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 Thursday, May 26, 2005     Volume 14   Number 21  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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web screenshotCDC's Office of Genomics and Disease Prevention (OGDP) is pleased to showcase the new design of our website. We hope these changes will provide easier navigation and we have also added several new features such as Popular Pages, Programs in Brief, and CDC sponsored meetings. Please feel free to send comments and suggestions to genetics@cdc.gov.

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CDC Announcements
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Newborn Screening for Cystic Fibrosis: Recommendations from the Centers for Disease Control and Prevention
(Editorial in the American Family Physician; April 15, 2005)

   
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Do we need genomic research for the prevention of diseases with environmental causes?
Khoury MJ et al. Am J Epidemiol (May 2005)
   
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HuGENet™ e-journal club
Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma
Boyapati, Sonia M et al.
Reviewed by Ajay Yesupriya
Emory University, Rollins School of Public Health
   
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HuGENet™ e-journal club
Type 2 Diabetes Mellitus and the Angiotensin-1 Converting Enzyme I/D Polymorphism
Stephens, JW et al.
Ridgely Fisk Green, Ph.D.
American Society of Human Genetics,
Pediatric Genetics Team, NCBDDD, CDC, Atlanta
Emory University, Rollins School of Public Health
   
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What's New in HuGENet™?
May, 2005

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Mormon records might help doctors” This reference links to a non-governmental website
(May 19) Big News Network reports, “Scientists plan to link the Mormon church's vast genealogical records with millions of medical files to create a database that might help unravel the genetics of certain diseases and disorders, University of Utah researchers said Wednesday.”

“Protein, called "eed," crucial to the regulation of genes in embryonic stem cells” This reference links to a non-governmental website
(May 26) News-Medical.net reports, “New research from University of North Carolina at Chapel Hill shows how a protein may be crucial to the regulation of genes in embryonic stem cells.”

“'Brown fat cells' hold clues for possible obesity treatments” This reference links to a non-governmental website
(May 26) News-Medical.net reports, “Joslin Diabetes Center scientists have discovered a group of genes that govern the genesis of calorie-burning fat cells. This discovery may lead to novel ways to treat obesity in humans.”

“Study supports the view that public concerns about genetic discrimination are substantial” This reference links to a non-governmental website
(May 25) News-Medical.net reports, “A new study - the largest to date of public attitudes about genetic discrimination - finds that 40 percent of people already undergoing genetic testing are worried that participation might affect their future insurance coverage.”

“Genpathway's Transcription Analysis Tech Helps Baylor College Find Breast Cancer Genes”
(May 25) GenomeWeb reports, Researchers at Genpathway and Baylor College of Medicine have used Genpathway's transcription analysis technology to identify genes involved in breast cancer, the San Diego-based company said today.”

“Father's age tied to miscarriage risk”
(May 25) Reuters reports, “ A couple's risk of having a pregnancy end in miscarriage appears to climb in tandem with the man's age, according to a new study.”

“Tailored treatments take aim at cancer” This reference links to a non-governmental website (last accessed 2/2008)
(May 25) USA Today reports, “ For all the wonders of modern medicine, experts say that some aspects of cancer care remain old-fashioned. Many diagnoses are still made with light microscopes — technology that's hundreds of years old, says Michael Heinrich, a professor at Oregon Health & Science University in Portland.”

“Teen girls with ADHD at higher risk of mental illness” This reference links to a non-governmental website (last accessed 2/2008)
(May 25) USA Today reports, “ Attention deficit/hyperactivity disorder (ADHD) is a serious problem for teenage girls, and those who have it appear to be at much higher risk for mental illness by age 17, a Harvard Medical School researcher reported Tuesday.”

“House Approves a Stem Cell Research Bill Opposed by Bush” This reference links to a non-governmental website
(May 24) The New York Times reports, “The House passed a bill on Tuesday to expand federal financing for embryonic stem cell research, defying a veto threat from President Bush, who appeared at the White House with babies and toddlers born of test-tube embryos and warned the measure "would take us across a critical ethical line."”

