Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, August 13, 2009       Volume 23   Number 7

 

Spotlight

Recommendations Released for Strengthening the Science Base of Personal Genomics
Professionals from government agencies, academic and research institutions, industry, and consumer groups make recommendations for strengthening the science base for using personal genomics to assess risk and prevent disease. A new paper published this month in Genetics in Medicine outlines these recommendations, which are based on a personal genomics workshop hosted by CDC and NIH in December 2008. Access the article  (PDF 416.96 KB).

 

---

 

Announcements

• The National Institutes of Health hosts the State-of-the-Science Conference: Family History and Improving Health on August 24-26, 2009, in Bethesda, Maryland. Deadline for Online Registration: August 21, 2009. Click here to register online.

Top of Page

---

 

Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Extreme diet linked to changes in breast cancer biomarkers and reduced gene expression, Medical News Today, August 11

Function of potential cancer-causing gene product uncovered by Conaway lab, Medical News Today, August 10

Scripps starts genomics study of breast cancer variants, Genome Web, August 10 [by free subscription only]

Genetic profiling of tumors could have 'Immediate Impact' on treating cancer, Medical News Today, August 8

Diabetes

Joslin study identifies gene linked to rare form of diabetes, Medical News Today, August 11

Ethical, Legal, and Social Issues (ELSI)

Health care reform needed to complete GINA's goals, Genetics & Public Policy Center, August

Update on genetic non-discrimination legislation, PHG Foundation, August 10

Genetic Testing

Center publishes new survey of state false advertising laws, Genetics & Public Policy Center, August 11

Center proposes blueprint for genetic test registry, Genetics & Public Policy Center, August

Febit's DNA-capture method selected by NCGR to re-sequence 400 genes involved in childhood diseases, News-Medical.Net, August 11

Good or bad, these patients want to know, Oncology Nursing News, August 11

Are you at increased risk for cancer? Genetic testing is an option to find out, WDBJ7, August 6

Infectious Disease

Flu tests miss many cases, U.S. CDC confirms, Reuters, August 6

Genomic signature in blood identifies underlying viral infection, EurekAlert, August 6

Mental Health

Genetic causes of schizophrenia, Medical News Today, August 12

Unlikely genetic suspect implicated in common brain defect, EurekAlert, August 9

Scientists discover new Alzheimer's gene, Physorg.com, August 7

Other News

Gene Therapy One year later: Patients healthy and maintain early visual improvement, NIH News, August 12

Leigh Syndrome: Discovery of genetic mutation, Medical News Today, August 12

3 brothers treated for rare genetic disorder in MN, WCCO, August 11

New gene linked to Muscular Dystrophy, Medical News Today, August 11

New genes at work in patients with hereditary lung disease, Medical News Today, August 11

With small team and at low cost Stanford professor sequences his entire genome, Medical News Today, August 11

Gene transcribing machine takes halting, backsliding trip along the DNA, Science Daily, August 9

Mutations in gene linked to ciliopathies, Physorg.com, August 9

Summer DNA camps: families that study nutrition and genetics together tailor foods and lifestyles, Examiner, August 9

University of the Basque Country researcher studies genes associated with Celiac Disease, Medical News Today, August 8

Secretary Sebelius announces Senate confirmation of Dr. Francis Collins as Director of the National Institutes of Health, NIH News, August 7

Carnegie Mellon develops innovative method to detect genetic causes of complex diseases, EurekAlert, August 6

NHGRI to fund genomics education, career development, Genome Web, August 6 [by free subscription only]

Top of Page

---

 

Genomics in Scientific Literature

 

Family History

Family History Study of the Familial Coaggregation of Borderline Personality Disorder With Axis I and Nonborderline Dramatic Cluster Axis II Disorders
Zanarini MC, et al.
J Pers Disord 2009 Aug;23(4):357-69

Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China
Gao Y, et al.
BMC Cancer 2009 Aug;9(1):269

Familial risks for hospitalized Graves' disease and goiter
Hemminki K, et al.
Eur J Endocrinol 2009 Aug

Strength of Family History in Predicting Levels of Blood Pressure, Plasma Glucose and Cholesterol
Wandeler G, et al.
Public Health Genomics 2009 Aug

Familiality of kidney stone disease in Iceland
Edvardsson VO, et al.
Scand J Urol Nephrol 2009 Aug:1-5

Genetic Testing

Use of Factor V Leiden genetic testing in practice and impact on management
Laberge AM, et al.
Genet Med 2009 Aug

Genome Wide

Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study
Broderick P, et al.
Cancer Res 2009 Aug

Hippocampal Atrophy as a Quantitative Trait in a Genome-Wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease
Potkin SG, et al.
PLoS One 2009;4(8):e6501

Genome-wide Association Study Reveals Multiple Nasopharyngeal Carcinoma-Associated Loci within the HLA Region at Chromosome 6p21.3
Tse KP, et al.
Am J Hum Genet 2009 Aug

Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and  nonresponders to interferon beta therapy in multiple sclerosis
Comabella M, et al.
Arch Neurol 2009 Aug;66(8):972-8

A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24
Grant SF, et al.
J Pediatr 2009 Aug

Pharmacogenomics

Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond
Karas-Kuzelicki N & Mlinaric-Rascan I
Pharmacogenomics 2009 Aug;10(8):1309-22

Introducing pharmacy students to pharmacogenomic analysis
Krynetskiy E & Lee Calligaro I
Am J Pharm Educ 2009 Jul;73(4):71

Pharmacogenetics of testosterone replacement therapy
Zitzmann M
Pharmacogenomics 2009 Aug;10(8):1341-9

Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance
Arnett DK & Claas SA
Pharmacogenomics 2009 Aug;10(8):1295-307

Pharmacogenetics of anti-inflammatory treatment in children with asthma: rationale and design of the PACMAN cohort
Koster ES, et al.
Pharmacogenomics 2009 Aug;10(8):1351-61

General Articles

Pathogenetic and Clinical Relevance of MicroRNAs in Colorectal Cancer
Valeri N, et al.
Cancer Genomics Proteomics 2009 Jul-2009 Aug;6(4):195-204

The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature
Kostner K, et al.
Anticancer Res 2009 Sep;29(9):3511-36

Genetics and pharmacogenetics of the leukotriene pathway
Tantisira KG & Drazen JM
J Allergy Clin Immunol 2009 Aug

Genome-wide association studies in systemic lupus erythematosus: a perspective
Cunninghame Graham DS
Arthritis Res Ther 2009 Jul;11(4):119

Genetics and Irritable Bowel Syndrome: From Genomics to Intermediate Phenotype and Pharmacogenetics
Camilleri M
Dig Dis Sci 2009 Aug

MultipleTesting in Genome-Wide Association Studies via Hidden Markov Models
Wei Z, et al.
Bioinformatics 2009 Aug

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

Top of Page

 

Send web sites that you would like to see included in a future update to cdcinfo@cdc.gov Sign-up for new Genomics and Health Weekly Updates through GovDelivery. You may return to GovDelivery to edit preferences. The CDC Office of Public Health Genomics makes available the above information as a public service only. Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.