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U.S. Genome Variation Estimates

XRCC1 Allele and Genotype Frequencies

Available polymorphism(s)

  Common Designations  

rs number

Nucleotide change Amino acid

Genotyping method

rs1001581

IVS2-216G>A

 

MGB Eclipse

rs1799782

Ex6-22C>T

Arg194Trp

TaqMan

rs25486

IVS9-59A>G

 

TaqMan

rs25487

Ex10-4G>A

Arg399Gln

TaqMan

rs25489

Ex9+16G>A

Arg280His

TaqMan

 

Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1001581 A G   AA AG GG    
Non-Hispanic White 39.9 (38.0, 41.9) 60.1 (58.1, 62.0) <0.001 15.3 (13.6, 17.3) 49.2 (46.0, 52.4) 35.5 (32.5, 38.5) <0.001 0.69
Non-Hispanic Black 36.7 (34.9, 38.5) 63.3 (61.5, 65.1) 14.6 (13.1, 16.2) 44.2 (41.7, 46.7) 41.2 (38.6, 43.9) 0.20
Mexican American 30.2 (27.8, 32.7) 69.8 (67.3, 72.2) 9.2 (7.6, 10.9) 42.1 (38.8, 45.4) 48.8 (44.9, 52.6) 0.92
Total* 38.9 (37.5, 40.3) 61.1 (59.7, 62.5)   14.9 (13.6, 16.3) 47.9 (45.6, 50.2) 37.2 (35.0, 39.4)    
rs1799782 C T   CC CT TT    
Non-Hispanic White 95.0 (94.4, 95.7) 5.0 (4.3, 5.6) <0.001 90.4 (89.1, 91.6) 9.3 (8.1, 10.6) 0.3 (0.1, 0.8) <0.001 0.97
Non-Hispanic Black 93.8 (92.9, 94.7) 6.2 (5.3, 7.1) 88.2 (86.6, 89.6) 11.3 (10.0, 12.6) 0.5 (0.2, 1.3) 0.13
Mexican American 85.2 (83.6, 86.7) 14.8 (13.3, 16.4) 73.0 (70.7, 75.1) 24.4 (23.0, 25.9) 2.6 (1.8, 3.8) 0.12
Total* 93.0 (92.3, 93.6) 7.0 (6.4, 7.7)   86.7 (85.6, 87.7) 12.6 (11.6, 13.7) 0.7 (0.5, 1.1)    
rs25486 A G   AA AG GG    
Non-Hispanic White 64.0 (62.2, 65.8) 36.0 (34.2, 37.8) <0.001 40.6 (37.4, 43.8) 46.9 (43.3, 50.5) 12.5 (11.0, 14.3) <0.001 0.70
Non-Hispanic Black 75.9 (73.7, 77.9) 24.1 (22.1, 26.3) 57.9 (54.9, 60.8) 35.9 (33.7, 38.3) 6.2 (4.7, 8.0) 0.26
Mexican American 74.2 (72.4, 76.0) 25.8 (24.0, 27.6) 55.3 (52.3, 58.3) 37.8 (35.4, 40.3) 6.9 (6.0, 7.9) 0.88
Total* 66.4 (65.1, 67.6) 33.6 (32.4, 34.9)   44.0 (41.8, 46.2) 44.7 (42.1, 47.2) 11.3 (10.1, 12.6)    
rs25487 A G   AA AG GG    
Non-Hispanic White 36.1 (34.3, 37.9) 63.9 (62.1, 65.7) <0.001 12.7 (11.1, 14.4) 46.9 (43.3, 50.5) 40.5 (37.3, 43.7) <0.001 0.67
Non-Hispanic Black 15.9 (14.4, 17.5) 84.1 (82.5, 85.6) 2.8 (2.0, 4.1) 26.1 (24.2, 28.2) 71.0 (68.6, 73.4) 0.16
