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TLR4 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs4986790

Ex4+636A>G

Asp299Gly

TaqMan

 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs4986790   A G   AA AG GG    
Non-Hispanic White 93.2 (92.5, 93.8) 6.8 (6.2, 7.5) <0.001 86.9 (85.7, 88.1) 12.5 (11.3, 13.8) 0.5 (0.3, 1.0) <0.001 0.50
Non-Hispanic Black 92.5 (91.8, 93.2) 7.5 (6.8, 8.2) 85.7 (84.3, 87.0) 13.7 (12.3, 15.2) 0.6 (0.3, 1.2) 0.73
Mexican American 97.5 (96.7, 98.2) 2.5 (1.8, 3.3) 95.1 (93.5, 96.4) 4.8 (3.6, 6.5) 0.0 (0.0, 0.2) 0.39
Total* 93.6 (93.0, 94.2) 6.4 (5.8, 7.0)   87.7 (86.5, 88.9) 11.8 (10.7, 13.1) 0.5 (0.3, 0.8)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4986790   A G   AA AG GG  
12-19 93.2 (91.2, 94.8) 6.8 (5.2, 8.8) 0.852 86.6 (82.6, 89.8) 13.3 (10.1, 17.3) 0.1 (0.0, 0.3) 0.013
20-39 93.5 (92.4, 94.4) 6.5 (5.6, 7.6) 87.7 (85.6, 89.6) 11.5 (9.6, 13.9) 0.7 (0.3, 1.7)
40-59 94.1 (92.6, 95.2) 5.9 (4.8, 7.4) 88.4 (85.5, 90.8) 11.3 (8.9, 14.2) 0.3 (0.1, 0.8)
>=60 93.5 (91.6, 95.0) 6.5 (5.0, 8.4) 87.4 (84.2, 90.1) 12.1 (9.8, 14.9) 0.5 (0.1, 1.7)
Total 93.6 (93.0, 94.2) 6.4 (5.8, 7.0)   87.7 (86.5, 88.9) 11.8 (10.7, 13.1) 0.5 (0.3, 0.8)  

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4986790   A G   AA AG GG  
Male 93.6 (92.3, 94.6) 6.4 (5.4, 7.7) 0.904 87.7 (85.2, 89.8) 11.8 (9.7, 14.3) 0.5 (0.2, 1.0) 0.953
Female 93.7 (93.1, 94.2) 6.3 (5.8, 6.9) 87.8 (86.7, 88.7) 11.8 (10.9, 12.8) 0.4 (0.2, 0.9)
Total 93.6 (93.0, 94.2) 6.4 (5.8, 7.0)   87.7 (86.5, 88.9) 11.8 (10.7, 13.1) 0.5 (0.3, 0.8)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs4986790     A G AA AG GG
Non-Hispanic White 12-19 92.6 (89.3, 94.9) 7.4 (5.1, 10.7) 85.1 (78.7, 89.9) 14.9 (10.1, 21.3) 0.0 (NA)
20-39 93.1 (91.8, 94.3) 6.9 (5.7, 8.2) 87.2 (84.6, 89.4) 11.9 (9.6, 14.8) 0.9 (0.3, 2.3)
40-59 93.5 (91.8, 94.8) 6.5 (5.2, 8.2) 87.2 (84.0, 89.9) 12.5 (9.8, 15.7) 0.3 (0.1, 0.9)
>=60 93.3 (91.2, 95.0) 6.7 (5.0, 8.8) 87.2 (83.6, 90.1) 12.2 (9.8, 15.2) 0.6 (0.2, 2.0)
Non-Hispanic Black 12-19 92.1 (89.9, 93.9) 7.9 (6.1, 10.1) 84.8 (80.4, 88.4) 14.5 (10.8, 19.3) 0.6 (0.2, 2.1)
20-39 91.8 (90.2, 93.1) 8.2 (6.9, 9.8) 84.3 (81.4, 86.8) 15.0 (12.5, 17.9) 0.7 (0.3, 1.9)
40-59 93.8 (91.8, 95.4) 6.2 (4.6, 8.2) 88.5 (85.0, 91.2) 10.7 (8.2, 13.8) 0.8 (0.3, 2.3)
>=60 93.1 (90.4, 95.1) 6.9 (4.9, 9.6) 86.2 (80.9, 90.2) 13.8 (9.8, 19.1) 0.0 (NA)
Mexican American 12-19 98.2 (96.3, 99.1) 1.8 (0.9, 3.7) 96.4 (92.7, 98.3) 3.6 (1.7, 7.3) 0.0 (NA)
20-39 97.3 (96.2, 98.0) 2.7 (2.0, 3.8) 94.6 (92.6, 96.1) 5.4 (3.9, 7.4) 0.1 (0.0, 0.4)
40-59 97.7 (94.8, 99.0) 2.3 (1.0, 5.2) 95.4 (89.8, 98.0) 4.6 (2.0, 10.2) 0.0 (NA)
>=60 97.2 (94.9, 98.5) 2.8 (1.5, 5.1) 94.7 (89.9, 97.2) 5.2 (2.6, 10.2) 0.2 (0.0, 1.4)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs4986790     A G AA AG GG
Non-Hispanic White Male 93.0 (91.6, 94.3) 7.0 (5.7, 8.4) 86.6 (83.8, 89.0) 12.8 (10.4, 15.7) 0.5 (0.2, 1.2)
Female 93.3 (92.5, 94.1) 6.7 (5.9, 7.5) 87.2 (85.8, 88.6) 12.2 (11.0, 13.6) 0.5 (0.3, 1.1)
Non-Hispanic Black Male 92.5 (91.3, 93.6) 7.5 (6.4, 8.7) 86.0 (83.5, 88.1) 13.2 (10.8, 15.9) 0.9 (0.4, 2.1)
Female 92.5 (91.6, 93.4) 7.5 (6.6, 8.4) 85.5 (83.7, 87.0) 14.1 (12.6, 15.8) 0.4 (0.2, 1.0)
Mexican American Male 98.0 (97.2, 98.6) 2.0 (1.4, 2.8) 96.0 (94.4, 97.2) 4.0 (2.8, 5.6) 0.0 (NA)
Female 97.1 (95.4, 98.1) 2.9 (1.9, 4.6) 94.2 (91.0, 96.3) 5.7 (3.6, 9.0) 0.1 (0.0, 0.4)

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