Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, July 16, 2009       Volume 23   Number 3

 

Spotlight

NIH to Host Family History Conference
On August 24-26, 2009, the National Institutes of Health will hold the first Family History State-of-the-Science Conference in Bethesda, Maryland to assess the available scientific evidence related to the use and effectiveness of family history information for predicting and improving patient health outcomes. Read more. Register for the conference.

 

Announcements

• The American Public Health Association (APHA) Genomics Forum launches a new website. Learn more about the forum and join today!
• New workshop summary titled, Innovations in Service Delivery in the Age of Genomics,  by the Institute of Medicine's Roundtable on Translating Genomic-Based Research for Health is now available.
• New paper, Developing the Blueprint for a Genetic Testing Registry,  (209 KB) published online ahead of print in the Public Health Genomics Journal. Authors: Javitt G, Katsanis S, Scott J, and Hudson K. Read the issue brief.
• The National Institutes of Health (NIH) hosts the Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation  workshop on July 21, 2009 in Bethesda, Maryland. Registration is now closed. For more information, email Linnea Bowman.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Scripps discovers genetic clues into formation of cancer tumors, Medical News Today, July 15

7 genes key to brain cancer survival ID’d, CBSNews.com, July 14

Network of altered genes appear to play role in development of brain tumors, ScienceDaily, July 14

Mortal Skin: race, genes, and cancer, Slate, July 14

Study: Gene mutation leads to high colon-cancer risk..., EndoNurse, July 13

Scientists find genes that double skin cancer risk, India eNews, July 13

Genetic factors limit growth of pathogenic muscle cells, biotechdaily.com, July 13

Cardiovascular Disease

Dilated cardiomyopathy: discovery of novel gene, Medical News Today, July 14

DeCODE discovers second common genetic risk factor for atrial fibrillation and stroke, Medical News Today, July 14

Family History

HHS grant funds maternal family history project, GenomeWeb Daily News, July 14

Genetic Testing

Pathway genomics joins the direct-to-consumer genomics parade, BioITWorld.com, July 15

Seeking our genetic fate, U.S. News, July 15

Genetic testing and your health, ABC Health & Wellbeing, July 15

Research and markets: Key trends fueling the boom in genetic testing..., SmartBrief, July 15

SeraCare expands genetic controls product portfolio with the introduction of cystic fibrosis controls, StreetInsider.com, July 14

Breakthroughs in DNA medicine to revolutionize doctors’ training, Times Online, July 13

Genetic testing for thrombosis: still no evidence of clinical benefit, phg foundation, July 12

Online gene testers propose their own regulations, MercuryNews.com, July 11

FDA clears Osmetech's cystic fibrosis genotyping test, Medical News Today, July 10

Possible benefit from online genetic testing for lung cancer, Science Daily, July 10

Mental Health

Learning of risk of Alzheimer’s seems to do no harm, New York Times, July 16

Scientists discover 27 genes associated with Asperger's syndrome, autistic traits and empathy, The Medical News, July 15

Evidence for a new genetic link to therapeutic efficacy for Alzheimer's disease..., GlobeInvestor.com, July 14

Genetic discovery may determine Alzheimer's disease risk and age of disease onset, DukeHealth.org, July 13

Hush little baby... Linking genes, brain and behavior in children, Association for Psychological Science, July 13

Linking Schizophrenia to specific DNA region with the help of LSUHSC research, Medical News Today, July 10

ADHD genes found, Advance, July 9

Obesity

Genetics 'not to blame for obese kids'..., The Daily Telegraph, July 13

Beer belly: It's the genes not just the beer , Baltimore Sun, July 9

Other News

A potential targeting gene therapy for developing HCV, EurekAlert, July 16

New map of genomic variation will enable disease research, Medical News Today, July 16

The persistent legacy of the 1918 influenza virus, The New England Journal of Medicine, July 16

Research reveals key genetic differences between blood and tissue cells, redOrbit, July 15

LincRNAs serve as genetic air-traffic controllers, Medical News Today, July 15

Researchers map how staph infections alter immune system, EurekAlert, July 14

Mystery E. coli genes essential for survival of many species, EurekAlert, July 13

Genomic clues to DNA treasure sometimes lead nowhere..., Science Magazine, July 10

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Genomics in Scientific Literature

General Articles

Genetics of systemic lupus erythematosus and Sjogren's syndrome
Scofield RH
Curr Opin Rheumatol 2009 Jul

High-resolution mapping and analysis of copy number variations in the human genome: A data resource for clinical and research applications
Shaikh TH, et al.
Genome Res 2009 Jul

The search for lupus biomarkers
Liu CC & Ahearn JM
Best Pract Res Clin Rheumatol 2009 Aug;23(4):507-23

The role of genes in the polycystic ovary syndrome: Predisposition and mechanisms
Deligeoroglou E, et al.
Gynecol Endocrinol 2009 Jul:1-7

Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human Cytochrome P450 1A2
Zhou SF, et al.
AAPS J 2009 Jul

An overview of the Guangzhou biobank Cohort study-cardiovascular disease Subcohort (GBCS-CVD): a platform for multidisciplinary collaboration
Jiang CQ, et al.
J Hum Hypertens 2009 Jul

The SCN1A variant database: a novel research and diagnostic tool
Claes LR, et al.
Hum Mutat 2009 Jul

Ethical issues in ocular genetics
Mezer E & Wygnanski-Jaffe T
Curr Opin Ophthalmol 2009 Jul

Genetics of age-related macular degeneration
Ting AY, et al.
Curr Opin Ophthalmol 2009 Jul

Myopia genetics: a review of current research and emerging trends
Hornbeak DM & Young TL
Curr Opin Ophthalmol 2009 Jul

The genetics of isolated orofacial clefts: from genotypes to subphenotypes
Jugessur A, et al.
Oral Dis 2009 Jul

Nicotine dependence and genetic variation in the nicotinic receptors
Bierut LJ
Drug Alcohol Depend 2009 Jul

Gene-environment interactions and obesity-Further aspects of genomewide association studies
Andreasen CH & Andersen G
Nutrition 2009 Jul

Family History

Recurrence of congenital heart defects in families
Oyen N, et al.
Circulation 2009 Jul

High medical co-morbidity and family history of dementia is associated with lower cognitive function in older patients
Morrow LA, et al.
Fam Pract 2009 Jul

On the use of sibling recurrence risks to select environmental factors liable to  interact with genetic risk factors
Kazma R, et al.
Eur J Hum Genet 2009 Jul

Genetic Testing

Emotional distress following genetic testing for hereditary breast and ovarian cancer: A meta-analytic review
Hamilton JG, et al.
Health Psychol 2009 Jul;28(4):510-8

Attitudes and anticipatedreactions to genetic testing for cancer among patients  in Mexico City
Romero-Hidalgo S, et al.
Genet Test Mol Biomarkers 2009 Jul

A collaborative approach to genetic testing: A community hospital's experience
Cohen SA, et al.
J Genet Couns 2009 Jul

Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy
Bos JM, et al.
J Am Coll Cardiol 2009 Jul;54(3):201-11

Prevalence of genetic thrombophilic polymorphisms in the Sri Lankan population -  implications for association study design and clinical genetic testing services
Dissanayake VH, et al.
Exp Mol Pathol 2009 Jul

Pharmacogenomics

Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to Imatinib therapy in chronic Myeloid Leukemia
Kim DH, et al.
Clin Cancer Res 2009 Jul

Targeting of tamoxifen to enhance antitumour action for the treatment and prevention of breast cancer: The 'personalised' approach?
Brauch H & Jordan VC
Eur J Cancer 2009 Jul

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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