Resources
Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease
Part IV:
CASE STUDIES: Using Human Genome Epidemiology Information to Improve Health
Chapter 22 Tables
Immunogenetic Factors in Chronic Beryllium Disease
Erin C. McCanlies, Michael E. Andrew, Ainsley Weston
Table 22-1
Some Uses of Beryllium
Industry Uses |
Application |
Current (C) / Discontinued (D) |
|---|---|---|
Aerospace |
Engines Braking systems Structures Rockets Satellites Gyroscopes Precision tools Mirrors (Hubble telescope) |
D D C C C C C C |
Telecommunications |
Undersea repeater housings Cell phones Personal computers Transistor mountings |
C C C C |
Energy/electrical |
Relays and switches Microelectronics Microwave devices Nuclear reactors Fluorescent lights |
C C C C D |
Biomedical |
X-ray tube window Scanning electron microscope Dental prostheses (Crowns, bridges and partial dentures) |
C C C |
Defense |
Tank mirrors Springs on submarine hatches Nuclear triggers Missile guidance Mast mounted sights |
C C C C C |
Fire prevention |
Non-sparking tools Sprinkler system springs |
C C |
Other |
Plastic molds Laser tubes Bellows (CuBe) Springs Formula 1 race car brakes Valve seats (drag racer engines) Air-bag triggers Jewelry (gems) Jewelry (rings) Golf clubs Bicycle framesa Camera shutters Pen clips |
C |
aVery limited use.
[back to chapter]
Table 22-2
Summary of HLA-DPB1 Genotyping Results
Allele/Marker |
Cases |
Controls |
OR (95% CI) |
|---|---|---|---|
D55, E56 (+) |
26 |
18 |
|
D55, E56 (-) |
7 |
26 |
5.4 (1.7 - 17.6) |
E69 (+) |
32 |
12 |
|
E69 (-) |
1 |
32 |
85.3 (10.9 - 3,578.0) |
*0201 (+) |
10 |
4 |
|
*0201 (-) |
23 |
40 |
4.3 (1.1 - 20.8) |
*0401 (+) |
5 |
21 |
|
*0401 (-) |
28 |
23 |
0.2 (0.05 - 0.7) |
Total (77) |
33 |
44 |
Source: From Richeldi et al., 1993(1).
Table 22-3
Odds of Chronic Beryllium Disease Associated with Machining Beryllium and Presence or Absence of HLA-DPB1E69*
Allele/Marker |
Cases |
Controls |
OR (95% CI) |
|---|---|---|---|
Machining (+) |
5 |
42 |
|
Machining (-) |
1 |
79 |
10.1 (1.1 - 93.7) |
E69 (+) |
5 |
36 |
|
E69 (-) |
1 |
85 |
85.3 (10.9 - 3,578.0) |
* Reference No.2
Table 22-4
Disease Prevalence by HLA-DPB1E69* Machining
E69/Machining |
Cases (N=6)* |
Controls (N=121) |
Prev. (95% CI)† |
|---|---|---|---|
-/- |
0 |
55 |
0.00 (0.00 - 0.06) |
-/+ |
1 |
30 |
0.03 (0.00 - 0.17) |
+/- |
1 |
24 |
0.04 (0.00 - 0.20) |
+/+ |
4 |
12 |
0.25 (0.07 - 0.52) |
Source: Reference No.2
Contact Us:
- CDC-INFO Contact Center
Phone: 800-232-4636 (800-CDC-INFO)
Hearing Impaired: 888-232-6348 - cdcinfo@cdc.gov
- Additional information for Public Health Genomics is available on our contact page.
