Genomics and Health

Breast and Ovarian Cancer: Family Health History and Genetic Testing

 

Family History Risk Categories in General Population of Women*

Average: 75 - 80 %

Moderate: 15 - 20 %

Strong: about 2%

 

*Breakdown estimated from multiple sources:

• Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Systematic Evidence Review for the U.S. Preventive Services Task Force
  Nelson HD, Huffman LH, Fu R, and Harris EL
  Ann Intern Med 2005 143: 362-379.
• Preliminary Estimates from the 2006 Michigan Behavioral Risk Factor Survey: Family History of Breast Cancer by Personal History
  Michigan Department of Community Health
• Referral for Cancer Genetics Consultation: A Review and Compilation of Risk Assessment Criteria
  Hampel H, Sweet K, Westman JA, Offit K, and Eng, C
  J Med Genet 2004 41:81-91
• Prevalence of Family History of Breast and Ovarian Cancer in a Single Primary Care Practice Using a Self-Administered Questionnaire
  Hughes KS, Roche C, Campbell CT, Siegel N, Salisbury L, Chekos A, et al.
  Breast J. 2003;9:19-25

 

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