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| Thursday, November 6, 2008 |
Volume
21 Number 19 |
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| This weekly update provides information about the impact of human genomic research on disease prevention & population health. |
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 Prevalence Estimates of Selected
Gene Variants of the U.S. Population Published
CDC reports the first estimates of gene variant frequency for a nationally-representative sample of the U.S. population, including major racial and ethnic subgroups. This work may help us to understand how these gene variants influence health and disease outcomes.
Read more.
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New publication, Public Health Genomics Approach to Type 2 Diabetes, published in the November 2008 issue of Diabetes. Authors: Khoury MJ, Valdez R, Albright A. |
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New NIH webinar, Genome-Wide Association Studies: The Basics of the Science and Related Policies, on November 20, 2008. To participate, email nhgriecib@mail.nih.gov |
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The President's Council of Advisors on Science and Technology issues 2008 report on Priorities for Personalized Medicine (2008),
(7 MB) outlining priority areas and policy recommendations for personalized medicine. |
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New genetics fellowship position with CDC’s Division of Laboratory Systems in the National Center for Preparedness, Detection, and Control of Infectious Disease. |

- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Cancer |
11 genotypes that may increase esophageal cancer risk, Medical News Today, November 5 |
Genomic biomarkers for risk stratification in prostate cancer, Medical News Today, November 3 |
Scientists decode set of cancer genes, The New York Times, November 5 |
Taking a new look at the 'Jewish breast cancer gene', Haaretz.com, November 3 |
Just one mutated SMAD4 allele is enough to cause cancer, News-Medical.Net, November 4 |
Two lung cancer genes identified, MSNBC, November 2 |
Targeting epigenetic changes helps tackle MLL-AF4 leukemias, News-Medical.Net, November 4 |
Aetna tackles quality issues in genetic testing for breast cancer - promoting evidence-based approach, Medical News Today, October 31 |
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Other News |
Discover of gene behind specific language impairment, News-Medical.Net, November 6 |
Alternative splicing in genes more prevalent than previously believed, News-Medical.Net, November 2 |
Two more human genomes mapped, U.S. News & World Report, November 6 |
Scientists develop genome-wide platform to study how specialized proteins regulate RNA in living, intact cells, News-Medical.Net, November 2 |
Destruction of joints by arthritis: Genetic disorder sheds light on enzyme's role in bone metabolism, Medical News Today, November 5 |
The environment in which our genes live explored in new journal, Medical News Today, November 1 |
New program to help physicians understand role of DNA-based preventive medicine, EurekAlert, November 4 |
MYH9 gene variations help explain high rate of kidney disease in African-Americans, Medical News Today, October 31 |
Second toddler diagnosed with rare genetic
disorder, Yahoo News, November 3 |
Exploring patient preferences for personalized medicine, Medical News Today, October 31 |
Shedding light on genetic differences that cause a childhood eye disease, Medical News Today, November 3 |
UC San Diego biologists discover a motor protein that rewinds DNA, UCSanDiego News Center, October 30 |
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Analysis of gene-gene interactions
Moore JH
Curr Protoc Hum Genet 2008 Oct;Chapter 1:Unit 1.14
Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy
Nguyen TV, et al.
Curr Opin Endocrinol Diabetes Obes 2008 Dec;15(6):481-8
Patient Attitudes Toward Genotyping in an Urban Women's Health Clinic
Haas DM, et al.
Obstet Gynecol 2008 Nov;112(5):1023-8
Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies
Duggal P, et al.
BMC Genomics 2008 Oct;9(1):516
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies
Keating BJ, et al.
PLoS ONE 2008;3(10):e3583
Clinical Impact of Genetic Studies in Lethal Inherited Cardiac Arrhythmias
Shimizu W
Circ J 2008 Nov
Gene by Environment Interaction in Asthma
London SJ & Romieu I
Annu Rev Public Health 2008 Nov
Genetic determinants of hypertension: an update
Harrison M, et al.
Curr Hypertens Rep 2008 Dec;10(6):488-95
Risky individuals and the politics of genetic research into aggressiveness and violence
Pieri E & Levitt M
Bioethics 2008 Nov;22(9):509-18
Gene-environment interaction and the metabolic syndrome
Adamo KB & Tesson F
Novartis Found Symp 2008;293:103-19; discussion 119-27
Practice and public policy in the era of gene-environment interactions
Dodge KA
Novartis Found Symp 2008;293:87-97; discussion 97-102, 122-7
Gene-environment interaction in complex diseases: asthma as an illustrative case
Martinez FD
Novartis Found Symp 2008;293:184-92; discussion 192-7
Gene-environment interactions in environmental lung diseases
Kleeberger SR & Cho HY
Novartis Found Symp 2008;293:168-78; discussion 178-83
Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections
Kotb M, et al.
Novartis Found Symp 2008;293:156-65; discussion 165-7, 181-3
Gene-environment interactions in breast cancer
Chia KS
Novartis Found Symp 2008;293:143-50; discussion 150-5, 181-3
Role of gene-stress interactions in gene-finding studies
Snieder H, et al.
Novartis Found Symp 2008;293:71-82; discussion 83-6, 122-7
Genetically elevated C-reactive protein and ischemic vascular disease
Zacho J, et al.
N Engl J Med 2008 Oct;359(18):1897-908
The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts
Karvanen J, et al.
Genet Epidemiol 2008 Oct
Sensitivity and frequencies of dystrophin gene mutations in Thai DMD/BMD patients as detected by multiplex PCR
Sura T, et al.
Dis Markers 2008;25(2):115-21
Life Trajectories, Genetic Testing, and Risk Reduction Decisions in 18-39 Year Old Women at Risk for Hereditary Breast and Ovarian Cancer
Hamilton R, et al.
J Genet Couns 2008 Nov
Parents' Concern About Their Own and Their Children's Genetic Disease Risk: Potential Effects of Family History vs Genetic Test Results
Tarini BA, et al.
Arch Pediatr Adolesc Med 2008 Nov;162(11):1079-83
Genome-wide association scan of attention deficit hyperactivity disorder
Neale BM, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Nov
Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE
Bertram L, et al.
Am J Hum Genet 2008 Oct
Common 5p15.33 and 6p21.33 variants influence lung cancer risk
Wang Y, et al.
Nat Genet 2008 Nov
Lung cancer susceptibility locus at 5p15.33
McKay JD, et al.
Nat Genet 2008 Nov
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Cooper JD, et al.
Nat Genet 2008 Nov
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