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U.S. Genome Variation Estimates

TNF Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1800629

-487G>A
-308G>A

 

TaqMan

rs1800750

-555G>A

 

TaqMan

rs361525

-417G>A
 -238G>A

 

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800629 A G   AA AG GG    
Non-Hispanic White 17.2 (15.6, 19.0) 82.8 (81.0, 84.4) <0.001 2.9 (2.1, 4.0) 28.7 (26.1, 31.5) 68.4 (65.4, 71.3) <0.001 0.78
Non-Hispanic Black 13.1 (11.9, 14.5) 86.9 (85.5, 88.1) 1.8 (1.3, 2.5) 22.7 (20.8, 24.6) 75.5 (73.2, 77.7) 0.87
Mexican American 7.3 (5.9, 9.1) 92.7 (90.9, 94.1) 0.5 (0.3, 0.8) 13.6 (10.8, 16.9) 85.9 (82.5, 88.7) 0.88
Total* 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)    
rs1800750 A G   AA AG GG    
Non-Hispanic White 1.3 (0.9, 2.0) 98.7 (98.0, 99.1) 0.007 0.1 (0.0, 0.2) 2.5 (1.6, 3.9) 97.4 (96.0, 98.3) <0.001 <0.01
Non-Hispanic Black 2.3 (1.9, 2.9) 97.7 (97.1, 98.1) 0.1 (0.0, 0.3) 4.5 (3.6, 5.6) 95.4 (94.3, 96.3) 0.41
Mexican American 2.5 (2.1, 2.9) 97.5 (97.1, 97.9) 0.0 (NA) 5.0 (4.3, 5.7) 95.0 (94.3, 95.7) 0.22
Total* 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)    
rs361525 A G   AA AG GG    
Non-Hispanic White 5.8 (5.0, 6.6) 94.2 (93.4, 95.0) 0.005 0.7 (0.4, 1.1) 10.1 (8.9, 11.4) 89.2 (87.7, 90.5) 0.022 0.06
Non-Hispanic Black 4.1 (3.3, 5.2) 95.9 (94.8, 96.7) 0.1 (0.0, 0.6) 8.0 (6.4, 9.8) 91.9 (89.9, 93.5) 0.53
Mexican American 5.8 (5.2, 6.5) 94.2 (93.5, 94.8) 0.2 (0.1, 0.5) 11.2 (9.9, 12.6) 88.6 (87.2, 89.8) 0.20
Total* 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800629 A G   AA AG GG  
12-19 14.9 (12.1, 18.1) 85.1 (81.9, 87.9) 0.579 0.9 (0.3, 2.4) 27.9 (22.6, 33.8) 71.2 (65.1, 76.6) 0.004
20-39 15.8 (13.5, 18.5) 84.2 (81.5, 86.5) 2.8 (1.7, 4.6) 26.1 (22.4, 30.1) 71.1 (66.7, 75.1)
40-59 14.4 (12.4, 16.6) 85.6 (83.4, 87.6) 2.8 (2.0, 3.9) 23.1 (19.8, 26.9) 74.0 (70.1, 77.6)
>=60 16.1 (14.3, 18.0) 83.9 (82.0, 85.7) 2.1 (1.3, 3.5) 27.9 (24.5, 31.6) 70.0 (66.4, 73.3)
Total 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)  
rs1800750 A G   AA AG GG  
12-19 1.2 (0.6, 2.2) 98.8 (97.8, 99.4) 0.743 0.0 (NA) 2.3 (1.2, 4.4) 97.7 (95.6, 98.8) 0.103
20-39 1.6 (1.1, 2.3) 98.4 (97.7, 98.9) 0.1 (0.0, 0.5) 3.0 (2.1, 4.5) 96.9 (95.5, 97.8)
40-59 1.6 (1.0, 2.6) 98.4 (97.4, 99.0) 0.0 (NA) 3.2 (2.0, 5.3) 96.8 (94.7, 98.0)
>=60 1.8 (1.0, 3.4) 98.2 (96.6, 99.0) 0.2 (0.0, 0.9) 3.3 (1.7, 6.3) 96.5 (93.5, 98.2)
