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Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
 
 
 Thursday, May 14, 2009 Volume 22   Number 19
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This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
EGAPP logo

CMS Uses EGAPP Methods to Evaluate Pharmacogenomic Testing for Warfarin
Earlier this year, the Medicare Evidence Development and Coverage Advisory Committee recommended that the Centers for Medicare and Medicaid Services (CMS) use the ACCE criteria on analytic validity, clinical validity, and clinical utility for assessing the evidence of genetic tests. CMS recently considered these criteria for pharmacogenomic testing for warfarin. These criteria are the basis for the Evaluation of Genomic Applications in Practice and Prevention (EGAPP) non-gov warning icon methods. Access the EGAPP methods. non-gov warning icon PDF icon(465 KB)


Sections

blue dotView Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events
Genomics Announcements
   
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NIH's National Cancer Institute solicits proposals from researchers for projects on comparative effectiveness research in genomic and personalized medicine. Deadline for proposals: May 27, 2009. Access the funding announcement. PDF icon(46.03 KB) Read about public health genomics priorities.

 
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National Coalition for Health Professional Education in Genetics (NCHPEG) non-gov warning icon makes a call for abstracts for its 12th Annual meeting, Genetics Education for Health Professional: What Are the Key Messages? How Do We Deliver Them? to be held September 23 – 24, 2009 in Bethesda, Maryland. Deadline: June 30, 2009. For more information, contact Dolores Astroth (dastroth@nchpeg.org).


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Gene in breast cancer pathway identified, non-gov warning icon Medical News Today, May 13

UNC study identifies genetic cause of most common form of breast cancer, non-gov warning icon EurekAlert, May 11

New biomarker for aggressive prostate cancer, study, non-gov warning icon Medical News Today, May 13

New technique may help detect potential breast cancer spread, non-gov warning icon Science Daily, May 9

Genetic research work opens up new horizons to the design of customized medicines against breast cancer, non-gov warning icon Science Daily, May 12

Breast cancer conference highlights, non-gov warning icon Medical News Today, May 8

Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract, non-gov warning icon 7th Space, May 12

New universal breast cancer marker predicts recurrence and clinical outcome, non-gov warning icon Science Daily, May 7

475,000 faulty cancer tests sent out, non-gov warning icon ABC News Australia, May 11  

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Cardiovascular Disease

Researchers uncover genetic clues to blood pressure, NIH News, May 10

Gene test determines risk of heart surgery complications, non-gov warning icon Science Daily, May 7

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Diabetes

25 new genes that may trigger diabetes identified, non-gov warning icon The Hindu, May 12

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Ethical, Legal and Social Issues (ELSI)

Do DNA patents spur science or stifle it? Both, non-gov warning icon MSNBC, May 13

ELSI panel addresses genomics consent and privacy at CSHL, non-gov warning icon GenomeWeb, May 8 [by free subscription only]

Cancer patients challenge the patenting of a gene, non-gov warning icon The New York Times, May 12

 

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Family History

Predicting future health problems, non-gov warning icon clickondetroit.com, May 11

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Flu

Landmark study reveals significant genetic variation between Mexico's population and world's other known genetic subgroups, non-gov warning icon Science Daily, May 12

British scientists produce first genetic fingerprint of Swine Flu virus infecting humans in Europe, non-gov warning icon Medical News Today, May 9

H1N1 flu hits Norway, global death toll 53: WHO, non-gov warning icon Reuters Health, May 11

Testing for the flu, from swab to finish, non-gov warning icon PE.com, May 8

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Genetic Testing

Heel stick: Genetic screening, non-gov warning icon Alternative Health Journal, May 13

The role of genetic assessment in determining a patient's disease risk, non-gov warning icon JAAPA, May 12

Developing a genetic test for pregnancy risks, non-gov warning icon Medical News Today, May 12

Direct-to-consumer genetics: Has a new era of healthcare arrived, non-gov warning icon Health News Digest, May 10

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Mental Health

UMMS researchers isolate first 'neuroprotective' gene in patients with amyotrophic lateral sclerosis, non-gov warning icon EurekAlert, May 11

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Other News

$3.3 million awarded to university of Liverpool, UK, for genomics hub, non-gov warning icon Medical News Today, May 14

Muscular dystrophy diagnosis delayed almost 2.5 years in boys, non-gov warning icon EurekAlert, May 11

Gene responsible for rare form of congenital anemia discovered, non-gov warning icon Science Daily, May 14

Novel genetic risk factors for kidney disease revealed by study, non-gov warning icon Medical News Today, May 11

Consumer genetics conference: Top thought leaders in health and genetics weigh in, non-gov warning icon Yahoo Finance, May 13

Vision loss in genetic diseases explained by protein-protein interaction, non-gov warning icon Medical News Today, May 11

What is Progeria, non-gov warning icon Medical News Today, May 13

TAU investigates MicroRNA and its role in human disease, non-gov warning icon Medical News Today, May 9

Geneticists streamline gene searches, non-gov warning icon The Money Times, May 12

Researchers uncovering variants in 1000 genomes pilot data, non-gov warning icon GenomeWeb, May 8 [by free subscription only]

Google, Microsoft may help usher in personalized medicine wave, says George Church, non-gov warning icon Xconomy Boston, May 12

Genetic factors for common traits in Asians, non-gov warning icon hum-molgen.org, May 7

