Volume 33 Number 15 October 16-22, 2014About the Update
October 18-22 ~ San Diego, CA
An approach to pediatric exome and genome sequencing
Biesecker LG & Biesecker BB Curr Opin Pediatr 2014 Oct
Obstetrician-gynecologists' knowledge of sickle cell disease screening and management
Azonobi IC, et al. BMC Pregnancy Childbirth 2014 Oct;14(1):356
Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Society for the Study of Lung Cancer/Association of Molecular Pathologists guideline
Natasha B. Leighl, et al. JCO.2014.57.3055
ASCO: Molecular testing for all lung adenocarcinomas, by Nick Mulcahy, Medscape, Oct 13 [by free subscription only]
Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome
Esplen M, et al. Clin Genet 2014 Oct
Template for Reporting Results of HER2 (ERBB2) Biomarker Testing of Specimens From Patients With Adenocarcinoma of the Stomach or Esophagogastric Junction.
Bartley AN, et al. Arch Pathol Lab Med. 2014 Oct 2.
College of American Pathologists guidelines for reporting HER2 test results in gastric cancer
Whitney-Miller C & Hicks DG Arch Pathol Lab Med 2014 Oct
What black women know and want to know about counseling and testing for BRCA1/2
Adams I, et al. J Cancer Educ 2014 Oct
Family communication in a population at risk for hypertrophic cardiomyopathy
Batte B, et al. J Genet Couns 2014 Oct
Changes on the horizon for consumer genomics in the EU
Louiza Kalokairinou et al. Science, October 17, 2014
Clinical integration of next generation sequencing: a policy analysis
Kaufman D, et al. J Law Med Ethics 2014 Sep;42 Suppl 1:5-8
NIH issues genomic data sharing policy
Nat Biotechnol 2014 Oct;32(10):966
Personal genomics and gene editing revolutions beg for global regulatory rethink, by Meredith Knight, Genetic Literacy Project, Oct 14
Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility
Bradbury AR, et al. Genet Med 2014 Oct
Development of the clinical next-generation sequencing industry in a shifting policy climate.
Margaret A Curnutte et al. Nature Biotechnology, October 9, 2014
Dispositional optimism and perceived risk interact to predict intentions to learn genome sequencing results
Taber JM, et al. Health Psychol 2014 Oct
Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies
Pushpa Narayanaswami, et al. Neurology October 14, 2014 vol. 83 no. 16 1453-1463
Guideline offers direction in genetic testing for certain types of muscular dystrophy, Medical Xpress, Oct 13
Individual genetic and genomic variation: a new opportunity for personalized nursing interventions
Munro CL J Adv Nurs 2014 Oct
Patient reported outcomes and patient empowerment in clinical genetics services
McAllister M & Dearing A Clin Genet 2014 Oct
Perceptions and attitudes about genetic counseling among residents of a Midwestern rural area
Riesgraf RJ, et al. J Genet Couns 2014 Oct
Public health genomics education in post-graduate schools of hygiene and preventive medicine: a cross-sectional survey
Ianuale C, et al. BMC Med Educ 2014 Oct;14(1):213
Oral, capsulized, frozen fecal microbiota transplantation for relapsing clostridium difficile infection
Ilan Youngster, et al. JAMA, October 11, 2014
Ebola virus disease in the Democratic Republic of Congo
Gaël D. Maganga, et al. NEJM, October 15, 2014
UCSC Ebola genome browser now online to aid researchers' response to crisis, by Guy Lasnier, UCSC News, Oct 1
House fly genome deciphered in hunt for pest, pathogen control clues, GenomeWeb, Oct 14 [by free subscription only]
Research looks for genetic link to Valley Fever, by Alexandra Olgin, KJZZ, Oct 13
OMICtools: an informative directory for multi-omic data analysis
Henry VJ, et al. Database, Jul 2014.
Culture-independent diagnostic testing: have we opened Pandora's box for good?
Janda JM, Abbott SA. Diag Microbiol Infect Dis 2014; 80(3): 171–176.
Leading the way: driving the delivery of pathogen genomics into practice, by Moorthie S, Luheshi L., PHG Foundation, Sep 2014
Bioinformatics tools extracted from a typical mammalian genome project, by Mangan M., OpenHelix blog post, Oct 6
New developments of RNAi in Paracoccidioides brasiliensis: prospects for high-throughput, genome-wide, functional genomics
Goes T, et al. PLoS Negl Trop Dis 2014; 8(10): e3173.
Resolution threshold of current molecular epidemiology of diphtheria
Mokrousov I. Emerg Infect Dis, Nov 2014.
Evaluation of broad-range 16S rRNA PCR for the diagnosis of bloodstream infections: two years of experience
Hassan RM, et al. J Infect Dev Ctries 2014;8(10):1252-1258.
Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates
Sanchez-Buso L, et al. Nat Genet, Oct 5, 2014.
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Gire SK, et al. Science 2014; 345: 1369-1372.
Portrait of a killer: genome of the 2014 EBOV outbreak strain
Basler CF. Cell Host Microbe 2014; 16(4): 419–421.
Insights into the early epidemic spread of Ebola in Sierra Leone provided by viral sequence data
Stadler T, et al. PLoS Curr (Outbreaks), Oct 6, 2014.
Molecular characterization of enteroviruses including a new type EV-C99 isolated from Xinjiang students in Shandong, China in 2011
Tao Z, et al. Sci Rep, Oct 9, 2014.
