Genomics & Health Weekly Update

This week, CDC’s Office of Public Health Genomics (OPHG) launches its newly designed and updated Web site, providing new features, easier navigation and credible information and resources on public health genomics, family history, genetic testing, and many other topics. Visit the new OPHG Web site. We welcome your feedback.

Thursday, July 23, 2009       Volume 23   Number 4

 

Spotlight

Visit the New Web site for CDC’s Office of Public Health Genomics

This week, CDC’s Office of Public Health Genomics launches its newly designed and updated Web site, providing new features, easier navigation and credible information and resources on public health genomics, family history, genetic testing, and many other topics. Visit the new OPHG website. We welcome your feedback.

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Announcements

• The U.S. Surgeon General’s Certificate of Appreciation was awarded to Muin J Khoury, MD, PhD and Rodolfo Valdez, PhD, MSc for their outstanding scientific, public health, and administrative contributions to the new My Family Health Portrait tool.

• The National Academy of Sciences’ Committee on Science, Technology, the Law and Board on Life Sciences, and the Institute of Medicine will host the Direct-to-Consumer Genetic Testing: A Cross-Academies Workshop in Washington, D.C. on August 31-September 1, 2009. Read the agenda. Register online.
• The American Public Health Association (APHA) Genomics Forum launches a new website.  Learn more about the forum and join today!

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Gene variant connected to higher risk of Non-Hodgkin lymphoma, Red Orbit, July 22

Identification of new breast cancer-promoting gene, Medical News Today, July 21

Link between gene and increasingly common type of blood cancer, Medical News Today, July 21

Network of altered genes appear to play role in development of brain tumors, Science Daily, July 21

Boston University dental researchers ID key gene to control tumor spread, Medical News Today, July 17

Cardiovascular Disease

Novel gene found for dilated cardiomyopathy, Science Daily, July 22

Estrogen can reduce stroke damage by inactivating a tumor-suppressing protein, The Medical News, July 17

Researchers uncover genetic variants linked to blood pressure in African-Americans, NIH News, July 16

Family History

Family history predicts frequency, severity of mental illness, VOA News, July 21

Genetic Testing

At-home genetic tests: What you should know, Health News Digest, July 22

Genetic tests advertised directly to the consumer, EurekAlert, July 21

Pathway Genomics launches and a look back at two years of DTC genomics, Genomics Law Report, July 15

Mental Health

A genetic basis for schizophrenia, EurekAlert, July 21

Alzheimer's gene may impair middle-aged memory, CNNhealth.com, July 16

Obesity

Study shows gene variant raises obesity risk, European Research Headlines, July 22

Other News

The business of personal genomes, Technology Review, July 23

Genetic marker linked to problem behaviors in adults with developmental disabilities, Science Daily, July 23

Gene variations can be barometer of behavior, choices, Medical News Today, July 22

Potential pathogenic mutation for restless legs syndrome, Science Daily, July 22

Nature or nurture? New epigenetic model blurs the line in the debate, EurekAlert, July 21

New DNA sequencers to speed up research, Australia, Medical News Today, July 21

NIH issues research plan on Fragile X Syndrome and associated disorders, NIH News, July 20

Genes and the environment interact to influence adolescent alcohol use, Medical News Today, July 17

Genetic source of Muscular Dystrophy neutralized, Medical News Today, July 17

La Jolla Institute discovers genetic trigger for disease-fighting antibodies, EurekAlert, July 16

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Genomics in Scientific Literature

 

Family History

Factors Associated with Insulin Resistance and Fasting Plasma Ghrelin Levels in Adolescents with Obesity and Family History of Type 2 Diabetes
Exp Clin Endocrinol Diabetes 2009 Jul

The impact of family history on the outcome of patients with colorectal cancer in a veterans' hospital
Kao PS, et al.
Int J Colorectal Dis 2009 Jul

Penetrance and risk profile in inherited cardiac diseases studied in a dedicated  screening clinic
Gimeno JR, et al.
Am J Cardiol 2009 Aug;104(3):406-10

Psychiatric family history and schizophrenia risk in Denmark: which mental disorders are relevant?
Mortensen PB, et al.
Psychol Med 2009 Jul:1-10

