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text: Genomics & Health Impact Update; background:a researcher thinking with DNA in background:a researcher thinking with DNA in background;pills forming a double helix;cancer cell with sequencing in background;a young woman looking depressed

Volume 33  Number 7  August 21-28, 2014About the Update


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Reports and Publications

Birth Defects & Child Health

mom looking at her baby

Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia
Michael R. DeBaun, et al. N Engl J Med 2014; 371:699-710 August 21, 2014

More blood for sickle cell anemia?
Martin H. Steinberg, N Engl J Med 2014; 371:775-776 August 21, 2014

Genetic testing and corresponding services among individuals with autism spectrum disorder (ASD)
Cuccaro ML, et al. Am J Med Genet A 2014 Aug

Somatic mutations in cerebral cortical malformations
Saumya S. Jamuar et al. New England Journal Medicine, August 20, 2014

Chronic Diseases

Infectious Diseases

an infected cell

Both Lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype dependent manner
Nordgren J, et al. Clin Infect Dis, Aug 5, 2014.

IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin
Meissner EG, et al. J Infect Dis 2014; 209 (11): 1700-1704.

A proteomics approach to the identification of plasma biomarkers for latent tuberculosis infection
Zhang X, et al. Diag Microbiol Infect Dis 2014; 79(4): 432-437.

Development and validation of a new HPV genotyping assay based on next-generation sequencing
Yi X, et al. Am J Clin Path 2014; 141: 796-804.

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes
Chewapreecha C, et al. PLoS Genet 2014; 10(8): e1004547.

Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Kirsten I. Bos, et al. Nature, August 20, 2014

Black plague modified human genes, no biotech needed, by Ben Locwin, Genetic Literacy Project, Aug 21

Therapeutic prospects for CRISPR genome editing, by Dr Philippa Brice, PHG Foundation, Aug 21

Real time genomic epidemiology comes to England, by Dr Leila Luheshi, PHG Foundation, Aug 20

Resistance genes mapped
Nature, Aug 13, 2014.

Unveiling viral–host interactions within the ‘microbial dark matter’.
Manuel Martínez-García et al. Nature Communications, August 14, 2014

Microbiology: Microbiome science needs a healthy dose of scepticism, by William P. Hanage, Nature News, Aug 20

Public Health England Initiative for Infectious Disease Genomics,  by Catherine Arnold,   PHG Foundation, Aug 19 

Newborn Screening


Reviews, News & Commentaries

stacked papers

A new window into the genetics of complex diseases
Linda Koch Nature Reviews Genetics, August 20, 2014

A review of the role of electronic health record in genomic research
Krishnamoorthy P, et al. J Cardiovasc Transl Res 2014 Aug

Genotype–phenotype correlation — Promiscuity in the era of next-generation sequencing
James T. Lu, et al.  N Engl J Med 2014; 371:593-596August 14, 2014

Genotype/phenotype correlation, disease discoveries shaken up by next generation sequencing, Medical News Today, Aug 15

Massive schizophrenia genomics study offers new drug directions
Elie Dolgin Nature Reviews Drug Discovery. August 18, 2014

You are what you eat, but what about your DNA?
Martha Susiarjo, et al.  Science 15 August 2014:  Vol. 345 no. 6198 pp. 733-734.

10 reasons why genetic testing is important, I have Lynch Syndrome Blog Post, Aug 20

Medi-Cal denies patients access to now-basic genetic tests, Jessica Carew Kraft, SF Gate, Aug 20

New horizons and future directions for epigenetics, by Susannah Locke, Genetic Literacy Project, Aug 20

Genes to pathways to drug targets, by Robert Plenge, Plenge Lab, Aug 20

Blood test that allegedly predicts suicide risk only looks promising in the media, not in science, by Cecile Janssens, Huffington Post, Aug 19

Cool videos: Myotonic dystrophy, by Dr. Francis Collins, NIH Director, NIH, Aug 19 

How one woman deciphered her own genetic mutation, Ed Yong, the Atlantic, Aug 19

Next-gen sequencing is a numbers game as technical and cost barriers fall, instrument firms move their systems into research and clinical markets, by Ann M. Thayer, CE &N, Aug 18

NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer, Aug 18

NIH Research Matters: Over 100 genetic sites tied to schizophrenia, Aug 18

NIH Research Matters: Gene linked to rare inflammatory disease in children, Aug 18