Total 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)  
rs361525 A G   AA AG GG  
12-19 5.2 (4.0, 6.7) 94.8 (93.3, 96.0) 0.277 0.0 (0.0, 0.3) 10.3 (7.9, 13.3) 89.7 (86.7, 92.0) <0.001
20-39 6.3 (5.1, 7.7) 93.7 (92.3, 94.9) 1.0 (0.6, 1.6) 10.6 (8.6, 13.0) 88.4 (85.9, 90.6)
40-59 4.8 (3.7, 6.2) 95.2 (93.8, 96.3) 0.4 (0.1, 1.3) 8.8 (6.8, 11.3) 90.8 (88.2, 92.9)
>=60 5.3 (4.0, 6.9) 94.7 (93.1, 96.0) 0.3 (0.1, 0.9) 10.1 (7.5, 13.4) 89.7 (86.4, 92.2)
Total 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800629 A G AA AG GG
Male 14.3 (12.5, 16.4) 85.7 (83.6, 87.5) 0.103 2.0 (1.3, 2.9) 24.7 (21.3, 28.5) 73.3 (69.5, 76.8) 0.233
Female 16.3 (14.6, 18.2) 83.7 (81.8, 85.4) 2.8 (2.0, 4.1) 26.9 (24.3, 29.8) 70.2 (67.1, 73.1)
Total 15.3 (14.0, 16.8) 84.7 (83.2, 86.0)   2.4 (1.8, 3.2) 25.9 (23.7, 28.2) 71.7 (69.2, 74.1)  
rs1800750 A G AA AG GG
Male 1.6 (1.2, 2.3) 98.4 (97.7, 98.8) 0.762 0.1 (0.0, 0.5) 3.2 (2.2, 4.5) 96.8 (95.5, 97.7) 0.887
Female 1.6 (1.1, 2.2) 98.4 (97.8, 98.9) 0.1 (0.0, 0.3) 2.9 (2.0, 4.2) 97.0 (95.7, 97.9)
Total 1.6 (1.2, 2.1) 98.4 (97.9, 98.8)   0.1 (0.0, 0.2) 3.0 (2.3, 4.1) 96.9 (95.8, 97.7)  
rs361525 A G AA AG GG
Male 5.0 (4.1, 6.0) 95.0 (94.0, 95.9) 0.050 0.3 (0.1, 0.9) 9.3 (7.8, 11.2) 90.4 (88.5, 92.0) 0.122
Female 6.0 (5.3, 6.9) 94.0 (93.1, 94.7) 0.8 (0.5, 1.3) 10.5 (9.3, 11.9) 88.7 (87.2, 90.0)
Total 5.5 (4.9, 6.2) 94.5 (93.8, 95.1)   0.5 (0.4, 0.8) 10.0 (8.8, 11.2) 89.5 (88.2, 90.7)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1800629 A G AA AG GG
Non-Hispanic White 12-19 16.8 (13.1, 21.3) 83.2 (78.7, 86.9) 0.7 (0.1, 4.8) 32.2 (25.1, 40.2) 67.1 (58.9, 74.3)
20-39 18.3 (15.3, 21.7) 81.7 (78.3, 84.7) 3.7 (2.1, 6.4) 29.2 (24.3, 34.6) 67.1 (61.5, 72.3)
40-59 16.4 (14.2, 18.7) 83.6 (81.3, 85.8) 3.3 (2.3, 4.6) 26.2 (22.6, 30.2) 70.5 (66.4, 74.4)
>=60 17.0 (15.0, 19.1) 83.0 (80.9, 85.0) 2.3 (1.3, 4.0) 29.3 (25.4, 33.4) 68.4 (64.5, 72.1)
Non-Hispanic Black 12-19 14.1 (11.5, 17.2) 85.9 (82.8, 88.5) 2.5 (1.2, 5.2) 23.3 (18.2, 29.3) 74.2 (68.6, 79.2)
20-39 14.1 (12.2, 16.3) 85.9 (83.7, 87.8) 1.8 (1.1, 2.9) 24.7 (21.8, 28.0) 73.5 (69.8, 76.9)
40-59 11.9 (10.2, 13.8) 88.1 (86.2, 89.8) 2.1 (1.1, 4.0) 19.6 (16.8, 22.8) 78.3 (75.1, 81.1)
>=60 11.0 (8.4, 14.3) 89.0 (85.7, 91.6) 0.6 (0.1, 2.7) 20.8 (16.3, 26.1) 78.6 (72.8, 83.4)
Mexican American 12-19 8.5 (5.2, 13.6) 91.5 (86.4, 94.8) 0.6 (0.1, 2.9) 15.8 (10.2, 23.6) 83.6 (74.9, 89.7)
