Genomics & Health Weekly Update
This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.
Thursday, November 19, 2009 Volume 23 Number 21
Spotlight
CDC, NIH, and Stakeholders Convene Successful Inaugural GAPPNet Meeting
Last month, CDC, NIH , and other stakeholders convened the inaugural meeting of the Genomic Applications in Practice and Prevention Network (GAPPNet) in Ann Arbor, Michigan, with more than 100 researchers and health professionals in attendance. This new collaborative initiative is working to effectively and responsibly move evidence-based genomic knowledge and applications into clinical and public health practice. Read more about the meeting and GAPPNet.
Announcements
- The Agency for Healthcare Research and Quality (AHRQ) releases new U.S. Preventive Services Task Force (USPSTF) guidelines on routine breast cancer screening for women. Family history of breast and/or ovarian cancer is one factor that may increase a woman’s risk. For more information, see CDC’s Web page on Breast and Ovarian Cancer and Family Health History. Read articles related to the new USPSTF guidelines in the November 17th issue of Annals of Internal Medicine.
- The Genetic Information Nondiscrimination Act (GINA) of 2008 goes into effect on November 21, 2009. Read guidelines for investigators. Read the fact sheet for researchers and health care professionals [PDF 35 KB].
- National Institutes of Health appoints Eric D. Green, MD, PhD, to be director of the National Human Genome Research Institute. Read the press release.
- The American College of Preventive Medicine now offers a continuing medical education program for primary care physicians to learn about genetic risk for diseases, genetic testing, and interventions. Learn more.
- CDC's Office of Public Health Genomics is seeking nominations for qualified individuals to serve on the EGAPP (Evaluation of Genomic Applications in Practice and Prevention) Working Group. The membership term will begin in February 2010. The deadline for nominations is December 15, 2009. Read more.
Genomics In The News
- The following are headlines from on-line news articles published during the past week.
- The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
- Free registration required for some articles.
Autoimmune Disorders
Researchers discover antibody receptor identity, propose renaming immune-system gene, Medical News Today, November 19
Cancer
Scientists find 'sibling' cancer genes work together to fight skin cancer, Medical News Today, November 17
Panel urges mammograms at 50, Not 40, The New York Times, November 16
Disease progression and survival of cervical cancer patients: genetic changes are important indicators, Medical News Today, November 13
Chronic Disease
Largest gene study in childhood IBD finds 5 new genes, Medical News Today, November 16
Diabetes
Low birth weight and diabetes have a common genetic background, Science Daily, November 13
Ethical, Legal, and Social Issues (ELSI)
Law seeks to ban misuse of genetic testing, The News York Times, November 15
Family History
Genetics: Family history and risk assessment, Nursing Times, November 17
Genetic Testing
Genetics: Genetic counseling, Nursing Times, November 17
Genetics: Genetic testing, Nursing Times, November 17
Neurological Disorders
New neuroimaging analysis technique identifies impact of Alzheimer's disease gene in healthy brains, Medical NewsToday, November 19
Study examines challenges of diagnosing neurofibromatosis type 1–like syndrome, EurekAlert, November 17
Researchers identify gene mutations underlying risk for most common form of Parkinson's disease, NIH News, November 16
Haematopoietic stem cell gene therapy for ALD, PHG Foundation, November 13
Personalized Medicine
Genome advances promise personalized medical treatment, Kansas City.com, November 18
Need medical treatment? Get it your way, chron.com, November 14
Obesity
Gene-diet interaction influencing BMI and obesity replicated in three independent studies, News-Medical.Net, November 18
Other News
Women at risk from vitamin A deficiency, EurekAlert, November 18
How Cells Tolerate DNA damage - MDC researchers identify start signal for cell survival program, Medical News Today, November 17
NIH appoints Eric D. Green, M.D., Ph.D. to be Director of the National Human Genome Research Institute, NIH News, November 17
Study links genetic variation to individual empathy, stress levels, Medical News Today, November 17
Second Annual Consumer Genetics Conference - The spotlight shines on Boston June 2-4, 2010, CNBC, November 16
Sequencing, sequencing, sequencing, Bio IT World, November 12
Genomics in the Scientific Literature
Cancer
Genome-wide Association Studies in Cancer - Current and Future Directions
Chung CC, et al.