“MUHC Scientists describe genetic resistance to rampant virus, cytomegalovirus (CMV)” This reference links to a non-governmental website
(May 24) Medical News Today reports, “MUHC researchers have defined genetic resistance to the widespread virus, cytomegalovirus (CMV) - a member of the viral group that causes some of the world's most prevalent diseases, such as herpes, chicken pox and mononucleosis.”

“Building a Human Kinase Gene Repository” This reference links to a non-governmental website
(May 24) Science Daily reports, “Using the human genome sequence annotation, high-throughput cloning methodologies, and automation, a group at the Harvard Institute of Proteomics lead by Leonardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequence information of all identified human kinase genes and have built a gene repository for this gene class.”

“Studies focusing on fibromyalgia” This reference links to a non-governmental website
(May 23) MyDNA reports, “Fibromyalgia, a disorder characterized by chronic muscle pain and unusually high pain sensitivity, is the focus of two ongoing studies at UAB.”

“Human Cells Can "Silence" HIV Genes” This reference links to a non-governmental website
(May 23) Hum-MolGen reports, “For the first time, scientists have shown that humans use an immune defense process common in plants and invertebrates to battle a virus.”

“National Institute on Aging awards UCI $9 million to continue Alzheimer's disease research: New research projects include the study of age-related changes in the brain and the role of mitochondrial defects in causing Alzheimer's” This reference links to a non-governmental website
(May 23) The University of California, Irvine, reports, “The National Institute on Aging has awarded $9 million to UC Irvine to support research and pilot projects that focus on discovering the loss of cognitive function with age, understanding the mechanisms causing Alzheimer's disease and developing pioneering treatments.”

“A Surprising Leap on Cloning” This reference links to a non-governmental website
(May 23) The New York Times reports, “South Korean scientists stunned their rivals around the world last week by announcing that they had produced the first human embryos that were genetic matches for diseased or injured patients, and had done so by a highly efficient method that could bring further rapid advances in cloning.”

“Gene Keeps Neural Cells on Correct Developmental Path” This reference links to a non-governmental website
(May20) The Howard Hughes Medical Institute reports, “Embryonic stem cells with identical genomes grow into distinctive tissues, such as heart, bone, and brain.”

“Nuclear Integration of Genome-wide Transcriptional Programs in Development and Diseases of the Neuroendocrine System” This reference links to a non-governmental website
(May 19) The Howard Hughes Medical Institute reports, “Michael Rosenfeld's laboratory is investigating the molecular strategies that integrate the actions of specific signaling pathways and underlie development and diseases of the neuroendocrine system.”

“Stalking the invisible enemy” This reference links to a non-governmental website
(May 18) Big News Network reports, “Hospitals and law-enforcement officials may soon have a new weapon in the battle against the invisible perils of bioterrorism and deadly diseases like SARS, thanks to the work of a pair of University of Toronto researchers.”

“Umbilical Cord Stem Cells May Save Infants -They offer hope for those with Krabbe disease “
(May 18) HealthDay reports, “Umbilical cord blood stem cells can help save infants with the fatal genetic disorder Krabbe disease, researchers report in the May 19 issue of the New England Journal of Medicine.”

“Mapping of a Single Locus Capable Of Complementing the Defective Heterochromatin Phenotype of RS Cells” This reference links to a non-governmental website
(May 17) Hum-Mol Gen reports, “Roberts syndrome (RS) is a developmental disorder characterized by tetraphocomelia and a broad spectrum of additional clinical features.”

Disentangling Fetal and Maternal Susceptibility for Pre-Eclampsia” This reference links to a non-governmental website
(May 17) Hum-Mol Gen reports, “Described are the results of extensive genotyping of seven candidate genes previously reported as conferring susceptibility to pre-eclampsia.“

“Allan-Herndon-Dudley Syndrome and the Monocarboxylate Transporter 8 (MCT8) Gene” This reference links to a non-governmental website
(May 17) Hum-Mol Gen reports, “Allan-Herndon-Dudley syndrome was among the first of the X-linked mental retardation syndromes to be described (in 1944) and among the first to be regionally mapped on the X chromosome (in 1990).”