20-39 6.8 (5.4, 8.7) 93.2 (91.3, 94.6) 0.1 (0.0, 1.0) 13.4 (10.5, 17.0) 86.5 (82.9, 89.4)
40-59 6.8 (4.9, 9.4) 93.2 (90.6, 95.1) 1.1 (0.6, 2.2) 11.3 (7.7, 16.3) 87.6 (82.6, 91.3)
>=60 8.6 (5.9, 12.2) 91.4 (87.8, 94.1) 0.9 (0.3, 2.9) 15.4 (10.6, 21.8) 83.8 (77.1, 88.8)
rs1800750 A G AA AG GG
Non-Hispanic White 12-19 1.0 (0.3, 2.8) 99.0 (97.2, 99.7) 0.0 (NA) 1.9 (0.7, 5.6) 98.1 (94.4, 99.3)
20-39 1.5 (0.9, 2.6) 98.5 (97.4, 99.1) 0.1 (0.0, 0.8) 2.8 (1.5, 5.1) 97.1 (94.9, 98.4)
40-59 1.2 (0.6, 2.6) 98.8 (97.4, 99.4) 0.0 (NA) 2.4 (1.1, 5.3) 97.6 (94.7, 98.9)
>=60 1.4 (0.8, 2.6) 98.6 (97.4, 99.2) 0.2 (0.1, 1.1) 2.3 (1.2, 4.5) 97.4 (95.3, 98.6)
Non-Hispanic Black 12-19 2.0 (1.2, 3.5) 98.0 (96.5, 98.8) 0.0 (NA) 4.1 (2.4, 6.9) 95.9 (93.1, 97.6)
20-39 3.0 (2.3, 4.1) 97.0 (95.9, 97.7) 0.2 (0.0, 0.8) 5.7 (4.3, 7.6) 94.1 (92.1, 95.6)
40-59 1.5 (0.8, 2.6) 98.5 (97.4, 99.2) 0.0 (NA) 2.9 (1.6, 5.3) 97.1 (94.7, 98.4)
>=60 2.1 (1.0, 4.5) 97.9 (95.5, 99.0) 0.0 (NA) 4.2 (1.9, 8.9) 95.8 (91.1, 98.1)
Mexican American 12-19 1.9 (1.3, 2.9) 98.1 (97.1, 98.7) 0.0 (NA) 3.9 (2.6, 5.7) 96.1 (94.3, 97.4)
20-39 2.2 (1.6, 3.2) 97.8 (96.8, 98.4) 0.0 (NA) 4.4 (3.1, 6.3) 95.6 (93.7, 96.9)
40-59 3.1 (1.9, 4.9) 96.9 (95.1, 98.1) 0.0 (NA) 6.1 (3.8, 9.8) 93.9 (90.2, 96.2)
>=60 3.9 (2.5, 6.0) 96.1 (94.0, 97.5) 0.0 (NA) 7.7 (4.9, 12.0) 92.3 (88.0, 95.1)
rs361525 A G AA AG GG
Non-Hispanic White 12-19 5.4 (3.9, 7.6) 94.6 (92.4, 96.1) 0.0 (NA) 10.9 (7.7, 15.2) 89.1 (84.8, 92.3)
20-39 7.1 (5.6, 8.9) 92.9 (91.1, 94.4) 1.4 (0.8, 2.4) 11.4 (9.0, 14.2) 87.3 (84.1, 89.9)
40-59 4.6 (3.4, 6.1) 95.4 (93.9, 96.6) 0.4 (0.1, 1.8) 8.4 (6.2, 11.2) 91.2 (88.4, 93.4)
>=60 5.3 (4.3, 6.5) 94.7 (93.5, 95.7) 0.3 (0.1, 1.1) 10.0 (7.9, 12.5) 89.7 (87.3, 91.8)
Non-Hispanic Black 12-19 5.1 (3.5, 7.4) 94.9 (92.6, 96.5) 0.0 (NA) 10.2 (7.0, 14.7) 89.8 (85.3, 93.0)
20-39 4.7 (3.6, 6.1) 95.3 (93.9, 96.4) 0.0 (NA) 9.3 (7.1, 12.1) 90.7 (87.9, 92.9)
40-59 3.1 (1.9, 5.0) 96.9 (95.0, 98.1) 0.5 (0.1, 2.5) 5.1 (3.1, 8.2) 94.4 (91.1, 96.4)
>=60 3.0 (1.7, 5.2) 97.0 (94.8, 98.3) 0.0 (NA) 6.0 (3.4, 10.3) 94.0 (89.7, 96.6)
Mexican American 12-19 5.5 (4.2, 7.0) 94.5 (93.0, 95.8) 0.4 (0.0, 2.9) 10.2 (7.9, 13.1) 89.4 (86.6, 91.7)
20-39 6.2 (5.2, 7.4) 93.8 (92.6, 94.8) 0.0 (NA) 12.4 (10.4, 14.8) 87.6 (85.2, 89.6)
40-59 5.1 (3.2, 8.1) 94.9 (91.9, 96.8) 0.6 (0.1, 2.5) 9.1 (5.9, 13.8) 90.4 (85.1, 93.9)
>=60 6.3 (4.6, 8.6) 93.7 (91.4, 95.4) 0.5 (0.1, 3.4) 11.6 (8.8, 15.0) 87.9 (84.1, 90.9)

