Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, May 21, 2009       Volume 22   Number 20

 

Spotlight

May is National Stroke Awareness Month
Stroke is the third leading cause of death and a major cause of disability in the United States. Genes play a role in the development of risk factors that can lead to a stroke, such as high blood pressure, heart disease, diabetes, and vascular conditions. Learn More

 

Announcements

• New article, The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004,   (PDF661KB) published in the May 2009 issue of Genetics in Medicine. Authors: Tiebin L, Valdez R, Yoon, PW, Crocker, D, Moonesinghe, R, and Khoury, MJ.
• The Office for Human Research Protections (OHRP) requests public comment about "whether OHRP should pursue a notice of proposed rulemaking (NPRM) to enable OHRP to hold institutional review boards (IRB) and the institutions or organizations operating the IRBs directly accountable for meeting certain regulatory requirements of the Department of Health and Human Services (HHS) regulations for the protection of human subjects". Deadline: June 3, 2009. Read more.
• NIH's National Cancer Institute solicits proposals from researchers for projects on comparative effectiveness research in genomic and personalized medicine. Deadline for proposals: May 27, 2009. Access the funding announcement.   (PDF 46.03 KB) Read other public health genomics priorities.

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Genomics In The News

The following are headlines from on-line news articles published during the past week. The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC. Free registration required for some articles.

Cancer

Gene signature helps predict breast cancer prognosis, Medical News Today, May 20

Whole genome sequencing of multiple myeloma samples to be performed by MMRF and the Broad Institute, Medical News Today, May 19

Whole genome sequencing of multiple myeloma samples to be performed by MMRF and the Broad Institute, Medical News Today, May 19

Early onset of prostate cancer may be predicted by genetic marker, Medical News Today, May 18

An entirely new direction for RNAi delivery - the future of personalized cancer treatment, Medical News Today, May 18

Perceived cancer risks may not reflect actual risks or prevention needs, EurekAlert, May 14

Should parents share the results of BRCA1/2 genetic testing with their children, EurekAlert, May 14

Ethical, Legal, and Social Issues (ELSI)

Parent consent for storage and use of newborn DNA should be required, Medical News Today, May 18

ACMG joins lawsuit challenging patents on breast cancer genes, Medical News Today, May 15

Decoding the use of gene patents, The American, May 15

Genetic Testing

Knome rolls out genome sequencing for $1 per gene, Mass High Tech, May 18

Will genetic test results drive lifestyle decisions, Sign on San Diego, May 17

Spit test shows promise in diagnosing, monitoring diabetes, USA Today, May 16

Creighton doc creates new cancer test, KETV7, May 15

Gene test predicts return of colon cancer, WebMD, May 14

Mental Health

New gene linked to autism risk, especially in boys, EurekAlert, May 19

Other News

Genetic anti-discrimination law starts Thursday, ABC News, May 20

NIH announces new program to develop therapeutics for rare and neglected diseases, NIH News, May 20

SCIENCE: Questions surround Mexican Genome Project, IPS, May 20

Volunteers needed for genetic map, The Gazette, May 20

Discovery of genetic links to age of first menstrual period and menopause, Medical News Today, May 19

New tool helps researchers identify DNA patterns of cancer, genetic disorders, EurekAlert, May 19

NHGRI Team develops SNP-trait database, Genome Web, May 19 [by free subscription only]

13,000 offer up DNA to put their genomes online, Computerworld, May 18

Affordable genome test key topic of bioconference, Tucson Citizen, May 15

Common genetic variant explains why some women find it more difficult to quit smoking during pregnancy, Medical News Today, May 15

Gene hunters target child kidney failure, Medical News Today, May 15

Good fences make good neighbors, Medical News Today, May 15

Prevention program helps teens override a gene linked to risky behavior, NIH News, May 15

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Genomics in Scientific Literature

Featured Item

A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database
Zintzaras E & Zdoukopoulos N
Am J Epidemiol 2009 May

General Articles

Risk Perception Among Women at Risk for Hereditary Breast and Ovarian Cancer
Pilarski R
J Genet Couns 2009 Apr

The Genetics of Bipolar Disorder
Barnett JH & Smoller JW
Neuroscience 2009 Apr

Recent progress in rheumatoid arthritis genetics: one step towards improved patient care
Plenge RM
Curr Opin Rheumatol 2009 Apr

Creating a genetic risk score for coronary artery disease
Dandona S & Roberts R
Curr Atheroscler Rep 2009 May;11(3):175-81

Gene-environment interaction tests for dichotomous traits in trios and sibships
Hoffmann TJ, et al.
Genet Epidemiol 2009 Apr

Viability of in-house datamarting approaches for population genetics analysis of  SNP genotypes
Amigo J, et al.
BMC Bioinformatics 2009;10 Suppl 3:S5

Genetics of stroke
Fornage M
Curr Atheroscler Rep 2009 May;11(3):167-74

The Inherited Genetic Component of Sporadic Pancreatic Adenocarcinoma
Milne RL, et al.
Pancreatology 2009 Apr;9(3):206-14

Susceptibility genes & modifiers for cardiac arrhythmias
Schulze-Bahr E
Prog Biophys Mol Biol 2008 Oct-2008 Nov;98(2-3):289-300

On testing for genetic association in case-control studies when population allele frequencies are known
Antonyuk A & Holmes C
Genet Epidemiol 2009 Apr

Family History

Lung Cancer Genetics: A Family Affair?
Christiani DC
Clin Cancer Res 2009 Apr

Family history of suicide and personality
Sarchiapone M, et al.
Arch Suicide Res 2009;13(2):178-84

Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway
Hemminki K, et al.
Lancet Oncol 2009 Apr

Genetic Testing

Genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC)
Hegde MR & Roa BB
Curr Protoc Hum Genet 2009 Apr;Chapter 10:Unit 10.12

Successful translation of pharmacogenetics into the clinic: the abacavir example
Phillips E & Mallal S
Mol Diagn Ther 2009;13(1):1-9

Clinical Predictors for Germline Mutations in Head and Neck Paraganglioma Patients: Cost Reduction Strategy in Genetic Diagnostic Process as Fall-Out
Neumann HP, et al.
Cancer Res 2009 Apr

Clinical utility of the ABCR400 microarray: basing a genetic service on a commercial gene chip
Roberts LJ, et al.
Arch Ophthalmol 2009 Apr;127(4):549-54

Development of Genomic Reference Materials for Cystic Fibrosis Genetic Testing
Pratt VM, et al.
J Mol Diagn 2009 Apr

A Decade of Genetic Counseling in Frontotemporal Dementia Affected Families: Few  Counseling Requests and much Familial Opposition to Testing
Riedijk SR, et al.
J Genet Couns 2009 Apr

Genome Wide

Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure
Kang H, et al.
Fertil Steril 2009 Apr;91(4 Suppl):1339-43

A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
Mangino M, et al.
J Med Genet 2009 Apr

Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population
Hiura Y, et al.
Circ J 2009 Apr

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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