Personalized Medicine Coalition publishes The Case for Personalized Medicine, non-gov warning icon Business Wire, May 12

In gene identification, random picks better than complicated process, non-gov warning icon Medical News Today, May 7

American College of Medical Genetics affirms importance of newborn screening dried blood spots, non-gov warning icon EurekAlert, May 11

“The future of genetic studies of complex human diseases”: Drs. Merikangas..., non-gov warning icon hum-molgen.org, May 7

Do-it-yourself genetic sleuthing, non-gov warning icon Boston.com, May 11

UAE GDA urges general public to get screened for genetic diseases, non-gov warning icon Zawya, May 7

Genetic make-up influences biased economic decision-making, study shows, non-gov warning icon Science Daily, May 11

 

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Genomics in Scientific Literature
Featured Item

New insights into the aetiology of colorectal cancer from genome-wide association studies
Tenesa A & Dunlop MG
Nat Rev Genet 2009 May


 General Articles

The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism
Depaolo J, et al.
Mov Disord 2009 May

Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as  a risk factor for gastrointestinal bleeding: Is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?
Agundez JA, et al.
Expert Opin Drug Metab Toxicol 2009 May

Fcgamma receptors: structure, function and role as genetic risk factors in SLE
Li X, et al.
Genes Immun 2009 May

Genetic and environmental pathways to complex diseases
Gohlke JM, et al.
BMC Syst Biol 2009 May;3(1):46

Pharmacogenetics in chemotherapy of colorectal cancer
Henriette Tanja L, et al.
Best Pract Res Clin Gastroenterol 2009;23(2):257-73

Hereditary pancreatic cancer: a clinical perspective
Greer JB, et al.
Best Pract Res Clin Gastroenterol 2009;23(2):159-70

Hereditary gastric cancer
Oliveira C, et al.
Best Pract Res Clin Gastroenterol 2009;23(2):147-57

Introduction to molecular and clinical genetics of colorectal cancer syndromes
Tops CM, et al.
Best Pract Res Clin Gastroenterol 2009;23(2):127-46

The genetics of Parkinson's syndromes: a critical review
Hardy J, et al.
Curr Opin Genet Dev 2009 May

Shrinkage estimation for robust and efficient screening of single-SNP association from case-control genome-wide association studies
Luo S, et al.
Genet Epidemiol 2009 May

Case-only genome-wide interaction study of disease risk, prognosis and treatment
Pierce BL & Ahsan H
Genet Epidemiol 2009 May

Avoiding the high Bonferroni penalty in genome-wide association studies
Gao X, et al.
Genet Epidemiol 2009 May

Genome-wide association studies: Detecting gene-gene interactions that underlie human diseases
Cordell HJ
Nat Rev Genet 2009 May

Genomics and the efficacy of aspirin in the treatment of cerebrovascular disease
Cavallari LH & Momary KM
Curr Treat Options Cardiovasc Med 2009 Jun;11(3):191-200

A Robust Genome-Wide Scan Statistic of the Wellcome Trust Case-Control Consortium
Joo J, et al.
Biometrics 2009 May

A Robust Test for Two-Stage Design in Genome-Wide Association Studies
Kwak M, et al.
Biometrics 2009 May


 Family History

Relationship between a family history of malignancy and the incidence of laryngeal carcinoma in the Liaoning province of China
Li XY, et al.
Clin Otolaryngol 2009 Apr;34(2):127-31

Familial Recurrence of Midline Birth Defects--A Nationwide Danish Cohort Study
Oyen N, et al.
Am J Epidemiol 2009 May

Family cancer history affecting risk of colorectal cancer in a prospective cohort of Chinese women
Murphy G, et al.
Cancer Causes Control 2009 May


 Genetic Testing

Genetic testing in gastroenterology: Lynch syndrome
Grover S & Syngal S
Best Pract Res Clin Gastroenterol 2009;23(2):185-96

Genetic testing in other GI diseases
Hodgson S & Ioannides AS
Best Pract Res Clin Gastroenterol 2009;23(2):245-56

Genetic counselling and genetic testing in hereditary gastrointestinal cancer syndromes
Raymond VM & Everett JN
Best Pract Res Clin Gastroenterol 2009;23(2):275-83


 Genome Wide

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Barrett JC, et al.
Nat Genet 2009 May

Genome-wide Association Analysis Identifies PDE4D as an Asthma-Susceptibility Gene
Himes BE, et al.
Am J Hum Genet 2009 May

Genome-wide association study of blood pressure and hypertension
Levy D, et al.
Nat Genet 2009 May

Multiple loci associated with indices of renal function and chronic kidney disease
Kottgen A, et al.
Nat Genet 2009 May

Genome-wide association study identifies eight loci associated with blood pressure
Newton-Cheh C, et al.
Nat Genet 2009 May

A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS)
Rich SS, et al.
Diabetologia 2009 May

Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
Scott LJ, et al.
Proc Natl Acad Sci U S A 2009 May;106(18):7501-6

Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan
Yang HC, et al.
PLoS ONE 2009;4(5):e5459


 HuGE

Please visit the HuGE Navigator.

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The CDC Office of Public Health Genomics makes available the above information as a public service only. Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

 
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Page last updated: May 14, 2009 (archived document)
Content source: National Center for Chronic Disease Prevention and Health Promotion, Public Health Genomics