Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, August 27, 2009       Volume 23   Number 9

 

Spotlight

NIH Releases Statement on Family Health History State-of-the Science
A multidisciplinary panel released a draft statement following the Family History State-of-the-Science Conference hosted by the National Institutes of Health in Bethesda, Maryland this week. Recommendations were aimed at informing the research agenda for using family history to improve health, focusing on these areas: what information should be collected, what are the optimal ways to collect and use this information, and patient outcomes. Read the draft statement.  Watch webinars of the proceedings.

 

Announcements

• Recommendations released for strengthening the science base for using personal genomics to assess risk and prevent disease. A new paper published this month in Genetics in Medicine outlines these recommendations, which are based on a personal genomics workshop hosted by CDC and NIH in December 2008. Access the article  (PDF 416.96 KB).

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Breast cancer in the family, KNDO, August 26

Gene assay to help to predict lung cancer treatment resistance, EurekAlert, August 26

New route to potential breast cancer cure discovered, Medical News Today, August 26

Discovery of genetic biomarkers enable targeted personalised medication for colorectal cancer, News-Medical.Net, August 24

The beginnings of cancer may be prevented by the ends of MRNAs, Medical News Today, August 22

Fecal DNA methylation detects gastric and colorectal cancers, EurekAlert, August 21

More evidence that genes increase a smokers' risk of lung cancer, Medical News Today, August 21

Cardiovascular Disease

Genetic variation associated with poorer response, cardiovascular outcomes with use of Clopidogrel, Medical News Today, August 26

Epigenomics

4th Asian Epigenomics Conference Attracts An Overwhelming International Scientific Delegation Of Over 300 - To Be Held In Singapore In August 2009, Medical News Today, August 25

Ethical, Legal, and Social Issues (ELSI)

Health ministry finalizing bill to regulate human genetic research, Pharmbiz.com, August 24

Proposals for revised biobank policies on children, PHG Foundation, August 24

Your genome isn't that precious – give it away, News Scientist, August 24

The battle to patent your genes, Axis of Logic, August 21

Genetic Testing

2-day symposium raises concerns about direct-to-consumer genetic testing, Medical News Today, August 27

Using at-home genetic testing doesn't mean you can skip a visit to a specialist, Cleveland.com, August 25

Awareness of personal genomics tests, PHG Foundation, August 21

Infectious Disease

Is endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C, EurekAlert, August 26

Newborn Screening

HHS to weigh blood spot screening storage issues, Genome Web, August 26 [by free subscription only]

"Blood Spots, Genetic Research And Privacy" Sept. 23, 2009, Medical News Today, August 25

Other News

Adults with genetic disorder PKU need to get back to the clinic, Medical News Today, August 27

Genetics and Public Policy Center receives funding for public consultation project, Genetics & Public Policy Center, August 26

New method to detect copy number variants using dna sequencing technologies developed by CSHL scientists, Medical News Today, August 26

Not only the gene itself, its abnormal regulation can also trigger short stature, Universitaets Klinikum Heidelberg, August 25

When cells run out of fuel Parkinson genes ensure the energy supply of neurons, Medical News Today, August 25

10th Functional Genomics: Chemical Biology 2009, Medical News Today, August 24

Messenger RNA lost in translation, demonstrated by Case Western Reserve University researcher, Medical News Today, August 24

Report: Scientists behind genome project will be able to create life in a few months, New York Daily News, August 23

Clues to gigantism provided by family in Borneo mountains, Van Andel Institute, August 21

Housekeeping gene study impacts Lesch Nyhan & Parkinson's, Medical News Today, August 21

Chronic kidney disease linked to malfunctioning mitochondria, EurekAlert, August 20

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Genomics in Scientific Literature

Family History

A review of prostate-specific antigen screening prevalence and risk perceptions for first-degree relatives of men with prostate cancer
McDowell ME, et al.
Eur J Cancer Care (Engl) 2009 Aug

Family history of pilonidal sinus predisposes to earlier onset of disease and a 50% long-term recurrence rate
Doll D, et al.
Dis Colon Rectum 2009 Sep;52(9):1610-5

Prostate cancer as a first and second cancer: effect of family history
Zhang H, et al.
Br J Cancer 2009 Aug

Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes?
Kim C, et al.
Am J Obstet Gynecol 2009 Aug

Knowledge About Type 2 Diabetes Risk and Prevention of African-American and Hispanic Adults and Adolescents With Family History of Type 2 Diabetes
Cullen KW & Buzek BB
Diabetes Educ 2009 Aug

Impact of a positive family history on diagnosis, management, and survival of breast cancer: different effects across socio-economic groups
Verkooijen HM, et al.
Cancer Causes Control 2009 Aug

Genetic Testing

Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings
Wilde A, et al.
Eur J Hum Genet 2009 Aug

Genetic Testing of Athletes
Williams AG & Wackerhage H
Med Sport Sci 2009;54:176-86

Pharmacogenomics

Polymorphisms in Methotrexate Pathways: What is Clinically Relevant, What is Not, and What is Promising
Gervasini G
Curr Drug Metab 2009 Sep

Pharmacogenetic of response efficacy to antipsychotics in schizophrenia: pharmacodynamic aspects. Review and implications for clinical research
Blanc O, et al.
Fundam Clin Pharmacol 2009 Aug

General Articles

Genetic risk and protective factors for the idiopathic inflammatory myopathies
O'Hanlon TP & Miller FW
Curr Rheumatol Rep 2009 Aug;11(4):287-94

Genomic profiling of pediatric ALK-positive anaplastic large cell lymphoma: A Children's Cancer and Leukaemia Group Study
Youssif C, et al.
Genes Chromosomes Cancer 2009 Aug

Migraine and genetic and acquired vasculopathies
Stam AH, et al.
Cephalalgia 2009 Sep;29(9):1006-17

Evaluation of common unfavourable genetic variants in cerebrovascular diseases: recommendation for supportive genetic examinations and methodological approaches  for common genetic variants
Szolnoki Z
Curr Med Chem 2009;16(24):3168-73

Risk perception after genetic counseling in patients with increased risk of cancer
Rantala J, et al.
Hered Cancer Clin Pract 2009 Aug;7(1):15

The Era of Genomic Epidemiology
Traynor BJ
Neuroepidemiology 2009 Aug;33(3):276-9

Nature versus Nurture in Determining Athletic Ability
Brutsaert TD & Parra EJ
Med Sport Sci 2009;54:11-27

Cyp46 Polymorphisms in Alzheimer's Disease: A Review
Garcia AN, et al.
J Mol Neurosci 2009 Aug

The role of genetic variation in the causation of mental illness: an evolution-informed framework
Uher R
Mol Psychiatry 2009 Aug

Effects of genetic counseling for hypertension on changes in lifestyle behaviors  among African-American women
Taylor JY & Wu CY
J Natl Black Nurses Assoc 2009 Jul;20(1):1-10

Association tests using kernel-based measures of multi-locus genotype similarity  between individuals
Mukhopadhyay I, et al.
Genet Epidemiol 2009 Aug

Angiotensin-Converting Enzyme, Renin-Angiotensin System and Human Performance
Woods D
Med Sport Sci 2009;54:72-87

Genes, Athlete Status and Training - An Overview
Ahmetov II & Rogozkin VA
Med Sport Sci 2009;54:43-71

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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