Nodding syndrome—a new hypothesis and new direction for research
Colebunders R, et al. Int J Infect Dis 2014; 27: 74–77.
Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups
Bialek-Davenet S, et al. Emerg Infect Dis, Nov 2014.
A delicate balance: maintaining mutualism to prevent disease
Van Tyne D, et al. Cell Host Microbe 2014; 16(4): 425–427.
Re-appraisal of old and new diagnostic tools in the current management of chronic hepatitis B, by Bessone F., Medscape [by free subscription only]
Reappraisal of known malaria resistance loci in a large multicenter study
Malaria Genomic Epidemiology Network. Nat Genet, Sep 28, 2014.
Malaria severity influenced by five human genes, say researchers, by Paddock C., Medical News Today, Sep 29
Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages
Marr AK, et al. PLoS Pathog 10(10): e1004419.
A modified γ-retrovirus vector for X-linked severe combined immunodeficiency
Hacein-Bey-Abina S, et al. N Engl J Med 2014; 371:1407-1417.
Genomic pathogen surveillance in animals: An early warning system for future pandemics? By Dr Chris Rands, PHG Foundation, Oct 7
Newborn screening for sickle cell disease in Jamaica: A review - past, present and future
King L, et al. West Indian Med J 2014 Apr;63(2):151-4
Clinical evidence supporting pharmacogenomic biomarker testing provided in US Food and Drug Administration drug labels
Bo Wang, et al. JAMA Intern Med. October 13, 2014.
A call for accurate pharmacogenetic labeling: Telling it like it is.
Burke W, et al. JAMA Intern Med. 2014 Oct 13.
Clinical perspective on the Clinical Pharmacogenetics Implementation Consortium updated 2014 guidelines for CYP2D6 and codeine
Nicholson WT & Formea CM Clin Chem 2014 Oct
Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics
Sadhasivam S, et al. The Pharmacogenomics Journal 2014 Oct 14
Preemptive clinical pharmacogenetics implementation: Current programs in five United States medical centers
Dunnenberger HM, et al. Annu Rev Pharmacol Toxicol 2014 Oct
Differential utilization of expanded genetic screening tests in patients of reproductive ages from private and academic practices
Schoen C, et al. J Perinat Med 2014 Oct
Low utilization of prenatal and preimplantation genetic diagnosis in Huntington disease - risk discounting in preventive genetics
Schulman JD & Stern HJ Clin Genet 2014 Oct
Developments in global non-invasive prenatal testing (NIPT) market, by Dr Philippa BriceMonday, PHG Foundation, Oct 13
Critical appraisal and data extraction for systematic reviews of prediction modelling studies: The CHARMS checklist
Karel G. M. Moon et al. PLOS Medicine, October 14, 2014
Unravelling the genomic targets of small molecules using high-throughput sequencing
Rodriguez R, et al. Nat Rev Genet. 2014 Oct 14.
Woman's quest to uncover family history using DNA tests upturns her life, by Virginia Hughes, National Geographic, Oct 15
Can big data cure cancer? If big data is so helpful in health care, why aren't more hospitals using it efficiently? By Lindsey Cook, US News Oct. 15
Giant gene banks take on disease, by Erika Check Hayden, Nature News, Oct 14
Generating knowledge from healthcare practice, by Sarah Greene, PCORNet blog post, Oct 13
Genetic testing for Alzheimer’s—without revealing the results, The Wall Street Journal, Oct 13
Cloud computing is forcing a reconsideration of intellectual property, by Quentin Hardy, New York Times, Oct 11
How to cope with a positive genetic test result, U.S. News and World Health Report, Oct 10
Genetics explains why you drink so much coffee, by Carl Engelking, Discover Magazine, Oct 7
The diseaseome could take medicine beyond the genome, by Cynthia Graber, NOVA, PBS, Oct 9
MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data
Zou D, et al. Nucl. Acids Res. (2014) Nov 7
CDC authors are indicated in bold
The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG).
Chen RT, Carbery B, Mac L, Berns KI, Chapman L, Condit RC, Excler JL, Gurwith M, Hendry M, Khan AS, Khuri-Bulos N, Klug B, Robertson JS, Seligman S, Sheets R, Williamson AL; for the V3SWG. Vaccine. 2014 Oct 8. pii: S0264-410X(14)01303-6.
Oseltamivir-Resistant Influenza A(H1N1)pdm09 Viruses, United States, 2013–14
Margaret Okomo-Adhiambo, Alicia M. Fry, Su Su, Ha T. Nguyen, Anwar Abd Elal, Elizabeth Negron, Julie Hand, Rebecca J. Garten, John Barnes, Xu Xiyan, Julie M. Villanueva, Larisa V. GubarevaComments to Author , and 2013–14 US Influenza Antiviral Working Group Emerg Infect Dis Jan, 2015.
Comparative genomic analysis of genogroup 1 (Wa-like) rotaviruses circulating in the USA, 2006-2009.
Roy S, Esona MD, Kirkness EF, Akopov A, Kyle McAllen J, Wikswo M, Cortese MM, Payne DC, Parashar U, Gentsch JR, Bowen MD; National Rotavirus Strain Surveillance System; New Vaccine Surveillance System. Infect Genet Evol. 2014 Oct 6. pii: S1567-1348(14)00353-0.
The Update includes genomics and health impact news and publications, CDC announcements, reports, blogs, podcasts, and other products. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science. Features of the week are archived under the Genomics & Health Resources A to Z page. To receive the update electronically every week sign-up here.
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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC. Note that some links may become invalid over time.
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