Mexican American 25.6 (23.9, 27.5) 74.4 (72.5, 76.1) 6.8 (5.8, 7.8) 37.7 (35.3, 40.2) 55.5 (52.6, 58.4) 0.76
Total* 32.6 (31.2, 34.1) 67.4 (65.9, 68.8)   11.0 (9.8, 12.4) 43.3 (40.6, 46.0) 45.7 (43.2, 48.2)    
rs25489 A G   AA AG GG    
Non-Hispanic White 4.0 (3.3, 4.8) 96.0 (95.2, 96.7) <0.001 0.1 (0.0, 0.3) 7.8 (6.4, 9.4) 92.2 (90.5, 93.5) <0.001 0.99
Non-Hispanic Black 3.5 (2.9, 4.2) 96.5 (95.8, 97.1) 0.2 (0.1, 0.4) 6.5 (5.2, 8.0) 93.3 (91.8, 94.5) 0.25
Mexican American 12.4 (10.8, 14.2) 87.6 (85.8, 89.2) 1.6 (1.3, 2.1) 21.6 (18.8, 24.6) 76.8 (73.5, 79.8) 0.44
Total* 4.7 (4.0, 5.4) 95.3 (94.6, 96.0)   0.2 (0.2, 0.4) 8.8 (7.6, 10.2) 90.9 (89.6, 92.1)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1001581 A G   AA AG GG  
12-19 36.0 (31.7, 40.5) 64.0 (59.5, 68.3) 0.360 13.4 (10.7, 16.5) 45.2 (39.7, 50.8) 41.4 (34.9, 48.3) 0.539
20-39 39.7 (37.4, 42.0) 60.3 (58.0, 62.6) 14.8 (12.7, 17.2) 49.8 (46.4, 53.2) 35.4 (32.2, 38.8)
40-59 39.1 (36.3, 41.9) 60.9 (58.1, 63.7) 15.7 (13.4, 18.4) 46.7 (42.9, 50.5) 37.6 (33.5, 41.8)
>=60 39.0 (37.1, 41.0) 61.0 (59.0, 62.9) 15.1 (12.7, 17.9) 47.8 (43.3, 52.3) 37.1 (33.8, 40.4)
Total 38.9 (37.5, 40.3) 61.1 (59.7, 62.5)   14.9 (13.6, 16.3) 47.9 (45.6, 50.2) 37.2 (35.0, 39.4)  
rs1799782 C T   CC CT TT  
12-19 91.9 (89.9, 93.6) 8.1 (6.4, 10.1) 0.683 84.7 (81.0, 87.8) 14.4 (11.4, 18.1) 0.8 (0.3, 2.1) 0.244
20-39 93.1 (91.9, 94.0) 6.9 (6.0, 8.1)   86.7 (84.5, 88.6) 12.8 (10.9, 14.9) 0.6 (0.3, 1.0)
40-59 93.2 (90.9, 95.0) 6.8 (5.0, 9.1)   87.4 (83.6, 90.4) 11.7 (9.1, 14.8) 1.0 (0.4, 2.2)
>=60 93.2 (91.9, 94.3) 6.8 (5.7, 8.1)   87.1 (84.6, 89.2) 12.2 (10.1, 14.8) 0.7 (0.3, 1.5)
Total 93.0 (92.3, 93.6) 7.0 (6.4, 7.7)   86.7 (85.6, 87.7) 12.6 (11.6, 13.7) 0.7 (0.5, 1.1)  
rs25486 A G   AA AG GG  
12-19 68.9 (64.1, 73.3) 31.1 (26.7, 35.9) 0.521 48.2 (42.3, 54.1) 41.4 (37.5, 45.4) 10.4 (7.1, 15.0) 0.335
20-39 66.0 (63.7, 68.3) 34.0 (31.7, 36.3) 42.8 (39.1, 46.6) 46.4 (42.3, 50.6) 10.8 (8.7, 13.2)
40-59 65.8 (63.2, 68.3) 34.2 (31.7, 36.8) 44.2 (40.4, 48.1) 43.1 (39.2, 47.1) 12.7 (10.3, 15.4)
>=60 66.1 (64.2, 68.0) 33.9 (32.0, 35.8) 43.3 (40.5, 46.1) 45.6 (42.3, 49.0) 11.0 (9.0, 13.5)
