Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, June 25, 2009       Volume 22   Number 25

 

Spotlight

CDC-Supported Family Healthware Study Methods Released
This month, the American Journal of Preventive Medicine published a paper that describes the methodology of an evaluation study of Family Healthware. Family Healthware is a web-based tool developed by CDC’s Office of Public Health Genomics for collecting family health history and assessing disease risk. The study was conducted by the University of Michigan School of Medicine, Evanston Northwestern Healthcare Research Institute, and Case Western Reserve University School of Medicine. Read the methods paper. Also available in PDF (PDF 263KB). Read about Family Healthware and preliminary results of this study.

 

Announcements

• CDC's Office of Public Health Genomics is recruiting health care providers from multiple disciplines (genetic counselors, general practitioners, oncologists, surgeons, pathologists, gastroenterologists, nurse practitioners, physicians’ assistants, etc) to participate in a health message survey for educational materials on the new EGAPP recommendation for Lynch Syndrome genetic testing. The survey will be conducted in July/August 2009 and will take participants about one hour to complete. To participate, please contact Sara Bedrosian.
• The National Institutes of Health hosts the State-of-the-Science Conference: Family History and Improving Health on August 24-26, 2009 at the Natcher Conference Center in Bethesda, Maryland. Deadline for Online Registration: August 21, 2009. Click here to register online.

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Genomics In The News

The following are headlines from on-line news articles published during the past week. The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC. Free registration required for some articles.

Cancer

Gene findings are revealing reasons for neuroblastoma risk, Medical News Today, June 18

Study pinpoints novel cancer gene and biomarker, Medical News Today, June 25

Bloodcenter of Wisconsin’s new genetic test identifies people at high risk for developing inherited form of leukemia, Earth Times, June 22

Fifty one genes predict breast cancer survival, Medical News Today, June 15

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer, Medical News Today, June 19

Cardiovascular Disease

Genes affect blood pressure risk, WebMD, June 16

Ethical, Legal, and Social Issues (ELSI)

Genetic Alliance asks FDA for public genetic test registry, Genome Web, June 24 [by free subscription only]

FDA's current ability to regulate genetic testing is problematic, FDLI-AAAS

colloquium attendees say, RBC Dain Raushcer, June 23

New comparative effectiveness bill enhances Dx, genomics focus, Genome Web, June 18 [by free subscription only]

Family History

Genetics - Recording a family history, Healthcare Republic, June 25

Genetic Testing

CDC's next gene-testing MMWR to cover biochemical testing, Genome Web, June 24 [by free subscription only]

Could a genetic test on stool samples make colonoscopies unnecessary someday, Scientific American, June 23

Genetic test for avoiding toxicity from a colon cancer drug, My Cancer Advisor, June 19

No proof found that genetic testing helps prevent blood clots, Medical News Today, June 19

'Personalized Medicine' advances colon cancer treatment ..., PR Web, June 19

Mental Health

ADHD genes found; known to play roles in neurodevelopment, Medical News Today, June 24

A genetic link between anorexia and autism, Time, June 19

Other News

Leicester geneticists unearth the roots of human genetic variation, Medical News Today, June 24

Backtracking on DNA, Physorg.com, June 23

Talking personal genomics, Genome Web, June 23 [by free subscription only]

Genome sequencing center opens in Dublin, Genome Web, June 22 [by free

What is Hemophilia? What causes Hemophilia, Medical News Today, June 22

Researchers identify new risk factor gene for rheumatoid arthritis, Hospital Newspaper, June 22

Like 2 genetic researchers in a pod, The Star, June 21

BRIT1 allows DNA repair teams access to damaged sites, Medical News Today, June 20

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Genomics in Scientific Literature

Featured Item

Public health genomics : The future is built today
Brand A, et al.
Bundesgesundheitsblatt Gesundheitsforschung  2009 Jun

General Articles

Genetics of Diabetic Nephropathy: Are There Clues to the Understanding of Common  Kidney Diseases?
Conway BR & Maxwell AP
Nephron Clin Pract 2009 Jun;112(4):c213-c221

Clinical impact of polymorphisms of transport proteins and enzymes involved in the metabolism of immunosuppressive drugs
Rosso Felipe C, et al.
Transplant Proc 2009 Jun;41(5):1441-55

Mutation prediction models in Lynch syndrome: evaluation in a clinical genetic setting
Ramsoekh D, et al.
J Med Genet 2009 Jun

Genetic and clinical factors relating to warfarin dosing
Jonas DE & McLeod HL
Trends Pharmacol Sci 2009 Jun

Role of genetics in anaesthesia-related variability
Textoris J, et al.
Ann Fr Anesth Reanim 2009 Jun

Genetic predictors of response to therapy in childhood asthma
Turner SW
Mol Diagn Ther 2009;13(2):127-35

Genetic prognostic and predictive markers in colorectal cancer
Walther A, et al.
Nat Rev Cancer 2009 Jun

Value of Adding Single-Nucleotide Polymorphism Genotypes to a Breast Cancer Risk  Model
Gail MH
J Natl Cancer Inst 2009 Jun

Genomic copy number variation, human health, and disease
Wain LV, et al.
Lancet 2009 Jun

Genetics of alcohol dependence
Gelernter J & Kranzler HR
Hum Genet 2009 Jun

Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review
Segal JB, et al.
JAMA 2009 Jun;301(23):2472-85

Accuracy of genome-wide imputation of untyped markers and impacts on statistical  power for association studies
Hao K, et al.
BMC Genet 2009 Jun;10(1):27

Pharmacogenomics of adverse drug reactions: practical applications and perspectives
Becquemont L
Pharmacogenomics 2009 Jun;10(6):961-9

Family History

Inflammatory bowel disease in children: the role of a positive family history
Roma ES, et al.
Eur J Gastroenterol Hepatol 2009 Jun

Familial association between type 1 diabetes and other autoimmune and related diseases
Hemminki K, et al.
Diabetologia 2009 Jun

Does the genetic and familial background of males undertaking ICSI affect the outcome?
Maiburg M, et al.
J Assist Reprod Genet 2009 Jun

Genetic Testing

Genetic counseling and cardiac care in predictively tested hypertrophic cardiomyopathy mutation carriers: The patients' perspective
Christiaans I, et al.
Am J Med Genet A 2009 Jun;149A(7):1444-51

Colon cancer screening practices and disclosure after receipt of positive or inconclusive genetic test results for hereditary nonpolyposis colorectal cancer
Ersig AL, et al.
Cancer 2009 Jun

Value of genetic profiling for the prediction of coronary heart disease
van der Net JB, et al.
Am Heart J 2009 Jul;158(1):105-10

A New Cystic Fibrosis Newborn Screening Algorithm: IRT/IRT1 upward arrow/DNA
Sontag MK, et al.J Pediatr 2009 Jun

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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