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U.S. Genome Variation Estimates

PPARG Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1801282

Ex4-49C>G

Pro12Ala

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801282CGCCCGGG
Non-Hispanic White86.8 (85.7, 87.8)13.2 (12.2, 14.3)<0.00175.8 (73.9, 77.6)22.0 (20.2, 23.9)2.2 (1.6, 3.0)<0.0010.93
Non-Hispanic Black97.5 (96.6, 98.1)2.5 (1.9, 3.4)95.0 (93.3, 96.3)4.9 (3.7, 6.6)0.0 (0.0, 0.4)0.95
Mexican American87.6 (86.6, 88.6)12.4 (11.4, 13.4)76.7 (75.0, 78.3)21.8 (20.4, 23.4)1.5 (1.0, 2.2)0.79
Total*88.4 (87.3, 89.4)11.6 (10.6, 12.7)78.5 (76.6, 80.3)19.7 (18.0, 21.5)1.8 (1.3, 2.4)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801282CGCCCGGG
12-1988.6 (85.6, 91.0)11.4 (9.0, 14.4)0.68978.2 (73.0, 82.6)20.8 (16.7, 25.5)1.1 (0.3, 3.3)0.050
20-3988.0 (86.4, 89.5)12.0 (10.5, 13.6)78.7 (75.7, 81.4)18.6 (15.8, 21.8)2.6 (1.8, 3.8)
40-5988.1 (85.8, 90.0)11.9 (10.0, 14.2)77.7 (73.8, 81.2)20.7 (17.3, 24.7)1.5 (0.7, 3.6)
>=6089.3 (88.1, 90.4)10.7 (9.6, 11.9)79.4 (77.1, 81.6)19.7 (17.4, 22.2)0.9 (0.4, 1.8)
Total88.4 (87.3, 89.4)11.6 (10.6, 12.7)78.5 (76.6, 80.3)19.7 (18.0, 21.5)1.8 (1.3, 2.4)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801282CGCCCGGG
Male88.6 (86.8, 90.1)11.4 (9.9, 13.2)0.71379.3 (75.9, 82.3)18.6 (15.6, 22.0)2.1 (1.4, 3.1)0.312
Female88.2 (86.8, 89.4)11.8 (10.6, 13.2)77.8 (75.6, 79.8)20.8 (19.0, 22.7)1.4 (0.9, 2.4)
Total88.4 (87.3, 89.4)11.6 (10.6, 12.7)78.5 (76.6, 80.3)19.7 (18.0, 21.5)1.8 (1.3, 2.4)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1801282CGCCCGGG
Non-Hispanic White12-1986.5 (82.1, 90.0)13.5 (10.0, 17.9)74.5 (67.2, 80.6)24.2 (18.6, 30.7)1.4 (0.3, 5.6)
20-3986.3 (84.2, 88.2)13.7 (11.8, 15.8)76.1 (72.5, 79.4)20.4 (17.3, 24.0)3.5 (2.4, 5.0)
40-5986.4 (84.1, 88.5)13.6 (11.5, 15.9)74.7 (70.4, 78.7)23.4 (19.2, 28.2)1.9 (0.7, 4.5)
>=6088.2 (86.8, 89.4)11.8 (10.6, 13.2)77.4 (74.7, 79.8)21.6 (19.1, 24.5)1.0 (0.5, 2.1)
Non-Hispanic Black12-1997.7 (95.5, 98.8)2.3 (1.2, 4.5)95.4 (91.1, 97.6)4.6 (2.4, 8.9)0.0 (NA)
20-3997.4 (96.6, 98.0)2.6 (2.0, 3.4)94.9 (93.4, 96.1)5.0 (3.8, 6.5)0.1 (0.0, 0.9)
40-5997.2 (95.6, 98.3)2.8 (1.7, 4.4)94.5 (91.3, 96.5)5.5 (3.5, 8.7)0.0 (NA)
>=6098.0 (95.9, 99.0)2.0 (1.0, 4.1)95.9 (91.9, 98.0)4.1 (2.0, 8.1)0.0 (NA)
Mexican American12-1987.9 (84.7, 90.5)12.1 (9.5, 15.3)77.9 (73.0, 82.1)20.0 (16.1, 24.6)2.1 (0.7, 6.2)
20-3987.0 (85.3, 88.5)13.0 (11.5, 14.7)75.6 (72.6, 78.3)22.8 (20.2, 25.5)1.7 (1.1, 2.6)
40-5988.2 (86.6, 89.6)11.8 (10.4, 13.4)76.9 (73.8, 79.8)22.5 (19.6, 25.7)0.6 (0.2, 1.9)
>=6089.2 (85.3, 92.2)10.8 (7.8, 14.7)79.6 (73.1, 84.8)19.2 (14.3, 25.4)1.2 (0.2, 7.0)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1801282CGCCCGGG
Non-Hispanic WhiteMale86.9 (84.5, 88.9)13.1 (11.1, 15.5)76.4 (72.2, 80.2)20.8 (17.1, 25.1)2.7 (1.8, 4.1)
Female86.7 (85.3, 88.1)13.3 (11.9, 14.7)75.2 (72.9, 77.3)23.1 (21.1, 25.3)1.7 (0.9, 3.2)
Non-Hispanic BlackMale97.2 (95.9, 98.1)2.8 (1.9, 4.1)94.6 (92.1, 96.3)5.3 (3.7, 7.7)0.1 (0.0, 0.8)
Female97.7 (96.9, 98.3)2.3 (1.7, 3.1)95.4 (93.8, 96.6)4.6 (3.4, 6.2)0.0 (NA)
Mexican AmericanMale88.2 (86.2, 89.9)11.8 (10.1, 13.8)78.0 (74.7, 81.0)20.4 (17.8, 23.3)1.6 (1.1, 2.4)
Female87.0 (85.1, 88.7)13.0 (11.3, 14.9)75.3 (72.1, 78.2)23.4 (20.7, 26.3)1.3 (0.6, 2.8)


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