Total 66.4 (65.1, 67.6) 33.6 (32.4, 34.9)   44.0 (41.8, 46.2) 44.7 (42.1, 47.2) 11.3 (10.1, 12.6)  
rs25487 A G   AA AG GG  
12-19 29.4 (24.8, 34.5) 70.6 (65.5, 75.2) 0.281 9.5 (6.3, 14.1) 39.8 (36.1, 43.6) 50.7 (44.5, 56.9) 0.265
20-39 32.7 (30.4, 35.2) 67.3 (64.8, 69.6) 10.3 (8.2, 12.8) 44.9 (40.2, 49.7) 44.8 (40.7, 49.0)
40-59 33.6 (31.0, 36.2) 66.4 (63.8, 69.0) 12.7 (10.3, 15.4) 41.8 (37.6, 46.1) 45.5 (41.5, 49.6)
>=60 33.5 (31.5, 35.4) 66.5 (64.6, 68.5) 11.1 (8.8, 13.9) 44.7 (41.0, 48.5) 44.2 (41.3, 47.1)
Total 32.6 (31.2, 34.1) 67.4 (65.9, 68.8)   11.0 (9.8, 12.4) 43.3 (40.6, 46.0) 45.7 (43.2, 48.2)  
rs25489 A G   AA AG GG  
12-19 4.4 (3.4, 5.9) 95.6 (94.1, 96.6) 0.411 0.2 (0.0, 0.9) 8.5 (6.7, 10.8) 91.3 (88.8, 93.3) 0.392
20-39 5.2 (4.1, 6.6) 94.8 (93.4, 95.9) 0.2 (0.2, 0.3) 10.0 (7.8, 12.8) 89.8 (87.0, 92.0)
40-59 4.2 (3.2, 5.6) 95.8 (94.4, 96.8) 0.2 (0.1, 0.8) 7.9 (5.8, 10.7) 91.8 (89.1, 93.9)
>=60 4.3 (3.5, 5.3) 95.7 (94.7, 96.5) 0.4 (0.1, 1.0) 7.9 (6.1, 10.2) 91.7 (89.7, 93.4)
Total 4.7 (4.0, 5.4) 95.3 (94.6, 96.0)   0.2 (0.2, 0.4) 8.8 (7.6, 10.2) 90.9 (89.6, 92.1)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1001581 A G   AA AG GG  
Male 38.7 (36.4, 41.1) 61.3 (58.9, 63.6) 0.832 14.3 (12.2, 16.7) 48.9 (45.1, 52.7) 36.9 (33.3, 40.6) 0.518
Female 39.0 (37.3, 40.8) 61.0 (59.2, 62.7) 15.5 (14.1, 17.0) 47.0 (44.0, 50.1) 37.5 (34.6, 40.5)
Total 38.9 (37.5, 40.3) 61.1 (59.7, 62.5)   14.9 (13.6, 16.3) 47.9 (45.6, 50.2) 37.2 (35.0, 39.4)  
rs1799782 C T   CC CT TT  
Male 93.3 (92.0, 94.3) 6.7 (5.7, 8.0) 0.510 87.0 (84.8, 89.0) 12.4 (10.7, 14.4) 0.5 (0.3, 1.1) 0.684
Female 92.7 (91.7, 93.6) 7.3 (6.4, 8.3) 86.3 (84.8, 87.7) 12.7 (11.6, 13.9) 0.9 (0.4, 1.9)
Total 93.0 (92.3, 93.6) 7.0 (6.4, 7.7)   86.7 (85.6, 87.7) 12.6 (11.6, 13.7) 0.7 (0.5, 1.1)  
rs25486 A G   AA AG GG  
Male 65.7 (63.6, 67.7) 34.3 (32.3, 36.4) 0.356 43.1 (40.0, 46.2) 45.2 (41.6, 48.8) 11.7 (9.6, 14.2) 0.652
Female 67.0 (65.1, 68.9) 33.0 (31.1, 34.9) 44.9 (41.2, 48.7) 44.2 (39.9, 48.5) 10.9 (9.4, 12.6)
Total 66.4 (65.1, 67.6) 33.6 (32.4, 34.9)   44.0 (41.8, 46.2) 44.7 (42.1, 47.2) 11.3 (10.1, 12.6)  
rs25487 A G   AA AG GG  
