Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, August 6, 2009       Volume 23   Number 6

 

Spotlight

NIH to Host Family History Conference
On August 24-26, 2009, the National Institutes of Health will hold the first Family History State-of-the-Science Conference in Bethesda, Maryland to assess the available scientific evidence related to the use and effectiveness of family history information for predicting and improving patient health outcomes. Read more. Register for the conference.

 

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Announcements

• CDC’s Office of Public Health Genomics launches its newly designed and updated Web site.
• New article, Systems-Based Candidate Genes for Human Response to Influenza Infection, published ahead of print in Infection, Genetics and Evolution. Authors: Zhang L, Katz JM, Gwinn M, Dowling NF, Khoury MJ.
• New article, Evaluation of risk prediction updates from commercial genome-wide scans , published ahead of print in Genetics in Medicine. Authors: Mihaescu R, van Hoek M, Sijbrands E, Uitterlinden A, Witteman J, Hofman A, et al.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Decoding leukemia patient genome leads scientists to mutations in other patients, EurekAlert, August 5

Gene that raises bladder cancer risk identified, Yahoo News, August 3

Gene variant that increases ovarian cancer risk discovered, Medical News Today, August 3

Risk of pancreatic cancer linked to variation in gene that determines blood type, NIH News, August 3

Scientists trace link between gene and breast cancer, The West Australian, August 3

Janet Rowley receives presidential medal of freedom for cancer chromosome studies in leukemias and lymphomas, Medical News Today, August 1

Mapping cancer, Bangor Daily News, August 1

New center to fight prostate cancer, Atlanta Business Chronicle, August 1

ELSI

Gene patents, The Law Report, August 4

Technological advances increase the risk of genetic identity theft, Genetic Engineering & Biotechnology News, August 1

Bill to regulate human genetic research soon, Business Standard, July 31

Family History

Why and how to put together a family medical history, US Health and World Report, July 30

Genetic Testing

Genetic testing when the cancers are inherited, The Dallas Morning News, August 5

In China, DNA tests on kids ID genetic gifts, careers, CNN, August 5

Your Genome: There's an app for that, Tech News World, August 3

Regular screening can save lives – doctor, Zawya, August 1

Genetic tests advertised directly to the consumer, Science Daily, July 31

Big Think: Esther Dyson urges widespread genetic testing, The Independent, July 30

Consumer genomics: your genes don't change, but your disease risk still might, Times Online, July 30

Infectious Disease

Scientists decode entire HIV genome, Medical News Today, August 6

Decoding the genomic sequences of H1N1 using isolates from outbreak in Argentina, Medical News Today, August 3

Genes key to staph disease severity, drug resistance found hitchhiking together, NIH News, July 31

Maternal and Child Health

Down syndrome to be discussed at monthly genetic series, BCM News, August 5

Genes, environment play role in kids' sleep apnea, Reuters Health, August 5

Maternal, paternal genes' tug-of-war may last well into childhood, Science Daily, August 3

Turner Syndrome Society of the United States announces ambitious goal to crush ignorance of Turner Syndrome (TS), Medical News Today, August 3

Mental Health

Cognitive performance impacted by genetic risk, not anesthesia exposure, Medical News Today, August 5

Abnormal brain circuits may prevent movement disorder, EurekAlert, August 4

Other News

Joint research into an enzyme that causes genetic diseases, Medical News Today, August 6

Boost for genetics, Otago Daily Times, August 4

New genomic resources and databases, PHG Foundation, August 4

Gene transcribing machine takes halting, backsliding trip along the DNA, Medical News Today, July 31

New journal devoted to gene therapy and human genetics, News-Medical.Net, July 31

New training and education programme introduced for the scientific workforce in genetics, UK, Medical News Today, July 31

NHS faces genetics revolution by bringing scientists into clinics, Times Online, July 30

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Genomics in Scientific Literature

 

Family History

Genetic contribution to variation in atherothrombotic phenotypes in the Asian Indian population. The Indian Atherosclerosis Research Study
Rao VS, et al.
Thromb Haemost 2009;102(2):379-88

Lipid Profile, Low-Density Lipoprotein Oxidation and Ceruloplasmin in the Progeny of Families With a Positive History of Cardiovascular Diseases and/or Hyperlipidemia
Makedou KG, et al.
Angiology 2009 Jul

Implications of living with a strong family history of breast cancer
Maheu C
Can J Nurs Res 2009 Jun;41(2):100-12

Genetic Testing

Clinical validity and clinical utility of molecular-genetic laboratory testing
Brdicka R
Cas Lek Cesk 2009;148(1):10-5

Evaluating the Psychological Effects of Genetic Testing in Symptomatic Patients:  A Systematic Review
Vansenne F, et al.
Genet Test Mol Biomarkers 2009 Aug

Genome Wide

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
Amundadottir L, et al.
Nat Genet 2009 Aug

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2
Song H, et al.
Nat Genet 2009 Aug

Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
Wu X, et al.
Nat Genet 2009 Aug

Pharmacogenomics

Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment
Shimoyama S
J Gastroenterol Hepatol 2009 Jun;24(6):970-81

Pharmacogenetics of Solid Tumors. Directed Therapy in Breast, Lung, and Colorectal Cancer
Snozek CL, et al.
J Mol Diagn 2009 Jul

Genomic advances and their impact on clinical trial design
Mandrekar SJ & Sargent DJ
Genome Med 2009 Jul;1(7):69

Application of principal component analysis to pharmacogenomic studies in Canada
Visscher H, et al.
Pharmacogenomics J 2009 Aug

General Articles

DNA-driven nutritional therapy of inflammatory bowel disease
Lee G & Buchman AL
Nutrition 2009 Sep;25(9):885-91

Genotype-guided tamoxifen therapy: time to pause for reflection?
Lash TL, et al.
Lancet Oncol 2009 Aug;10(8):825-33

Genetic Aspects of Behavioral Neurotoxicology
Levin ED, et al.
Neurotoxicology 2009 Jul

The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Ober C & Chupp GL
Curr Opin Allergy Clin Immunol 2009 Jul

Genetics and epidemiology: asthma and infection
Bartlett NW, et al.
Curr Opin Allergy Clin Immunol 2009 Jul

Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases
Zhong H & Prentice RL
Genet Epidemiol 2009 Jul

Genomic electronic health records: opportunities and challenges
Al-Ubaydli M & Navarro R
Genome Med 2009 Jul;1(7):73

Genetic susceptibility to psoriasis: an emerging picture
Smith RL, et al.
Genome Med 2009 Jul;1(7):72

Statistical power of model selection strategies for genome-wide association studies
Wu Z & Zhao H
PLoS Genet 2009 Jul;5(7):e1000582

Genotyping whole-genome-amplified DNA from 3- to 25-year-old neonatal dried blood spot samples with reference to fresh genomic DNA
Hollegaard MV, et al.
Electrophoresis 2009 Jul;30(14):2532-5

Univariate/Multivariate Genome-Wide Association Scans Using Data from Families and Unrelated Samples
Zhang L, et al.
PLoS One 2009;4(8):e6502

Epigenetics of Endometriosis
Guo SW
Mol Hum Reprod 2009 Aug

Genetics terminology for respiratory physicians
Collins FA
Paediatr Respir Rev 2009 Sep;10(3):124-33

GWAS Meets Microarray: Are the Results of Genome-Wide Association Studies and Gene-Expression Profiling Consistent? Prostate Cancer as an Example
Gorlov IP, et al.
PLoS One 2009;4(8):e6511

HLA-G polymorphism in relation to expression, function and disease
Larsen MH & Thomas VF
Hum Immunol 2009 Jul

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

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