NIH Research Matters: Detecting human prion disease, Aug 18

How Ebola patients survived – Experts, Vanguard Report, Aug 18

A revolution in classifying cancer? Andre Goy, Onclive, Aug 18

Do gut bacteria rule our minds?  In an ecosystem within us, microbes evolved to sway food choices, by Jeffrey Norris, UCSF Aug 15

Our beautiful sons could die before us, Nick Taussig, The Guardian, Aug 15 

Taking the yuck out of microbiome medicine, by Carl Zimmer, National Geographic, Aug 15

Epigenetics by any other name? What epigenetics should and should not be, Epigenetics Guy blog post, Aug 13

Next generation sequencing shakes up genotype/phenotype correlation, disease discoveries, Medical Xpress, Aug 13

Gene sequence but not structure? The costs of excluding epigenetics from genomics, Nexus of Epigenetics blog, Aug 1

Tools and Databases

numbers on a grid

Cordova: web-based management of genetic variation data
Ephraim SS, et al. Bioinformatics 2014 Aug

Phen-Gen: combining phenotype and genotype to analyze rare disorders.
Javed A,, et al. Nat Methods. 2014 Aug 3.

Scientists develop genome-wide mutation hunting computational software for genomic medicine, Medical Xpress, Aug 19

Disease InfoSearch Database: locates quality information from a database of more than 13,000 conditions and thousands of support groups and foundations.

NCBI resources on genetic testing: Video webinar: MedGen, GTR, and ClinVar (June, 2014)

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CDC-Authored Genomics Publications

hand holding a pen on an article

CDC authors are indicated in bold

Rapid and sensitive approach to simultaneous detection of genomes of hepatitis A, B, C, D and E viruses
Kodani M, Mixson-Hayden T, Drobeniuc J, Kamili S. J Clin Virol. 2014 Jul 5.

Discovery and full genome characterization of a new SIV lineage infecting red-tailed guenons (Cercopithecus ascanius schmidti) in Kibale National Park, Uganda
Lauck M, Switzer WM, Sibley SD, Hyeroba D, Tumukunde A, Weny G, Shankar A, Greene JM, Ericsen AJ, Zheng H, Ting N, Chapman CA, Friedrich TC, Goldberg TL, O'Connor DH.
Retrovirology. 2014 Jul;11(1):55.

Understanding and improving health education among first-time parents of infants with sickle cell anemia in Alabama: A mixed methods approach.
Lebensburger JD, Grosse SD, Altice JL, Thierry JM, Ivankova NV. J Pediatr Hematol Oncol. 2014 Jul 28.

Identification and genetic characterization of Clostridium botulinum serotype A strains from commercially pasteurized carrot juice
Marshall KM, Nowaczyk L, Raphael BH, Skinner GE, Rukma Reddy N. Food Microbiol. 2014 Dec;44:149-55.

Genetic History of Hepatitis C Virus in Pakistan.
Rehman IU, Vaughan G, Purdy MA, Xia GL, Forbi JC, Rossi LM, Butt S, Idrees M, Khudyakov YE. Infect Genet Evol. 2014 Aug 12. pii: S1567-1348(14)00292-5.

Population-based association and gene by environment interactions in genetic analysis workshop 18.
Satten GA, Biswas S, Papachristou C, Turkmen A, König IR. Genet Epidemiol. 2014 Sep;38 Suppl 1:S49-56.

Molecular xenomonitoring using mosquitoes to map lymphatic filariasis after mass drug administration in American Samoa.
Schmaedick MA, Koppel AL, Pilotte N, Torres M, Williams SA, Dobson SL, Lammie PJ, Won KY. PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3087.

View previous CDC-authored publications

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About the Genomics & Health Impact Update

The Update includes genomics and health impact news and publications, CDC announcements, reports, blogs, podcasts, and other products. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  Features of the week are archived under the Genomics & Health Resources A to Z page. To receive the update electronically every week sign-up here.


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The CDC Office of Public Health Genomics makes available the above information as a public service only. The items in the update come from news articles and scientific articles and abstracts published during the past week. The headlines and lead sentences are exactly as they appear & do not necessarily reflect the opinions, recommendations, or endorsement by the CDC.  Note that some links may become invalid over time.


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