Cascade Testing to Identify FH Cases
Patient with a clinical diagnosis of FH (arrow down)
Has an FH gene mutation been identified? (double arrow down to "yes" or "no")
Yes = Use the mutation, and not LDL cholesterol measurements, to identify affected biological relatives.
No = Use specialized gender- and age-specific LDL cholesterol criteria to identify affected biological relatives.
Include at least first- and second-degree (and if possible, third-degree) biological relatives.
- Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: a long term cohort study. BMJ. 2008;337:a2423.
- Neil A, Cooper J, Betteridge J, et al Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J. 2008;29:2625-2633.