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U.S. Genome Variation Estimates

PPARG Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1801282

Ex4-49C>G

Pro12Ala

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801282 C G   CC CG GG    
Non-Hispanic White 86.8 (85.7, 87.8) 13.2 (12.2, 14.3) <0.001 75.8 (73.9, 77.6) 22.0 (20.2, 23.9) 2.2 (1.6, 3.0) <0.001 0.93
Non-Hispanic Black 97.5 (96.6, 98.1) 2.5 (1.9, 3.4) 95.0 (93.3, 96.3) 4.9 (3.7, 6.6) 0.0 (0.0, 0.4) 0.95
Mexican American 87.6 (86.6, 88.6) 12.4 (11.4, 13.4) 76.7 (75.0, 78.3) 21.8 (20.4, 23.4) 1.5 (1.0, 2.2) 0.79
Total* 88.4 (87.3, 89.4) 11.6 (10.6, 12.7)   78.5 (76.6, 80.3) 19.7 (18.0, 21.5) 1.8 (1.3, 2.4)    

 

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801282 C G   CC CG GG  
12-19 88.6 (85.6, 91.0) 11.4 (9.0, 14.4) 0.689 78.2 (73.0, 82.6) 20.8 (16.7, 25.5) 1.1 (0.3, 3.3) 0.050
20-39 88.0 (86.4, 89.5) 12.0 (10.5, 13.6) 78.7 (75.7, 81.4) 18.6 (15.8, 21.8) 2.6 (1.8, 3.8)
40-59 88.1 (85.8, 90.0) 11.9 (10.0, 14.2) 77.7 (73.8, 81.2) 20.7 (17.3, 24.7) 1.5 (0.7, 3.6)
>=60 89.3 (88.1, 90.4) 10.7 (9.6, 11.9) 79.4 (77.1, 81.6) 19.7 (17.4, 22.2) 0.9 (0.4, 1.8)
Total 88.4 (87.3, 89.4) 11.6 (10.6, 12.7)   78.5 (76.6, 80.3) 19.7 (18.0, 21.5) 1.8 (1.3, 2.4)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801282 C G CC CG GG
Male 88.6 (86.8, 90.1) 11.4 (9.9, 13.2) 0.713 79.3 (75.9, 82.3) 18.6 (15.6, 22.0) 2.1 (1.4, 3.1) 0.312
Female 88.2 (86.8, 89.4) 11.8 (10.6, 13.2) 77.8 (75.6, 79.8) 20.8 (19.0, 22.7) 1.4 (0.9, 2.4)
Total 88.4 (87.3, 89.4) 11.6 (10.6, 12.7)   78.5 (76.6, 80.3) 19.7 (18.0, 21.5) 1.8 (1.3, 2.4)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1801282 C G CC CG GG
Non-Hispanic White 12-19 86.5 (82.1, 90.0) 13.5 (10.0, 17.9) 74.5 (67.2, 80.6) 24.2 (18.6, 30.7) 1.4 (0.3, 5.6)
20-39 86.3 (84.2, 88.2) 13.7 (11.8, 15.8) 76.1 (72.5, 79.4) 20.4 (17.3, 24.0) 3.5 (2.4, 5.0)
40-59 86.4 (84.1, 88.5) 13.6 (11.5, 15.9) 74.7 (70.4, 78.7) 23.4 (19.2, 28.2) 1.9 (0.7, 4.5)
>=60 88.2 (86.8, 89.4) 11.8 (10.6, 13.2) 77.4 (74.7, 79.8) 21.6 (19.1, 24.5) 1.0 (0.5, 2.1)
Non-Hispanic Black 12-19 97.7 (95.5, 98.8) 2.3 (1.2, 4.5) 95.4 (91.1, 97.6) 4.6 (2.4, 8.9) 0.0 (NA)
20-39 97.4 (96.6, 98.0) 2.6 (2.0, 3.4) 94.9 (93.4, 96.1) 5.0 (3.8, 6.5) 0.1 (0.0, 0.9)
40-59 97.2 (95.6, 98.3) 2.8 (1.7, 4.4) 94.5 (91.3, 96.5) 5.5 (3.5, 8.7) 0.0 (NA)
>=60 98.0 (95.9, 99.0) 2.0 (1.0, 4.1) 95.9 (91.9, 98.0) 4.1 (2.0, 8.1) 0.0 (NA)
Mexican American 12-19 87.9 (84.7, 90.5) 12.1 (9.5, 15.3) 77.9 (73.0, 82.1) 20.0 (16.1, 24.6) 2.1 (0.7, 6.2)
20-39 87.0 (85.3, 88.5) 13.0 (11.5, 14.7) 75.6 (72.6, 78.3) 22.8 (20.2, 25.5) 1.7 (1.1, 2.6)
40-59 88.2 (86.6, 89.6) 11.8 (10.4, 13.4) 76.9 (73.8, 79.8) 22.5 (19.6, 25.7) 0.6 (0.2, 1.9)
>=60 89.2 (85.3, 92.2) 10.8 (7.8, 14.7) 79.6 (73.1, 84.8) 19.2 (14.3, 25.4) 1.2 (0.2, 7.0)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1801282 C G CC CG GG
Non-Hispanic White Male 86.9 (84.5, 88.9) 13.1 (11.1, 15.5) 76.4 (72.2, 80.2) 20.8 (17.1, 25.1) 2.7 (1.8, 4.1)
Female 86.7 (85.3, 88.1) 13.3 (11.9, 14.7) 75.2 (72.9, 77.3) 23.1 (21.1, 25.3) 1.7 (0.9, 3.2)
Non-Hispanic Black Male 97.2 (95.9, 98.1) 2.8 (1.9, 4.1) 94.6 (92.1, 96.3) 5.3 (3.7, 7.7) 0.1 (0.0, 0.8)
Female 97.7 (96.9, 98.3) 2.3 (1.7, 3.1) 95.4 (93.8, 96.6) 4.6 (3.4, 6.2) 0.0 (NA)
Mexican American Male 88.2 (86.2, 89.9) 11.8 (10.1, 13.8) 78.0 (74.7, 81.0) 20.4 (17.8, 23.3) 1.6 (1.1, 2.4)
Female 87.0 (85.1, 88.7) 13.0 (11.3, 14.9) 75.3 (72.1, 78.2) 23.4 (20.7, 26.3) 1.3 (0.6, 2.8)


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