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Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
 
 
 Thursday, February 12, 2009 Volume 22   Number 6
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This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates
Spotlight
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Recommendations from the STrengthening the REporting of Genetic Association studies (STREGA) Initiative Released
Recommendations non-gov warning icon of the STREGA initiative non-gov warning icon are being published in seven medical journals this month. The initiative builds on the current STROBE Statement non-gov warning icon (STrengthening the Reporting of OBservational studies in Epidemiology) to help researchers standardize results and make sense of evidence uncovered from human genetic associations studies. Read the news release. non-gov warning icon

Sections

blue dotView Current Update
blue dotAnnouncements
blue dotGenomics In The News
blue dotScientific Literature
blue dotHuGE Articles
blue dotBack Issues

 Upcoming Events
Genomics Announcements
   
announcement
Extended deadline: February 17, 2009 - The American Public Health Association (APHA) Genomics Forum non-gov warning icon announces a call for abstracts PDF only(576KB) for the 137th APHA Annual Meeting & Expo non-gov warning icon to be held November 7-11, 2009, in Philadelphia, Pennsylvania. For more information, contact Dean Hosgood.


Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Cancer

Camouflaging of viral DNA could be crucial step in progression of cancers, non-gov warning icon Medical News Today, February 11

Physicians from the Burzynski Clinic present initial results of..., non-gov warning icon Medical News Today, February 8

Gene controllers crucial for cancer spread, non-gov warning icon News-Medical.Net, February 11

New genes involved in acute lymphoblastic leukemia play..., non-gov warning icon Basque Research, February 6

New understanding of how leukemia develops, non-gov warning icon News-Medical.Net, February 9

Gene study finds link to cancer of thyroid, non-gov warning icon The New York Times, February 6



Cardiovascular Disease

Great progress in heart disease gene research, but more to do, says BHF, non-gov warning icon Medical News Today, February 9

International study identifies gene variants associated with early heart attack, non-gov warning icon EurekAlert, February 8

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Ethical, Legal and Social Issues (ELSI)

Parents 'avoid pregnancy' rather than face testing choices, non-gov warning icon EurekAlert, February 11

The map of life, non-gov warning icon Times Online, February 9

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Family History

Family medical history aids doctors, patients, non-gov warning icon The Herald News, February 11

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Genetic Testing

The largest scale study so far on asthma genetics sheds light on disease mechanisms, non-gov warning icon Medical News Today, February 12 

Genetic test for heart disease risk in the works, non-gov warning icon Health Day, February 9

New genomic test can personalize breast cancer treatment, non-gov warning icon News-Medical.Net, February 10

Lenetix launches screening study of new Down Syndrome test, non-gov warning icon Medical News Today, February 6

Multinational deCODE study identifies new link between inflammation and heart attack, non-gov warning icon Sun Herald, February 9

Personalized medicine using genetic testing still far off, non-gov warning icon Medpage Today, February 6

Genetic mapping of babies by 2019 will transform preventive medicine, non-gov warning icon Times Online, February 9

 

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Mental Health

Case Western Reserve research finds that the lack of specific gene plays role in autism, non-gov warning icon EureAlert, February 6

Scientists propose new direction in the search for genetic causes of schizophrenia, non-gov warning icon Medical News Today, February 6

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Other News

First data released on genetic basis of adverse drug events, non-gov warning icon Medical-News.Net, February 11

1 in 200 human genes superfluous, non-gov warning icon Medical News Today, February 7

Financial risk taking: Blame it on the genes, non-gov warning icon EurekAlert, February 10

Genome sequencing falls to $5000, non-gov warning icon New Scientist, February 6

Drug startup’s treatment for genetic disorder may help with teen liver disease, non-gov warning icon North Bay Business Journal, February 9

Seeing sounds or hearing colors: Scientists narrow search for genes associated with synesthesia, non-gov warning icon Science Daily, February 6

For the first time proof-of-concept data released by Complete Genomics for its sequencing technology, non-gov warning icon Medical News Today, February 9

The nonsense in our genes, non-gov warning icon EurekAlert, February 5

Mathematical models reveal how organisms transcend the sum of their genes, non-gov warning icon Medical News Today, February 9  
   
