Genomics & Health Impact Update

Published by the Office of Public Health Genomics (OPHG), the Update includes CDC announcements, publications, blogs and other products. The Update also includes links to genomics and health impact news and publications. The Update features genomic tests, family history, programs and practice, policy and legislation and public health science.  To receive this update electronically every week sign-up here.

Thursday, July 26, 2012       Volume 29   Number 4

Spotlight

New Publication: Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice.
Kolor K, Duquette D, Zlot A, et al. Genet Med. 2012 Jul 19.

• New Blog Post: Think After You Spit: Personal Genomic Tests May Offer a Teachable Moment

---

Genomic Pulse

• Only a small percentage of people in the United States have used personal genomic tests that are available directly to consumers. People who have used these tests often shared the results with their healthcare provider. This underscores the importance of provider knowledge and evidence-based recommendations.  To find out more, click here
  

---

Announcements

• July 28^th is World Hepatitis Day
  • Find out about genes related to hepatitis from the HuGE Navigator Phenopedia
• New EGAPP sponsored evidence review - Multigene Panels in Prostate Cancer Risk Assessment [PDF 1.48 MB] - conducted by investigators at the McMaster University AHRQ Evidence-based Practice Center.

• July is National Hemochromatosis Awareness Month

---

Topics of the Week

Cancer

• A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis
  Wan YW, et al. Int J Oncol 2012 Jul

• Analytical sensitivity and stability of DNA methylation testing in stool samples  for colorectal cancer detection
  Bosch LJ, et al. Cell Oncol (Dordr) 2012 Jul

• Association between family history of prostate cancer and positive biopsies in a  Brazilian screening program
  Muller RL, et al. World J Urol 2012 Jul

• Individual and family characteristics associated with BRCA1/2 genetic testing in high-risk families
  Katapodi MC, et al. Psychooncology 2012 Jul

• Comprehensive molecular characterization of human colon and rectal cancer.
  Cancer Genome Atlas Network. Nature. 2012 Jul 18;487(7407):330-7.

  • Study shows colon and rectal tumors constitute a single type of cancer, Genome.gov, July 19
  • Genetic aberrations seen as path to stop colon cancer, The New York Times, July 18

Family History

• Maternal and paternal family history of type 2 diabetes differently influence lipid parameters in young nondiabetic Japanese women
  Sasaki K, et al. Environ Health Prev Med 2012 Jul

Evaluation of Genomic Tests

• Economic impact of a genetic test for cisplatin-induced ototoxicity
  Dionne F, et al. Pharmacogenomics J 2012 Aug;12(4):359

• Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial
  Hollands GJ, et al. BMJ 2012;345:e4708

• Impact of literacy and numeracy on motivation for behavior change after diabetes genetic risk testing.
  Vassy JL, O'Brien KE, Waxler JL, et al. Med Decis Making. 2012 Jul;32(4):606-15.

  • How individual genetic test disclosure may affect population health 
    Schapira MM Med Decis Making 2012 Jul;32(4):525-6
• Impact of genetic notification on smoking cessation: systematic review and pooled-analysis
  de Viron S, et al. PLoS One 2012;7(7):e40230

Genomics in Practice

• Genetics of dementia: Update and guidelines for the clinician
  Cohn-Hokke PE, et al. Am J Med Genet B Neuropsychiatr Genet 2012 Jul
  • Europe nears first approval for gene therapy treatment, Nature News, July 20
  • European agency backs approval of a gene therapy, The New York Times, July 20 [by free
    subscription only]
• The great gene-patent debate, Nature News, July 20
  • Circuit court re-hears Myriad case in wake of prometheus ruling, Genome Web, July 20 [by free subscription only]

Top of Page

---

CDC-Authored Genomics Publications

CDC authors are indicated in bold

View previous CDC-authored publications

Top of Page