consumer gene tests give conflicting results, Reuters, October 7

Future MDs will put their DNA to the test, Boston Globe, October 5

Healthy Aging

Genes linked to brittle bone identified, sify news, October 7

Genetic mutation a strong indicator of age-related hearing loss risk, Red Orbit, October 6

Maternal and Child Health

NIDCR launches the FaceBase consortium, NIH News, October 5

Mental Health

Autism: Genome-wide hunt reveals new genetic links, Medical News Today, October 8

Autism is on the rise (or is it?), Newsweek, October 6

Other News

Genetic diseases in the Arab world, PHG Foundation, October 8

Jumping genes, gene loss and genome dark matter, Science Daily, October 8

The American Society of Human Genetics to host press briefing on 'Personalized medicine and the future of health care practice' at 59th Annual Meeting, Trading Markets, October 7

Computer models begin to unravel how single DNA strands combine, Medical News Today, October 7

Novel polymer delivers genetic medicine, allows tracking, Medical News Today, October 7

University of Washington receives $25 million to create Northwest Genomics Center, Medical News Today, October 7

Chromosome protection mechanism wins 2009 Nobel Prize, PHG Foundation, October 5

I.B.M. Joins Pursuit of $1,000 Personal Genome, The New York Times, October 5

NIH announces expansion of Rare Diseases Clinical Research Network, NIH News, October 5

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Genomics in Scientific Literature

 

Family History

Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical features
Otabe S, et al.
Acta Diabetol 2009 Sep

Inherited predisposition to chronic lymphocytic leukemia
Brown JR
Expert Rev Hematol 2008 Oct;1(1):51-61

Lung cancer and family history of cancer
Ergun D, et al.
Tuberk Toraks 2009;57(3):251-8

Genetic Testing

Attitudes and Practice of Genetic Counselors Regarding Anonymous Testing for BRCA1/2
Ader T, et al.
J Genet Couns 2009 Oct

An audit of genetic testing in diagnosis of inherited retinal disorders: a prerequisite for gene-specific intervention
Pradhan M, et al.
Clin Experiment Ophthalmol 2009 Sep;37(7):703-11

Recent advances of genetic ancestry testing in biomedical research and direct to  consumer testing
Via M, et al.
Clin Genet 2009 Sep;76(3):225-35

Prophylactic thyroidectomy in ethnic Chinese patients with multiple endocrine neoplasia type 2A syndrome after the introduction of genetic testing
Lau GS, et al.
Hong Kong Med J 2009 Oct;15(5):326-31

Genome Wide

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Rivadeneira F, et al.
Nat Genet 2009 Oct

Genetic determinants of circulating sphingolipid concentrations in European populations
Hicks AA, et al.
PLoS Genet 2009 Oct;5(10):e1000672

Pharmacogenomics

Pharmacogenetics and interactions of antidepressants in the treatment of co-morbid illness
Mihaljevic-Peles A, et al.
Psychiatr Danub 2009 Sep;21(3):399-400

Drug monitoring in inflammatory bowel disease: helpful or dispensable?
Bruns T & Stallmach A
Dig Dis 2009;27(3):394-403

The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer
Monzon FA, et al.
Arch Pathol Lab Med 2009 Oct;133(10):1600-6

Personalized pharmacotherapy in psychiatry
Filakovic P & Petek A
Psychiatr Danub 2009 Sep;21(3):341-6

General Articles

An updating meta-analysis of the glutathione S-transferase T1 polymorphisms and colorectal cancer risk: a HuGE review
Liao C, et al.
Int J Colorectal Dis 2009 Oct

Is there a primary role of the mitochondrial genome in Alzheimer's disease?
Mancuso M, et al.
J Bioenerg Biomembr 2009 Oct

Allelic Based Gene-Gene Interaction in Case-Control Studies
Jung J & Zhao Y
Hum Hered 2009 Oct;69(1):14-27

A Unified Framework for Detecting Genetic Association with Multiple SNPs in a Candidate Gene or Region: Contrasting Genotype Scores and LD Patterns between Cases and Controls
Pan W
Hum Hered 2009 Oct;69(1):1-13

Genome-wide association studies and colorectal cancer
Le Marchand L
Surg Oncol Clin N Am 2009 Oct;18(4):663-8

Provision of Genetic Services for Hearing Loss: Results from a National Survey and Comparison to Insights Obtained from Previous Focus Group Discussions
Withrow KA, et al.
J Genet Couns 2009 Oct

Social sharing of genetic information in the family: A study on hereditary breast and ovarian cancers
Christophe V, et al.
J Health Psychol 2009 Oct;14(7):855-60

Gene patents and personalized medicine - what lies ahead?
Chandrasekharan S & Cook-Deegan R
Genome Med 2009 Sep;1(9):92

LRRK2 in Parkinson's disease: genetic and clinical studies from patients
Kumari U & Tan EK
FEBS J 2009 Oct

Evolution in Health and Medicine Sackler Colloquium: Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration
Frank SA
Proc Natl Acad Sci U S A 2009 Oct

A new locus-specific database (LSDB) for mutations in the folliculin (FLCN) gene
Lim DH, et al.
Hum Mutat 2009 Oct

Women's Decision Making about Risk-Reducing Strategies in the Context of Hereditary Breast and Ovarian Cancer: A Systematic Review
Howard AF, et al.
J Genet Couns 2009 Oct

A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies
Jacobs KB, et al.
Nat Genet 2009 Oct

Disparities in BRCA testing: when insurance coverage is not a barrier
Olaya W, et al.
Am J Surg 2009 Oct;198(4):562-5

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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