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| Thursday, March 20, 2008 |
Volume
20 Number 12 |
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This weekly update provides information about the impact of human genomic research on disease prevention & population health. |
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Cancer |
Focus on the genetics of brain tumor formation identifies potential new neuronal tumor
suppressor, Medical News Today, March 18 |
Nuclear protein SATB1 triggers aggressive breast cancer, News-Medical.Net, March 17 |
One gene closer to understanding pancreatic
cancer, The New York Times, March 18 |
Innovative study finds alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC, Medical News Today, March 14 |
Breast cancer risk increased by gene variant, 
Medical News Today, March 17 |
DNA detectives find genetic markers for lung cancers most likely to recur, News-Medical.Net, March 13 |


| Ethics, Legal and Social Issues (ELSI) |
Genomic tests for use at home considered premature, Medical News Today, March 19 |
Rony Duncan on genetic testing and young
people, The University of Melbourne Voice, March 17 |
Family communication impacts attitude about genetic counseling/testing for breast cancer, EurekAert, March 18 |
Better regulation of home genetic tests needed, researchers urge, Science Daily, March 16 |
Is genetic testing ready for the public, WABC-TV, March 18 |
Will genetic screening become a way of life, ABC News, March 14 |
Genomic medicine coming: Health professionals, public unprepared, Science Daily, March 18 |
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Other News |
New Tool Reassesses Osteoporosis Risk, npr.org, March 20 |
Genotype foods still a decade from the shelves: experts, Food production daily.com, March 17 |
Europeans can now check out on-line the credentials of laboratories offering genetic tests, News-Medical.Net, March 19 |
Grant could help with Montville boy's disorder, Daily Record, March 17 |
Bone fractures and bone mineral density linked to gene variants, Medical News Today, March 18 |
No pain, no protection, Courant.com, March 17 |
Common gene variants linked to osteoporosis, Reuters Health, March 18 |
Lifetime award in genetics presented to Peter H. Byers by March of Dimes, Medical News Today, March 16 |
Gene targeting raises cure hopes, BBC News, March 18 |
UT-ORNL and UCSD researchers find promise in HIV 'switch', EurekAlert, March 16 |
Inbred Romanian community provides insight into genetic factors associated with vitiligo, News-Medical.Net, March 18 |
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The use of hierarchical models for estimating relative risks of individual genetic variants: An application to a study of melanoma
Capanu M, et al.
Stat Med 2008 Mar
Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience
Christensen KD, et al.
Genet Med 2008 Mar;10(3):207-14
The Hitchhiker's Guide to the Child Neurologist's Genetic Evaluation of Epilepsy
Grill MF, et al.
Semin Pediatr Neurol 2008 Mar;15(1):32-40
Testing informative missingness in genetic studies using case-parent triads
Guo CY, et al.
Eur J Hum Genet 2008 Mar
The HapMap: Charting a Course for Genetic Discovery in Neurological Diseases
Hardy J & Singleton A
Arch Neurol 2008 Mar;65(3):319-21
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
Pe'er I, et al.
Genet Epidemiol 2008 Mar
Large scale DNA sequencing: new challenges emerge-the 2007 Human Genome Variation Society scientific meeting
Oetting WS
Hum Mutat 2008 Mar
Genetic Polymorphisms and Human Aging: Association Studies Deliver
Melzer D
Rejuvenation Res 2008 Mar
Increased genetic counseling support improves communication of genetic information in families
Forrest LE, et al.
Genet Med 2008 Mar;10(3):167-72
Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers
Bradbury AR, et al.
Genet Med 2008 Mar;10(3):161-6
Models for predicting BRCA1 and BRCA2 mutations in Han Chinese familial breast and/or ovarian cancer patients
Rao NY, et al.
Breast Cancer Res Treat 2008 Mar
Family history as a predictor of uptake of cancer preventive procedures by women with a BRCA1 or BRCA2 mutation
Metcalfe KA, et al.
Clin Genet 2008 Mar
Adult Transition From At-Risk Drinking to Alcohol Dependence: The Relationship of Family History and Drinking Motives
Beseler CL, et al.
Alcohol Clin Exp Res 2008 Mar
| Genome-Wide Association Studies |
Genomewide association for schizophrenia in the CATIE study: results of stage 1
Sullivan PF, et al.
Mol Psychiatry 2008 Mar
Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia
Inada T, et al.
Pharmacogenet Genomics 2008 Apr;18(4):317-23
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the
HuGENet™ home page
For more information on HuGE, please visit the
HuGENet™ home page
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