Male 33.3 (31.1, 35.6) 66.7 (64.4, 68.9) 0.413 11.4 (9.2, 14.0) 43.8 (40.3, 47.4) 44.8 (41.6, 48.1) 0.714
Female 32.0 (30.0, 34.2) 68.0 (65.8, 70.0) 10.6 (9.1, 12.3) 42.9 (38.6, 47.2) 46.5 (42.6, 50.5)
Total 32.6 (31.2, 34.1) 67.4 (65.9, 68.8)   11.0 (9.8, 12.4) 43.3 (40.6, 46.0) 45.7 (43.2, 48.2)  
rs25489 A G   AA AG GG  
Male 4.6 (3.7, 5.8) 95.4 (94.2, 96.3) 0.984 0.3 (0.1, 0.6) 8.8 (6.8, 11.2) 91.0 (88.7, 92.8) 0.927
Female 4.7 (3.9, 5.5) 95.3 (94.5, 96.1) 0.2 (0.1, 0.4) 8.9 (7.5, 10.5) 90.9 (89.3, 92.3)
Total 4.7 (4.0, 5.4) 95.3 (94.6, 96.0)   0.2 (0.2, 0.4) 8.8 (7.6, 10.2) 90.9 (89.6, 92.1)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1001581 A G AA AG GG
Non-Hispanic White 12-19 34.9 (27.2, 43.4) 65.1 (56.6, 72.8) 12.0 (7.4, 18.9) 45.7 (38.9, 52.7) 42.3 (31.7, 53.6)
20-39 41.9 (39.0, 44.9) 58.1 (55.1, 61.0) 16.1 (13.0, 19.7) 51.7 (46.8, 56.5) 32.2 (28.2, 36.6)
40-59 40.3 (36.9, 43.7) 59.7 (56.3, 63.1) 16.1 (13.6, 19.1) 48.2 (43.1, 53.4) 35.6 (30.4, 41.2)
>=60 38.9 (37.3, 40.6) 61.1 (59.4, 62.7) 14.9 (12.3, 18.0) 48.1 (42.6, 53.6) 37.0 (33.5, 40.6)
Non-Hispanic Black 12-19 36.6 (33.4, 39.9) 63.4 (60.1, 66.6) 14.5 (11.7, 17.8) 44.2 (38.7, 49.7) 41.3 (36.2, 46.6)
20-39 35.3 (32.1, 38.7) 64.7 (61.3, 67.9) 13.4 (11.3, 15.8) 43.9 (40.5, 47.3) 42.8 (38.1, 47.5)
40-59 36.0 (32.8, 39.3) 64.0 (60.7, 67.2) 14.6 (11.5, 18.3) 42.9 (38.0, 47.9) 42.5 (37.9, 47.3)
>=60 42.2 (37.1, 47.4) 57.8 (52.6, 62.9) 18.4 (13.6, 24.5) 47.5 (42.1, 53.0) 34.1 (28.1, 40.5)
Mexican American 12-19 31.4 (26.5, 36.7) 68.6 (63.3, 73.5) 8.7 (5.9, 12.8) 45.3 (36.8, 54.1) 45.9 (37.3, 54.8)
20-39 29.3 (26.6, 32.3) 70.7 (67.7, 73.4) 8.4 (6.5, 10.7) 41.9 (37.3, 46.7) 49.7 (44.9, 54.5)
40-59 30.6 (26.8, 34.7) 69.4 (65.3, 73.2) 10.9 (8.5, 13.9) 39.4 (33.2, 45.9) 49.7 (43.1, 56.4)
>=60 31.3 (27.5, 35.5) 68.7 (64.5, 72.5) 10.3 (7.8, 13.5) 42.1 (34.9, 49.8) 47.6 (40.5, 54.8)
rs1799782 C T CC CT TT
Non-Hispanic White 12-19 94.2 (91.0, 96.3) 5.8 (3.7, 9.0) 88.6 (82.2, 92.9) 11.1 (6.7, 17.9) 0.3 (0.0, 1.9)
20-39 95.9 (95.2, 96.6) 4.1 (3.4, 4.8) 92.1 (90.7, 93.4) 7.6 (6.4, 9.1) 0.3 (0.1, 0.8)
40-59 95.1 (92.5, 96.8) 4.9 (3.2, 7.5) 90.5 (86.1, 93.7) 9.1 (6.2, 13.1) 0.4 (0.0, 2.9)
