Genomics & Health Weekly Update

This weekly update provides information about the impact of human genomic research on disease prevention & population health. Learn more about the Genomics & Health Weekly Update.

Thursday, September 2, 2010       Volume 25   Number 10

Spotlight

4^th National Conference on Genomics Announces Call for Abstracts

Abstracts will be accepted August 1-September 6, 2010 for the 4th National Conference on Genomics and Public Health, which will be held on December 8-10, 2010, in Bethesda, Maryland. The conference planning committee invites abstracts for both oral and poster presentation related to genomic and public health practice, knowledge synthesis, communication, global health, preparedness and response, and new development. Learn more about submitting an abstract. Learn more about the conference. Please note that the abstract submission deadline has been extended. Abstracts can be submitted online through midnight EST on Monday, September 6, 2010.

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Announcements

• NIH’s National Cancer Institute (NCI) and CDC’s Office of Public Health Genomics (OPHG) are collaborating on a newly added Public Health Genomics topic on the Cancer Control P.L.A.N.E.T. portal. They have also organized a cyber-seminar about “Genomics and Cancer Control: What to Know and What to Do” on September 14th, 2010 from 2:00 to 3:00 p.m. Register now.
• The HuGE Navigator, developed by OPHG, has a new look and a new feature called the Cancer GAMAdb database. This database was developed through a collaboration with NCI and allows users to search for genetic associations from meta analyses and genome-wide association studies. The HuGE Navigator also offers a new social networking feature using Google Friend Connect, which allows users to join networks, share information, and post comments.
• The Institutes of Medicine has released a summary report, The Value of Genetic and Genomic Technologies, following the Roundtable on Translating Genomic-Based Research for Health workshop held on March 22, 2010.  This report summarizes the diverse perspectives shared at the workshop on the value of genetic testing and its use in clinical practice.

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Genomics In The News

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Cancer

Microsoft excel-based algorithm predicts cancer prognosis, Medical News Today, September 2

Anti-cancer gene to be activated by researchers, Medical News Today, September 1

Hereditary cancers: Prevent them with surgery,  U.S. News and World Report, September 1

Cardiovascular Disease

Genetic variations in Y chromosome affect men's risk of coronary heart disease, News-Medical.Net, August 30

Diabetes

Genetic variations associated with development of end-stage kidney disease in Chinese patients with diabetes, Medical News Today, August 29

Genetic Testing

Current DTC genetic testing market smaller than expected, PHG Foundation, August 30

NIH plans to create new genetics testing registry of molecular diagnostics tests offered by clinical pathology laboratories, Dark Daily, August 30

DNA test flip-flop stirs debate at UC, SFGate, August 28

Researchers recruit kids at state fair for genetic study, MPR News, August 26

Infectious Disease

New genomic marker for tuberculosis may help identify patients who will develop the disease, EurekAlert, August 30

Neurologic Conditions

Gene mutations that express LRRK2 linked to increased risk of Parkinson's disease: Researchers, News-Medical.Net, September 2

Cause of Lou Gehrig's disease, Amyotrophic Lateral Sclerosis (ALS) linked to chromosome nine, Medical News Today, August 31

Genetic link to migraine found, in DNA variant on chromosome 8, Medical News Today, August 30

Rare gene for Mabry syndrome found with faster simulateneous genome analysis, Medical News Today, August 30

Scientists link genetic 'typos' to schizophrenia, The Globe and Mail, August 27

New Parkinson's gene is linked to immune system, Medical News Today, August 28

Obesity

Study: Exercise can counteract obesity genes, Time, August 31

Other

Third generation map of human genetic variation published, NIH News, September 1

Analysis of Ashkenazi Jewish genomes reveals diversity, history, Medical News Today, August 30

The first atomic view of a key genetic processes, Medical News Today, August 28

Yale team finds a genetic rarity: A mutation that restores health, EurekAlert, August 26

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Genomics in the Scientific Literature

Autoimmune Disease

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility
Pradhan V, et al.
J Postgrad Med 2010 Jul-2010 Sep;56(3):239-42

Cancer

Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair
Sterpone S & Cozzi R
J Nucleic Acids 2010;2010

Lung Cancer Genomic Signatures
Agullo-Ortuno MT, et al.
J Thorac Oncol 2010 Aug

Epigenomics

Proteomic investigation of epigenetics in neuropsychiatric disorders: A missing link between genetics and behavior?
Plazas-Mayorca MD & Vrana KE
J Proteome Res 2010 Aug

Genetic Testing

Awareness, Perceptions, and Provider Recommendation Related to Genetic Testing for Hereditary Breast Cancer Risk among At-Risk Hispanic Women: Similarities and  Variations by Sub-Ethnicity
Vadaparampil ST, et al.
J Genet Couns 2010 Aug

Preparation and validation of the first WHO international genetic reference panel for Fragile X syndrome
Hawkins M, et al.
Eur J Hum Genet 2010 Aug

Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II
Lee HC, et al.
Diagn Mol Pathol 2010 Sep;19(3):184-6

Statement of the ESHG on direct-to-consumer genetic testing for health-related purposes
Eur J Hum Genet 2010 Aug

Infectious Disease

Infectious diseases not immune to genome-wide association
de Bakker PI & Telenti A
Nat Genet 2010 Sep;42(9):731-2

Neurologic Conditions

Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study
Laaksovirta H, et al.
Lancet Neurol 2010 Aug

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
Shatunov A, et al.
Lancet Neurol 2010 Aug

Genome-wide association study of genetic loci and Alzheimer disease
Brown AM, et al.
JAMA 2010 Aug;304(8):858; author reply 858

Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Anttila V, et al.
Nat Genet 2010 Aug

Pharmacogenomics

Communicating Pharmacogenetic Research Results to Breastfeeding Mothers Taking Codeine: A Pilot Study of Perceptions and Benefits
Madadi P, et al.
Clin Pharmacol Ther 2010 Aug

Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions
Brousse G, et al.
Med Hypotheses 2010 Aug

Other

Communication of biobanks' research results: What do (potential) participants want?
Meulenkamp TM, et al.
Am J Med Genet A 2010 Aug

Genetics and women's health issues-The commitment of EMS to women scientists and  gender-associated disease topics
Witt KL, et al.
Environ Mol Mutagen 2010 Aug

Genome-wide association studies on IgE regulation: are genetics of IgE also genetics of atopic disease?
Weidinger S, et al.
Curr Opin Allergy Clin Immunol 2010 Oct;10(5):408-17

HuGE

For this week's human genome epidemiology articles, please visit the HuGE Navigator.

GAPP

For the most recent information on genomic applications in practice and prevention, please visit the GAPP Knowledge Base.

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