Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, July 30, 2009       Volume 23   Number 5

 

Spotlight

Visit the New Web site for CDC’s Office of Public Health Genomics

CDC’s Office of Public Health Genomics launches its newly designed and updated Web site, providing new features, easier navigation and credible information and resources on public health genomics, family history, genetic testing, and many other topics. Visit the new OPHG website. We welcome your feedback.

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Announcements

• The National Academy of Sciences’ Committee on Science, Technology, the Law and Board on Life Sciences, and the Institute of Medicine will host the Direct-to-Consumer Genetic Testing: A Cross-Academies Workshop in Washington, D.C. on August 31-September 1, 2009. Read the agenda. Register online.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Genistein targets MEK4 in human prostate cancer cells, Medical News Today, July 29

Only a few genetic changes behind childhood acute myeloid leukemia, MedIndia, July 29

Cancer's distinctive pattern of gene expression could aid early screening and prevention, Medical News Today, July 28

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease, Medical News Today, July 28

Tracking a rare cancer, Times Leader, July 28

Could therapeutic vaccines treat hard to beat breast cancers. EurekAlert, July 27

Key event in prostate cancer progression discovered by scientists, Medical News Today, July 24

Diabetes

Diabetes gene raises odds of lower birth weight, Science Daily, July 29

Genetic Testing

Another reason to leave DTC gene-testing shops alone, Genome Web, July 29 [by free subscription only]

Concerns and prospects for pharmacogenomic testing, PHG Foundation, July 29

NHGRI study suggests DTC genetic-risk testing motivates consumers to improve health, Genome Web, July 29 [by free subscription only]

Gene testing doesn't help predict heart disease, Reuters Health, July 28

Genetic testing may be valuable in treating colorectal cancer, Medical News Today, July 28

At-home test reveals potential risk for diseases, CBS4, July 27

Mental Health

Those who learn through genetic testing take Alzheimer's news OK, Daily News, July 27

Other News

Enzyme modification brings 'corrective genes' closer, Medical News Today, July 29

Faster, cheaper genome sequencing featured at the 15-minute genome 2009 industrial physics forum, Medical News Today, July 28

ACCP should not fear DTC genetic-testing advertising, Genome Web, July 27

DNA Athlete – Patrice Harris, Fox 45, July 27

NIH seeks genetics and environment breast cancer studies, Genome Web, July 27

Discovery of gene mutation responsible for hereditary neuroendocrine tumor, Medical News Today, July 24

Genetic variant linked to improved survival in leukopenic HIV-positive blacks, The Job Cure, July 23

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Genomics in Scientific Literature

 

Family History

Family history of diabetes mellitus as an independent risk factor for macrosomia  and cesarean delivery
Levy A, et al.
J Matern Fetal Neonatal Med 2009 Jul:1-5

Effect of Family History on the Incidence of Varicose Veins: A Population-Based Follow-Up Study in Finland
Ahti TM, et al.
Angiology 2009 Jul

Increased mortality risk in patients with phenotypic Hereditary Hemochromatosis but not in their first-degree relatives
Elmberg M, et al.
Gastroenterology 2009 Jul

Frontotemporal dementia in association with a family history of dementia and ApoE polymorphism
Zintl M, et al.
Nervenarzt 2009 Jul

Genetic Testing

The importance of genetic testing in the clinical management of patients with marfan syndrome and related disorders
Arslan-Kirchner M, et al.
Dtsch Arztebl Int 2008 Jul;105(27):483-91

KRAS Testing in Metastatic Colorectal Cancer: Implications on the Use of Biologic Agents
Bekaii-Saab T
Clin Colorectal Cancer 2009 Jul;8(3):135-40

Genome Wide

Three susceptible loci associated with primary open-angle glaucoma identified by  genome-wide association study in a Japanese population
Nakano M, et al.
Proc Natl Acad Sci U S A 2009 Jul

Pharmacogenomics

Clopidogrel Pharmacogenetics and Its Clinical Implications
Singh M, et al.
Am J Ther 2009 Jul

Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
Normanno N, et al.
Nat Rev Clin Oncol 2009 Jul

Cancer Pharmacoethnicity: Ethnic Differences in Susceptibility to the Effects of  Chemotherapy
O'Donnell PH & Dolan ME
Clin Cancer Res 2009 Jul

General Articles

The HapMap and genome-wide association studies in diagnosis and therapy
Manolio TA & Collins FS
Annu Rev Med 2009;60:443-56

On quality control measures in genome-wide association studies: a test to assess  the genotyping quality of individual probands in family-based association studies and an application to the HapMap data
Fardo DW, et al.
PLoS Genet 2009 Jul;5(7):e1000572

Genome-wide association database developed in the Japanese Integrated Database Project
Koike A, et al.
J Hum Genet 2009 Jul

Path: a tool to facilitate pathway-based genetic association analysis
Zamar D, et al.
Bioinformatics 2009 Jul

Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations
Potkin SG, et al.
Cogn Neuropsychiatry 2009 Jul;14(4):391-418

Genetics of susceptibility to infection with enteric pathogens
Flores J & Okhuysen PC
Curr Opin Infect Dis 2009 Jul

Genetic susceptibility to the respiratory effects of air pollution
Yang IA, et al.
Postgrad Med J 2009 Aug;85(1006):428-36

Genetic Backgrounds of Asthma and COPD
Hizawa N
Allergol Int 2009 Jul;58(3):307-14

The 'I' in personalized genetics: 2008 Ian Constable lecture
Mackey DA
Clin Experiment Ophthalmol 2009 Jul;37(5):434-43

Combining Case-Control and Case-Trio Data From the Same Population in Genetic Association Analyses: Overview of Approaches and Illustration With a Candidate Gene Study
Infante-Rivard C, et al.
Am J Epidemiol 2009 Jul

Does enhanced information at cancer genetic counseling improve counselees' knowledge, risk perception, satisfaction and negotiation of information to at-risk relatives? - a randomized study
Roshanai AH, et al.
Acta Oncol 2009 Jul:1-11

Recent advances in the genetics of obsessive-compulsive disorder
Samuels JF
Curr Psychiatry Rep 2009 Aug;11(4):277-82

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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