>=60 93.9 (92.5, 95.1) 6.1 (4.9, 7.5) 88.2 (85.4, 90.5) 11.5 (9.2, 14.2) 0.3 (0.1, 1.2)
Non-Hispanic Black 12-19 94.2 (92.6, 95.5) 5.8 (4.5, 7.4) 89.4 (87.0, 91.4) 9.7 (7.8, 12.0) 0.9 (0.2, 3.4)
20-39 93.7 (92.3, 94.8) 6.3 (5.2, 7.7) 87.5 (84.9, 89.7) 12.3 (10.2, 14.7) 0.2 (0.0, 1.1)
40-59 92.6 (90.6, 94.3) 7.4 (5.7, 9.4) 86.0 (82.5, 88.9) 13.2 (10.4, 16.6) 0.7 (0.2, 3.5)
>=60 95.8 (94.1, 97.1) 4.2 (2.9, 5.9) 92.4 (89.3, 94.7) 6.8 (4.7, 9.7) 0.8 (0.4, 1.6)
Mexican American 12-19 86.8 (82.8, 90.0) 13.2 (10.0, 17.2) 75.5 (68.9, 81.2) 22.5 (17.3, 28.8) 1.9 (0.7, 5.5)
20-39 84.9 (82.4, 87.1) 15.1 (12.9, 17.6) 72.8 (69.2, 76.1) 24.3 (22.0, 26.9) 2.9 (1.7, 4.9)
40-59 85.4 (83.5, 87.1) 14.6 (12.9, 16.5) 72.3 (68.7, 75.7) 26.0 (22.7, 29.7) 1.6 (1.0, 2.5)
>=60 82.4 (76.6, 87.0) 17.6 (13.0, 23.4) 69.8 (61.0, 77.4) 25.2 (18.7, 33.2) 4.9 (2.4, 9.8)
rs25486 A G AA AG GG
Non-Hispanic White 12-19 67.7 (59.5, 74.9) 32.3 (25.1, 40.5) 46.5 (36.7, 56.5) 42.4 (36.9, 48.2) 11.1 (6.3, 18.7)
20-39 62.5 (59.5, 65.4) 37.5 (34.6, 40.5) 37.5 (33.0, 42.2) 50.0 (44.8, 55.2) 12.5 (9.7, 16.0)
40-59 63.9 (60.6, 67.1) 36.1 (32.9, 39.4) 41.5 (36.6, 46.6) 44.8 (39.6, 50.1) 13.7 (10.9, 17.0)
>=60 64.7 (62.9, 66.4) 35.3 (33.6, 37.1) 41.3 (38.3, 44.3) 46.8 (42.8, 50.9) 11.9 (9.7, 14.4)
Non-Hispanic Black 12-19 76.1 (73.3, 78.6) 23.9 (21.4, 26.7) 60.0 (56.3, 63.6) 32.2 (28.9, 35.6) 7.8 (5.6, 10.8)
20-39 77.5 (74.8, 80.0) 22.5 (20.0, 25.2) 60.1 (55.6, 64.5) 34.8 (31.1, 38.7) 5.1 (4.1, 6.4)
40-59 73.4 (70.4, 76.2) 26.6 (23.8, 29.6) 54.1 (50.1, 58.1) 38.6 (33.3, 44.2) 7.3 (4.2, 12.3)
>=60 74.8 (71.3, 78.0) 25.2 (22.0, 28.7) 55.0 (49.9, 60.0) 39.7 (35.6, 44.0) 5.3 (3.4, 8.3)
Mexican American 12-19 74.3 (69.8, 78.3) 25.7 (21.7, 30.2) 54.5 (47.8, 61.0) 39.7 (34.5, 45.0) 5.9 (3.8, 9.1)
20-39 74.7 (72.4, 76.9) 25.3 (23.1, 27.6) 55.8 (52.1, 59.4) 37.9 (34.4, 41.5) 6.4 (4.9, 8.2)
40-59 73.5 (70.0, 76.8) 26.5 (23.2, 30.0) 55.8 (49.3, 62.1) 35.4 (29.4, 41.9) 8.8 (7.6, 10.2)
>=60 73.2 (68.7, 77.2) 26.8 (22.8, 31.3) 53.6 (45.9, 61.1) 39.2 (31.4, 47.5) 7.2 (4.6, 11.1)
rs25487 A G AA AG GG
Non-Hispanic White 12-19 32.1 (24.7, 40.4) 67.9 (59.6, 75.3) 10.7 (6.1, 18.0) 42.8 (37.0, 48.8) 46.5 (36.4, 57.0)
