Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, July 2, 2009       Volume 23   Number 1

 

Spotlight

GAPPNet: A New Genomics Translation Initiative
CDC’s Office of Public Health Genomics, NCI’s Division of Cancer Control and Population Sciences, and other stakeholders have launched the Genomic Applications in Practice and Prevention Network (GAPPNet) to help accelerate and streamline effective and responsible use of validated and useful genomic knowledge and applications into clinical and public health practice. Visit the GAPPNet Web page. Access a new scientific article about GAPPNet  (PDF 311 KB).

 

Announcements

• CDC’s Office of Public Health Genomics releases the 2008 Program Review  (PDF 286 KB).
• The National Institutes of Health hosts the State-of-the-Science Conference: Family History and Improving Health on August 24-26, 2009 at the Natcher Conference Center in Bethesda, Maryland. Deadline for Online Registration: August 21, 2009. Click here to register online.
• Michigan Department of Community Health to proceed with developing a population-based biobank of residual newborn blood samples, which could help advance medical breakthroughs for preventing disease and improving health. Read the press release and news article
• Connecticut Department of Public Health - Genomics Office  hosts family history workshop "Incorporating Family Health History into Your Health Outreach Promotion Efforts" in May. Presentations now available.
• New article, Population Screening for Genetic Disorders in the 21st Century: Evidence, Economics, and Ethics  (PDF 194 KB) published online in the June 2009 issue of Public Health Genomics. Authors: Grosse SD, Rogowski WH, Ross LF, Cornel MC, Dondorp WJ, and Khoury MJ.
• New article, Challenges of Translating Genetic Tests into Clinical and Public Health Practice  (PDF 257 KB) published in the June 2009 issue of Nature Reviews Genetics. Authors: Rogowski WH, Grosse SD, and Khoury MJ.
• New article, Detecting Undiagnosed Type 2 Diabetes: Family History as a Risk Factor and Screening Tool  (PDF 284 KB) published online in the July 2009 issue of the Journal of Diabetes Science and Technology. Author: Valdez R.

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Genomics In The News

The following are headlines from on-line news articles published during the past week. The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC. Free registration required for some articles.

Cancer

Colorectal Cancer - MDC researchers identify genetic markers for metastasis formation, Medical News Today, July 2

Colorectal cancer risk increased by single-base change in the human genome, Science Daily, June 29

Genomic health reports favorable commentary on value of multigene assays from the St. Gallen expert consensus meeting on the primary treatment of early breast cancer, Red Orbit, June 26

New biomarker method could increase the number of diagnostic tests for cancer, NIH News, June 28

Cancer researchers link DICER1 gene mutation to rare childhood cancer, Medical News Today, June 27

Second gene linked to familial testicular cancer, NIH News, June 29

Cardiovascular Disease

Genomic discovery: protecting kidney function during heart failure, Science Daily, June 26

Epigenetics

Novel epigenetic markers of melanoma may herald new treatments for patients, Science Daily, June 30

Ethical, Legal, and Social Issues (ELSI)

Blood samples raise questions of privacy, The Washington Post, June 30

Family History

A family tree, a rare cancer, and a hunt for its cause, Scientific American, June 26

Genetic Testing

Possible benefit from online genetic testing for lung cancer, Medical News Today, July 1

No benefit in testing for genes linked to leg clots, Tehran Times, June 27

CDC's Office of Public Health Genomics recruiting docs for survey on EGAPP plans, Genome Web, June 25

Genetic cholesterol test warning, BBC News, June 26

'A simple test saved my family', BBC News, June 26

Outcomes of genetic testing in adults with a history of venous thromboembolism, Kinship, June 25

Mental Health

Schizophrenia and bipolar disorder share genetic roots, NIH News, July 1

More gene mutations linked to autism risk, Medical News Today, June 26

New gene for autism gives hope for future, Medical News Today, June 26

Gene predicts how brain responds to fatigue, human study shows, Medical News Today, June 26