 

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1800629 A G AA AG GG
Non-Hispanic White Male 16.2 (13.9, 18.7) 83.8 (81.3, 86.1) 2.4 (1.6, 3.6) 27.5 (23.4, 32.1) 70.1 (65.4, 74.4)
Female 18.3 (16.0, 20.8) 81.7 (79.2, 84.0) 3.4 (2.2, 5.2) 29.8 (26.4, 33.5) 66.8 (62.8, 70.6)
Non-Hispanic Black Male 11.7 (9.9, 13.8) 88.3 (86.2, 90.1) 1.1 (0.5, 2.2) 21.3 (18.3, 24.6) 77.6 (74.0, 80.9)
Female 14.3 (12.8, 16.0) 85.7 (84.0, 87.2) 2.4 (1.8, 3.3) 23.8 (21.6, 26.1) 73.8 (71.1, 76.3)
Mexican American Male 6.5 (4.8, 8.7) 93.5 (91.3, 95.2) 0.3 (0.1, 0.9) 12.3 (8.7, 17.0) 87.4 (82.8, 90.9)
Female 8.2 (6.7, 9.9) 91.8 (90.1, 93.3) 0.7 (0.3, 1.4) 15.0 (12.3, 18.2) 84.3 (81.0, 87.1)
rs1800750 A G AA AG GG
Non-Hispanic White Male 1.3 (0.9, 2.0) 98.7 (98.0, 99.1) 0.1 (0.0, 0.7) 2.5 (1.6, 3.8) 97.4 (96.1, 98.3)
Female 1.3 (0.7, 2.4) 98.7 (97.6, 99.3) 0.1 (0.0, 0.5) 2.5 (1.3, 4.6) 97.4 (95.4, 98.6)
Non-Hispanic Black Male 2.4 (1.7, 3.5) 97.6 (96.5, 98.3) 0.0 (NA) 4.9 (3.4, 7.0) 95.1 (93.0, 96.6)
Female 2.3 (1.7, 3.0) 97.7 (97.0, 98.3) 0.1 (0.0, 0.6) 4.2 (3.1, 5.7) 95.6 (94.1, 96.8)
Mexican American Male 2.6 (2.0, 3.2) 97.4 (96.8, 98.0) 0.0 (NA) 5.1 (4.0, 6.4) 94.9 (93.6, 96.0)
Female 2.4 (1.8, 3.2) 97.6 (96.8, 98.2) 0.0 (NA) 4.8 (3.6, 6.4) 95.2 (93.6, 96.4)
rs361525 A G AA AG GG
Non-Hispanic White Male 5.1 (4.2, 6.2) 94.9 (93.8, 95.8) 0.4 (0.1, 1.3) 9.5 (8.0, 11.3) 90.1 (88.2, 91.7)
Female 6.3 (5.4, 7.4) 93.7 (92.6, 94.6) 1.0 (0.6, 1.7) 10.7 (9.3, 12.2) 88.3 (86.6, 89.8)
Non-Hispanic Black Male 3.9 (3.0, 5.1) 96.1 (94.9, 97.0) 0.1 (0.0, 1.0) 7.6 (5.8, 10.0) 92.3 (89.9, 94.1)
Female 4.3 (3.2, 5.7) 95.7 (94.3, 96.8) 0.1 (0.0, 1.2) 8.3 (6.2, 10.9) 91.6 (88.9, 93.7)
Mexican American Male 5.2 (4.2, 6.5) 94.8 (93.5, 95.8) 0.1 (0.0, 0.8) 10.2 (8.1, 12.7) 89.7 (87.2, 91.8)
Female 6.5 (5.7, 7.4) 93.5 (92.6, 94.3) 0.4 (0.2, 0.7) 12.2 (10.6, 14.0) 87.4 (85.7, 89.0)

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