Genomics in Scientific Literature
Featured Item

Trends in Pharmacogenomic Epidemiology: 2001-2007
Guessous I, et al.
Public Health Genomics 2009;12(3):142-8


 General Articles

Host Genetic Determinants of HIV Infection and Disease Progression in Children
Singh KK & Spector SA
Pediatr Res 2009 Jan

Testing Hardy-Weinberg equilibrium using mother-child case-control samples
Chen J, et al.
Genet Epidemiol 2009 Feb

From a Genetic Predisposition to an Interactive Predisposition: Rethinking the Ethical Implications of Screening for Gene-Environment Interactions
Tabery J
J Med Philos 2009 Feb

Developing a curriculum statement based on clinical practice: genetics in primary care
Burke S, et al.
Br J Gen Pract 2009 Feb;59(559):99-103

Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer
Tabares-Seisdedos R & Rubenstein JL
Mol Psychiatry 2009 Feb

A neurologist's guide to genome-wide association studies
Mullen SA, et al.
Neurology 2009 Feb;72(6):558-65

Progress in searching for the febrile seizure susceptibility genes
Nakayama J
Brain Dev 2009 Feb

Candidate Endophenotypes for Genetic Studies of Suicidal Behavior
Mann JJ, et al.
Biol Psychiatry 2009 Feb

 

 Family History

Hereditary colorectal cancer in the gastroenterology clinic: how common are at-risk patients and how do we find them?
Dudley-Brown S & Freivogel M
Gastroenterol Nurs 2009 Jan-2009 Feb;32(1):8-16

Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer
Ashton KA, et al.
Gynecol Oncol 2009 Feb

A method to assess the clinical significance of unclassified variants (UVs) in the BRCA1 and BRCA2 genes based on cancer family history
Gomez Garcia EB, et al.
Breast Cancer Res 2009 Feb;11(1):R8

 

 Genetic Testing

Pharmacogenetics of Tamoxifen: Who Should Undergo CYP2D6 Genetic Testing?
Higgins MJ, et al.
J Natl Compr Canc Netw 2009 Feb;7(2):203-13

Clinician Perspectives about Molecular Genetic Testing for Heritable Conditions and Development of a Clinician-Friendly Laboratory Report
Lubin IM, et al.
J Mol Diagn 2009 Feb

Detection of Epidermal Thickening in GJB2 Carriers with Epidermal US
Guastalla P, et al.
Radiology 2009 Feb

Increasing the number of diagnostic mutations in malignant hyperthermia
Levano S, et al.
Hum Mutat 2009 Feb

Five families living with hereditary breast and ovarian cancer risk
Norris J, et al.
Clin J Oncol Nurs 2009 Jan;13(1):73-80

Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers
Jakobsdottir J, et al.
PLoS Genet 2009 Feb;5(2):e1000337

Racial distribution of patient population and family physician endorsed importance of screening patients for inherited predisposition to cancer
J Health Care Poor Underserved 2009 Feb;20(1):50-4

 

 Genome Wide

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Gudbjartsson DF, et al.
Nat Genet 2009 Feb

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae
Lowe JK, et al.
PLoS Genet 2009 Feb;5(2):e1000365

Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease
Garcia-Barcelo MM, et al.
Proc Natl Acad Sci U S A 2009 Feb

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
Chio A, et al.
Hum Mol Genet 2009 Feb

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations
Gudmundsson J, et al.
Nat Genet 2009 Feb

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
Tregouet DA, et al.
Nat Genet 2009 Feb

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Kathiresan S, et al.
Nat Genet 2009 Feb

New susceptibility locus for coronary artery disease on chromosome 3q22.3
Erdmann J, et al.
Nat Genet 2009 Feb

 

 HuGE

Testing...DOI is 10.1158_1055-9965.EPI-08-8888
Stevens VL, et al.
Cancer Epidemiol Biomarkers Prev 2008;17(12):3517-25

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Page last updated: February 12, 2009 (archived document)
Content source: National Center for Chronic Disease Prevention and Health Promotion, Public Health Genomics