“Gene analysis predicts response to chemo” This reference links to a non-governmental website
(May 17) MyDNA reports, “A Mayo Clinic-led study has revealed a genetic biomarker that can predict which patients are most likely to experience unwanted side effects from one of the most commonly used and highly effective chemotherapy regimens designed to treat colorectal cancer.”

“US scientists push for go-ahead to genetically modify smallpox virus” This reference links to a non-governmental website
(May 16) The Guardian reports,” US scientists are awaiting World Health Assembly approval to begin experiments to genetically modify the smallpox virus, one of the most lethal organisms the planet has known.”

 
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Genomics in Scientific Literature
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Pharmacogenomics and the drug discovery pipeline: when should it be implemented?
Penny MA & McHale D
Am J Pharmacogenomics. 2005;5(1):53-62.

Do women in the community recognize hereditary and sporadic breast cancer risk factors?
Katapodi MC & Aouizerat BE
Oncol Nurs Forum 2005 May 10;32(3):617-23.

Cancer risk prediction models: a workshop on development, evaluation, and application
Freedman AN, et al.
J Natl Cancer Inst 2005 May;97(10):715-23

Alcohol and gene interactions
Whitfield JB
Clin Chem Lab Med 2005;43(5):480-7

The investigation of gene-environment interaction using case-control comparisons
Kellen E, et al.
Ned Tijdschr Geneeskd 2005 Apr;149(18):977-82

The genetics of atopic dermatitis: recent findings and future options
Hoffjan S & Epplen JT
J Mol Med 2005 May

Pediatric Disorders with Autonomic Dysfunction: What Role for PHOX2B?
Gaultier C, et al.
Pediatr Res 2005 May

Allele Frequencies and the r(2) Measure of Linkage Disequilibrium: Impact on Design and Interpretation of Association Studies
Wray NR
Twin Res Hum Genet 2005 Apr;8(2):87-94

Molecular genetics of multiple endocrine neoplasia types 1 and 2
Marx SJ
Nat Rev Cancer 2005 May;5(5):367-75

Is family history related to preventive health behaviors and medical management in breast cancer patients?
Madlensky L, et al.
Breast Cancer Res Treat 2005 Mar;90(1):47-54

Randomized Comparison of Group Versus Individual Genetic Education and Counseling for Familial Breast and/or Ovarian Cancer
Calzone KA, et al.
J Clin Oncol 2005 May;23(15):3455-64

What should we want to know about our future? A kantian view on predictive genetic testing
Heinrichs B
Med Health Care Philos 2005;8(1):29-37

 
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 25, 2005, there are HuGE articles in the following areas:

Gene Variant Frequency
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

 
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Upcoming Events
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British Society for Human Genetics Annual Conference
September 12 - 14, 2005 ~ York, United Kingdom

New this week

5th International Symposium on Inherited Diseases of the Pancreas
June 7 – 10, 2005 ~ Tampere, Finland

New this week

Genetics in Public Health
October 3- 14, 2005 ~ Goteborg, Sweden

New this week

Costing the Future: Genetics and Insurance
October 26, 2005 ~ London, United Kingdom

New this week 11th International Congress of Human Genetics This reference links to a non-governmental website
August 6 – 10, 2006 ~ Brisbane, Australia
 
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Let's Go Surfing
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GeneTests.org This reference links to a non-governmental website
This publicly funded medical genetics information resource developed for physicians, other healthcare providers, and researchers, is available at no cost to all interested persons.

HealthyNJ: Genetic Disorders Diseases & Conditions This reference links to a non-governmental website
HealthyNJ is a product of the University Libraries at the University of Medicine and Dentistry of New Jersey. The Consumer Health Information Task Force, comprised of librarians from each of the four UMDNJ Campus Libraries, developed the content of the website to meet the health care information needs of consumers, particularly the citizens of New Jersey.

Primary Immune Deficiency Foundation This reference links to a non-governmental website (last accessed 2/2008)
This website provides genetic information about primary immune deficiencies.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers  for Disease Control and Prevention.
Page last reviewed: May 26, 2005 (archived document)
Page last updated: November 2, 2007
Content Source: CDC's Office of Public Health Genomics