Carcinogenesis 2009 Nov
Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors
Falchetti A, et al.
Genet Med 2009 Nov
Our changing view of the genomic landscape of cancer
Bell DW
J Pathol 2009 Nov
Steroid 5-{alpha}-Reductase Type 2 (SRD5a2) Gene Polymorphisms and Risk of Prostate Cancer: A HuGE Review
Li J, et al.
Am J Epidemiol 2009 Nov
Chronic Disease
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population
Asano K, et al.
Nat Genet 2009 Nov
Common variants at five new loci associated with early-onset inflammatory bowel disease
Imielinski M, et al.
Nat Genet 2009 Nov
Genome-wide association studies - A summary for the clinical gastroenterologist
Melum E, et al.
World J Gastroenterol 2009 Nov;15(43):5377-96
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
Barrett JC, et al.
Nat Genet 2009 Nov
Genetic mechanisms and modifying factors in hereditary hemochromatosis
Weiss G
Nat Rev Gastroenterol Hepatol 2009 Nov
Epigenomics
MicroRNAs and cancer epigenetics: a macrorevolution
Davalos V & Esteller M
Curr Opin Oncol 2009 Nov
The potential role of epigenetic therapy in multiple myeloma
Smith EM, et al.
Br J Haematol 2009 Nov
Ethical, Legal, and Social Issues (ELSI)
Attitude towards genetic testing for breast cancer susceptibility: a comparison of affected and unaffected women
Bruno M, et al.
Eur J Cancer Care (Engl) 2009 Nov
Family History
Age of onset in familial breast cancer as background data for medical surveillance
Brandt A, et al.
Br J Cancer 2009 Nov
Heredity, diet and lifestyle as determining risk factors for the esophageal cancer on Nanao Island in Southern China
Liu M, et al.
Fam Cancer 2009 Nov
Genetic Testing
Family Screening in Patients with Retinal Angiomatosis
Kreusel KM, et al.
Klin Monbl Augenheilkd 2009 Nov;226(11):939-43
Neurologic Conditions
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
Satake W, et al.
Nat Genet 2009 Nov
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Simon-Sanchez J, et al.
Nat Genet 2009 Nov
The genetics of Tourette syndrome: a review
O'Rourke JA, et al.
J Psychosom Res 2009 Dec;67(6):533-45
Newborn Screening
Newborn Population Screening for Classic Homocystinuria by Determination of Total Homocysteine from Guthrie Cards
Gan-Schreier H, et al.
J Pediatr 2009 Nov
Personalized Medicine
Enabling personal genomics with an explicit test of epistasis
Greene CS, et al.
Pac Symp Biocomput 2010:327-36
Progress towards personalized medicine
Bates S
Drug Discov Today 2009 Nov
Pharmacogenomics
Pharmacogenetics of breast cancer therapies
Hertz DL, et al.
Breast 2009 Oct;18S3:S59-S63
Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance: Part II
Zhou SF
Clin Pharmacokinet 2009;48(12):761-804
Respiratory Disease
A genome-wide association study on African-ancestry populations for asthma
Mathias RA, et al.
J Allergy Clin Immunol 2009 Nov
Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans
Wu H, et al.
J Allergy Clin Immunol 2009 Nov
Other
Alerting the general population to genetic risks: The value of health messages communicating the existence of genetic risk factors for public health promotion
Smerecnik CM, et al.
Health Psychol 2009 Nov;28(6):734-45
Comparing apples and oranges: equating the power of case-control and quantitative trait association studies
Yang J, et al.
Genet Epidemiol 2009 Nov
Genome-wide Association Studies and Human Disease: From Trickle to Flood
Visscher PM & Montgomery GW
JAMA 2009 Nov;302(18):2028-9
Reporting and evaluating genetic association studies
Peters SP
Respir Res 2009 Nov;10(1):109
HuGE
For this week's human genome epidemiology articles, please visit the HuGE Navigator.
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