20-39 37.2 (34.3, 40.2) 62.8 (59.8, 65.7) 12.3 (9.3, 15.9) 49.9 (44.4, 55.4) 37.9 (33.3, 42.6)
40-59 36.7 (33.8, 39.8) 63.3 (60.2, 66.2) 14.4 (11.7, 17.5) 44.7 (39.4, 50.1) 40.9 (36.1, 45.9)
>=60 35.6 (33.9, 37.3) 64.4 (62.7, 66.1) 12.2 (9.7, 15.1) 46.9 (42.4, 51.5) 40.9 (38.0, 43.9)
Non-Hispanic Black 12-19 16.6 (14.0, 19.6) 83.4 (80.4, 86.0) 4.1 (2.4, 6.8) 25.1 (20.5, 30.3) 70.8 (65.8, 75.4)
20-39 14.5 (12.5, 16.7) 85.5 (83.3, 87.5) 2.5 (1.6, 3.8) 24.0 (21.1, 27.2) 73.5 (69.9, 76.8)
40-59 17.1 (14.9, 19.5) 82.9 (80.5, 85.1) 2.5 (1.4, 4.4) 29.1 (24.9, 33.6) 68.4 (64.0, 72.5)
>=60 17.2 (13.8, 21.2) 82.8 (78.8, 86.2) 2.8 (1.2, 6.4) 28.8 (24.4, 33.6) 68.5 (62.5, 73.8)
Mexican American 12-19 25.9 (21.9, 30.4) 74.1 (69.6, 78.1) 6.0 (3.8, 9.3) 39.9 (35.5, 44.5) 54.1 (47.8, 60.3)
20-39 25.2 (23.2, 27.3) 74.8 (72.7, 76.8) 6.3 (4.9, 8.2) 37.7 (34.0, 41.6) 56.0 (52.3, 59.5)
40-59 25.8 (22.5, 29.4) 74.2 (70.6, 77.5) 7.9 (6.4, 9.8) 35.7 (29.7, 42.1) 56.4 (50.0, 62.6)
>=60 27.1 (23.3, 31.2) 72.9 (68.8, 76.7) 8.3 (5.5, 12.2) 37.6 (30.0, 45.8) 54.2 (46.9, 61.3)
rs25489 A G AA AG GG
Non-Hispanic White 12-19 3.9 (2.5, 6.0) 96.1 (94.0, 97.5) 0.0 (NA) 7.8 (5.0, 12.0) 92.2 (88.0, 95.0)
20-39 4.1 (3.1, 5.5) 95.9 (94.5, 96.9) 0.0 (NA) 8.3 (6.1, 11.1) 91.7 (88.9, 93.9)
40-59 3.8 (2.6, 5.7) 96.2 (94.3, 97.4) 0.1 (0.0, 0.5) 7.5 (5.0, 11.2) 92.4 (88.7, 95.0)
>=60 3.9 (3.1, 5.0) 96.1 (95.0, 96.9) 0.4 (0.1, 1.2) 7.1 (5.2, 9.8) 92.5 (90.1, 94.3)
Non-Hispanic Black 12-19 3.8 (2.5, 5.8) 96.2 (94.2, 97.5) 0.0 (NA) 7.6 (5.0, 11.6) 92.4 (88.4, 95.0)
20-39 3.4 (2.7, 4.3) 96.6 (95.7, 97.3) 0.4 (0.1, 1.6) 6.1 (4.7, 7.9) 93.5 (91.9, 94.9)
40-59 2.7 (1.9, 3.9) 97.3 (96.1, 98.1) 0.2 (0.0, 2.0) 4.9 (3.5, 6.9) 94.8 (92.7, 96.3)
>=60 4.6 (2.9, 7.3) 95.4 (92.7, 97.1) 0.1 (0.0, 1.0) 9.0 (5.5, 14.5) 90.9 (85.6, 94.4)
Mexican American 12-19 12.9 (9.6, 17.1) 87.1 (82.9, 90.4) 0.5 (0.1, 2.4) 24.8 (18.2, 32.8) 74.7 (66.7, 81.4)
20-39 13.2 (11.4, 15.3) 86.8 (84.7, 88.6) 2.2 (1.6, 3.0) 22.2 (19.4, 25.1) 75.7 (72.1, 78.9)
40-59 10.4 (8.5, 12.7) 89.6 (87.3, 91.5) 1.3 (0.7, 2.3) 18.3 (14.8, 22.3) 80.4 (76.2, 84.0)
>=60 11.6 (9.5, 14.2) 88.4 (85.8, 90.5) 2.3 (1.1, 4.6) 18.7 (15.2, 22.9) 79.0 (74.8, 82.7)