Genetic Testing

Laboratory Tests for Patients With Ileal Pouch-Anal Anastomosis: Clinical Utility in Predicting, Diagnosing, and Monitoring Pouch Disorders
Navaneethan U & Shen B
Am J Gastroenterol 2009 Jul

Disclosure of APOE genotype for risk of Alzheimer's disease
Green RC, et al.
N Engl J Med 2009 Jul;361(3):245-54

Colorectal Cancer Risk Perception on the Basis of Genetic Test Results in Individuals at Risk for Lynch Syndrome
Grover S, et al.
J Clin Oncol 2009 Jul

Genetic testing: considerations for pediatric nephrologists
Guay-Woodford LM & Knoers NV
Semin Nephrol 2009 Jul;29(4):338-48

On the development of a decision support intervention for mothers undergoing BRCA1/2 cancer genetic testing regarding communicating test results to their children
Peshkin BN, et al.
Fam Cancer 2009 Jul

Cost-effectiveness of population-based BRCA1/2 testing and ovarian cancer prevention for Ashkenazi Jews: A call for dialogue
Rubinstein WS, et al.
Genet Med 2009 Jul

Characteristics of users of online personalized genomic risk assessments: Implications for physician-patient interactions
McBride CM, et al.
Genet Med 2009 Jul

Effect of genetic testing for risk of Alzheimer's disease
Kane RA & Kane RL
N Engl J Med 2009 Jul;361(3):298-9

Thiopurine methyltransferase and thiopurine metabolite testing in patients with inflammatory bowel disease who are taking thiopurine drugs
Sheffield LJ, et al.
Pharmacogenomics 2009 Jul;10(7):1091-9

Pharmacogenomics

Gender and interindividual variability in pharmacokinetics
Nicolas JM, et al.
Drug Metab Rev 2009;41(3):408-21

Role of pharmacotherapy in cardiac ion channelopathies
El-Sherif N, et al.
Curr Vasc Pharmacol 2009 Jul;7(3):358-66

Genetic modulation of the pharmacological treatment of pain
Lotsch J, et al.
Pharmacol Ther 2009 Jul

General Articles

Premature ovarian failure and gene polymorphisms
van Dooren MF, et al.
Curr Opin Obstet Gynecol 2009 Aug;21(4):313-7

Clinical implications of genetic variation in the serotonin transporter promoter  region: a review
Luddington NS, et al.
Prim Care Companion J Clin Psychiatry 2009;11(3):93-102

The Genetics of Otosclerosis
Ealy M & Smith RJ
Hear Res 2009 Jul

Factor V Leiden: impact on infusion nursing practice
Weinstein SM
J Infus Nurs 2009 Jul-2009 Aug;32(4):219-23

SHARE: an adaptive algorithm to select the most informative set of SNPs for candidate genetic association
Dai JY, et al.
Biostatistics 2009 Jul

The ClinSeq Project: Piloting large-scale genome sequencing for research in genomic medicine
Biesecker L, et al.
Genome Res 2009 Jul

Instrumenting the health care enterprise for discovery research in the genomic era
Murphy S, et al.
Genome Res 2009 Jul

Genetic and molecular approaches to the immunopathogenesis of multiple sclerosis: an update
Holmoy T, et al.
Curr Mol Med 2009 Jul;9(5):591-611

An Algorithm for Learning Maximum Entropy Probability Models of Disease Risk That Efficiently Searches and Sparingly Encodes Multilocus Genomic Interactions
Miller DJ, et al.
Bioinformatics 2009 Jul

A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases - schizophrenia as a case
Sun J, et al.
Bioinformatics 2009 Jul

Quality assurance in medical and public health genetics services: A systematic review
Chou AF, et al.
Am J Med Genet C Semin Med Genet 2009 Jul

Outcomes of genetics services: Creating an inclusive definition and outcomes menu for public health and clinical genetics services
Silvey K, et al.
Am J Med Genet C Semin Med Genet 2009 Jul

Understanding genes, environment and their interaction in ADHD: Is there a role for neuroimaging?
Plomp E, et al.
Neuroscience 2009 Jul

An exploration of attitudes among black americans towards psychiatric genetic research
Murphy E & Thompson A
Psychiatry 2009 Summer;72(2):177-94

 

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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