Scientists uncover patterns of genetic changes in mental retardation, EurekAlert, June 25

Obesity

New gene discovery links obesity to the brain, Medical News Today, June 26

Reproductive Health

Will IVF work for a particular patient? The answer may be found in her blood, EurekAlert, July 1

Genetic and chromosomal abnormalities in embryos detected by new test, Medical News Today, July 1

C-section births cause genetic changes that may increase odds for developing diseases in later life, Medical News Today, June 30

New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis, News-Medical.Net, June 29

Universal embryo test 'very near', BBC News, June 30

Now, test that predicts when a woman will reach menopause, Medindia, June 29

Other News

$500,000 Gruber Genetics Prize awarded to cancer geneticist Janet Davison Rowley, Medical News Today, July 2

Study rewrites textbook on key genetic phenomenon, Medical News Today, July 2

Discovery of a genetic link to risk of kidney stones and osteoporosis, News-Medical.Net, June 30

Gene expression findings a step toward better classification and treatment of juvenile arthritis, NIH News, June 29

Symposium & live announcement of genetics and neuroscience prize recipients: Gruber prize program 10th anniversary, Medical News Today, June 29

The gene puzzle, Newsweek, June 27

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Genomics in Scientific Literature

General Articles

Population Screening for Genetic Disorders in the 21st Century: Evidence, Economics, and Ethics
Grosse SD, et al.
Public Health Genomics 2009 Jun

Genomics of type 2 diabetes mellitus: implications for the clinician
Stolerman ES & Florez JC
Nat Rev Endocrinol 2009 Jun

Interaction between Helicobacter pylori, diet, and genetic polymorphisms as related to non-cancer diseases
Izzotti A, et al.
Mutat Res 2009 Jul;667(1-2):142-57

Gene-environment interactions in chronic pulmonary diseases
Hirvonen A
Mutat Res 2009 Jul;667(1-2):132-41

Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison
Kim S, et al.
Genet Epidemiol 2009 Jun

High marks for GWAS
Chanock S
Nat Genet 2009 Jul;41(7):765-6

Harnessing the Information Contained Within Genome-wide Association Studies to Improve Individual Prediction of Complex Disease Risk
Evans DM, et al.
Hum Mol Genet 2009 Jun

Genome-wide association studies in bladder cancer: first results and potential relevance
Kiemeney LA, et al.
Curr Opin Urol 2009 Jun

Genetic Risk factors for soft tissue injuries 101: A Practical summary to help Clinicians understand the role of Genetics And 'Personalised Medicine'
Collins M
Br J Sports Med 2009 Jun

International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia
Faughnan ME, et al.
J Med Genet 2009 Jun

Genetics and treatment of dystonia
Schwarz CS & Bressman SB
Neurol Clin 2009 Aug;27(3):697-718, vi

Family History

Occurrence of Depression in Families with Frontotemporal Dementia: A Family History Study
Horstmann V & Grasbeck A
Neuroepidemiology 2009 Jun;33(2):124-30

Cancer risk among patients with cystic fibrosis and their first degree relatives
Johannesson M, et al.
Int J Cancer 2009 Jun

Estimation of absolute risk for prostate cancer using genetic markers and family  history
Xu J, et al.
Prostate 2009 Jun

Genetic Testing

Developing the Blueprint for a Genetic Testing Registry
Javitt G, et al.
Public Health Genomics 2009 Jun

Pharmacogenetics

Pharmacogenetics in heart failure: promises and challenges
de Boer RA, et al.
Expert Opin Pharmacother 2009 Jun

Pharmacogenetics of selective serotonin reuptake inhibitors and associated adverse drug reactions
Thomas KL & Ellingrod VL
Pharmacotherapy 2009 Jul;29(7):822-31

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm
Bertrand J, et al.
J Pharmacokinet Pharmacodyn 2009 Jun

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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