 

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1001581 A G AA AG GG
Non-Hispanic White Male 40.2 (37.1, 43.4) 59.8 (56.6, 62.9) 15.2 (12.4, 18.5) 50.1 (44.8, 55.5) 34.7 (29.8, 39.9)
Female 39.6 (37.3, 42.0) 60.4 (58.0, 62.7) 15.5 (14.0, 17.1) 48.3 (44.7, 51.8) 36.2 (32.5, 40.2)
Non-Hispanic Black Male 36.5 (34.3, 38.8) 63.5 (61.2, 65.7) 14.8 (13.0, 16.8) 43.5 (39.3, 47.9) 41.7 (37.8, 45.7)
Female 36.8 (35.0, 38.6) 63.2 (61.4, 65.0) 14.4 (12.5, 16.6) 44.7 (42.6, 46.9) 40.8 (38.7, 43.0)
Mexican American Male 30.2 (27.1, 33.4) 69.8 (66.6, 72.9) 8.6 (6.8, 11.0) 43.1 (37.9, 48.3) 48.3 (43.0, 53.7)
Female 30.2 (27.6, 33.0) 69.8 (67.0, 72.4) 9.7 (8.0, 11.7) 41.1 (37.4, 44.8) 49.2 (45.0, 53.5)
rs1799782 C T CC CT TT
Non-Hispanic White Male 95.7 (94.4, 96.8) 4.3 (3.2, 5.6) 91.6 (88.9, 93.7) 8.3 (6.2, 10.9) 0.1 (0.0, 0.6)
Female 94.4 (93.6, 95.1) 5.6 (4.9, 6.4) 89.2 (87.9, 90.5) 10.3 (9.1, 11.6) 0.5 (0.1, 1.4)
Non-Hispanic Black Male 93.2 (91.5, 94.7) 6.8 (5.3, 8.5) 87.3 (84.5, 89.7) 11.8 (9.7, 14.2) 0.9 (0.3, 2.6)
Female 94.3 (93.5, 95.0) 5.7 (5.0, 6.5) 88.9 (87.4, 90.2) 10.9 (9.6, 12.3) 0.3 (0.1, 0.9)
Mexican American Male 85.5 (83.5, 87.3) 14.5 (12.7, 16.5) 73.1 (69.9, 76.0) 24.7 (22.3, 27.3) 2.2 (1.3, 3.5)
Female 84.9 (82.8, 86.8) 15.1 (13.2, 17.2) 72.9 (69.7, 75.8) 24.1 (21.7, 26.7) 3.1 (2.0, 4.7)
rs25486 A G AA AG GG
Non-Hispanic White Male 62.8 (60.0, 65.7) 37.2 (34.3, 40.0) 39.4 (34.8, 44.2) 46.9 (41.7, 52.2) 13.7 (11.1, 16.7)
Female 65.1 (62.8, 67.4) 34.9 (32.6, 37.2) 41.7 (37.1, 46.4) 46.8 (41.7, 52.1) 11.5 (10.0, 13.1)
Non-Hispanic Black Male 75.3 (72.6, 77.8) 24.7 (22.2, 27.4) 56.8 (53.3, 60.3) 36.9 (34.5, 39.4) 6.3 (4.6, 8.5)
