Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, May 28, 2009       Volume 22   Number 21

 

Spotlight

May is National Stroke Awareness Month
Stroke is the third leading cause of death and a major cause of disability in the United States. Genes play a role in the development of risk factors that can lead to a stroke, such as high blood pressure, heart disease, diabetes, and vascular conditions. Learn More

 

Announcements

• New article, The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004,   (PDF661KB) published in the May 2009 issue of Genetics in Medicine. Authors: Tiebin L, Valdez R, Yoon, PW, Crocker, D, Moonesinghe, R, and Khoury, MJ.
• The Office for Human Research Protections (OHRP) requests public comment about "whether OHRP should pursue a notice of proposed rulemaking (NPRM) to enable OHRP to hold institutional review boards (IRB) and the institutions or organizations operating the IRBs directly accountable for meeting certain regulatory requirements of the Department of Health and Human Services (HHS) regulations for the protection of human subjects". Deadline: June 3, 2009. Read more.

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Genomics In The News

The following are headlines from on-line news articles published during the past week. The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC. Free registration required for some articles.

Cancer

A cancer gene switch for repairing damaged DNA, Medical News Today, May 27

Quintiles advances cancer treatment through new genetic tests, Medical News Today, May 27

Genetic testing for breast or ovarian cancer risk may be greatly underutilized, News-Medical.Net, May 22

Novel marker of colorectal carcinoma, Science Daily, May 22

Cardiovascular Disease

Families of sudden unexplained death victims should receive comprehensive cardiogenetic testing, Medical News Today, May 26

Gene links gum disease and heart attack risk, Medical News Today, May 26

Ethical, Legal, and Social Issues (ELSI)

What's the point in patenting genes, Technology Review, May 27

Flu

International Team publishes swine flu genetic analysis, Genome Web, May 22 [by free subscription only]

Genetic Testing

Genetics-based products stir concerns, The Boston Globe, May 27

Genetic testing, Bay News 9, May 27

Will consumers sustain direct-to-consumer genomics, Bio-It World, May 27

Mental Health

New study points to genetic link for autism, KHQ, May 26

Other News

Discovery of faulty genes could reveal risk of bone disease, Medical News Today, May 28

Researchers discover genetic cause for primary biliary cirrhosis, Medical News Today, May 28

Alexander G. Bearn, pioneer in genetic disease, dies at 86, The News York Times, May 27

In a rare disorder, a familiar protein disrupts gene function, Medical News Today, May 27

GWAS evaluates malaria susceptibility in West Africa, Genome Web, May 25 [by free subscription only]

Now that you know, what will you do, Count on 2 News, May 25

Genetic defects linked with rare bearded lady, Medical News Today, May 22

Gene test determines transplant drug tolerance, Medical News Today, May 22

Almac, Pfizer, PETACC 3 launch colorectal cancer gene-expression study, Genome Web, May 21

The vagaries of genome variation: Do you copy, Bio-IT World, May 21

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Genomics in Scientific Literature

Featured Item

Familial risk for common diseases in primary care: the Family Healthware Impact Trial
O'Neill SM, et al.
Am J Prev Med 2009 Jun;36(6):506-14

General Articles

TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases
Balistreri CR, et al.
J Clin Immunol 2009 May

Semantic web-based integration of cancer pathways and allele frequency data
Holford ME, et al.
Cancer Inform 2009;8:19-30

Nutrient gene interactions in lipid metabolism
Minihane AM
Curr Opin Clin Nutr Metab Care 2009 May

Retention of medical genetics knowledge and skills by medical students
Greb AE, et al.
Genet Med 2009 May;11(5):365-70

The Genetics of Crohn's Disease
Van Limbergen J, et al.
Annu Rev Genomics Hum Genet 2009 May

The potential role of pharmacogenomic and genomic in the adjuvant treatment of early stage non small cell lung cancer
Schettino C, et al.
Curr Genomics 2008 Jun;9(4):252-62

Testing communication strategies to convey genomic concepts using virtual reality technology
Kaphingst KA, et al.
J Health Commun 2009 Jun;14(4):384-99

Melanoma genetics: an update on risk-associated genes
Udayakumar D & Tsao H
Hematol Oncol Clin North Am 2009 Jun;23(3):415-29

Role of the MTHFR polymorphisms in cancer risk modification and treatment
Kim YI
Future Oncol 2009 May;5(4):523-42

Histamine pharmacogenomics
Garcia-Martin E, et al.
Pharmacogenomics 2009 May;10(5):867-83

Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review
van der Zwaluw CS, et al.
Pharmacogenomics 2009 May;10(5):853-66

Application of pharmacogenomics to vaccines
Poland GA, et al.
Pharmacogenomics 2009 May;10(5):837-52

Epilepsy pharmacogenetics
Kasperaviciute D & Sisodiya SM
Pharmacogenomics 2009 May;10(5):817-36

Family History

Hormone Replacement Therapy, Family History, and Breast Cancer Risk Among Postmenopausal Women
Gramling R, et al.
Epidemiology 2009 May

The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004
Liu T, et al.
Genet Med 2009 May;11(5):323-8

Familial aggregation of parkinsonism in progressive supranuclear palsy
Donker Kaat L, et al.
Neurology 2009 May

Genetic Testing

Guidelines for Genetic Risk Assessment of Hereditary Breast and Ovarian Cancer: Early Disagreements and Low Utilization
Levy DE, et al.
J Gen Intern Med 2009 May

Telephoned BRCA1/2 Genetic Test Results: Prevalence, Practice, and Patient Satisfaction
Baumanis L, et al.
J Genet Couns 2009 May

Impact of genetic risk information and type of disease on perceived risk, anticipated affect, and expected consequences of genetic tests
Cameron LD, et al.
Health Psychol 2009 May;28(3):307-16

Survey of unaffected BRCA and mismatch repair (MMR) mutation positive individuals
McKinnon W, et al.
Fam Cancer 2009 May

Attitude and Knowledge about Genetics and Genetic Testing
Etchegary H, et al.
Public Health Genomics 2009 May

Genetic Testing in Israel: An Overview
Rosner G, et al.
Annu Rev Genomics Hum Genet 2009 May

The succinate dehydrogenase genetic testing in a large prospective series of patients with paragangliomas
Burnichon N, et al.
J Clin Endocrinol Metab 2009 May

The Effectiveness of Family History Questionnaires in Cancer Genetic Counseling
Randall Armel S, et al.
J Genet Couns 2009 May

Genome Wide

Genome-wide association study identifies single-nucleotide polymorphism in KCNB1  associated with left ventricular mass in humans: The HyperGEN Study
Arnett DK, et al.
BMC Med Genet 2009 May;10(1):43

A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
Ma D, et al.
Ann Hum Genet 2009 May;73(Pt 3):263-73

Genome-wide Association Study and Follow-up Analysis of Adiposity Traits in Hispanic Americans: The IRAS Family Study
Norris JM, et al.
Obesity (Silver Spring) 2009 May

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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