Female 76.3 (73.9, 78.6) 23.7 (21.4, 26.1) 58.7 (55.2, 62.2) 35.1 (31.9, 38.5) 6.1 (4.4, 8.4)
Mexican American Male 73.3 (70.6, 75.9) 26.7 (24.1, 29.4) 53.4 (48.9, 57.8) 39.9 (36.0, 43.8) 6.7 (5.6, 8.1)
Female 75.2 (73.3, 77.0) 24.8 (23.0, 26.7) 57.4 (54.4, 60.2) 35.7 (33.3, 38.1) 7.0 (6.0, 8.1)
rs25487 A G AA AG GG
Non-Hispanic White Male 37.3 (34.5, 40.1) 62.7 (59.9, 65.5) 13.8 (11.2, 16.8) 47.0 (42.1, 52.0) 39.2 (34.9, 43.8)
Female 35.0 (32.8, 37.2) 65.0 (62.8, 67.2) 11.6 (10.2, 13.2) 46.8 (41.7, 51.9) 41.6 (37.2, 46.2)
Non-Hispanic Black Male 16.3 (14.1, 18.7) 83.7 (81.3, 85.9) 3.0 (2.0, 4.6) 26.5 (23.4, 29.9) 70.5 (66.5, 74.1)
Female 15.6 (13.8, 17.5) 84.4 (82.5, 86.2) 2.6 (1.7, 4.1) 25.9 (23.0, 28.9) 71.5 (68.3, 74.5)
Mexican American Male 26.5 (24.1, 28.9) 73.5 (71.1, 75.9) 6.6 (5.4, 8.0) 39.8 (36.3, 43.4) 53.6 (49.6, 57.6)
Female 24.7 (22.7, 26.8) 75.3 (73.2, 77.3) 7.0 (5.9, 8.2) 35.5 (33.0, 38.1) 57.5 (54.3, 60.7)
rs25489 A G AA AG GG
Non-Hispanic White Male 3.9 (3.0, 5.2) 96.1 (94.8, 97.0) 0.1 (0.0, 0.5) 7.6 (5.6, 10.3) 92.3 (89.7, 94.3)
Female 4.0 (3.2, 5.0) 96.0 (95.0, 96.8) 0.1 (0.0, 0.4) 7.9 (6.3, 9.8) 92.0 (90.1, 93.7)
Non-Hispanic Black Male 2.9 (2.1, 4.0) 97.1 (96.0, 97.9) 0.3 (0.0, 1.7) 5.3 (3.8, 7.2) 94.4 (92.5, 95.9)
Female 4.0 (2.8, 5.6) 96.0 (94.4, 97.2) 0.2 (0.1, 0.8) 7.5 (5.0, 11.0) 92.3 (88.9, 94.7)
Mexican American Male 11.7 (10.0, 13.6) 88.3 (86.4, 90.0) 1.2 (0.7, 2.0) 21.0 (17.8, 24.5) 77.8 (74.2, 81.1)
Female 13.2 (10.9, 16.0) 86.8 (84.0, 89.1) 2.1 (1.4, 3.3) 22.2 (18.5, 26.5) 75.7 (70.9, 79.9)

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